Reviewed, UniProtKB/Swiss-Prot Q7Z6G8 (ANS1B_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat and sterile alpha motif domain-containing protein 1B
Alternative name(s):
    Amyloid-beta protein intracellular domain-associated protein 1
      Short name=AIDA-1
    E2A-PBX1-associated protein
      Short name=EB-1

Gene names

Name:

ANKS1B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Ref.2 Ref.7 Isoform 3 can regulate global protein synthesis by altering nucleolar numbers By similarity. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. Ref.2 Ref.7
Subunit structure	Isoform 3 interacts with DLG4 By similarity. Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interacts with EPHA8.
Subcellular location	Cytoplasm. Isoform 2: Nucleus. Isoform 3: Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell projection › dendritic spine. Nucleus. Nucleus › Cajal body. Note: The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner By similarity. Isoform 4: Nucleus. Note: The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed. Ref.2 Ref.7 Ref.1 Isoform 6: Nucleus.
Tissue specificity	Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines. Ref.7 Ref.6
Induction	Transcriptionally up-regulated in t(1:19) pre-B cell acute lymphocytic leukemia by the chimeric TCF3-PBX1. Not expressed in pre-B cell that lack this translocation. Ref.6 Ref.8
Post-translational modification	Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage By similarity.
Sequence similarities	Contains 7 ANK repeats. Contains 1 PID domain. Contains 2 SAM (sterile alpha motif) domains.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Membrane Nucleus Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	Cajal body Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell dendritic spine Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z6G8-1)

Also known as: AIDA-1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z6G8-2)

Also known as: AIDA-1c;

The sequence of this isoform differs from the canonical sequence as follows:
     1-775: Missing.
     776-808: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     964-1023: Missing.
     1226-1249: DLLHASHTGQEPSERHTEEALRKF → QIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Isoform 3 (identifier: Q7Z6G8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-775: Missing.
     776-808: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     1023-1023: Q → QSSVCEIWTNQNAGFPFSAIHQVHN
     1226-1249: DLLHASHTGQEPSERHTEEALRKF → QIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Note: The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity).

Isoform 4 (identifier: Q7Z6G8-4)

Also known as: AIDA-1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-775: Missing.
     776-808: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     1226-1249: DLLHASHTGQEPSERHTEEALRKF → PFCFKADRPI

Note: The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed. Ref.2 Ref.7 Ref.1

Isoform 5 (identifier: Q7Z6G8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-775: Missing.
     776-808: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     964-1023: EPSGNHTPPQ...RSKLERQMAQ → SSVCEIWTNQNAGFPFSAIHQVHN
     1226-1249: DLLHASHTGQEPSERHTEEALRKF → QIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Isoform 6 (identifier: Q7Z6G8-6)

Also known as: AIDA-1bDeltaAnk;

The sequence of this isoform differs from the canonical sequence as follows:
     1-421: Missing.
     805-808: Missing.
     964-1023: Missing.

Isoform 7 (identifier: Q7Z6G8-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-775: Missing.
     776-808: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     964-1023: Missing.

Isoform 8 (identifier: Q7Z6G8-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-832: Missing.
     928-1023: VLKINLIGHR...RSKLERQMAQ → QSSVCEIWTNQNAGFPFSAIHQVHN
     1226-1249: DLLHASHTGQEPSERHTEEALRKF → IDRSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 1249

1248

Ankyrin repeat and sterile alpha motif domain-containing protein 1B

PRO_0000327259

Regions

Repeat

2 – 31

30

ANK 1

Repeat

58 – 87

30

ANK 2

Repeat

91 – 120

30

ANK 3

Repeat

127 – 156

30

ANK 4

Repeat

160 – 189

30

ANK 5

Repeat

193 – 222

30

ANK 6

Repeat

225 – 254

30

ANK 7

Domain

811 – 877

67

SAM 1

Domain

885 – 950

66

SAM 2

Domain

1057 – 1214

158

PID

Amino acid modifications

Modified residue

902

1

Phosphotyrosine By similarity

Natural variations

Alternative sequence

1 – 832

832

Missing in isoform 8.

VSP_032701

Alternative sequence

1 – 775

775

Missing in isoform 3, isoform 4, isoform 5, isoform 2 and isoform 7.

VSP_032702

Alternative sequence

1 – 421

421

Missing in isoform 6.

VSP_032703

Alternative sequence

776 – 808

33

SFTSE…GETTR → MMWQCHLSAQDYRYYPVDGY SLLKRFPLHPLTG in isoform 3, isoform 4, isoform 5, isoform 2 and isoform 7.

VSP_032704

Alternative sequence

805 – 808

4

Missing in isoform 6.

VSP_032705

Alternative sequence

928 – 1023

96

VLKIN…RQMAQ → QSSVCEIWTNQNAGFPFSAI HQVHN in isoform 8.

VSP_032706

Alternative sequence

964 – 1023

60

Missing in isoform 2, isoform 6 and isoform 7.

VSP_032707

Alternative sequence

964 – 1023

60

EPSGN…RQMAQ → SSVCEIWTNQNAGFPFSAIH QVHN in isoform 5.

VSP_032708

Alternative sequence

1023

1

Q → QSSVCEIWTNQNAGFPFSAI HQVHN in isoform 3.

VSP_032709

Alternative sequence

1226 – 1249

24

DLLHA…ALRKF → QIDPSEQKTLANLPWIVEPG QEAKRGINTKYETTIF in isoform 3, isoform 5 and isoform 2.

VSP_032710

Alternative sequence

1226 – 1249

24

DLLHA…ALRKF → PFCFKADRPI in isoform 4.

VSP_032711

Alternative sequence

1226 – 1249

24

DLLHA…ALRKF → IDRSEQKTLANLPWIVEPGQ EAKRGINTKYETTIF in isoform 8.

VSP_032712

Experimental info

Sequence conflict

814

1

Q → L in BAF82457. Ref.4

Sequence conflict

855

1

E → G in AAI42670. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

1249

Helix Strand Turn

Details...

Helix

819 – 822

4

Helix

826 – 828

3

Helix

829 – 834

6

Turn

840 – 842

3

Helix

852 – 855

4

Helix

864 – 873

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (AIDA-1b) [UniParc]. Last modified October 1, 2003. Version 1. Checksum: B8CDF79E1EF027A7	FASTA	1,249	138,185
	10 20 30 40 50 60 MGKDQELLEA ARTGNVALVE KLLSGRKGGI LGGGSGPLPL SNLLSIWRGP NVNCTDSSGY 70 80 90 100 110 120 TALHHAALNG HKDIVLKLLQ YEASTNVADN KGYFPIHLAA WKGDVEIVKI LIHHGPSHSR 130 140 150 160 170 180 VNEQNNENET ALHCAAQYGH SEVVAVLLEE LTDPTIRNSK LETPLDLAAL YGRLRVVKMI 190 200 210 220 230 240 ISAHPNLMSC NTRKHTPLHL AARNGHKAVV QVLLEAGMDV SCQTEKGSAL HEAALFGKVD 250 260 270 280 290 300 VVRVLLETGI DANIKDSLGR TVLDILKEHP SQKSLQIATL LQEYLEGVGK YATVLEEPVQ 310 320 330 340 350 360 EDATQETHIS SPVESPSQKT KSETVTGELS KLLDEIKLCQ EKDYSFEDLC HTISDHYLDN 370 380 390 400 410 420 LSKISEEELG KNGSQSVRTS STINLSPGEV EEEDDDENTC GPSGLWEALT PCNGCRNLGF 430 440 450 460 470 480 PMLAQESYPK KRNYTMEIVP SASLDTFPSE NENFLCDLMD TAVTKKPCSL EIARAPSPRT 490 500 510 520 530 540 DNASEVAVTT PGTSNHRNSS TGPTPDCSPP SPDTALKNIV KVIRPQPKQR TSIVSSLDFH 550 560 570 580 590 600 RMNHNQEYFE INTSTGCTSF TASPPASPPT SSVGTTEVKN EGTNHTDDLS RQDDNDPPKE 610 620 630 640 650 660 YDPGQFAGLL HGSSPACESP ENPFHLYGKR EQCEKGQDEV SLANSPLPFK QSPIENNSEP 670 680 690 700 710 720 LVKKIKPKVV SRTIFHKKSN QLENHTIVGT RSTRSGSRNG DQWVMNAGGF VERACTLGRI 730 740 750 760 770 780 RSLPKALIDM HLSKSVSKSD SDLIAYPSNE KTSRVNWSES STAEHSSKGN SERTPSFTSE 790 800 810 820 830 840 WEEIDKIMSS IDVGINNELK EMNGETTRPR CPVQTVGQWL ESIGLPQYEN HLMANGFDNV 850 860 870 880 890 900 QFMGSNVMED QDLLEIGILN SGHRQRILQA IQLLPKMRPI GHDGYHPTSV AEWLDSIELG 910 920 930 940 950 960 DYTKAFLING YTSMDLLKKI WEVELINVLK INLIGHRKRI LASLGDRLHD DPPQKPPRSI 970 980 990 1000 1010 1020 TLREPSGNHT PPQLSPSLSQ STYTTGGSLD VPHIIMQGDA RRRRNENYFD DIPRSKLERQ 1030 1040 1050 1060 1070 1080 MAQTGDWGEP SITLRPPNEA TASTPVQYWQ HHPEKLIFQS CDYKAFYLGS MLIKELRGTE 1090 1100 1110 1120 1130 1140 STQDACAKMR ANCQKSTEQM KKVPTIILSV SYKGVKFIDA TNKNIIAEHE IRNISCAAQD 1150 1160 1170 1180 1190 1200 PEDLSTFAYI TKDLKSNHHY CHVFTAFDVN LAYEIILTLG QAFEVAYQLA LQARKGGHSS 1210 1220 1230 1240 TLPESFENKP SKPIPKPRVS IRKSVDLLHA SHTGQEPSER HTEEALRKF
	Isoform 2 (AIDA-1c). Checksum: 0AE12663DD16CAC2	FASTA	426	48,432
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLRTG DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE 250 260 270 280 290 300 LRGTESTQDA CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS 310 320 330 340 350 360 CAAQDPEDLS TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK 370 380 390 400 410 420 GGHSSTLPES FENKPSKPIP KPRVSIRKSV QIDPSEQKTL ANLPWIVEPG QEAKRGINTK YETTIF
	Isoform 3. Checksum: 882DB0117D894E54	FASTA	510	57,865
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLREP SGNHTPPQLS PSLSQSTYTT GGSLDVPHII MQGDARRRRN ENYFDDIPRS 250 260 270 280 290 300 KLERQMAQSS VCEIWTNQNA GFPFSAIHQV HNTGDWGEPS ITLRPPNEAT ASTPVQYWQH 310 320 330 340 350 360 HPEKLIFQSC DYKAFYLGSM LIKELRGTES TQDACAKMRA NCQKSTEQMK KVPTIILSVS 370 380 390 400 410 420 YKGVKFIDAT NKNIIAEHEI RNISCAAQDP EDLSTFAYIT KDLKSNHHYC HVFTAFDVNL 430 440 450 460 470 480 AYEIILTLGQ AFEVAYQLAL QARKGGHSST LPESFENKPS KPIPKPRVSI RKSVQIDPSE 490 500 510 QKTLANLPWI VEPGQEAKRG INTKYETTIF
	Isoform 4 (AIDA-1a). Checksum: 34A6DD31C86685CD	FASTA	460	52,273
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLREP SGNHTPPQLS PSLSQSTYTT GGSLDVPHII MQGDARRRRN ENYFDDIPRS 250 260 270 280 290 300 KLERQMAQTG DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE 310 320 330 340 350 360 LRGTESTQDA CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS 370 380 390 400 410 420 CAAQDPEDLS TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK 430 440 450 460 GGHSSTLPES FENKPSKPIP KPRVSIRKSV PFCFKADRPI
	Isoform 5. Checksum: 7513E87841E4A57C	FASTA	450	51,100
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLRSS VCEIWTNQNA GFPFSAIHQV HNTGDWGEPS ITLRPPNEAT ASTPVQYWQH 250 260 270 280 290 300 HPEKLIFQSC DYKAFYLGSM LIKELRGTES TQDACAKMRA NCQKSTEQMK KVPTIILSVS 310 320 330 340 350 360 YKGVKFIDAT NKNIIAEHEI RNISCAAQDP EDLSTFAYIT KDLKSNHHYC HVFTAFDVNL 370 380 390 400 410 420 AYEIILTLGQ AFEVAYQLAL QARKGGHSST LPESFENKPS KPIPKPRVSI RKSVQIDPSE 430 440 450 QKTLANLPWI VEPGQEAKRG INTKYETTIF
	Isoform 6 (AIDA-1bDeltaAnk). Checksum: 7C107E6688522EF0	FASTA	764	85,202
	10 20 30 40 50 60 MLAQESYPKK RNYTMEIVPS ASLDTFPSEN ENFLCDLMDT AVTKKPCSLE IARAPSPRTD 70 80 90 100 110 120 NASEVAVTTP GTSNHRNSST GPTPDCSPPS PDTALKNIVK VIRPQPKQRT SIVSSLDFHR 130 140 150 160 170 180 MNHNQEYFEI NTSTGCTSFT ASPPASPPTS SVGTTEVKNE GTNHTDDLSR QDDNDPPKEY 190 200 210 220 230 240 DPGQFAGLLH GSSPACESPE NPFHLYGKRE QCEKGQDEVS LANSPLPFKQ SPIENNSEPL 250 260 270 280 290 300 VKKIKPKVVS RTIFHKKSNQ LENHTIVGTR STRSGSRNGD QWVMNAGGFV ERACTLGRIR 310 320 330 340 350 360 SLPKALIDMH LSKSVSKSDS DLIAYPSNEK TSRVNWSESS TAEHSSKGNS ERTPSFTSEW 370 380 390 400 410 420 EEIDKIMSSI DVGINNELKE MNGPRCPVQT VGQWLESIGL PQYENHLMAN GFDNVQFMGS 430 440 450 460 470 480 NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD SIELGDYTKA 490 500 510 520 530 540 FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK PPRSITLRTG 550 560 570 580 590 600 DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE LRGTESTQDA 610 620 630 640 650 660 CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS CAAQDPEDLS 670 680 690 700 710 720 TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK GGHSSTLPES 730 740 750 760 FENKPSKPIP KPRVSIRKSV DLLHASHTGQ EPSERHTEEA LRKF
	Isoform 7. Checksum: AD92EB5F8954E011	FASTA	414	47,104
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLRTG DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE 250 260 270 280 290 300 LRGTESTQDA CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS 310 320 330 340 350 360 CAAQDPEDLS TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK 370 380 390 400 410 GGHSSTLPES FENKPSKPIP KPRVSIRKSV DLLHASHTGQ EPSERHTEEA LRKF
	Isoform 8. Checksum: 04DF1F322BFC2835	FASTA	357	40,336
	10 20 30 40 50 60 MANGFDNVQF MGSNVMEDQD LLEIGILNSG HRQRILQAIQ LLPKMRPIGH DGYHPTSVAE 70 80 90 100 110 120 WLDSIELGDY TKAFLINGYT SMDLLKKIWE VELINQSSVC EIWTNQNAGF PFSAIHQVHN 130 140 150 160 170 180 TGDWGEPSIT LRPPNEATAS TPVQYWQHHP EKLIFQSCDY KAFYLGSMLI KELRGTESTQ 190 200 210 220 230 240 DACAKMRANC QKSTEQMKKV PTIILSVSYK GVKFIDATNK NIIAEHEIRN ISCAAQDPED 250 260 270 280 290 300 LSTFAYITKD LKSNHHYCHV FTAFDVNLAY EIILTLGQAF EVAYQLALQA RKGGHSSTLP 310 320 330 340 350 ESFENKPSKP IPKPRVSIRK SVIDRSEQKT LANLPWIVEP GQEAKRGINT KYETTIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing." Ghersi E., Vito P., Lopez P., Abdallah M., D'Adamio L. J. Alzheimers Dis. 6:67-78(2004) [PubMed: 15004329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6 AND 4), INTERACTION WITH APP, SUBCELLULAR LOCATION. Tissue: Fetal brain.
[2]	"A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin." Xu H., Hebert M.D. BMC Cell Biol. 6:23-23(2005) [PubMed: 15862129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH COIL, SUBCELLULAR LOCATION. Tissue: Brain.
[3]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Adrenal gland.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 5; 7 AND 8). Tissue: Brain and Hippocampus.
[6]	"EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1." Fu X., McGrath S., Pasillas M., Nakazawa S., Kamps M.P. Oncogene 18:4920-4929(1999) [PubMed: 10490826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-1248 (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY.
[7]	"Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner." Ghersi E., Noviello C., D'Adamio L. J. Biol. Chem. 279:49105-49112(2004) [PubMed: 15347684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 425-1192 (ISOFORM 1), FUNCTION, INTERACTION WITH APP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line." Casagrande G., te Kronnie G., Basso G. Haematologica 91:765-771(2006) [PubMed: 16769578] [Abstract] Cited for: INDUCTION.
[9]	"Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function." Shin J., Gu C., Park E., Park S. Mol. Cell. Biol. 27:8113-8126(2007) [PubMed: 17875921] [Abstract] Cited for: INTERACTION WITH EPHA8.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AY281131 mRNA. Translation: AAP37612.1.
AY281132 mRNA. Translation: AAP37613.1.
AY283057 mRNA. Translation: AAP38184.2. Different initiation.
AY753193 mRNA. Translation: AAV28691.1.
AF164792 mRNA. Translation: AAF80756.1.
AK289768 mRNA. Translation: BAF82457.1.
BC026313 mRNA. Translation: AAH26313.2.
BC068451 mRNA. Translation: AAH68451.1.
BC142669 mRNA. Translation: AAI42670.1.
BC150204 mRNA. Translation: AAI50205.1.
AF145204 mRNA. Translation: AAD33951.1.
AY620824 mRNA. Translation: AAT39519.1.

IPI

IPI00183620.
IPI00375174.
IPI00385409.
IPI00432458.
IPI00450411.
IPI00477368.
IPI00855765.
IPI00889592.

RefSeq

NP_064525.1.
NP_690001.3.
NP_858056.2.

UniGene

Hs.506458

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EAM	NMR	-	A	809-875	[»]
2KIV	NMR	-	A	813-947	[»]

ModBase

Search...

PTM databases

PhosphoSite

Q7Z6G8.

Proteomic databases

PRIDE

Q7Z6G8.

Genome annotation databases

Ensembl

ENST00000329257; ENSP00000331381; ENSG00000185046; Homo sapiens. [Genome view]

GeneID

56899.

KEGG

hsa:56899.

UCSC

uc001tgd.1. human.
uc001tge.1. human.
uc001tgf.1. human.
uc001tgg.2. human.
uc001tgi.1. human.
uc001tgj.1. human.
uc009ztr.1. human.
uc009zts.1. human.

Organism-specific databases

CTD

56899.

GeneCards

GC12M097653.

HGNC

HGNC:24600. ANKS1B.

MIM

607815. gene.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q7Z6G8.

HOVERGEN

Q7Z6G8.

Gene expression databases

ArrayExpress

Q7Z6G8.

Bgee

Q7Z6G8.

Genevestigator

Q7Z6G8.

Family and domain databases

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011993. PH_type.
IPR006020. PTB_PID.
IPR001660. SAM.
IPR010993. SAM_homology.
IPR013761. SAM_type.
[Graphical view]

Gene3D

G3DSA:1.25.40.20. ANK. 1 hit.
G3DSA:2.30.29.30. PH_type. 1 hit.
G3DSA:1.10.150.50. SAM_type. 2 hits.

Pfam

PF00023. Ank. 6 hits.
PF00640. PID. 1 hit.
PF00536. SAM_1. 2 hits.
[Graphical view]

SMART

SM00248. ANK. 6 hits.
SM00462. PTB. 1 hit.
SM00454. SAM. 2 hits.
[Graphical view]

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS01179. PID. 1 hit.
PS50105. SAM_DOMAIN. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

62343.

SOURCE

Search...

Entry information

Entry name

ANS1B_HUMAN

Accession

Primary (citable) accession number: Q7Z6G8
Secondary accession number(s): A5PKY5 , A7E259, A8K153, Q5XLJ0, Q6IVB5, Q6NUS4, Q7Z6G6, Q7Z6G7, Q8TAP3, Q9NRX7, Q9Y5K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 1, 2003
Last modified:	November 24, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.