Q7Z6G8 (ANS1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Alternative name(s):
Amyloid-beta protein intracellular domain-associated protein 1
Short name=AIDA-1
E2A-PBX1-associated protein
Short name=EB-1

Gene names

Name:

ANKS1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1248 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Ref.2 Ref.8 Isoform 3 can regulate global protein synthesis by altering nucleolar numbers By similarity. Ref.2 Ref.8 Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. Ref.2 Ref.8
Subunit structure	Isoform 3 interacts with DLG4 By similarity. Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interacts with EPHA8. Ref.1 Ref.2 Ref.8 Ref.10
Subcellular location	Cytoplasm Ref.1 Ref.2 Ref.8 Ref.11. Isoform 2: Nucleus Ref.1 Ref.2 Ref.8 Ref.11. Isoform 3: Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell projection › dendritic spine. Nucleus Ref.1 Ref.2 Ref.8 Ref.11. Nucleus › Cajal body. Note: The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner By similarity. Ref.1 Ref.2 Ref.8 Ref.11 Isoform 4: Nucleus Ref.1 Ref.2 Ref.8 Ref.11. Note: The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed. Ref.1 Ref.2 Ref.8 Ref.11 Isoform 6: Nucleus Ref.1 Ref.2 Ref.8 Ref.11.
Tissue specificity	Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines. Ref.7 Ref.8
Induction	Transcriptionally up-regulated in t(1:19) pre-B cell acute lymphocytic leukemia by the chimeric TCF3-PBX1. Not expressed in pre-B cell that lack this translocation. Ref.7 Ref.9
Post-translational modification	Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage By similarity.
Sequence similarities	Contains 7 ANK repeats. Contains 1 PID domain. Contains 2 SAM (sterile alpha motif) domains.
Sequence caution	The sequence AAP38184.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Membrane Nucleus Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Cajal body Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z6G8-1)

Also known as: AIDA-1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z6G8-2)

Also known as: AIDA-1c;

The sequence of this isoform differs from the canonical sequence as follows:
     1-774: Missing.
     775-807: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     963-1022: Missing.
     1225-1248: DLLHASHTGQEPSERHTEEALRKF → QIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Isoform 3 (identifier: Q7Z6G8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-774: Missing.
     775-807: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     1022-1022: Q → QSSVCEIWTNQNAGFPFSAIHQVHN
     1225-1248: DLLHASHTGQEPSERHTEEALRKF → QIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Isoform 4 (identifier: Q7Z6G8-4)

Also known as: AIDA-1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-774: Missing.
     775-807: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     1225-1248: DLLHASHTGQEPSERHTEEALRKF → PFCFKADRPI

Isoform 5 (identifier: Q7Z6G8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-774: Missing.
     775-807: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     963-1022: EPSGNHTPPQ...RSKLERQMAQ → SSVCEIWTNQNAGFPFSAIHQVHN
     1225-1248: DLLHASHTGQEPSERHTEEALRKF → QIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Isoform 6 (identifier: Q7Z6G8-6)

Also known as: AIDA-1bDeltaAnk;

The sequence of this isoform differs from the canonical sequence as follows:
     1-420: Missing.
     804-807: Missing.
     963-1022: Missing.

Isoform 7 (identifier: Q7Z6G8-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-774: Missing.
     775-807: SFTSEWEEIDKIMSSIDVGINNELKEMNGETTR → MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTG
     963-1022: Missing.

Isoform 8 (identifier: Q7Z6G8-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-831: Missing.
     927-1022: VLKINLIGHR...RSKLERQMAQ → QSSVCEIWTNQNAGFPFSAIHQVHN
     1225-1247: DLLHASHTGQEPSERHTEEALRK → IDPSEQKTLANLPWIVEPGQEAKRGINTKYETTI

Isoform 9 (identifier: Q7Z6G8-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-994: Missing.

Note: No experimental confirmation available.

Isoform 10 (identifier: Q7Z6G8-10)

The sequence of this isoform differs from the canonical sequence as follows:
     3-807: Missing.
     963-1022: Missing.
     1225-1247: DLLHASHTGQEPSERHTEEALRK → IDPSEQKTLANLPWIVEPGQEAKRGINTKYETTI

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1248

1248

Ankyrin repeat and sterile alpha motif domain-containing protein 1B

PRO_0000327259

Regions

Repeat

2 – 31

30

ANK 1

Repeat

58 – 87

30

ANK 2

Repeat

91 – 120

30

ANK 3

Repeat

127 – 156

30

ANK 4

Repeat

160 – 189

30

ANK 5

Repeat

193 – 222

30

ANK 6

Repeat

225 – 254

30

ANK 7

Domain

810 – 876

67

SAM 1

Domain

884 – 949

66

SAM 2

Domain

1056 – 1213

158

PID

Motif

935 – 938

4

Nuclear localization signal Ref.11

Amino acid modifications

Modified residue

901

1

Phosphotyrosine By similarity

Natural variations

Alternative sequence

1 – 994

994

Missing in isoform 9.

VSP_046414

Alternative sequence

1 – 831

831

Missing in isoform 8.

VSP_032701

Alternative sequence

1 – 774

774

Missing in isoform 3, isoform 4, isoform 5, isoform 2 and isoform 7.

VSP_032702

Alternative sequence

1 – 420

420

Missing in isoform 6.

VSP_032703

Alternative sequence

3 – 807

805

Missing in isoform 10.

VSP_046415

Alternative sequence

775 – 807

33

SFTSE…GETTR → MMWQCHLSAQDYRYYPVDGY SLLKRFPLHPLTG in isoform 3, isoform 4, isoform 5, isoform 2 and isoform 7.

VSP_032704

Alternative sequence

804 – 807

4

Missing in isoform 6.

VSP_032705

Alternative sequence

927 – 1022

96

VLKIN…RQMAQ → QSSVCEIWTNQNAGFPFSAI HQVHN in isoform 8.

VSP_032706

Alternative sequence

963 – 1022

60

Missing in isoform 2, isoform 6, isoform 7 and isoform 10.

VSP_032707

Alternative sequence

963 – 1022

60

EPSGN…RQMAQ → SSVCEIWTNQNAGFPFSAIH QVHN in isoform 5.

VSP_032708

Alternative sequence

1022

1

Q → QSSVCEIWTNQNAGFPFSAI HQVHN in isoform 3.

VSP_032709

Alternative sequence

1225 – 1248

24

DLLHA…ALRKF → QIDPSEQKTLANLPWIVEPG QEAKRGINTKYETTIF in isoform 3, isoform 5 and isoform 2.

VSP_032710

Alternative sequence

1225 – 1248

24

DLLHA…ALRKF → PFCFKADRPI in isoform 4.

VSP_032711

Alternative sequence

1225 – 1247

23

DLLHA…EALRK → IDPSEQKTLANLPWIVEPGQ EAKRGINTKYETTI in isoform 8 and isoform 10.

VSP_032712

Experimental info

Sequence conflict

290 – 291

2

RS → KYA in AAP37612. Ref.1

Sequence conflict

813

1

Q → L in BAF82457. Ref.4

Sequence conflict

854

1

E → G in AAI42670. Ref.6

Sequence conflict

1160

1

C → R in BAG57507. Ref.4

Sequence conflict

1167

1

D → G in BAG58059. Ref.4

Isoform 8:

Sequence conflict

325

1

P → R in AAH68451. Ref.6

Secondary structure

1

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1248

Helix Strand Turn

Details...

Helix

815 – 822

8

Helix

825 – 827

3

Helix

828 – 833

6

Turn

834 – 837

4

Turn

839 – 841

3

Beta strand

842 – 847

6

Helix

851 – 854

4

Helix

860 – 872

13

Helix

889 – 894

6

Turn

895 – 897

3

Helix

901 – 908

8

Helix

913 – 916

4

Helix

921 – 927

7

Helix

933 – 943

11

Turn

1056 – 1058

3

Beta strand

1059 – 1074

16

Helix

1078 – 1091

14

Beta strand

1094 – 1097

4

Beta strand

1104 – 1110

7

Beta strand

1113 – 1121

9

Beta strand

1124 – 1128

5

Helix

1130 – 1132

3

Beta strand

1133 – 1138

6

Beta strand

1145 – 1150

6

Turn

1153 – 1155

3

Beta strand

1156 – 1167

12

Helix

1168 – 1186

19

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (AIDA-1b) [UniParc]. Last modified May 3, 2011. Version 2. Checksum: EC3921C45083426D	FASTA	1,248	138,066
	10 20 30 40 50 60 MGKDQELLEA ARTGNVALVE KLLSGRKGGI LGGGSGPLPL SNLLSIWRGP NVNCTDSSGY 70 80 90 100 110 120 TALHHAALNG HKDIVLKLLQ YEASTNVADN KGYFPIHLAA WKGDVEIVKI LIHHGPSHSR 130 140 150 160 170 180 VNEQNNENET ALHCAAQYGH SEVVAVLLEE LTDPTIRNSK LETPLDLAAL YGRLRVVKMI 190 200 210 220 230 240 ISAHPNLMSC NTRKHTPLHL AARNGHKAVV QVLLEAGMDV SCQTEKGSAL HEAALFGKVD 250 260 270 280 290 300 VVRVLLETGI DANIKDSLGR TVLDILKEHP SQKSLQIATL LQEYLEGVGR STVLEEPVQE 310 320 330 340 350 360 DATQETHISS PVESPSQKTK SETVTGELSK LLDEIKLCQE KDYSFEDLCH TISDHYLDNL 370 380 390 400 410 420 SKISEEELGK NGSQSVRTSS TINLSPGEVE EEDDDENTCG PSGLWEALTP CNGCRNLGFP 430 440 450 460 470 480 MLAQESYPKK RNYTMEIVPS ASLDTFPSEN ENFLCDLMDT AVTKKPCSLE IARAPSPRTD 490 500 510 520 530 540 NASEVAVTTP GTSNHRNSST GPTPDCSPPS PDTALKNIVK VIRPQPKQRT SIVSSLDFHR 550 560 570 580 590 600 MNHNQEYFEI NTSTGCTSFT ASPPASPPTS SVGTTEVKNE GTNHTDDLSR QDDNDPPKEY 610 620 630 640 650 660 DPGQFAGLLH GSSPACESPE NPFHLYGKRE QCEKGQDEVS LANSPLPFKQ SPIENNSEPL 670 680 690 700 710 720 VKKIKPKVVS RTIFHKKSNQ LENHTIVGTR STRSGSRNGD QWVMNAGGFV ERACTLGRIR 730 740 750 760 770 780 SLPKALIDMH LSKSVSKSDS DLIAYPSNEK TSRVNWSESS TAEHSSKGNS ERTPSFTSEW 790 800 810 820 830 840 EEIDKIMSSI DVGINNELKE MNGETTRPRC PVQTVGQWLE SIGLPQYENH LMANGFDNVQ 850 860 870 880 890 900 FMGSNVMEDQ DLLEIGILNS GHRQRILQAI QLLPKMRPIG HDGYHPTSVA EWLDSIELGD 910 920 930 940 950 960 YTKAFLINGY TSMDLLKKIW EVELINVLKI NLIGHRKRIL ASLGDRLHDD PPQKPPRSIT 970 980 990 1000 1010 1020 LREPSGNHTP PQLSPSLSQS TYTTGGSLDV PHIIMQGDAR RRRNENYFDD IPRSKLERQM 1030 1040 1050 1060 1070 1080 AQTGDWGEPS ITLRPPNEAT ASTPVQYWQH HPEKLIFQSC DYKAFYLGSM LIKELRGTES 1090 1100 1110 1120 1130 1140 TQDACAKMRA NCQKSTEQMK KVPTIILSVS YKGVKFIDAT NKNIIAEHEI RNISCAAQDP 1150 1160 1170 1180 1190 1200 EDLSTFAYIT KDLKSNHHYC HVFTAFDVNL AYEIILTLGQ AFEVAYQLAL QARKGGHSST 1210 1220 1230 1240 LPESFENKPS KPIPKPRVSI RKSVDLLHAS HTGQEPSERH TEEALRKF
	Isoform 2 (AIDA-1c) [UniParc]. Checksum: 0AE12663DD16CAC2	FASTA	426	48,432
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLRTG DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE 250 260 270 280 290 300 LRGTESTQDA CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS 310 320 330 340 350 360 CAAQDPEDLS TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK 370 380 390 400 410 420 GGHSSTLPES FENKPSKPIP KPRVSIRKSV QIDPSEQKTL ANLPWIVEPG QEAKRGINTK YETTIF
	Isoform 3 [UniParc]. Checksum: 882DB0117D894E54	FASTA	510	57,865
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLREP SGNHTPPQLS PSLSQSTYTT GGSLDVPHII MQGDARRRRN ENYFDDIPRS 250 260 270 280 290 300 KLERQMAQSS VCEIWTNQNA GFPFSAIHQV HNTGDWGEPS ITLRPPNEAT ASTPVQYWQH 310 320 330 340 350 360 HPEKLIFQSC DYKAFYLGSM LIKELRGTES TQDACAKMRA NCQKSTEQMK KVPTIILSVS 370 380 390 400 410 420 YKGVKFIDAT NKNIIAEHEI RNISCAAQDP EDLSTFAYIT KDLKSNHHYC HVFTAFDVNL 430 440 450 460 470 480 AYEIILTLGQ AFEVAYQLAL QARKGGHSST LPESFENKPS KPIPKPRVSI RKSVQIDPSE 490 500 510 QKTLANLPWI VEPGQEAKRG INTKYETTIF
	Isoform 4 (AIDA-1a) [UniParc]. Checksum: 34A6DD31C86685CD	FASTA	460	52,273
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLREP SGNHTPPQLS PSLSQSTYTT GGSLDVPHII MQGDARRRRN ENYFDDIPRS 250 260 270 280 290 300 KLERQMAQTG DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE 310 320 330 340 350 360 LRGTESTQDA CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS 370 380 390 400 410 420 CAAQDPEDLS TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK 430 440 450 460 GGHSSTLPES FENKPSKPIP KPRVSIRKSV PFCFKADRPI
	Isoform 5 [UniParc]. Checksum: 7513E87841E4A57C	FASTA	450	51,100
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLRSS VCEIWTNQNA GFPFSAIHQV HNTGDWGEPS ITLRPPNEAT ASTPVQYWQH 250 260 270 280 290 300 HPEKLIFQSC DYKAFYLGSM LIKELRGTES TQDACAKMRA NCQKSTEQMK KVPTIILSVS 310 320 330 340 350 360 YKGVKFIDAT NKNIIAEHEI RNISCAAQDP EDLSTFAYIT KDLKSNHHYC HVFTAFDVNL 370 380 390 400 410 420 AYEIILTLGQ AFEVAYQLAL QARKGGHSST LPESFENKPS KPIPKPRVSI RKSVQIDPSE 430 440 450 QKTLANLPWI VEPGQEAKRG INTKYETTIF
	Isoform 6 (AIDA-1bDeltaAnk) [UniParc]. Checksum: 7C107E6688522EF0	FASTA	764	85,202
	10 20 30 40 50 60 MLAQESYPKK RNYTMEIVPS ASLDTFPSEN ENFLCDLMDT AVTKKPCSLE IARAPSPRTD 70 80 90 100 110 120 NASEVAVTTP GTSNHRNSST GPTPDCSPPS PDTALKNIVK VIRPQPKQRT SIVSSLDFHR 130 140 150 160 170 180 MNHNQEYFEI NTSTGCTSFT ASPPASPPTS SVGTTEVKNE GTNHTDDLSR QDDNDPPKEY 190 200 210 220 230 240 DPGQFAGLLH GSSPACESPE NPFHLYGKRE QCEKGQDEVS LANSPLPFKQ SPIENNSEPL 250 260 270 280 290 300 VKKIKPKVVS RTIFHKKSNQ LENHTIVGTR STRSGSRNGD QWVMNAGGFV ERACTLGRIR 310 320 330 340 350 360 SLPKALIDMH LSKSVSKSDS DLIAYPSNEK TSRVNWSESS TAEHSSKGNS ERTPSFTSEW 370 380 390 400 410 420 EEIDKIMSSI DVGINNELKE MNGPRCPVQT VGQWLESIGL PQYENHLMAN GFDNVQFMGS 430 440 450 460 470 480 NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD SIELGDYTKA 490 500 510 520 530 540 FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK PPRSITLRTG 550 560 570 580 590 600 DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE LRGTESTQDA 610 620 630 640 650 660 CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS CAAQDPEDLS 670 680 690 700 710 720 TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK GGHSSTLPES 730 740 750 760 FENKPSKPIP KPRVSIRKSV DLLHASHTGQ EPSERHTEEA LRKF
	Isoform 7 [UniParc]. Checksum: AD92EB5F8954E011	FASTA	414	47,104
	10 20 30 40 50 60 MMWQCHLSAQ DYRYYPVDGY SLLKRFPLHP LTGPRCPVQT VGQWLESIGL PQYENHLMAN 70 80 90 100 110 120 GFDNVQFMGS NVMEDQDLLE IGILNSGHRQ RILQAIQLLP KMRPIGHDGY HPTSVAEWLD 130 140 150 160 170 180 SIELGDYTKA FLINGYTSMD LLKKIWEVEL INVLKINLIG HRKRILASLG DRLHDDPPQK 190 200 210 220 230 240 PPRSITLRTG DWGEPSITLR PPNEATASTP VQYWQHHPEK LIFQSCDYKA FYLGSMLIKE 250 260 270 280 290 300 LRGTESTQDA CAKMRANCQK STEQMKKVPT IILSVSYKGV KFIDATNKNI IAEHEIRNIS 310 320 330 340 350 360 CAAQDPEDLS TFAYITKDLK SNHHYCHVFT AFDVNLAYEI ILTLGQAFEV AYQLALQARK 370 380 390 400 410 GGHSSTLPES FENKPSKPIP KPRVSIRKSV DLLHASHTGQ EPSERHTEEA LRKF
	Isoform 8 [UniParc]. Checksum: 07892A522BFC2835	FASTA	357	40,277
	10 20 30 40 50 60 MANGFDNVQF MGSNVMEDQD LLEIGILNSG HRQRILQAIQ LLPKMRPIGH DGYHPTSVAE 70 80 90 100 110 120 WLDSIELGDY TKAFLINGYT SMDLLKKIWE VELINQSSVC EIWTNQNAGF PFSAIHQVHN 130 140 150 160 170 180 TGDWGEPSIT LRPPNEATAS TPVQYWQHHP EKLIFQSCDY KAFYLGSMLI KELRGTESTQ 190 200 210 220 230 240 DACAKMRANC QKSTEQMKKV PTIILSVSYK GVKFIDATNK NIIAEHEIRN ISCAAQDPED 250 260 270 280 290 300 LSTFAYITKD LKSNHHYCHV FTAFDVNLAY EIILTLGQAF EVAYQLALQA RKGGHSSTLP 310 320 330 340 350 ESFENKPSKP IPKPRVSIRK SVIDPSEQKT LANLPWIVEP GQEAKRGINT KYETTIF
	Isoform 9 [UniParc]. Checksum: 33299F04446DCF7F	FASTA	254	28,943
	10 20 30 40 50 60 MQGDARRRRN ENYFDDIPRS KLERQMAQTG DWGEPSITLR PPNEATASTP VQYWQHHPEK 70 80 90 100 110 120 LIFQSCDYKA FYLGSMLIKE LRGTESTQDA CAKMRANCQK STEQMKKVPT IILSVSYKGV 130 140 150 160 170 180 KFIDATNKNI IAEHEIRNIS CAAQDPEDLS TFAYITKDLK SNHHYCHVFT AFDVNLAYEI 190 200 210 220 230 240 ILTLGQAFEV AYQLALQARK GGHSSTLPES FENKPSKPIP KPRVSIRKSV DLLHASHTGQ 250 EPSERHTEEA LRKF
	Isoform 10 [UniParc]. Checksum: D921575BBFF3C4C6	FASTA	394	44,522
	10 20 30 40 50 60 MGPRCPVQTV GQWLESIGLP QYENHLMANG FDNVQFMGSN VMEDQDLLEI GILNSGHRQR 70 80 90 100 110 120 ILQAIQLLPK MRPIGHDGYH PTSVAEWLDS IELGDYTKAF LINGYTSMDL LKKIWEVELI 130 140 150 160 170 180 NVLKINLIGH RKRILASLGD RLHDDPPQKP PRSITLRTGD WGEPSITLRP PNEATASTPV 190 200 210 220 230 240 QYWQHHPEKL IFQSCDYKAF YLGSMLIKEL RGTESTQDAC AKMRANCQKS TEQMKKVPTI 250 260 270 280 290 300 ILSVSYKGVK FIDATNKNII AEHEIRNISC AAQDPEDLST FAYITKDLKS NHHYCHVFTA 310 320 330 340 350 360 FDVNLAYEII LTLGQAFEVA YQLALQARKG GHSSTLPESF ENKPSKPIPK PRVSIRKSVI 370 380 390 DPSEQKTLAN LPWIVEPGQE AKRGINTKYE TTIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing." Ghersi E., Vito P., Lopez P., Abdallah M., D'Adamio L. J. Alzheimers Dis. 6:67-78(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6 AND 4), INTERACTION WITH APP, SUBCELLULAR LOCATION. Tissue: Fetal brain.
[2]	"A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin." Xu H., Hebert M.D. BMC Cell Biol. 6:23-23(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH COIL, SUBCELLULAR LOCATION. Tissue: Brain.
[3]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Adrenal gland.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 9 AND 10). Tissue: Amygdala and Brain.
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 5; 7 AND 8). Tissue: Brain and Hippocampus.
[7]	"EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1." Fu X., McGrath S., Pasillas M., Nakazawa S., Kamps M.P. Oncogene 18:4920-4929(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-1248 (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY.
[8]	"Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner." Ghersi E., Noviello C., D'Adamio L. J. Biol. Chem. 279:49105-49112(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 425-1192 (ISOFORM 1), FUNCTION, INTERACTION WITH APP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[9]	"The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line." Casagrande G., te Kronnie G., Basso G. Haematologica 91:765-771(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[10]	"Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function." Shin J., Gu C., Park E., Park S. Mol. Cell. Biol. 27:8113-8126(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EPHA8.
[11]	"A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import." Kurabi A., Brener S., Mobli M., Kwan J.J., Donaldson L.W. J. Mol. Biol. 392:1168-1177(2009) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 813-947, SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY281131 mRNA. Translation: AAP37612.1.
AY281132 mRNA. Translation: AAP37613.1.
AY283057 mRNA. Translation: AAP38184.2. Different initiation.
AY753193 mRNA. Translation: AAV28691.1.
AF164792 mRNA. Translation: AAF80756.1.
AK289768 mRNA. Translation: BAF82457.1.
AK294191 mRNA. Translation: BAG57507.1.
AK294994 mRNA. Translation: BAG58059.1.
AC008126 Genomic DNA. No translation available.
AC011248 Genomic DNA. No translation available.
AC021653 Genomic DNA. No translation available.
AC048330 Genomic DNA. No translation available.
AC069437 Genomic DNA. No translation available.
AC078916 Genomic DNA. No translation available.
AC079954 Genomic DNA. No translation available.
AC084374 Genomic DNA. No translation available.
AC117377 Genomic DNA. No translation available.
AC126616 Genomic DNA. No translation available.
AC141554 Genomic DNA. No translation available.
AC141555 Genomic DNA. No translation available.
AC141556 Genomic DNA. No translation available.
BC026313 mRNA. Translation: AAH26313.2.
BC068451 mRNA. Translation: AAH68451.1.
BC142669 mRNA. Translation: AAI42670.1.
BC150204 mRNA. Translation: AAI50205.1.
AF145204 mRNA. Translation: AAD33951.1.
AY620824 mRNA. Translation: AAT39519.1.

IPI

IPI00183620.
IPI00375174.
IPI00385409.
IPI00432458.
IPI00450411.
IPI00477368.
IPI00855765.
IPI00889592.
IPI00980571.
IPI00985108.
IPI01025466.

RefSeq

NP_001190994.1. NM_001204065.1.
NP_001190995.1. NM_001204066.1.
NP_001190996.1. NM_001204067.1.
NP_001190997.1. NM_001204068.1.
NP_001190998.1. NM_001204069.1.
NP_001190999.1. NM_001204070.1.
NP_001191008.1. NM_001204079.1.
NP_001191009.1. NM_001204080.1.
NP_001191010.1. NM_001204081.1.
NP_064525.1. NM_020140.3.
NP_690001.3. NM_152788.4.
NP_858056.2. NM_181670.3.

UniGene

Hs.506458.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EAM	NMR	-	A	808-874	[»]
2KE7	NMR	-	A	808-893	[»]
2KIV	NMR	-	A	813-946	[»]
2M38	NMR	-	A	1042-1194	[»]

ProteinModelPortal

Q7Z6G8.

SMR

Q7Z6G8. Positions 5-307, 812-946, 1066-1188.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-258807.

PTM databases

PhosphoSite

Q7Z6G8.

Polymorphism databases

DMDM

74759233.

Proteomic databases

PaxDb

Q7Z6G8.

PRIDE

Q7Z6G8.

Protocols and materials databases

DNASU

56899.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000341752; ENSP00000345510; ENSG00000185046.
ENST00000546568; ENSP00000448205; ENSG00000185046.
ENST00000546960; ENSP00000447839; ENSG00000185046.
ENST00000547010; ENSP00000448512; ENSG00000185046.
ENST00000547446; ENSP00000450015; ENSG00000185046.
ENST00000547776; ENSP00000449629; ENSG00000185046.
ENST00000549025; ENSP00000447312; ENSG00000185046.
ENST00000549493; ENSP00000448203; ENSG00000185046.
ENST00000549558; ENSP00000448993; ENSG00000185046.
ENST00000550693; ENSP00000447999; ENSG00000185046.

GeneID

56899.

KEGG

hsa:56899.

UCSC

uc001tgd.2. human.
uc001tge.2. human.
uc001tgf.2. human.
uc001tgg.4. human.
uc001tgi.3. human.
uc001tgj.3. human.
uc009ztr.3. human.
uc009zts.2. human.
uc010svd.2. human.
uc010svg.2. human.

Organism-specific databases

CTD

56899.

GeneCards

GC12M099129.

HGNC

HGNC:24600. ANKS1B.

HPA

HPA044628.

MIM

607815. gene.

neXtProt

NX_Q7Z6G8.

PharmGKB

PA128394692.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0666.

HOVERGEN

HBG050506.

InParanoid

Q7Z6G8.

OMA

RNGDQWV.

OrthoDB

EOG4FN4HZ.

Gene expression databases

ArrayExpress

Q7Z6G8.

Bgee

Q7Z6G8.

Genevestigator

Q7Z6G8.

Family and domain databases

Gene3D

1.10.150.50. 2 hits.
1.25.40.20. 3 hits.
2.30.29.30. 1 hit.

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011993. PH_like_dom.
IPR006020. PTyr_interaction_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]

Pfam

PF12796. Ank_2. 2 hits.
PF00640. PID. 1 hit.
PF00536. SAM_1. 2 hits.
[Graphical view]

PRINTS

PR01415. ANKYRIN.

SMART

SM00248. ANK. 6 hits.
SM00462. PTB. 1 hit.
SM00454. SAM. 2 hits.
[Graphical view]

SUPFAM

SSF48403. ANK. 1 hit.
SSF47769. SAM_homology. 2 hits.

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS01179. PID. 1 hit.
PS50105. SAM_DOMAIN. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ANKS1B. human.

EvolutionaryTrace

Q7Z6G8.

GenomeRNAi

56899.

NextBio

62343.

SOURCE

Search...

Entry information

Entry name

ANS1B_HUMAN

Accession

Primary (citable) accession number: Q7Z6G8
Secondary accession number(s): A5PKY5 , A7E259, A8K153, A8MSN4, B4DFP6, B4DH98, F8VPM3, F8VZR9, F8WC27, Q5XLJ0, Q6IVB5, Q6NUS4, Q7Z6G6, Q7Z6G7, Q8TAP3, Q9NRX7, Q9Y5K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 3, 2011
Last modified:	May 29, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.