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Protein

B- and T-lymphocyte attenuator

Gene

BTLA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

BioCyciZFISH:G66-32505-MONOMER.
ReactomeiR-HSA-388841. Costimulation by the CD28 family.

Names & Taxonomyi

Protein namesi
Recommended name:
B- and T-lymphocyte attenuator
Alternative name(s):
B- and T-lymphocyte-associated protein
CD_antigen: CD272
Gene namesi
Name:BTLA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:21087. BTLA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 157ExtracellularSequence analysisAdd BLAST127
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 289CytoplasmicSequence analysisAdd BLAST111

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi226Y → F: No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-257 and/or F-282. 2 Publications1
Mutagenesisi257Y → F: No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-226 and/or F-282. 2 Publications1
Mutagenesisi282Y → F: No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-226 and/or F-257. 2 Publications1

Organism-specific databases

DisGeNETi151888.
OpenTargetsiENSG00000186265.
PharmGKBiPA134968341.

Polymorphism and mutation databases

BioMutaiBTLA.
DMDMi296439425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001452331 – 289B- and T-lymphocyte attenuatorAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 63PROSITE-ProRule annotation1 Publication
Disulfide bondi58 ↔ 115PROSITE-ProRule annotation1 Publication
Disulfide bondi72 ↔ 79PROSITE-ProRule annotation1 Publication
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7Z6A9.
PeptideAtlasiQ7Z6A9.
PRIDEiQ7Z6A9.
TopDownProteomicsiQ7Z6A9-1. [Q7Z6A9-1]
Q7Z6A9-2. [Q7Z6A9-2]

PTM databases

iPTMnetiQ7Z6A9.
PhosphoSitePlusiQ7Z6A9.
SwissPalmiQ7Z6A9.

Expressioni

Gene expression databases

BgeeiENSG00000186265.
CleanExiHS_BTLA.
GenevisibleiQ7Z6A9. HS.

Organism-specific databases

HPAiHPA047211.
HPA062029.

Interactioni

Subunit structurei

Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.4 Publications

Protein-protein interaction databases

BioGridi127411. 2 interactors.
DIPiDIP-48795N.
IntActiQ7Z6A9. 3 interactors.
MINTiMINT-8020099.
STRINGi9606.ENSP00000333919.

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 49Combined sources6
Beta strandi54 – 61Combined sources8
Beta strandi63 – 65Combined sources3
Beta strandi68 – 74Combined sources7
Beta strandi79 – 81Combined sources3
Beta strandi87 – 91Combined sources5
Beta strandi96 – 104Combined sources9
Helixi107 – 109Combined sources3
Beta strandi111 – 119Combined sources9
Beta strandi122 – 125Combined sources4
Beta strandi129 – 134Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AW2X-ray2.80A/X26-137[»]
ProteinModelPortaliQ7Z6A9.
SMRiQ7Z6A9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z6A9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 132Ig-like V-typeAdd BLAST102

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYZD. Eukaryota.
ENOG410ZATJ. LUCA.
GeneTreeiENSGT00390000017390.
HOGENOMiHOG000168895.
HOVERGENiHBG080937.
InParanoidiQ7Z6A9.
KOiK06707.
OMAiYAAICVR.
OrthoDBiEOG091G0I5G.
PhylomeDBiQ7Z6A9.
TreeFamiTF337694.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTLPAMLGT GKLFWVFFLI PYLDIWNIHG KESCDVQLYI KRQSEHSILA
60 70 80 90 100
GDPFELECPV KYCANRPHVT WCKLNGTTCV KLEDRQTSWK EEKNISFFIL
110 120 130 140 150
HFEPVLPNDN GSYRCSANFQ SNLIESHSTT LYVTDVKSAS ERPSKDEMAS
160 170 180 190 200
RPWLLYRLLP LGGLPLLITT CFCLFCCLRR HQGKQNELSD TAGREINLVD
210 220 230 240 250
AHLKSEQTEA STRQNSQVLL SETGIYDNDP DLCFRMQEGS EVYSNPCLEE
260 270 280
NKPGIVYASL NHSVIGPNSR LARNVKEAPT EYASICVRS
Length:289
Mass (Da):32,834
Last modified:May 18, 2010 - v3
Checksum:iF4D1FF775D7D33F3
GO
Isoform 2 (identifier: Q7Z6A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-182: Missing.

Show »
Length:241
Mass (Da):27,317
Checksum:i991AFF2495C3F612
GO

Sequence cautioni

The sequence BAD18396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105V → M in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti138S → G in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti148M → V in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti171C → W in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti219L → P in BAD18396 (PubMed:14702039).Curated1
Sequence conflicti223T → A in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti243Y → C in AAP44003 (PubMed:12796776).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056027124I → V.Corresponds to variant rs16859633dbSNPEnsembl.1
Natural variantiVAR_027607157R → S.3 PublicationsCorresponds to variant rs2931761dbSNPEnsembl.1
Natural variantiVAR_027608267P → L.5 PublicationsCorresponds to variant rs9288952dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040305135 – 182Missing in isoform 2. 3 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY293286 mRNA. Translation: AAP44003.1.
AY599411 mRNA. Translation: AAT44901.1.
DQ198368 mRNA. Translation: ABA54407.1.
AC092894 Genomic DNA. No translation available.
BC107091 mRNA. Translation: AAI07092.1.
BC107092 mRNA. Translation: AAI07093.1.
AK131204 mRNA. Translation: BAD18396.1. Different initiation.
CCDSiCCDS33819.1. [Q7Z6A9-1]
CCDS43130.1. [Q7Z6A9-2]
RefSeqiNP_001078826.1. NM_001085357.1. [Q7Z6A9-2]
NP_861445.3. NM_181780.3.
XP_016861237.1. XM_017005748.1. [Q7Z6A9-1]
UniGeneiHs.445162.

Genome annotation databases

EnsembliENST00000334529; ENSP00000333919; ENSG00000186265. [Q7Z6A9-1]
ENST00000383680; ENSP00000373178; ENSG00000186265. [Q7Z6A9-2]
GeneIDi151888.
KEGGihsa:151888.
UCSCiuc003dza.5. human. [Q7Z6A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY293286 mRNA. Translation: AAP44003.1.
AY599411 mRNA. Translation: AAT44901.1.
DQ198368 mRNA. Translation: ABA54407.1.
AC092894 Genomic DNA. No translation available.
BC107091 mRNA. Translation: AAI07092.1.
BC107092 mRNA. Translation: AAI07093.1.
AK131204 mRNA. Translation: BAD18396.1. Different initiation.
CCDSiCCDS33819.1. [Q7Z6A9-1]
CCDS43130.1. [Q7Z6A9-2]
RefSeqiNP_001078826.1. NM_001085357.1. [Q7Z6A9-2]
NP_861445.3. NM_181780.3.
XP_016861237.1. XM_017005748.1. [Q7Z6A9-1]
UniGeneiHs.445162.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AW2X-ray2.80A/X26-137[»]
ProteinModelPortaliQ7Z6A9.
SMRiQ7Z6A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127411. 2 interactors.
DIPiDIP-48795N.
IntActiQ7Z6A9. 3 interactors.
MINTiMINT-8020099.
STRINGi9606.ENSP00000333919.

PTM databases

iPTMnetiQ7Z6A9.
PhosphoSitePlusiQ7Z6A9.
SwissPalmiQ7Z6A9.

Polymorphism and mutation databases

BioMutaiBTLA.
DMDMi296439425.

Proteomic databases

PaxDbiQ7Z6A9.
PeptideAtlasiQ7Z6A9.
PRIDEiQ7Z6A9.
TopDownProteomicsiQ7Z6A9-1. [Q7Z6A9-1]
Q7Z6A9-2. [Q7Z6A9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334529; ENSP00000333919; ENSG00000186265. [Q7Z6A9-1]
ENST00000383680; ENSP00000373178; ENSG00000186265. [Q7Z6A9-2]
GeneIDi151888.
KEGGihsa:151888.
UCSCiuc003dza.5. human. [Q7Z6A9-1]

Organism-specific databases

CTDi151888.
DisGeNETi151888.
GeneCardsiBTLA.
HGNCiHGNC:21087. BTLA.
HPAiHPA047211.
HPA062029.
MIMi607925. gene.
neXtProtiNX_Q7Z6A9.
OpenTargetsiENSG00000186265.
PharmGKBiPA134968341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYZD. Eukaryota.
ENOG410ZATJ. LUCA.
GeneTreeiENSGT00390000017390.
HOGENOMiHOG000168895.
HOVERGENiHBG080937.
InParanoidiQ7Z6A9.
KOiK06707.
OMAiYAAICVR.
OrthoDBiEOG091G0I5G.
PhylomeDBiQ7Z6A9.
TreeFamiTF337694.

Enzyme and pathway databases

BioCyciZFISH:G66-32505-MONOMER.
ReactomeiR-HSA-388841. Costimulation by the CD28 family.

Miscellaneous databases

EvolutionaryTraceiQ7Z6A9.
GeneWikiiBTLA.
GenomeRNAii151888.
PROiQ7Z6A9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186265.
CleanExiHS_BTLA.
GenevisibleiQ7Z6A9. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTLA_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6A9
Secondary accession number(s): Q3B831, Q3HS85, Q6ZNH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.