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Q7Z6A8

- Q7Z6A8_HUMAN

UniProt

Q7Z6A8 - Q7Z6A8_HUMAN

Protein
Submitted name:

Interleukin-1 receptor associated kinase 4 mutant form 1

Gene

IRAK4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. magnesium ion binding Source: InterPro
    3. protein serine/threonine kinase activity Source: InterPro

    GO - Biological processi

    1. signal transduction Source: InterPro

    Keywords - Molecular functioni

    KinaseImported, ReceptorImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interleukin-1 receptor associated kinase 4 mutant form 1Imported
    Gene namesi
    Name:IRAK4Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z6A8.
    SMRiQ7Z6A8. Positions 1-113, 163-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG066836.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR017428. IL-1_rcpt-assoc_kin4.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038189. IRAK4. 1 hit.
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z6A8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ    50
    FHIRRFEALL QTGKSPTSEL LFDWGTTNCT AGDLVDLLIQ NEFFAPASLL 100
    LPDAVPKTAN TLPSKEAITV QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS 150
    SSPENKSLEV SDTRFHSFSF YELKNVTNNF DERPISVGGN KMGEGGFGVV 200
    YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC QHENLVELLG 250
    FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IA 292
    Length:292
    Mass (Da):32,704
    Last modified:October 1, 2003 - v1
    Checksum:i58F1708A63BD3BE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY283670 mRNA. Translation: AAP57089.1.
    UniGeneiHs.138499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY283670 mRNA. Translation: AAP57089.1 .
    UniGenei Hs.138499.

    3D structure databases

    ProteinModelPortali Q7Z6A8.
    SMRi Q7Z6A8. Positions 1-113, 163-292.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG066836.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR017428. IL-1_rcpt-assoc_kin4.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038189. IRAK4. 1 hit.
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections."
      Medvedev A.E., Lentschat A., Kuhns D.B., Blanco J.C.G., Salkowski C., Zhang S., Arditi M., Gallin J.I., Vogel S.N.
      J. Exp. Med. 198:521-531(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ7Z6A8_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z6A8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.