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Protein

Uncharacterized aarF domain-containing protein kinase 2

Gene

ADCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei311ATPBy similarity1
Active sitei445Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 214ATPBy similarity9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 2 (EC:2.7.11.-)
Gene namesi
Name:ADCK2
Synonyms:AARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19039. ADCK2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133597.
PharmGKBiPA134902329.

Polymorphism and mutation databases

BioMutaiADCK2.
DMDMi74723374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717921 – 626Uncharacterized aarF domain-containing protein kinase 2Add BLAST626

Proteomic databases

PaxDbiQ7Z695.
PeptideAtlasiQ7Z695.
PRIDEiQ7Z695.

PTM databases

iPTMnetiQ7Z695.
PhosphoSitePlusiQ7Z695.

Expressioni

Gene expression databases

BgeeiENSG00000133597.
CleanExiHS_ADCK2.
ExpressionAtlasiQ7Z695. baseline and differential.
GenevisibleiQ7Z695. HS.

Organism-specific databases

HPAiHPA036036.

Interactioni

Protein-protein interaction databases

BioGridi124782. 16 interactors.
STRINGi9606.ENSP00000072869.

Structurei

3D structure databases

ProteinModelPortaliQ7Z695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 618Protein kinaseAdd BLAST419

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1236. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00390000001536.
HOGENOMiHOG000252975.
HOVERGENiHBG080821.
InParanoidiQ7Z695.
KOiK08869.
OMAiTLWLHLL.
OrthoDBiEOG091G054C.
PhylomeDBiQ7Z695.
TreeFamiTF315018.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7Z695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV
60 70 80 90 100
VSLCGDVGEG APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW
110 120 130 140 150
LRAGALLVKF FPLLLLYPLT YLAPSVSTLW LHLLLKATET SGPTYIKLGQ
160 170 180 190 200
WASTRRDLFS EAFCAQFSKL HVRVTPHPWT HTERFLRQAF GDDWGSILSF
210 220 230 240 250
ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP FSHTGAVGGL
260 270 280 290 300
RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP
310 320 330 340 350
EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV
360 370 380 390 400
EEFEKLMVQQ IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE
410 420 430 440 450
TYEESVPVSS YQQAGIPVDL KRKIARLGIN MLLKMIFVDN FVHADLHPGN
460 470 480 490 500
ILVQGANGLS SSQEAQLQQA DICDTLVVAV PSSLCPLRLV LLDAGIVAEL
510 520 530 540 550
QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE GFKTEMAMLV
560 570 580 590 600
TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL
610 620
GRSLDPKLDI LEAARPFLLT GPVCPP
Length:626
Mass (Da):68,982
Last modified:October 1, 2003 - v1
Checksum:iF8E25DB672017AF4
GO

Sequence cautioni

The sequence AAH14107 differs from that shown. Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06099066S → G.Corresponds to variant rs2968558dbSNPEnsembl.1
Natural variantiVAR_029992307S → P.1 PublicationCorresponds to variant rs1140034dbSNPEnsembl.1
Natural variantiVAR_041418418V → L.1 PublicationCorresponds to variant rs3748092dbSNPEnsembl.1
Natural variantiVAR_029993418V → M.Corresponds to variant rs3748092dbSNPEnsembl.1
Natural variantiVAR_029994622P → L.1 PublicationCorresponds to variant rs1046515dbSNPEnsembl.1
Natural variantiVAR_041419626P → L.1 PublicationCorresponds to variant rs55922126dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302592 mRNA. Translation: AAP60021.1.
AC006344 Genomic DNA. Translation: AAD43192.1.
AC006452 Genomic DNA. No translation available.
BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
CCDSiCCDS5861.1.
RefSeqiNP_443085.2. NM_052853.3.
UniGeneiHs.744886.

Genome annotation databases

EnsembliENST00000072869; ENSP00000072869; ENSG00000133597.
GeneIDi90956.
KEGGihsa:90956.
UCSCiuc003vvy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302592 mRNA. Translation: AAP60021.1.
AC006344 Genomic DNA. Translation: AAD43192.1.
AC006452 Genomic DNA. No translation available.
BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
CCDSiCCDS5861.1.
RefSeqiNP_443085.2. NM_052853.3.
UniGeneiHs.744886.

3D structure databases

ProteinModelPortaliQ7Z695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124782. 16 interactors.
STRINGi9606.ENSP00000072869.

PTM databases

iPTMnetiQ7Z695.
PhosphoSitePlusiQ7Z695.

Polymorphism and mutation databases

BioMutaiADCK2.
DMDMi74723374.

Proteomic databases

PaxDbiQ7Z695.
PeptideAtlasiQ7Z695.
PRIDEiQ7Z695.

Protocols and materials databases

DNASUi90956.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000072869; ENSP00000072869; ENSG00000133597.
GeneIDi90956.
KEGGihsa:90956.
UCSCiuc003vvy.2. human.

Organism-specific databases

CTDi90956.
GeneCardsiADCK2.
HGNCiHGNC:19039. ADCK2.
HPAiHPA036036.
neXtProtiNX_Q7Z695.
OpenTargetsiENSG00000133597.
PharmGKBiPA134902329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1236. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00390000001536.
HOGENOMiHOG000252975.
HOVERGENiHBG080821.
InParanoidiQ7Z695.
KOiK08869.
OMAiTLWLHLL.
OrthoDBiEOG091G054C.
PhylomeDBiQ7Z695.
TreeFamiTF315018.

Miscellaneous databases

GenomeRNAii90956.
PROiQ7Z695.

Gene expression databases

BgeeiENSG00000133597.
CleanExiHS_ADCK2.
ExpressionAtlasiQ7Z695. baseline and differential.
GenevisibleiQ7Z695. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiADCK2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z695
Secondary accession number(s): Q96CN6, Q9Y6T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.