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Q7Z695 (ADCK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized aarF domain-containing protein kinase 2

EC=2.7.11.-
Gene names
Name:ADCK2
Synonyms:AARF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH14107.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626Uncharacterized aarF domain-containing protein kinase 2
PRO_0000271792

Regions

Transmembrane103 – 12321Helical; Potential
Domain200 – 618419Protein kinase
Nucleotide binding206 – 2149ATP By similarity

Sites

Active site4451Proton acceptor By similarity
Binding site3111ATP By similarity

Natural variations

Natural variant661S → G.
Corresponds to variant rs2968558 [ dbSNP | Ensembl ].
VAR_060990
Natural variant3071S → P. Ref.4
Corresponds to variant rs1140034 [ dbSNP | Ensembl ].
VAR_029992
Natural variant4181V → L. Ref.4
Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
VAR_041418
Natural variant4181V → M.
Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
VAR_029993
Natural variant6221P → L. Ref.4
Corresponds to variant rs1046515 [ dbSNP | Ensembl ].
VAR_029994
Natural variant6261P → L. Ref.4
Corresponds to variant rs55922126 [ dbSNP | Ensembl ].
VAR_041419

Sequences

Sequence LengthMass (Da)Tools
Q7Z695 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F8E25DB672017AF4

FASTA62668,982
        10         20         30         40         50         60 
MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV VSLCGDVGEG 

        70         80         90        100        110        120 
APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW LRAGALLVKF FPLLLLYPLT 

       130        140        150        160        170        180 
YLAPSVSTLW LHLLLKATET SGPTYIKLGQ WASTRRDLFS EAFCAQFSKL HVRVTPHPWT 

       190        200        210        220        230        240 
HTERFLRQAF GDDWGSILSF ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP 

       250        260        270        280        290        300 
FSHTGAVGGL RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP 

       310        320        330        340        350        360 
EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV EEFEKLMVQQ 

       370        380        390        400        410        420 
IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE TYEESVPVSS YQQAGIPVDL 

       430        440        450        460        470        480 
KRKIARLGIN MLLKMIFVDN FVHADLHPGN ILVQGANGLS SSQEAQLQQA DICDTLVVAV 

       490        500        510        520        530        540 
PSSLCPLRLV LLDAGIVAEL QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE 

       550        560        570        580        590        600 
GFKTEMAMLV TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL 

       610        620 
GRSLDPKLDI LEAARPFLLT GPVCPP 

« Hide

References

« Hide 'large scale' references
[1]Huang C.Q., Shan Y.X., Cheng Z.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-388.
Tissue: Muscle.
[4]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-307; LEU-418; LEU-622 AND LEU-626.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY302592 mRNA. Translation: AAP60021.1.
AC006344 Genomic DNA. Translation: AAD43192.1.
AC006452 Genomic DNA. No translation available.
BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
CCDSCCDS5861.1.
RefSeqNP_443085.2. NM_052853.3.
UniGeneHs.744886.

3D structure databases

ProteinModelPortalQ7Z695.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124782. 2 interactions.
STRING9606.ENSP00000072869.

PTM databases

PhosphoSiteQ7Z695.

Polymorphism databases

DMDM74723374.

Proteomic databases

PaxDbQ7Z695.
PRIDEQ7Z695.

Protocols and materials databases

DNASU90956.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000072869; ENSP00000072869; ENSG00000133597.
GeneID90956.
KEGGhsa:90956.
UCSCuc003vvy.1. human.

Organism-specific databases

CTD90956.
GeneCardsGC07P140372.
HGNCHGNC:19039. ADCK2.
HPAHPA036036.
neXtProtNX_Q7Z695.
PharmGKBPA134902329.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0661.
HOGENOMHOG000252975.
HOVERGENHBG080821.
InParanoidQ7Z695.
KOK08869.
OMAIPTMEWL.
OrthoDBEOG7SFHWC.
PhylomeDBQ7Z695.
TreeFamTF315018.

Gene expression databases

ArrayExpressQ7Z695.
BgeeQ7Z695.
CleanExHS_ADCK2.
GenevestigatorQ7Z695.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
ProtoNetSearch...

Other

GenomeRNAi90956.
NextBio77044.
PROQ7Z695.

Entry information

Entry nameADCK2_HUMAN
AccessionPrimary (citable) accession number: Q7Z695
Secondary accession number(s): Q96CN6, Q9Y6T5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM