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Q7Z695

- ADCK2_HUMAN

UniProt

Q7Z695 - ADCK2_HUMAN

Protein

Uncharacterized aarF domain-containing protein kinase 2

Gene

ADCK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei311 – 3111ATPBy similarity
    Active sitei445 – 4451Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi206 – 2149ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 2 (EC:2.7.11.-)
    Gene namesi
    Name:ADCK2
    Synonyms:AARF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:19039. ADCK2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134902329.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 626626Uncharacterized aarF domain-containing protein kinase 2PRO_0000271792Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z695.
    PRIDEiQ7Z695.

    PTM databases

    PhosphoSiteiQ7Z695.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z695.
    BgeeiQ7Z695.
    CleanExiHS_ADCK2.
    GenevestigatoriQ7Z695.

    Organism-specific databases

    HPAiHPA036036.

    Interactioni

    Protein-protein interaction databases

    BioGridi124782. 2 interactions.
    STRINGi9606.ENSP00000072869.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z695.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini200 – 618419Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0661.
    HOGENOMiHOG000252975.
    HOVERGENiHBG080821.
    InParanoidiQ7Z695.
    KOiK08869.
    OMAiIPTMEWL.
    OrthoDBiEOG7SFHWC.
    PhylomeDBiQ7Z695.
    TreeFamiTF315018.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view]
    PfamiPF03109. ABC1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q7Z695-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV    50
    VSLCGDVGEG APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW 100
    LRAGALLVKF FPLLLLYPLT YLAPSVSTLW LHLLLKATET SGPTYIKLGQ 150
    WASTRRDLFS EAFCAQFSKL HVRVTPHPWT HTERFLRQAF GDDWGSILSF 200
    ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP FSHTGAVGGL 250
    RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP 300
    EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV 350
    EEFEKLMVQQ IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE 400
    TYEESVPVSS YQQAGIPVDL KRKIARLGIN MLLKMIFVDN FVHADLHPGN 450
    ILVQGANGLS SSQEAQLQQA DICDTLVVAV PSSLCPLRLV LLDAGIVAEL 500
    QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE GFKTEMAMLV 550
    TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL 600
    GRSLDPKLDI LEAARPFLLT GPVCPP 626
    Length:626
    Mass (Da):68,982
    Last modified:October 1, 2003 - v1
    Checksum:iF8E25DB672017AF4
    GO

    Sequence cautioni

    The sequence AAH14107.1 differs from that shown. Reason: Aberrant splicing.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661S → G.
    Corresponds to variant rs2968558 [ dbSNP | Ensembl ].
    VAR_060990
    Natural varianti307 – 3071S → P.1 Publication
    Corresponds to variant rs1140034 [ dbSNP | Ensembl ].
    VAR_029992
    Natural varianti418 – 4181V → L.1 Publication
    Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
    VAR_041418
    Natural varianti418 – 4181V → M.
    Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
    VAR_029993
    Natural varianti622 – 6221P → L.1 Publication
    Corresponds to variant rs1046515 [ dbSNP | Ensembl ].
    VAR_029994
    Natural varianti626 – 6261P → L.1 Publication
    Corresponds to variant rs55922126 [ dbSNP | Ensembl ].
    VAR_041419

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY302592 mRNA. Translation: AAP60021.1.
    AC006344 Genomic DNA. Translation: AAD43192.1.
    AC006452 Genomic DNA. No translation available.
    BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
    CCDSiCCDS5861.1.
    RefSeqiNP_443085.2. NM_052853.3.
    UniGeneiHs.744886.

    Genome annotation databases

    EnsembliENST00000072869; ENSP00000072869; ENSG00000133597.
    GeneIDi90956.
    KEGGihsa:90956.
    UCSCiuc003vvy.1. human.

    Polymorphism databases

    DMDMi74723374.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY302592 mRNA. Translation: AAP60021.1 .
    AC006344 Genomic DNA. Translation: AAD43192.1 .
    AC006452 Genomic DNA. No translation available.
    BC014107 mRNA. Translation: AAH14107.1 . Sequence problems.
    CCDSi CCDS5861.1.
    RefSeqi NP_443085.2. NM_052853.3.
    UniGenei Hs.744886.

    3D structure databases

    ProteinModelPortali Q7Z695.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124782. 2 interactions.
    STRINGi 9606.ENSP00000072869.

    PTM databases

    PhosphoSitei Q7Z695.

    Polymorphism databases

    DMDMi 74723374.

    Proteomic databases

    PaxDbi Q7Z695.
    PRIDEi Q7Z695.

    Protocols and materials databases

    DNASUi 90956.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000072869 ; ENSP00000072869 ; ENSG00000133597 .
    GeneIDi 90956.
    KEGGi hsa:90956.
    UCSCi uc003vvy.1. human.

    Organism-specific databases

    CTDi 90956.
    GeneCardsi GC07P140372.
    HGNCi HGNC:19039. ADCK2.
    HPAi HPA036036.
    neXtProti NX_Q7Z695.
    PharmGKBi PA134902329.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0661.
    HOGENOMi HOG000252975.
    HOVERGENi HBG080821.
    InParanoidi Q7Z695.
    KOi K08869.
    OMAi IPTMEWL.
    OrthoDBi EOG7SFHWC.
    PhylomeDBi Q7Z695.
    TreeFami TF315018.

    Miscellaneous databases

    GenomeRNAii 90956.
    NextBioi 77044.
    PROi Q7Z695.

    Gene expression databases

    ArrayExpressi Q7Z695.
    Bgeei Q7Z695.
    CleanExi HS_ADCK2.
    Genevestigatori Q7Z695.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view ]
    Pfami PF03109. ABC1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Huang C.Q., Shan Y.X., Cheng Z.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-388.
      Tissue: Muscle.
    4. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-307; LEU-418; LEU-622 AND LEU-626.

    Entry informationi

    Entry nameiADCK2_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z695
    Secondary accession number(s): Q96CN6, Q9Y6T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3