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Protein

Uncharacterized aarF domain-containing protein kinase 2

Gene

ADCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei311 – 3111ATPBy similarity
Active sitei445 – 4451Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi206 – 2149ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 2 (EC:2.7.11.-)
Gene namesi
Name:ADCK2
Synonyms:AARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:19039. ADCK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Uncharacterized aarF domain-containing protein kinase 2PRO_0000271792Add
BLAST

Proteomic databases

PaxDbiQ7Z695.
PRIDEiQ7Z695.

PTM databases

PhosphoSiteiQ7Z695.

Expressioni

Gene expression databases

BgeeiQ7Z695.
CleanExiHS_ADCK2.
ExpressionAtlasiQ7Z695. baseline and differential.
GenevestigatoriQ7Z695.

Organism-specific databases

HPAiHPA036036.

Interactioni

Protein-protein interaction databases

BioGridi124782. 2 interactions.
STRINGi9606.ENSP00000072869.

Structurei

3D structure databases

ProteinModelPortaliQ7Z695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 618419Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0661.
GeneTreeiENSGT00390000001536.
HOGENOMiHOG000252975.
HOVERGENiHBG080821.
InParanoidiQ7Z695.
KOiK08869.
OMAiIPTMEWL.
OrthoDBiEOG7SFHWC.
PhylomeDBiQ7Z695.
TreeFamiTF315018.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7Z695-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV
60 70 80 90 100
VSLCGDVGEG APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW
110 120 130 140 150
LRAGALLVKF FPLLLLYPLT YLAPSVSTLW LHLLLKATET SGPTYIKLGQ
160 170 180 190 200
WASTRRDLFS EAFCAQFSKL HVRVTPHPWT HTERFLRQAF GDDWGSILSF
210 220 230 240 250
ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP FSHTGAVGGL
260 270 280 290 300
RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP
310 320 330 340 350
EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV
360 370 380 390 400
EEFEKLMVQQ IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE
410 420 430 440 450
TYEESVPVSS YQQAGIPVDL KRKIARLGIN MLLKMIFVDN FVHADLHPGN
460 470 480 490 500
ILVQGANGLS SSQEAQLQQA DICDTLVVAV PSSLCPLRLV LLDAGIVAEL
510 520 530 540 550
QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE GFKTEMAMLV
560 570 580 590 600
TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL
610 620
GRSLDPKLDI LEAARPFLLT GPVCPP
Length:626
Mass (Da):68,982
Last modified:October 1, 2003 - v1
Checksum:iF8E25DB672017AF4
GO

Sequence cautioni

The sequence AAH14107.1 differs from that shown.Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661S → G.
Corresponds to variant rs2968558 [ dbSNP | Ensembl ].
VAR_060990
Natural varianti307 – 3071S → P.1 Publication
Corresponds to variant rs1140034 [ dbSNP | Ensembl ].
VAR_029992
Natural varianti418 – 4181V → L.1 Publication
Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
VAR_041418
Natural varianti418 – 4181V → M.
Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
VAR_029993
Natural varianti622 – 6221P → L.1 Publication
Corresponds to variant rs1046515 [ dbSNP | Ensembl ].
VAR_029994
Natural varianti626 – 6261P → L.1 Publication
Corresponds to variant rs55922126 [ dbSNP | Ensembl ].
VAR_041419

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302592 mRNA. Translation: AAP60021.1.
AC006344 Genomic DNA. Translation: AAD43192.1.
AC006452 Genomic DNA. No translation available.
BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
CCDSiCCDS5861.1.
RefSeqiNP_443085.2. NM_052853.3.
UniGeneiHs.744886.

Genome annotation databases

EnsembliENST00000072869; ENSP00000072869; ENSG00000133597.
GeneIDi90956.
KEGGihsa:90956.
UCSCiuc003vvy.1. human.

Polymorphism databases

DMDMi74723374.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302592 mRNA. Translation: AAP60021.1.
AC006344 Genomic DNA. Translation: AAD43192.1.
AC006452 Genomic DNA. No translation available.
BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
CCDSiCCDS5861.1.
RefSeqiNP_443085.2. NM_052853.3.
UniGeneiHs.744886.

3D structure databases

ProteinModelPortaliQ7Z695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124782. 2 interactions.
STRINGi9606.ENSP00000072869.

PTM databases

PhosphoSiteiQ7Z695.

Polymorphism databases

DMDMi74723374.

Proteomic databases

PaxDbiQ7Z695.
PRIDEiQ7Z695.

Protocols and materials databases

DNASUi90956.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000072869; ENSP00000072869; ENSG00000133597.
GeneIDi90956.
KEGGihsa:90956.
UCSCiuc003vvy.1. human.

Organism-specific databases

CTDi90956.
GeneCardsiGC07P140372.
HGNCiHGNC:19039. ADCK2.
HPAiHPA036036.
neXtProtiNX_Q7Z695.
PharmGKBiPA134902329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0661.
GeneTreeiENSGT00390000001536.
HOGENOMiHOG000252975.
HOVERGENiHBG080821.
InParanoidiQ7Z695.
KOiK08869.
OMAiIPTMEWL.
OrthoDBiEOG7SFHWC.
PhylomeDBiQ7Z695.
TreeFamiTF315018.

Miscellaneous databases

GenomeRNAii90956.
NextBioi77044.
PROiQ7Z695.

Gene expression databases

BgeeiQ7Z695.
CleanExiHS_ADCK2.
ExpressionAtlasiQ7Z695. baseline and differential.
GenevestigatoriQ7Z695.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Shan Y.X., Cheng Z.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-388.
    Tissue: Muscle.
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-307; LEU-418; LEU-622 AND LEU-626.

Entry informationi

Entry nameiADCK2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z695
Secondary accession number(s): Q96CN6, Q9Y6T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2003
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.