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Q7Z695

- ADCK2_HUMAN

UniProt

Q7Z695 - ADCK2_HUMAN

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Protein
Uncharacterized aarF domain-containing protein kinase 2
Gene
ADCK2, AARF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei311 – 3111ATP By similarity
Active sitei445 – 4451Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi206 – 2149ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 2 (EC:2.7.11.-)
Gene namesi
Name:ADCK2
Synonyms:AARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:19039. ADCK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Uncharacterized aarF domain-containing protein kinase 2
PRO_0000271792Add
BLAST

Proteomic databases

PaxDbiQ7Z695.
PRIDEiQ7Z695.

PTM databases

PhosphoSiteiQ7Z695.

Expressioni

Gene expression databases

ArrayExpressiQ7Z695.
BgeeiQ7Z695.
CleanExiHS_ADCK2.
GenevestigatoriQ7Z695.

Organism-specific databases

HPAiHPA036036.

Interactioni

Protein-protein interaction databases

BioGridi124782. 2 interactions.
STRINGi9606.ENSP00000072869.

Structurei

3D structure databases

ProteinModelPortaliQ7Z695.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 618419Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0661.
HOGENOMiHOG000252975.
HOVERGENiHBG080821.
InParanoidiQ7Z695.
KOiK08869.
OMAiIPTMEWL.
OrthoDBiEOG7SFHWC.
PhylomeDBiQ7Z695.
TreeFamiTF315018.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7Z695-1 [UniParc]FASTAAdd to Basket

« Hide

MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV    50
VSLCGDVGEG APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW 100
LRAGALLVKF FPLLLLYPLT YLAPSVSTLW LHLLLKATET SGPTYIKLGQ 150
WASTRRDLFS EAFCAQFSKL HVRVTPHPWT HTERFLRQAF GDDWGSILSF 200
ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP FSHTGAVGGL 250
RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP 300
EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV 350
EEFEKLMVQQ IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE 400
TYEESVPVSS YQQAGIPVDL KRKIARLGIN MLLKMIFVDN FVHADLHPGN 450
ILVQGANGLS SSQEAQLQQA DICDTLVVAV PSSLCPLRLV LLDAGIVAEL 500
QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE GFKTEMAMLV 550
TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL 600
GRSLDPKLDI LEAARPFLLT GPVCPP 626
Length:626
Mass (Da):68,982
Last modified:October 1, 2003 - v1
Checksum:iF8E25DB672017AF4
GO

Sequence cautioni

The sequence AAH14107.1 differs from that shown. Reason: Aberrant splicing.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661S → G.
Corresponds to variant rs2968558 [ dbSNP | Ensembl ].
VAR_060990
Natural varianti307 – 3071S → P.1 Publication
Corresponds to variant rs1140034 [ dbSNP | Ensembl ].
VAR_029992
Natural varianti418 – 4181V → L.1 Publication
Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
VAR_041418
Natural varianti418 – 4181V → M.
Corresponds to variant rs3748092 [ dbSNP | Ensembl ].
VAR_029993
Natural varianti622 – 6221P → L.1 Publication
Corresponds to variant rs1046515 [ dbSNP | Ensembl ].
VAR_029994
Natural varianti626 – 6261P → L.1 Publication
Corresponds to variant rs55922126 [ dbSNP | Ensembl ].
VAR_041419

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY302592 mRNA. Translation: AAP60021.1.
AC006344 Genomic DNA. Translation: AAD43192.1.
AC006452 Genomic DNA. No translation available.
BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
CCDSiCCDS5861.1.
RefSeqiNP_443085.2. NM_052853.3.
UniGeneiHs.744886.

Genome annotation databases

EnsembliENST00000072869; ENSP00000072869; ENSG00000133597.
GeneIDi90956.
KEGGihsa:90956.
UCSCiuc003vvy.1. human.

Polymorphism databases

DMDMi74723374.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY302592 mRNA. Translation: AAP60021.1 .
AC006344 Genomic DNA. Translation: AAD43192.1 .
AC006452 Genomic DNA. No translation available.
BC014107 mRNA. Translation: AAH14107.1 . Sequence problems.
CCDSi CCDS5861.1.
RefSeqi NP_443085.2. NM_052853.3.
UniGenei Hs.744886.

3D structure databases

ProteinModelPortali Q7Z695.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124782. 2 interactions.
STRINGi 9606.ENSP00000072869.

PTM databases

PhosphoSitei Q7Z695.

Polymorphism databases

DMDMi 74723374.

Proteomic databases

PaxDbi Q7Z695.
PRIDEi Q7Z695.

Protocols and materials databases

DNASUi 90956.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000072869 ; ENSP00000072869 ; ENSG00000133597 .
GeneIDi 90956.
KEGGi hsa:90956.
UCSCi uc003vvy.1. human.

Organism-specific databases

CTDi 90956.
GeneCardsi GC07P140372.
HGNCi HGNC:19039. ADCK2.
HPAi HPA036036.
neXtProti NX_Q7Z695.
PharmGKBi PA134902329.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0661.
HOGENOMi HOG000252975.
HOVERGENi HBG080821.
InParanoidi Q7Z695.
KOi K08869.
OMAi IPTMEWL.
OrthoDBi EOG7SFHWC.
PhylomeDBi Q7Z695.
TreeFami TF315018.

Miscellaneous databases

GenomeRNAii 90956.
NextBioi 77044.
PROi Q7Z695.

Gene expression databases

ArrayExpressi Q7Z695.
Bgeei Q7Z695.
CleanExi HS_ADCK2.
Genevestigatori Q7Z695.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view ]
Pfami PF03109. ABC1. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Shan Y.X., Cheng Z.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-388.
    Tissue: Muscle.
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-307; LEU-418; LEU-622 AND LEU-626.

Entry informationi

Entry nameiADCK2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z695
Secondary accession number(s): Q96CN6, Q9Y6T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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