Q7Z695 (ADCK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized aarF domain-containing protein kinase 2
EC=2.7.11.-

Gene names

Name:	ADCK2
Synonyms:	AARF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence AAH14107.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	Uncharacterized aarF domain-containing protein kinase 2		PRO_0000271792
Regions
	Transmembrane	103 – 123	21	Helical; Potential
	Domain	200 – 618	419	Protein kinase
	Nucleotide binding	206 – 214	9	ATP By similarity
Sites
	Active site	445	1	Proton acceptor By similarity
	Binding site	311	1	ATP By similarity
Natural variations
	Natural variant	66	1	S → G. Corresponds to variant rs2968558 [ dbSNP | Ensembl ].		VAR_060990
	Natural variant	307	1	S → P. Ref.4 Corresponds to variant rs1140034 [ dbSNP | Ensembl ].		VAR_029992
	Natural variant	418	1	V → L. Ref.4		VAR_041418
	Natural variant	418	1	V → M. Corresponds to variant rs3748092 [ dbSNP | Ensembl ].		VAR_029993
	Natural variant	622	1	P → L. Ref.4 Corresponds to variant rs1046515 [ dbSNP | Ensembl ].		VAR_029994
	Natural variant	626	1	P → L. Ref.4 Corresponds to variant rs55922126 [ dbSNP | Ensembl ].		VAR_041419

Sequences

	Sequence		Length	Mass (Da)
	Q7Z695 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: F8E25DB672017AF4	FASTA	626	68,982
	10 20 30 40 50 60 MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV VSLCGDVGEG 70 80 90 100 110 120 APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW LRAGALLVKF FPLLLLYPLT 130 140 150 160 170 180 YLAPSVSTLW LHLLLKATET SGPTYIKLGQ WASTRRDLFS EAFCAQFSKL HVRVTPHPWT 190 200 210 220 230 240 HTERFLRQAF GDDWGSILSF ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP 250 260 270 280 290 300 FSHTGAVGGL RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP 310 320 330 340 350 360 EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV EEFEKLMVQQ 370 380 390 400 410 420 IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE TYEESVPVSS YQQAGIPVDL 430 440 450 460 470 480 KRKIARLGIN MLLKMIFVDN FVHADLHPGN ILVQGANGLS SSQEAQLQQA DICDTLVVAV 490 500 510 520 530 540 PSSLCPLRLV LLDAGIVAEL QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE 550 560 570 580 590 600 GFKTEMAMLV TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL 610 620 GRSLDPKLDI LEAARPFLLT GPVCPP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Huang C.Q., Shan Y.X., Cheng Z. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-388. Tissue: Muscle.
[4]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-307; LEU-418; LEU-622 AND LEU-626.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY302592 mRNA. Translation: AAP60021.1. AC006344 Genomic DNA. Translation: AAD43192.1. AC006452 Genomic DNA. No translation available. BC014107 mRNA. Translation: AAH14107.1. Sequence problems.
IPI	IPI00815807.
RefSeq	NP_443085.2. NM_052853.3.
UniGene	Hs.741217.
3D structure databases
ProteinModelPortal	Q7Z695.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000072869.
PTM databases
PhosphoSite	Q7Z695.
Polymorphism databases
DMDM	74723374.
Proteomic databases
PaxDb	Q7Z695.
PRIDE	Q7Z695.
Protocols and materials databases
DNASU	90956.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000072869; ENSP00000072869; ENSG00000133597.
GeneID	90956.
KEGG	hsa:90956.
UCSC	uc003vvy.1. human.
Organism-specific databases
CTD	90956.
GeneCards	GC07P140372.
HGNC	HGNC:19039. ADCK2.
HPA	HPA036036.
neXtProt	NX_Q7Z695.
PharmGKB	PA134902329.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0661.
HOGENOM	HOG000252975.
HOVERGEN	HBG080821.
InParanoid	Q7Z695.
KO	K08869.
OMA	TLWLHLL.
OrthoDB	EOG4H19VG.
PhylomeDB	Q7Z695.
Gene expression databases
ArrayExpress	Q7Z695.
Bgee	Q7Z695.
CleanEx	HS_ADCK2.
Genevestigator	Q7Z695.
Family and domain databases
InterPro	IPR004147. UbiB_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90956.
NextBio	77044.

Entry information

Entry name

ADCK2_HUMAN

Accession

Primary (citable) accession number: Q7Z695
Secondary accession number(s): Q96CN6, Q9Y6T5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.