ID   GP141_HUMAN             Reviewed;         305 AA.
AC   Q7Z602; A4D1X7; Q0VAR5; Q86SP3;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   24-JAN-2024, entry version 135.
DE   RecName: Full=Probable G-protein coupled receptor 141;
DE   AltName: Full=G-protein coupled receptor PGR13;
GN   Name=GPR141; Synonyms=PGR13;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA   Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA   Schioeth H.B.;
RT   "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT   lacking close relatives.";
RL   FEBS Lett. 554:381-388(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-219.
RX   PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA   Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA   Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA   Bergmann J.E., Gaitanaris G.A.;
RT   "The G protein-coupled receptor repertoires of human and mouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN   [5]
RP   VARIANT HIS-72.
RX   PubMed=25787250; DOI=10.1073/pnas.1503696112;
RA   Cromer M.K., Choi M., Nelson-Williams C., Fonseca A.L., Kunstman J.W.,
RA   Korah R.M., Overton J.D., Mane S., Kenney B., Malchoff C.D., Stalberg P.,
RA   Akerstroem G., Westin G., Hellman P., Carling T., Bjoerklund P.,
RA   Lifton R.P.;
RT   "Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in
RT   insulin-producing adenomas.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:4062-4067(2015).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- INTERACTION:
CC       Q7Z602; P07339: CTSD; NbExp=3; IntAct=EBI-21649723, EBI-2115097;
CC       Q7Z602; G5E9A7: DMWD; NbExp=3; IntAct=EBI-21649723, EBI-10976677;
CC       Q7Z602; P28799: GRN; NbExp=3; IntAct=EBI-21649723, EBI-747754;
CC       Q7Z602; P04792: HSPB1; NbExp=3; IntAct=EBI-21649723, EBI-352682;
CC       Q7Z602; P42858: HTT; NbExp=3; IntAct=EBI-21649723, EBI-466029;
CC       Q7Z602; O60333-2: KIF1B; NbExp=3; IntAct=EBI-21649723, EBI-10975473;
CC       Q7Z602; D3DTS7: PMP22; NbExp=3; IntAct=EBI-21649723, EBI-25882629;
CC       Q7Z602; O60260-5: PRKN; NbExp=3; IntAct=EBI-21649723, EBI-21251460;
CC       Q7Z602; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-21649723, EBI-396669;
CC       Q7Z602; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-21649723, EBI-5235340;
CC       Q7Z602; P02766: TTR; NbExp=3; IntAct=EBI-21649723, EBI-711909;
CC       Q7Z602; O76024: WFS1; NbExp=3; IntAct=EBI-21649723, EBI-720609;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY288420; AAP72129.1; -; mRNA.
DR   EMBL; CH236951; EAL23980.1; -; Genomic_DNA.
DR   EMBL; BC120951; AAI20952.1; -; mRNA.
DR   EMBL; BC120952; AAI20953.1; -; mRNA.
DR   EMBL; AY255538; AAO85050.1; -; mRNA.
DR   CCDS; CCDS5451.1; -.
DR   RefSeq; NP_001316922.1; NM_001329993.1.
DR   RefSeq; NP_001316923.1; NM_001329994.1.
DR   RefSeq; NP_861456.1; NM_181791.2.
DR   RefSeq; XP_011513687.1; XM_011515385.2.
DR   RefSeq; XP_011513688.1; XM_011515386.2.
DR   RefSeq; XP_011513690.1; XM_011515388.2.
DR   RefSeq; XP_011513691.1; XM_011515389.2.
DR   RefSeq; XP_016867654.1; XM_017012165.1.
DR   RefSeq; XP_016867655.1; XM_017012166.1.
DR   AlphaFoldDB; Q7Z602; -.
DR   SMR; Q7Z602; -.
DR   BioGRID; 131689; 23.
DR   IntAct; Q7Z602; 24.
DR   STRING; 9606.ENSP00000390410; -.
DR   ChEMBL; CHEMBL4523879; -.
DR   GlyCosmos; Q7Z602; 2 sites, No reported glycans.
DR   GlyGen; Q7Z602; 2 sites.
DR   iPTMnet; Q7Z602; -.
DR   PhosphoSitePlus; Q7Z602; -.
DR   BioMuta; GPR141; -.
DR   DMDM; 62900364; -.
DR   MassIVE; Q7Z602; -.
DR   PaxDb; 9606-ENSP00000390410; -.
DR   PeptideAtlas; Q7Z602; -.
DR   Antibodypedia; 66618; 72 antibodies from 14 providers.
DR   DNASU; 353345; -.
DR   Ensembl; ENST00000334425.2; ENSP00000334540.1; ENSG00000187037.9.
DR   Ensembl; ENST00000447769.1; ENSP00000390410.1; ENSG00000187037.9.
DR   GeneID; 353345; -.
DR   KEGG; hsa:353345; -.
DR   MANE-Select; ENST00000334425.2; ENSP00000334540.1; NM_001381946.1; NP_001368875.1.
DR   UCSC; uc003tfm.1; human.
DR   AGR; HGNC:19997; -.
DR   CTD; 353345; -.
DR   DisGeNET; 353345; -.
DR   GeneCards; GPR141; -.
DR   HGNC; HGNC:19997; GPR141.
DR   HPA; ENSG00000187037; Tissue enriched (bone).
DR   MIM; 609045; gene.
DR   neXtProt; NX_Q7Z602; -.
DR   OpenTargets; ENSG00000187037; -.
DR   PharmGKB; PA134923895; -.
DR   VEuPathDB; HostDB:ENSG00000187037; -.
DR   eggNOG; ENOG502RXS2; Eukaryota.
DR   GeneTree; ENSGT01030000234518; -.
DR   HOGENOM; CLU_069285_0_0_1; -.
DR   InParanoid; Q7Z602; -.
DR   OMA; FRIYYLY; -.
DR   OrthoDB; 4064164at2759; -.
DR   PhylomeDB; Q7Z602; -.
DR   TreeFam; TF333221; -.
DR   PathwayCommons; Q7Z602; -.
DR   SignaLink; Q7Z602; -.
DR   BioGRID-ORCS; 353345; 11 hits in 1146 CRISPR screens.
DR   ChiTaRS; GPR141; human.
DR   GeneWiki; GPR141; -.
DR   GenomeRNAi; 353345; -.
DR   Pharos; Q7Z602; Tdark.
DR   PRO; PR:Q7Z602; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q7Z602; Protein.
DR   Bgee; ENSG00000187037; Expressed in monocyte and 89 other cell types or tissues.
DR   ExpressionAtlas; Q7Z602; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0008142; F:oxysterol binding; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR047160; GP183-like.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24237; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24237:SF35; G-PROTEIN COUPLED RECEPTOR 141-RELATED; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..305
FT                   /note="Probable G-protein coupled receptor 141"
FT                   /id="PRO_0000069618"
FT   TOPO_DOM        1..22
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..50
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..89
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..305
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        9
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         72
FT                   /note="R -> H (in dbSNP:rs772202718)"
FT                   /evidence="ECO:0000269|PubMed:25787250"
FT                   /id="VAR_074185"
SQ   SEQUENCE   305 AA;  35464 MW;  CC078FF8AE34DF39 CRC64;
     MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV TTMAVINLVV
     VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY LTFLFYVVIL VTRYLIFFKC
     KDKVEFYRKL HAVAASAGMW TLVIVIVVPL VVSRYGIHEE YNEEHCFKFH KELAYTYVKI
     INYMIVIFVI AVAVILLVFQ VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP
     YQFFRIYYLN VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN
     CVLCR
//