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Q7Z602

- GP141_HUMAN

UniProt

Q7Z602 - GP141_HUMAN

Protein

Probable G-protein coupled receptor 141

Gene

GPR141

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 141
    Alternative name(s):
    G-protein coupled receptor PGR13
    Gene namesi
    Name:GPR141
    Synonyms:PGR13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:19997. GPR141.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134923895.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Probable G-protein coupled receptor 141PRO_0000069618Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7Z602.
    PRIDEiQ7Z602.

    PTM databases

    PhosphoSiteiQ7Z602.

    Expressioni

    Gene expression databases

    BgeeiQ7Z602.
    CleanExiHS_GPR141.
    GenevestigatoriQ7Z602.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334540.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z602.
    SMRiQ7Z602. Positions 20-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini44 – 507CytoplasmicSequence Analysis
    Topological domaini72 – 8918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini111 – 13121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini153 – 18331ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini205 – 22723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini249 – 26719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini289 – 30517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG139824.
    HOGENOMiHOG000090258.
    HOVERGENiHBG051782.
    InParanoidiQ7Z602.
    KOiK08429.
    OMAiHQEFWAQ.
    OrthoDBiEOG7CNZGZ.
    PhylomeDBiQ7Z602.
    TreeFamiTF333221.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z602-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV    50
    TTMAVINLVV VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY 100
    LTFLFYVVIL VTRYLIFFKC KDKVEFYRKL HAVAASAGMW TLVIVIVVPL 150
    VVSRYGIHEE YNEEHCFKFH KELAYTYVKI INYMIVIFVI AVAVILLVFQ 200
    VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP YQFFRIYYLN 250
    VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN 300
    CVLCR 305
    Length:305
    Mass (Da):35,464
    Last modified:October 1, 2003 - v1
    Checksum:iCC078FF8AE34DF39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288420 mRNA. Translation: AAP72129.1.
    CH236951 Genomic DNA. Translation: EAL23980.1.
    BC120951 mRNA. Translation: AAI20952.1.
    BC120952 mRNA. Translation: AAI20953.1.
    AY255538 mRNA. Translation: AAO85050.1.
    CCDSiCCDS5451.1.
    RefSeqiNP_861456.1. NM_181791.1.
    UniGeneiHs.688230.

    Genome annotation databases

    EnsembliENST00000334425; ENSP00000334540; ENSG00000187037.
    ENST00000447769; ENSP00000390410; ENSG00000187037.
    GeneIDi353345.
    KEGGihsa:353345.
    UCSCiuc003tfm.1. human.

    Polymorphism databases

    DMDMi62900364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288420 mRNA. Translation: AAP72129.1 .
    CH236951 Genomic DNA. Translation: EAL23980.1 .
    BC120951 mRNA. Translation: AAI20952.1 .
    BC120952 mRNA. Translation: AAI20953.1 .
    AY255538 mRNA. Translation: AAO85050.1 .
    CCDSi CCDS5451.1.
    RefSeqi NP_861456.1. NM_181791.1.
    UniGenei Hs.688230.

    3D structure databases

    ProteinModelPortali Q7Z602.
    SMRi Q7Z602. Positions 20-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334540.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7Z602.

    Polymorphism databases

    DMDMi 62900364.

    Proteomic databases

    PaxDbi Q7Z602.
    PRIDEi Q7Z602.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334425 ; ENSP00000334540 ; ENSG00000187037 .
    ENST00000447769 ; ENSP00000390410 ; ENSG00000187037 .
    GeneIDi 353345.
    KEGGi hsa:353345.
    UCSCi uc003tfm.1. human.

    Organism-specific databases

    CTDi 353345.
    GeneCardsi GC07P037724.
    HGNCi HGNC:19997. GPR141.
    MIMi 609045. gene.
    neXtProti NX_Q7Z602.
    PharmGKBi PA134923895.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG139824.
    HOGENOMi HOG000090258.
    HOVERGENi HBG051782.
    InParanoidi Q7Z602.
    KOi K08429.
    OMAi HQEFWAQ.
    OrthoDBi EOG7CNZGZ.
    PhylomeDBi Q7Z602.
    TreeFami TF333221.

    Miscellaneous databases

    GeneWikii GPR141.
    GenomeRNAii 353345.
    NextBioi 99794.
    PROi Q7Z602.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7Z602.
    CleanExi HS_GPR141.
    Genevestigatori Q7Z602.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-219.

    Entry informationi

    Entry nameiGP141_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z602
    Secondary accession number(s): A4D1X7, Q0VAR5, Q86SP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3