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Q7Z602 (GP141_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 141
Alternative name(s):
G-protein coupled receptor PGR13
Gene names
Name:GPR141
Synonyms:PGR13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Probable G-protein coupled receptor 141
PRO_0000069618

Regions

Topological domain1 – 2222Extracellular Potential
Transmembrane23 – 4321Helical; Name=1; Potential
Topological domain44 – 507Cytoplasmic Potential
Transmembrane51 – 7121Helical; Name=2; Potential
Topological domain72 – 8918Extracellular Potential
Transmembrane90 – 11021Helical; Name=3; Potential
Topological domain111 – 13121Cytoplasmic Potential
Transmembrane132 – 15221Helical; Name=4; Potential
Topological domain153 – 18331Extracellular Potential
Transmembrane184 – 20421Helical; Name=5; Potential
Topological domain205 – 22723Cytoplasmic Potential
Transmembrane228 – 24821Helical; Name=6; Potential
Topological domain249 – 26719Extracellular Potential
Transmembrane268 – 28821Helical; Name=7; Potential
Topological domain289 – 30517Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation91N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7Z602 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: CC078FF8AE34DF39

FASTA30535,464
        10         20         30         40         50         60 
MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV TTMAVINLVV 

        70         80         90        100        110        120 
VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY LTFLFYVVIL VTRYLIFFKC 

       130        140        150        160        170        180 
KDKVEFYRKL HAVAASAGMW TLVIVIVVPL VVSRYGIHEE YNEEHCFKFH KELAYTYVKI 

       190        200        210        220        230        240 
INYMIVIFVI AVAVILLVFQ VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP 

       250        260        270        280        290        300 
YQFFRIYYLN VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN 


CVLCR 

« Hide

References

« Hide 'large scale' references
[1]"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-219.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY288420 mRNA. Translation: AAP72129.1.
CH236951 Genomic DNA. Translation: EAL23980.1.
BC120951 mRNA. Translation: AAI20952.1.
BC120952 mRNA. Translation: AAI20953.1.
AY255538 mRNA. Translation: AAO85050.1.
CCDSCCDS5451.1.
RefSeqNP_861456.1. NM_181791.1.
UniGeneHs.688230.

3D structure databases

ProteinModelPortalQ7Z602.
SMRQ7Z602. Positions 20-212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334540.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ7Z602.

Polymorphism databases

DMDM62900364.

Proteomic databases

PaxDbQ7Z602.
PRIDEQ7Z602.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334425; ENSP00000334540; ENSG00000187037.
ENST00000447769; ENSP00000390410; ENSG00000187037.
GeneID353345.
KEGGhsa:353345.
UCSCuc003tfm.1. human.

Organism-specific databases

CTD353345.
GeneCardsGC07P037724.
HGNCHGNC:19997. GPR141.
MIM609045. gene.
neXtProtNX_Q7Z602.
PharmGKBPA134923895.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG139824.
HOGENOMHOG000090258.
HOVERGENHBG051782.
InParanoidQ7Z602.
KOK08429.
OMAHQEFWAQ.
OrthoDBEOG7CNZGZ.
PhylomeDBQ7Z602.
TreeFamTF333221.

Gene expression databases

BgeeQ7Z602.
CleanExHS_GPR141.
GenevestigatorQ7Z602.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR141.
GenomeRNAi353345.
NextBio99794.
PROQ7Z602.
SOURCESearch...

Entry information

Entry nameGP141_HUMAN
AccessionPrimary (citable) accession number: Q7Z602
Secondary accession number(s): A4D1X7, Q0VAR5, Q86SP3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries