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Protein

Probable G-protein coupled receptor 141

Gene

GPR141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 141
Alternative name(s):
G-protein coupled receptor PGR13
Gene namesi
Name:GPR141
Synonyms:PGR13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19997. GPR141.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini44 – 507CytoplasmicSequence Analysis
Transmembranei51 – 7121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini72 – 8918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini111 – 13121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini153 – 18331ExtracellularSequence AnalysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini205 – 22723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei228 – 24821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini249 – 26719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini289 – 30517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923895.

Polymorphism and mutation databases

BioMutaiGPR141.
DMDMi62900364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Probable G-protein coupled receptor 141PRO_0000069618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z602.
PRIDEiQ7Z602.

PTM databases

PhosphoSiteiQ7Z602.

Expressioni

Gene expression databases

BgeeiQ7Z602.
CleanExiHS_GPR141.
ExpressionAtlasiQ7Z602. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi131689. 10 interactions.
STRINGi9606.ENSP00000334540.

Structurei

3D structure databases

ProteinModelPortaliQ7Z602.
SMRiQ7Z602. Positions 20-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG139824.
GeneTreeiENSGT00730000111106.
HOGENOMiHOG000090258.
HOVERGENiHBG051782.
InParanoidiQ7Z602.
KOiK08429.
OMAiHQEFWAQ.
OrthoDBiEOG7CNZGZ.
PhylomeDBiQ7Z602.
TreeFamiTF333221.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV
60 70 80 90 100
TTMAVINLVV VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY
110 120 130 140 150
LTFLFYVVIL VTRYLIFFKC KDKVEFYRKL HAVAASAGMW TLVIVIVVPL
160 170 180 190 200
VVSRYGIHEE YNEEHCFKFH KELAYTYVKI INYMIVIFVI AVAVILLVFQ
210 220 230 240 250
VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP YQFFRIYYLN
260 270 280 290 300
VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN

CVLCR
Length:305
Mass (Da):35,464
Last modified:October 1, 2003 - v1
Checksum:iCC078FF8AE34DF39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288420 mRNA. Translation: AAP72129.1.
CH236951 Genomic DNA. Translation: EAL23980.1.
BC120951 mRNA. Translation: AAI20952.1.
BC120952 mRNA. Translation: AAI20953.1.
AY255538 mRNA. Translation: AAO85050.1.
CCDSiCCDS5451.1.
RefSeqiNP_861456.1. NM_181791.1.
XP_011513686.1. XM_011515384.1.
XP_011513687.1. XM_011515385.1.
XP_011513688.1. XM_011515386.1.
XP_011513689.1. XM_011515387.1.
XP_011513690.1. XM_011515388.1.
XP_011513691.1. XM_011515389.1.
UniGeneiHs.688230.

Genome annotation databases

EnsembliENST00000334425; ENSP00000334540; ENSG00000187037.
ENST00000447769; ENSP00000390410; ENSG00000187037.
GeneIDi353345.
KEGGihsa:353345.
UCSCiuc003tfm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288420 mRNA. Translation: AAP72129.1.
CH236951 Genomic DNA. Translation: EAL23980.1.
BC120951 mRNA. Translation: AAI20952.1.
BC120952 mRNA. Translation: AAI20953.1.
AY255538 mRNA. Translation: AAO85050.1.
CCDSiCCDS5451.1.
RefSeqiNP_861456.1. NM_181791.1.
XP_011513686.1. XM_011515384.1.
XP_011513687.1. XM_011515385.1.
XP_011513688.1. XM_011515386.1.
XP_011513689.1. XM_011515387.1.
XP_011513690.1. XM_011515388.1.
XP_011513691.1. XM_011515389.1.
UniGeneiHs.688230.

3D structure databases

ProteinModelPortaliQ7Z602.
SMRiQ7Z602. Positions 20-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131689. 10 interactions.
STRINGi9606.ENSP00000334540.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7Z602.

Polymorphism and mutation databases

BioMutaiGPR141.
DMDMi62900364.

Proteomic databases

PaxDbiQ7Z602.
PRIDEiQ7Z602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334425; ENSP00000334540; ENSG00000187037.
ENST00000447769; ENSP00000390410; ENSG00000187037.
GeneIDi353345.
KEGGihsa:353345.
UCSCiuc003tfm.1. human.

Organism-specific databases

CTDi353345.
GeneCardsiGC07P037724.
HGNCiHGNC:19997. GPR141.
MIMi609045. gene.
neXtProtiNX_Q7Z602.
PharmGKBiPA134923895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG139824.
GeneTreeiENSGT00730000111106.
HOGENOMiHOG000090258.
HOVERGENiHBG051782.
InParanoidiQ7Z602.
KOiK08429.
OMAiHQEFWAQ.
OrthoDBiEOG7CNZGZ.
PhylomeDBiQ7Z602.
TreeFamiTF333221.

Miscellaneous databases

GeneWikiiGPR141.
GenomeRNAii353345.
NextBioi99794.
PROiQ7Z602.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z602.
CleanExiHS_GPR141.
ExpressionAtlasiQ7Z602. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-219.

Entry informationi

Entry nameiGP141_HUMAN
AccessioniPrimary (citable) accession number: Q7Z602
Secondary accession number(s): A4D1X7, Q0VAR5, Q86SP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.