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Protein

Probable G-protein coupled receptor 141

Gene

GPR141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31673-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 141
Alternative name(s):
G-protein coupled receptor PGR13
Gene namesi
Name:GPR141
Synonyms:PGR13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19997. GPR141.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 50CytoplasmicSequence analysis7
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 89ExtracellularSequence analysisAdd BLAST18
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 131CytoplasmicSequence analysisAdd BLAST21
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 183ExtracellularSequence analysisAdd BLAST31
Transmembranei184 – 204Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini205 – 227CytoplasmicSequence analysisAdd BLAST23
Transmembranei228 – 248Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini249 – 267ExtracellularSequence analysisAdd BLAST19
Transmembranei268 – 288Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini289 – 305CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi353345.
OpenTargetsiENSG00000187037.
PharmGKBiPA134923895.

Polymorphism and mutation databases

BioMutaiGPR141.
DMDMi62900364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696181 – 305Probable G-protein coupled receptor 141Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z602.
PRIDEiQ7Z602.

PTM databases

iPTMnetiQ7Z602.
PhosphoSitePlusiQ7Z602.

Expressioni

Gene expression databases

BgeeiENSG00000187037.
CleanExiHS_GPR141.
ExpressionAtlasiQ7Z602. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi131689. 12 interactors.
STRINGi9606.ENSP00000334540.

Structurei

3D structure databases

ProteinModelPortaliQ7Z602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IN12. Eukaryota.
ENOG410Y9TY. LUCA.
GeneTreeiENSGT00730000111106.
HOGENOMiHOG000090258.
HOVERGENiHBG051782.
InParanoidiQ7Z602.
KOiK08429.
OMAiHQEFWAQ.
OrthoDBiEOG091G0UEI.
PhylomeDBiQ7Z602.
TreeFamiTF333221.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV
60 70 80 90 100
TTMAVINLVV VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY
110 120 130 140 150
LTFLFYVVIL VTRYLIFFKC KDKVEFYRKL HAVAASAGMW TLVIVIVVPL
160 170 180 190 200
VVSRYGIHEE YNEEHCFKFH KELAYTYVKI INYMIVIFVI AVAVILLVFQ
210 220 230 240 250
VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP YQFFRIYYLN
260 270 280 290 300
VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN

CVLCR
Length:305
Mass (Da):35,464
Last modified:October 1, 2003 - v1
Checksum:iCC078FF8AE34DF39
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07418572R → H.1 PublicationCorresponds to variant rs772202718dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288420 mRNA. Translation: AAP72129.1.
CH236951 Genomic DNA. Translation: EAL23980.1.
BC120951 mRNA. Translation: AAI20952.1.
BC120952 mRNA. Translation: AAI20953.1.
AY255538 mRNA. Translation: AAO85050.1.
CCDSiCCDS5451.1.
RefSeqiNP_001316922.1. NM_001329993.1.
NP_001316923.1. NM_001329994.1.
NP_861456.1. NM_181791.2.
XP_011513687.1. XM_011515385.2.
XP_011513688.1. XM_011515386.2.
XP_011513690.1. XM_011515388.2.
XP_011513691.1. XM_011515389.2.
XP_016867654.1. XM_017012165.1.
XP_016867655.1. XM_017012166.1.
UniGeneiHs.563492.
Hs.688230.

Genome annotation databases

EnsembliENST00000334425; ENSP00000334540; ENSG00000187037.
ENST00000447769; ENSP00000390410; ENSG00000187037.
GeneIDi353345.
KEGGihsa:353345.
UCSCiuc003tfm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288420 mRNA. Translation: AAP72129.1.
CH236951 Genomic DNA. Translation: EAL23980.1.
BC120951 mRNA. Translation: AAI20952.1.
BC120952 mRNA. Translation: AAI20953.1.
AY255538 mRNA. Translation: AAO85050.1.
CCDSiCCDS5451.1.
RefSeqiNP_001316922.1. NM_001329993.1.
NP_001316923.1. NM_001329994.1.
NP_861456.1. NM_181791.2.
XP_011513687.1. XM_011515385.2.
XP_011513688.1. XM_011515386.2.
XP_011513690.1. XM_011515388.2.
XP_011513691.1. XM_011515389.2.
XP_016867654.1. XM_017012165.1.
XP_016867655.1. XM_017012166.1.
UniGeneiHs.563492.
Hs.688230.

3D structure databases

ProteinModelPortaliQ7Z602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131689. 12 interactors.
STRINGi9606.ENSP00000334540.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ7Z602.
PhosphoSitePlusiQ7Z602.

Polymorphism and mutation databases

BioMutaiGPR141.
DMDMi62900364.

Proteomic databases

PaxDbiQ7Z602.
PRIDEiQ7Z602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334425; ENSP00000334540; ENSG00000187037.
ENST00000447769; ENSP00000390410; ENSG00000187037.
GeneIDi353345.
KEGGihsa:353345.
UCSCiuc003tfm.1. human.

Organism-specific databases

CTDi353345.
DisGeNETi353345.
GeneCardsiGPR141.
HGNCiHGNC:19997. GPR141.
MIMi609045. gene.
neXtProtiNX_Q7Z602.
OpenTargetsiENSG00000187037.
PharmGKBiPA134923895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN12. Eukaryota.
ENOG410Y9TY. LUCA.
GeneTreeiENSGT00730000111106.
HOGENOMiHOG000090258.
HOVERGENiHBG051782.
InParanoidiQ7Z602.
KOiK08429.
OMAiHQEFWAQ.
OrthoDBiEOG091G0UEI.
PhylomeDBiQ7Z602.
TreeFamiTF333221.

Enzyme and pathway databases

BioCyciZFISH:G66-31673-MONOMER.

Miscellaneous databases

GeneWikiiGPR141.
GenomeRNAii353345.
PROiQ7Z602.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187037.
CleanExiHS_GPR141.
ExpressionAtlasiQ7Z602. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP141_HUMAN
AccessioniPrimary (citable) accession number: Q7Z602
Secondary accession number(s): A4D1X7, Q0VAR5, Q86SP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.