Q7Z602 (GP141_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 141

Alternative name(s):
G-protein coupled receptor PGR13

Gene names

Name:	GPR141
Synonyms:	PGR13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Probable G-protein coupled receptor 141		PRO_0000069618
Regions
	Topological domain	1 – 22	22	Extracellular Potential
	Transmembrane	23 – 43	21	Helical; Name=1; Potential
	Topological domain	44 – 50	7	Cytoplasmic Potential
	Transmembrane	51 – 71	21	Helical; Name=2; Potential
	Topological domain	72 – 89	18	Extracellular Potential
	Transmembrane	90 – 110	21	Helical; Name=3; Potential
	Topological domain	111 – 131	21	Cytoplasmic Potential
	Transmembrane	132 – 152	21	Helical; Name=4; Potential
	Topological domain	153 – 183	31	Extracellular Potential
	Transmembrane	184 – 204	21	Helical; Name=5; Potential
	Topological domain	205 – 227	23	Cytoplasmic Potential
	Transmembrane	228 – 248	21	Helical; Name=6; Potential
	Topological domain	249 – 267	19	Extracellular Potential
	Transmembrane	268 – 288	21	Helical; Name=7; Potential
	Topological domain	289 – 305	17	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	9	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7Z602 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: CC078FF8AE34DF39	FASTA	305	35,464
	10 20 30 40 50 60 MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV TTMAVINLVV 70 80 90 100 110 120 VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY LTFLFYVVIL VTRYLIFFKC 130 140 150 160 170 180 KDKVEFYRKL HAVAASAGMW TLVIVIVVPL VVSRYGIHEE YNEEHCFKFH KELAYTYVKI 190 200 210 220 230 240 INYMIVIFVI AVAVILLVFQ VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP 250 260 270 280 290 300 YQFFRIYYLN VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN CVLCR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives." Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B. FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-219.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY288420 mRNA. Translation: AAP72129.1. CH236951 Genomic DNA. Translation: EAL23980.1. BC120951 mRNA. Translation: AAI20952.1. BC120952 mRNA. Translation: AAI20953.1. AY255538 mRNA. Translation: AAO85050.1.
IPI	IPI00328432.
RefSeq	NP_861456.1. NM_181791.1.
UniGene	Hs.688230.
3D structure databases
ProteinModelPortal	Q7Z602.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000334540.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q7Z602.
Polymorphism databases
DMDM	62900364.
Proteomic databases
PaxDb	Q7Z602.
PRIDE	Q7Z602.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334425; ENSP00000334540; ENSG00000187037. ENST00000447769; ENSP00000390410; ENSG00000187037.
GeneID	353345.
KEGG	hsa:353345.
UCSC	uc003tfm.1. human.
Organism-specific databases
CTD	353345.
GeneCards	GC07P037724.
HGNC	HGNC:19997. GPR141.
MIM	609045. gene.
neXtProt	NX_Q7Z602.
PharmGKB	PA134923895.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG139824.
HOGENOM	HOG000090258.
HOVERGEN	HBG051782.
InParanoid	Q7Z602.
KO	K08429.
OMA	HQEFWAQ.
PhylomeDB	Q7Z602.
Gene expression databases
ArrayExpress	Q7Z602.
Bgee	Q7Z602.
CleanEx	HS_GPR141.
Genevestigator	Q7Z602.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	353345.
NextBio	99794.
SOURCE	Search...

Entry information

Entry name

GP141_HUMAN

Accession

Primary (citable) accession number: Q7Z602
Secondary accession number(s): A4D1X7, Q0VAR5, Q86SP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.