Q7Z601 (GP142_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 142

Alternative name(s):
G-protein coupled receptor PGR2

Gene names

Name:	GPR142
Synonyms:	PGR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Exclusively expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus. Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cell junction Inferred from direct assay. Source: HPA cytoplasm Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: HPA
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Probable G-protein coupled receptor 142		PRO_0000069620
Regions
	Topological domain	1 – 152	152	Extracellular Potential
	Transmembrane	153 – 173	21	Helical; Name=1; Potential
	Topological domain	174 – 195	22	Cytoplasmic Potential
	Transmembrane	196 – 216	21	Helical; Name=2; Potential
	Topological domain	217 – 233	17	Extracellular Potential
	Transmembrane	234 – 254	21	Helical; Name=3; Potential
	Topological domain	255 – 278	24	Cytoplasmic Potential
	Transmembrane	279 – 299	21	Helical; Name=4; Potential
	Topological domain	300 – 316	17	Extracellular Potential
	Transmembrane	317 – 337	21	Helical; Name=5; Potential
	Topological domain	338 – 357	20	Cytoplasmic Potential
	Transmembrane	358 – 378	21	Helical; Name=6; Potential
	Topological domain	379 – 397	19	Extracellular Potential
	Transmembrane	398 – 418	21	Helical; Name=7; Potential
	Topological domain	419 – 462	44	Cytoplasmic Potential
Natural variations
	Natural variant	132	1	H → N. Ref.3 Corresponds to variant rs2382647 [ dbSNP | Ensembl ].		VAR_061219

Sequences

	Sequence		Length	Mass (Da)
	Q7Z601 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: E9120B52372C75CA	FASTA	462	51,106
	10 20 30 40 50 60 MSIMMLPMEQ KIQWVPTSLQ DITAVLGTEA YTEEDKSMVS HAQKSQHSCL SHSRWLRSPQ 70 80 90 100 110 120 VTGGSWDLRI RPSKDSSSFR QAQCLRKDPG ANNHLESQGV RGTAGDADRE LRGPSEKATA 130 140 150 160 170 180 GQPRVTLLPT PHVSGLSQEF ESHWPEIAER SPCVAGVIPV IYYSVLLGLG LPVSLLTAVA 190 200 210 220 230 240 LARLATRTRR PSYYYLLALT ASDIIIQVVI VFAGFLLQGA VLARQVPQAV VRTANILEFA 250 260 270 280 290 300 ANHASVWIAI LLTVDRYTAL CHPLHHRAAS SPGRTRRAIA AVLSAALLTG IPFYWWLDMW 310 320 330 340 350 360 RDTDSPRTLD EVLKWAHCLT VYFIPCGVFL VTNSAIIHRL RRRGRSGLQP RVGKSTAILL 370 380 390 400 410 420 GITTLFTLLW APRVFVMLYH MYVAPVHRDW RVHLALDVAN MVAMLHTAAN FGLYCFVSKT 430 440 450 460 FRATVRQVIH DAYLPCTLAS QPEGMAAKPV MEPPGLPTGA EV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives." Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B. FEBS Lett. 554:381-388(2003) [PubMed: 14623098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system." Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J., Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y. Biochem. Biophys. Res. Commun. 331:363-369(2005) [PubMed: 15845401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed: 12679517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-436, VARIANT ASN-132.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY288421 mRNA. Translation: AAP72130.1. AB196530 mRNA. Translation: BAD97441.1. AY255622 mRNA. Translation: AAO85134.1.
IPI	IPI00376210.
RefSeq	NP_861455.1. NM_181790.1.
UniGene	Hs.574368.
3D structure databases
ProteinModelPortal	Q7Z601.
SMR	Q7Z601. Positions 396-430.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7Z601.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	83288229.
Proteomic databases
PRIDE	Q7Z601.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335666; ENSP00000335158; ENSG00000196169.
GeneID	350383.
KEGG	hsa:350383.
UCSC	uc002jko.1. human.
Organism-specific databases
CTD	350383.
GeneCards	GC17P072322.
HGNC	HGNC:20088. GPR142.
HPA	HPA031392.
MIM	609046. gene.
neXtProt	NX_Q7Z601.
PharmGKB	PA134891802.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09409.
GeneTree	ENSGT00390000006613.
HOVERGEN	HBG051783.
InParanoid	Q7Z601.
PhylomeDB	Q7Z601.
Gene expression databases
ArrayExpress	Q7Z601.
CleanEx	HS_GPR142.
Genevestigator	Q7Z601.
GermOnline	ENSG00000196169. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K08430.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	99538.
SOURCE	Search...

Entry information

Entry name

GP142_HUMAN

Accession

Primary (citable) accession number: Q7Z601
Secondary accession number(s): A4CYJ8, Q86SL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	October 1, 2003
Last modified:	December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.