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Protein

Probable G-protein coupled receptor 142

Gene

GPR142

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 142
Alternative name(s):
G-protein coupled receptor PGR2
Gene namesi
Name:GPR142
Synonyms:PGR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20088. GPR142.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 152ExtracellularSequence analysisAdd BLAST152
Transmembranei153 – 173Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini174 – 195CytoplasmicSequence analysisAdd BLAST22
Transmembranei196 – 216Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini217 – 233ExtracellularSequence analysisAdd BLAST17
Transmembranei234 – 254Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini255 – 278CytoplasmicSequence analysisAdd BLAST24
Transmembranei279 – 299Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini300 – 316ExtracellularSequence analysisAdd BLAST17
Transmembranei317 – 337Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini338 – 357CytoplasmicSequence analysisAdd BLAST20
Transmembranei358 – 378Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini379 – 397ExtracellularSequence analysisAdd BLAST19
Transmembranei398 – 418Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini419 – 462CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000257008.
PharmGKBiPA134891802.

Chemistry databases

ChEMBLiCHEMBL2069161.
GuidetoPHARMACOLOGYi132.

Polymorphism and mutation databases

BioMutaiGPR142.
DMDMi83288229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696201 – 462Probable G-protein coupled receptor 142Add BLAST462

Proteomic databases

EPDiQ7Z601.
PaxDbiQ7Z601.
PeptideAtlasiQ7Z601.
PRIDEiQ7Z601.

PTM databases

iPTMnetiQ7Z601.
PhosphoSitePlusiQ7Z601.

Expressioni

Tissue specificityi

Exclusively expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.1 Publication

Gene expression databases

BgeeiENSG00000257008.
CleanExiHS_GPR142.
ExpressionAtlasiQ7Z601. baseline and differential.

Organism-specific databases

HPAiHPA031392.

Interactioni

Protein-protein interaction databases

BioGridi131570. 1 interactor.
STRINGi9606.ENSP00000335158.

Chemistry databases

BindingDBiQ7Z601.

Structurei

3D structure databases

ProteinModelPortaliQ7Z601.
SMRiQ7Z601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG051783.
InParanoidiQ7Z601.
KOiK08430.
OMAiHWPEIPE.
OrthoDBiEOG091G0HIF.
PhylomeDBiQ7Z601.
TreeFamiTF334275.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMMLPMEQ KIQWVPTSLQ DITAVLGTEA YTEEDKSMVS HAQKSQHSCL
60 70 80 90 100
SHSRWLRSPQ VTGGSWDLRI RPSKDSSSFR QAQCLRKDPG ANNHLESQGV
110 120 130 140 150
RGTAGDADRE LRGPSEKATA GQPRVTLLPT PHVSGLSQEF ESHWPEIAER
160 170 180 190 200
SPCVAGVIPV IYYSVLLGLG LPVSLLTAVA LARLATRTRR PSYYYLLALT
210 220 230 240 250
ASDIIIQVVI VFAGFLLQGA VLARQVPQAV VRTANILEFA ANHASVWIAI
260 270 280 290 300
LLTVDRYTAL CHPLHHRAAS SPGRTRRAIA AVLSAALLTG IPFYWWLDMW
310 320 330 340 350
RDTDSPRTLD EVLKWAHCLT VYFIPCGVFL VTNSAIIHRL RRRGRSGLQP
360 370 380 390 400
RVGKSTAILL GITTLFTLLW APRVFVMLYH MYVAPVHRDW RVHLALDVAN
410 420 430 440 450
MVAMLHTAAN FGLYCFVSKT FRATVRQVIH DAYLPCTLAS QPEGMAAKPV
460
MEPPGLPTGA EV
Length:462
Mass (Da):51,106
Last modified:October 1, 2003 - v1
Checksum:iE9120B52372C75CA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061219132H → N.1 PublicationCorresponds to variant rs2382647dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288421 mRNA. Translation: AAP72130.1.
AB196530 mRNA. Translation: BAD97441.1.
AY255622 mRNA. Translation: AAO85134.1.
CCDSiCCDS11698.1.
RefSeqiNP_861455.1. NM_181790.1.
UniGeneiHs.574368.

Genome annotation databases

EnsembliENST00000335666; ENSP00000335158; ENSG00000257008.
GeneIDi350383.
KEGGihsa:350383.
UCSCiuc032fqt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288421 mRNA. Translation: AAP72130.1.
AB196530 mRNA. Translation: BAD97441.1.
AY255622 mRNA. Translation: AAO85134.1.
CCDSiCCDS11698.1.
RefSeqiNP_861455.1. NM_181790.1.
UniGeneiHs.574368.

3D structure databases

ProteinModelPortaliQ7Z601.
SMRiQ7Z601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131570. 1 interactor.
STRINGi9606.ENSP00000335158.

Chemistry databases

BindingDBiQ7Z601.
ChEMBLiCHEMBL2069161.
GuidetoPHARMACOLOGYi132.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ7Z601.
PhosphoSitePlusiQ7Z601.

Polymorphism and mutation databases

BioMutaiGPR142.
DMDMi83288229.

Proteomic databases

EPDiQ7Z601.
PaxDbiQ7Z601.
PeptideAtlasiQ7Z601.
PRIDEiQ7Z601.

Protocols and materials databases

DNASUi350383.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335666; ENSP00000335158; ENSG00000257008.
GeneIDi350383.
KEGGihsa:350383.
UCSCiuc032fqt.2. human.

Organism-specific databases

CTDi350383.
GeneCardsiGPR142.
HGNCiHGNC:20088. GPR142.
HPAiHPA031392.
MIMi609046. gene.
neXtProtiNX_Q7Z601.
OpenTargetsiENSG00000257008.
PharmGKBiPA134891802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG051783.
InParanoidiQ7Z601.
KOiK08430.
OMAiHWPEIPE.
OrthoDBiEOG091G0HIF.
PhylomeDBiQ7Z601.
TreeFamiTF334275.

Enzyme and pathway databases

BioCyciZFISH:G66-31549-MONOMER.

Miscellaneous databases

GeneWikiiGPR142.
GenomeRNAii350383.
PROiQ7Z601.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257008.
CleanExiHS_GPR142.
ExpressionAtlasiQ7Z601. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP142_HUMAN
AccessioniPrimary (citable) accession number: Q7Z601
Secondary accession number(s): A4CYJ8, Q86SL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.