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Protein

Probable G-protein coupled receptor 142

Gene

GPR142

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 142
Alternative name(s):
G-protein coupled receptor PGR2
Gene namesi
Name:GPR142
Synonyms:PGR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20088. GPR142.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 152152ExtracellularSequence analysisAdd
BLAST
Transmembranei153 – 17321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini174 – 19522CytoplasmicSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini217 – 23317ExtracellularSequence analysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini255 – 27824CytoplasmicSequence analysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini300 – 31617ExtracellularSequence analysisAdd
BLAST
Transmembranei317 – 33721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini338 – 35720CytoplasmicSequence analysisAdd
BLAST
Transmembranei358 – 37821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini379 – 39719ExtracellularSequence analysisAdd
BLAST
Transmembranei398 – 41821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini419 – 46244CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891802.

Chemistry

ChEMBLiCHEMBL2069161.
GuidetoPHARMACOLOGYi132.

Polymorphism and mutation databases

BioMutaiGPR142.
DMDMi83288229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Probable G-protein coupled receptor 142PRO_0000069620Add
BLAST

Proteomic databases

EPDiQ7Z601.
PaxDbiQ7Z601.
PRIDEiQ7Z601.

PTM databases

PhosphoSiteiQ7Z601.

Expressioni

Tissue specificityi

Exclusively expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.1 Publication

Gene expression databases

BgeeiQ7Z601.
CleanExiHS_GPR142.
ExpressionAtlasiQ7Z601. baseline and differential.

Organism-specific databases

HPAiHPA031392.

Interactioni

Protein-protein interaction databases

BioGridi131570. 1 interaction.
STRINGi9606.ENSP00000335158.

Chemistry

BindingDBiQ7Z601.

Structurei

3D structure databases

ProteinModelPortaliQ7Z601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG051783.
InParanoidiQ7Z601.
KOiK08430.
OMAiHWPEIPE.
OrthoDBiEOG7XSTDW.
PhylomeDBiQ7Z601.
TreeFamiTF334275.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMMLPMEQ KIQWVPTSLQ DITAVLGTEA YTEEDKSMVS HAQKSQHSCL
60 70 80 90 100
SHSRWLRSPQ VTGGSWDLRI RPSKDSSSFR QAQCLRKDPG ANNHLESQGV
110 120 130 140 150
RGTAGDADRE LRGPSEKATA GQPRVTLLPT PHVSGLSQEF ESHWPEIAER
160 170 180 190 200
SPCVAGVIPV IYYSVLLGLG LPVSLLTAVA LARLATRTRR PSYYYLLALT
210 220 230 240 250
ASDIIIQVVI VFAGFLLQGA VLARQVPQAV VRTANILEFA ANHASVWIAI
260 270 280 290 300
LLTVDRYTAL CHPLHHRAAS SPGRTRRAIA AVLSAALLTG IPFYWWLDMW
310 320 330 340 350
RDTDSPRTLD EVLKWAHCLT VYFIPCGVFL VTNSAIIHRL RRRGRSGLQP
360 370 380 390 400
RVGKSTAILL GITTLFTLLW APRVFVMLYH MYVAPVHRDW RVHLALDVAN
410 420 430 440 450
MVAMLHTAAN FGLYCFVSKT FRATVRQVIH DAYLPCTLAS QPEGMAAKPV
460
MEPPGLPTGA EV
Length:462
Mass (Da):51,106
Last modified:October 1, 2003 - v1
Checksum:iE9120B52372C75CA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321H → N.1 Publication
Corresponds to variant rs2382647 [ dbSNP | Ensembl ].
VAR_061219

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288421 mRNA. Translation: AAP72130.1.
AB196530 mRNA. Translation: BAD97441.1.
AY255622 mRNA. Translation: AAO85134.1.
CCDSiCCDS11698.1.
RefSeqiNP_861455.1. NM_181790.1.
UniGeneiHs.574368.

Genome annotation databases

EnsembliENST00000335666; ENSP00000335158; ENSG00000257008.
GeneIDi350383.
KEGGihsa:350383.
UCSCiuc032fqt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288421 mRNA. Translation: AAP72130.1.
AB196530 mRNA. Translation: BAD97441.1.
AY255622 mRNA. Translation: AAO85134.1.
CCDSiCCDS11698.1.
RefSeqiNP_861455.1. NM_181790.1.
UniGeneiHs.574368.

3D structure databases

ProteinModelPortaliQ7Z601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131570. 1 interaction.
STRINGi9606.ENSP00000335158.

Chemistry

BindingDBiQ7Z601.
ChEMBLiCHEMBL2069161.
GuidetoPHARMACOLOGYi132.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7Z601.

Polymorphism and mutation databases

BioMutaiGPR142.
DMDMi83288229.

Proteomic databases

EPDiQ7Z601.
PaxDbiQ7Z601.
PRIDEiQ7Z601.

Protocols and materials databases

DNASUi350383.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335666; ENSP00000335158; ENSG00000257008.
GeneIDi350383.
KEGGihsa:350383.
UCSCiuc032fqt.2. human.

Organism-specific databases

CTDi350383.
GeneCardsiGPR142.
HGNCiHGNC:20088. GPR142.
HPAiHPA031392.
MIMi609046. gene.
neXtProtiNX_Q7Z601.
PharmGKBiPA134891802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG051783.
InParanoidiQ7Z601.
KOiK08430.
OMAiHWPEIPE.
OrthoDBiEOG7XSTDW.
PhylomeDBiQ7Z601.
TreeFamiTF334275.

Miscellaneous databases

GeneWikiiGPR142.
GenomeRNAii350383.
NextBioi99538.
PROiQ7Z601.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z601.
CleanExiHS_GPR142.
ExpressionAtlasiQ7Z601. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system."
    Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J., Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.
    Biochem. Biophys. Res. Commun. 331:363-369(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-436, VARIANT ASN-132.

Entry informationi

Entry nameiGP142_HUMAN
AccessioniPrimary (citable) accession number: Q7Z601
Secondary accession number(s): A4CYJ8, Q86SL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2003
Last modified: March 16, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.