Q7Z5Y7 (KCD20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BTB/POZ domain-containing protein KCTD20

Gene names

Name:	KCTD20
Synonyms:	C6orf69

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Part of a complex containing MARK4.
Sequence similarities	Contains 1 BTB (POZ) domain.
Sequence caution	The sequence CAH72192.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI19118.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z5Y7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z5Y7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: D → G
     55-220: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	BTB/POZ domain-containing protein KCTD20		PRO_0000255248
Regions
	Domain	117 – 191	75	BTB
Natural variations
	Alternative sequence	54	1	D → G in isoform 2.		VSP_021277
	Alternative sequence	55 – 220	166	Missing in isoform 2.		VSP_021278
	Natural variant	171	1	S → T. Corresponds to variant rs2239808 [ dbSNP | Ensembl ].		VAR_028854
Experimental info
	Sequence conflict	70	1	H → R in CAH10583. Ref.6
	Sequence conflict	205	1	L → P in CAH10583. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 71B5D35EA02714EC	FASTA	419	47,480
	10 20 30 40 50 60 MNVHRGSDSD RLLRQEASCL VDDTLAVAQE KEANSLASSG PHNLTYPLGP RNEDLSLDYA 70 80 90 100 110 120 SQPANLQFPH IMPLAEDIKG SCFQSGNKRN HEPFIAPERF GNSSVGFGSN SHSQAPEKVT 130 140 150 160 170 180 LLVDGTRFVV NPQIFTAHPD TMLGRMFGPG REYNFTRPNE KGEYEIAEGI SATVFRTVLD 190 200 210 220 230 240 YYKTGIINCP DGISIPDLRD TCDYLCINFD FNTIRCQDLS ALLHELSNDG AHKQFDHYLE 250 260 270 280 290 300 ELILPIMVGC AKKGERECHI VVLTDEDSVD WDEDHPPPMG EEYSQILYSS KLYRFFKYIE 310 320 330 340 350 360 NRDVAKTVLK ERGLKNIRIG IEGYPTCKEK IKRRPGGRSE VIYNYVQRPF IQMSWEKEEG 370 380 390 400 410 KSRHVDFQCV RSKSLTNLVA AGDDVLEDQE ILMHHPPQVD ELDRLNAPLS QMASNDFQD
	Isoform 2 [UniParc]. Checksum: FD685CD0E4995090	FASTA	253	28,892
	10 20 30 40 50 60 MNVHRGSDSD RLLRQEASCL VDDTLAVAQE KEANSLASSG PHNLTYPLGP RNEGALLHEL 70 80 90 100 110 120 SNDGAHKQFD HYLEELILPI MVGCAKKGER ECHIVVLTDE DSVDWDEDHP PPMGEEYSQI 130 140 150 160 170 180 LYSSKLYRFF KYIENRDVAK TVLKERGLKN IRIGIEGYPT CKEKIKRRPG GRSEVIYNYV 190 200 210 220 230 240 QRPFIQMSWE KEEGKSRHVD FQCVRSKSLT NLVAAGDDVL EDQEILMHHP PQVDELDRLN 250 APLSQMASND FQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Huang C.Q., Chen Z., Wu S.L., Shan Y.X., Liu S., Xiao P.J. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Trachea.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-419 (ISOFORM 1). Tissue: Skeletal muscle.
[7]	"Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network." Brajenovic M., Joberty G., Kuster B., Bouwmeester T., Drewes G. J. Biol. Chem. 279:12804-12811(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MARK4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY305862 mRNA. Translation: AAP74385.1. AK304377 mRNA. Translation: BAG65215.1. AL136135, Z85986 Genomic DNA. Translation: CAH72192.1. Sequence problems. Z85986, AL136135 Genomic DNA. Translation: CAI19118.1. Sequence problems. CH471081 Genomic DNA. Translation: EAX03892.1. BC023525 mRNA. Translation: AAH23525.1. AL832381 mRNA. Translation: CAH10583.1.
IPI	IPI00418430. IPI00796097.
RefSeq	NP_775833.2. NM_173562.3.
UniGene	Hs.188757.
3D structure databases
ProteinModelPortal	Q7Z5Y7.
SMR	Q7Z5Y7. Positions 117-210.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z5Y7. 2 interactions.
STRING	9606.ENSP00000362836.
PTM databases
PhosphoSite	Q7Z5Y7.
Polymorphism databases
DMDM	74750149.
Proteomic databases
PaxDb	Q7Z5Y7.
PRIDE	Q7Z5Y7.
Protocols and materials databases
DNASU	222658.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373731; ENSP00000362836; ENSG00000112078. ENST00000449081; ENSP00000412205; ENSG00000112078.
GeneID	222658.
KEGG	hsa:222658.
UCSC	uc003ome.3. human. uc010jwk.3. human.
Organism-specific databases
CTD	222658.
GeneCards	GC06P036410.
HGNC	HGNC:21052. KCTD20.
HPA	HPA030092.
neXtProt	NX_Q7Z5Y7.
PharmGKB	PA134913479.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG309152.
HOGENOM	HOG000261659.
HOVERGEN	HBG059410.
InParanoid	Q7Z5Y7.
OMA	DYASQPA.
OrthoDB	EOG4N30NX.
Gene expression databases
ArrayExpress	Q7Z5Y7.
Bgee	Q7Z5Y7.
CleanEx	HS_KCTD20.
Genevestigator	Q7Z5Y7.
GermOnline	ENSG00000112078. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR003131. T1-type_BTB. [Graphical view]
Pfam	PF02214. K_tetra. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	222658.
NextBio	91647.

Entry information

Entry name

KCD20_HUMAN

Accession

Primary (citable) accession number: Q7Z5Y7
Secondary accession number(s): B4E2Q3 , Q5W105, Q69YQ7, Q8IZ55

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.