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Q7Z5Y7 (KCD20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BTB/POZ domain-containing protein KCTD20
Gene names
Name:KCTD20
Synonyms:C6orf69
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Part of a complex containing MARK4.

Sequence similarities

Contains 1 BTB (POZ) domain.

Sequence caution

The sequence CAH72192.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI19118.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein homooligomerization

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z5Y7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z5Y7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: D → G
     55-220: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419BTB/POZ domain-containing protein KCTD20
PRO_0000255248

Regions

Domain117 – 19175BTB

Natural variations

Alternative sequence541D → G in isoform 2.
VSP_021277
Alternative sequence55 – 220166Missing in isoform 2.
VSP_021278
Natural variant1711S → T.
Corresponds to variant rs2239808 [ dbSNP | Ensembl ].
VAR_028854

Experimental info

Sequence conflict701H → R in CAH10583. Ref.6
Sequence conflict2051L → P in CAH10583. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 71B5D35EA02714EC

FASTA41947,480
        10         20         30         40         50         60 
MNVHRGSDSD RLLRQEASCL VDDTLAVAQE KEANSLASSG PHNLTYPLGP RNEDLSLDYA 

        70         80         90        100        110        120 
SQPANLQFPH IMPLAEDIKG SCFQSGNKRN HEPFIAPERF GNSSVGFGSN SHSQAPEKVT 

       130        140        150        160        170        180 
LLVDGTRFVV NPQIFTAHPD TMLGRMFGPG REYNFTRPNE KGEYEIAEGI SATVFRTVLD 

       190        200        210        220        230        240 
YYKTGIINCP DGISIPDLRD TCDYLCINFD FNTIRCQDLS ALLHELSNDG AHKQFDHYLE 

       250        260        270        280        290        300 
ELILPIMVGC AKKGERECHI VVLTDEDSVD WDEDHPPPMG EEYSQILYSS KLYRFFKYIE 

       310        320        330        340        350        360 
NRDVAKTVLK ERGLKNIRIG IEGYPTCKEK IKRRPGGRSE VIYNYVQRPF IQMSWEKEEG 

       370        380        390        400        410 
KSRHVDFQCV RSKSLTNLVA AGDDVLEDQE ILMHHPPQVD ELDRLNAPLS QMASNDFQD 

« Hide

Isoform 2 [UniParc].

Checksum: FD685CD0E4995090
Show »

FASTA25328,892

References

« Hide 'large scale' references
[1]Huang C.Q., Chen Z., Wu S.L., Shan Y.X., Liu S., Xiao P.J.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Trachea.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-419 (ISOFORM 1).
Tissue: Skeletal muscle.
[7]"Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network."
Brajenovic M., Joberty G., Kuster B., Bouwmeester T., Drewes G.
J. Biol. Chem. 279:12804-12811(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MARK4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY305862 mRNA. Translation: AAP74385.1.
AK304377 mRNA. Translation: BAG65215.1.
AL136135, Z85986 Genomic DNA. Translation: CAH72192.1. Sequence problems.
Z85986, AL136135 Genomic DNA. Translation: CAI19118.1. Sequence problems.
CH471081 Genomic DNA. Translation: EAX03892.1.
BC023525 mRNA. Translation: AAH23525.1.
AL832381 mRNA. Translation: CAH10583.1.
RefSeqNP_001273508.1. NM_001286579.1.
NP_001273509.1. NM_001286580.1.
NP_775833.2. NM_173562.4.
XP_005248997.1. XM_005248940.2.
UniGeneHs.188757.

3D structure databases

ProteinModelPortalQ7Z5Y7.
SMRQ7Z5Y7. Positions 116-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128809. 5 interactions.
IntActQ7Z5Y7. 2 interactions.
STRING9606.ENSP00000362836.

PTM databases

PhosphoSiteQ7Z5Y7.

Polymorphism databases

DMDM74750149.

Proteomic databases

PaxDbQ7Z5Y7.
PRIDEQ7Z5Y7.

Protocols and materials databases

DNASU222658.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373731; ENSP00000362836; ENSG00000112078. [Q7Z5Y7-1]
ENST00000449081; ENSP00000412205; ENSG00000112078. [Q7Z5Y7-2]
GeneID222658.
KEGGhsa:222658.
UCSCuc003ome.3. human. [Q7Z5Y7-1]
uc010jwk.3. human. [Q7Z5Y7-2]

Organism-specific databases

CTD222658.
GeneCardsGC06P036410.
HGNCHGNC:21052. KCTD20.
HPAHPA030092.
neXtProtNX_Q7Z5Y7.
PharmGKBPA134913479.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309152.
HOGENOMHOG000261659.
HOVERGENHBG059410.
InParanoidQ7Z5Y7.
OMADYASQPA.
OrthoDBEOG78M01S.
PhylomeDBQ7Z5Y7.
TreeFamTF314369.

Gene expression databases

ArrayExpressQ7Z5Y7.
BgeeQ7Z5Y7.
CleanExHS_KCTD20.
GenevestigatorQ7Z5Y7.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi222658.
NextBio91647.
PROQ7Z5Y7.

Entry information

Entry nameKCD20_HUMAN
AccessionPrimary (citable) accession number: Q7Z5Y7
Secondary accession number(s): B4E2Q3 expand/collapse secondary AC list , Q5W105, Q69YQ7, Q8IZ55
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM