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Q7Z5Y7

- KCD20_HUMAN

UniProt

Q7Z5Y7 - KCD20_HUMAN

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Protein

BTB/POZ domain-containing protein KCTD20

Gene

KCTD20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Promotes the phosphorylation of AKT family members.By similarity

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD20
Alternative name(s):
Potassium channel tetramerization domain containing 20
Gene namesi
Name:KCTD20
Synonyms:C6orf69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21052. KCTD20.

Subcellular locationi

Cytoplasm By similarity
Note: Colocalizes with BTBD10 in filamentous structures.By similarity

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419BTB/POZ domain-containing protein KCTD20PRO_0000255248Add
BLAST

Proteomic databases

MaxQBiQ7Z5Y7.
PaxDbiQ7Z5Y7.
PRIDEiQ7Z5Y7.

PTM databases

PhosphoSiteiQ7Z5Y7.

Expressioni

Gene expression databases

BgeeiQ7Z5Y7.
CleanExiHS_KCTD20.
ExpressionAtlasiQ7Z5Y7. baseline and differential.
GenevestigatoriQ7Z5Y7.

Organism-specific databases

HPAiHPA030092.

Interactioni

Subunit structurei

Interacts with AKT1; AKT2 and AKT3 (By similarity). Associates with PP2CA (By similarity). Part of a complex containing MARK4 (PubMed:14676191).By similarity1 Publication

Protein-protein interaction databases

BioGridi128809. 6 interactions.
IntActiQ7Z5Y7. 2 interactions.
STRINGi9606.ENSP00000362836.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5Y7.
SMRiQ7Z5Y7. Positions 116-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 19175BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiNOG309152.
GeneTreeiENSGT00390000007975.
HOGENOMiHOG000261659.
HOVERGENiHBG059410.
InParanoidiQ7Z5Y7.
OMAiDYASQPA.
OrthoDBiEOG78M01S.
PhylomeDBiQ7Z5Y7.
TreeFamiTF314369.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z5Y7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVHRGSDSD RLLRQEASCL VDDTLAVAQE KEANSLASSG PHNLTYPLGP
60 70 80 90 100
RNEDLSLDYA SQPANLQFPH IMPLAEDIKG SCFQSGNKRN HEPFIAPERF
110 120 130 140 150
GNSSVGFGSN SHSQAPEKVT LLVDGTRFVV NPQIFTAHPD TMLGRMFGPG
160 170 180 190 200
REYNFTRPNE KGEYEIAEGI SATVFRTVLD YYKTGIINCP DGISIPDLRD
210 220 230 240 250
TCDYLCINFD FNTIRCQDLS ALLHELSNDG AHKQFDHYLE ELILPIMVGC
260 270 280 290 300
AKKGERECHI VVLTDEDSVD WDEDHPPPMG EEYSQILYSS KLYRFFKYIE
310 320 330 340 350
NRDVAKTVLK ERGLKNIRIG IEGYPTCKEK IKRRPGGRSE VIYNYVQRPF
360 370 380 390 400
IQMSWEKEEG KSRHVDFQCV RSKSLTNLVA AGDDVLEDQE ILMHHPPQVD
410
ELDRLNAPLS QMASNDFQD
Length:419
Mass (Da):47,480
Last modified:October 1, 2003 - v1
Checksum:i71B5D35EA02714EC
GO
Isoform 2 (identifier: Q7Z5Y7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: D → G
     55-220: Missing.

Note: No experimental confirmation available.

Show »
Length:253
Mass (Da):28,892
Checksum:iFD685CD0E4995090
GO
Isoform 3 (identifier: Q7Z5Y7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.

Show »
Length:274
Mass (Da):31,669
Checksum:i6C4ABB9B0D986630
GO

Sequence cautioni

The sequence CAH72192.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI19118.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701H → R in CAH10583. (PubMed:17974005)Curated
Sequence conflicti205 – 2051L → P in CAH10583. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711S → T.1 Publication
Corresponds to variant rs2239808 [ dbSNP | Ensembl ].
VAR_028854

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 145145Missing in isoform 3. 1 PublicationVSP_055669Add
BLAST
Alternative sequencei54 – 541D → G in isoform 2. 1 PublicationVSP_021277
Alternative sequencei55 – 220166Missing in isoform 2. 1 PublicationVSP_021278Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305862 mRNA. Translation: AAP74385.1.
AK302861 mRNA. Translation: BAG64045.1.
AK304377 mRNA. Translation: BAG65215.1.
AL136135, Z85986 Genomic DNA. Translation: CAH72192.1. Sequence problems.
Z85986, AL136135 Genomic DNA. Translation: CAI19118.1. Sequence problems.
CH471081 Genomic DNA. Translation: EAX03892.1.
BC023525 mRNA. Translation: AAH23525.1.
AL832381 mRNA. Translation: CAH10583.1.
CCDSiCCDS4821.1. [Q7Z5Y7-1]
CCDS69096.1. [Q7Z5Y7-2]
CCDS69097.1. [Q7Z5Y7-3]
RefSeqiNP_001273508.1. NM_001286579.1. [Q7Z5Y7-2]
NP_001273509.1. NM_001286580.1. [Q7Z5Y7-3]
NP_775833.2. NM_173562.4. [Q7Z5Y7-1]
XP_005248997.1. XM_005248940.2. [Q7Z5Y7-1]
XP_006715086.1. XM_006715023.1. [Q7Z5Y7-1]
UniGeneiHs.188757.

Genome annotation databases

EnsembliENST00000373731; ENSP00000362836; ENSG00000112078. [Q7Z5Y7-1]
ENST00000449081; ENSP00000412205; ENSG00000112078. [Q7Z5Y7-2]
ENST00000536244; ENSP00000439118; ENSG00000112078. [Q7Z5Y7-3]
GeneIDi222658.
KEGGihsa:222658.
UCSCiuc003ome.3. human. [Q7Z5Y7-1]
uc010jwk.3. human. [Q7Z5Y7-2]

Polymorphism databases

DMDMi74750149.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305862 mRNA. Translation: AAP74385.1 .
AK302861 mRNA. Translation: BAG64045.1 .
AK304377 mRNA. Translation: BAG65215.1 .
AL136135 , Z85986 Genomic DNA. Translation: CAH72192.1 . Sequence problems.
Z85986 , AL136135 Genomic DNA. Translation: CAI19118.1 . Sequence problems.
CH471081 Genomic DNA. Translation: EAX03892.1 .
BC023525 mRNA. Translation: AAH23525.1 .
AL832381 mRNA. Translation: CAH10583.1 .
CCDSi CCDS4821.1. [Q7Z5Y7-1 ]
CCDS69096.1. [Q7Z5Y7-2 ]
CCDS69097.1. [Q7Z5Y7-3 ]
RefSeqi NP_001273508.1. NM_001286579.1. [Q7Z5Y7-2 ]
NP_001273509.1. NM_001286580.1. [Q7Z5Y7-3 ]
NP_775833.2. NM_173562.4. [Q7Z5Y7-1 ]
XP_005248997.1. XM_005248940.2. [Q7Z5Y7-1 ]
XP_006715086.1. XM_006715023.1. [Q7Z5Y7-1 ]
UniGenei Hs.188757.

3D structure databases

ProteinModelPortali Q7Z5Y7.
SMRi Q7Z5Y7. Positions 116-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128809. 6 interactions.
IntActi Q7Z5Y7. 2 interactions.
STRINGi 9606.ENSP00000362836.

PTM databases

PhosphoSitei Q7Z5Y7.

Polymorphism databases

DMDMi 74750149.

Proteomic databases

MaxQBi Q7Z5Y7.
PaxDbi Q7Z5Y7.
PRIDEi Q7Z5Y7.

Protocols and materials databases

DNASUi 222658.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373731 ; ENSP00000362836 ; ENSG00000112078 . [Q7Z5Y7-1 ]
ENST00000449081 ; ENSP00000412205 ; ENSG00000112078 . [Q7Z5Y7-2 ]
ENST00000536244 ; ENSP00000439118 ; ENSG00000112078 . [Q7Z5Y7-3 ]
GeneIDi 222658.
KEGGi hsa:222658.
UCSCi uc003ome.3. human. [Q7Z5Y7-1 ]
uc010jwk.3. human. [Q7Z5Y7-2 ]

Organism-specific databases

CTDi 222658.
GeneCardsi GC06P036410.
HGNCi HGNC:21052. KCTD20.
HPAi HPA030092.
MIMi 615932. gene.
neXtProti NX_Q7Z5Y7.
PharmGKBi PA134913479.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309152.
GeneTreei ENSGT00390000007975.
HOGENOMi HOG000261659.
HOVERGENi HBG059410.
InParanoidi Q7Z5Y7.
OMAi DYASQPA.
OrthoDBi EOG78M01S.
PhylomeDBi Q7Z5Y7.
TreeFami TF314369.

Miscellaneous databases

ChiTaRSi KCTD20. human.
GenomeRNAii 222658.
NextBioi 35476454.
PROi Q7Z5Y7.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z5Y7.
CleanExi HS_KCTD20.
ExpressionAtlasi Q7Z5Y7. baseline and differential.
Genevestigatori Q7Z5Y7.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Chen Z., Wu S.L., Shan Y.X., Liu S., Xiao P.J.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT THR-171.
    Tissue: Trachea.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-419 (ISOFORM 1).
    Tissue: Skeletal muscle.
  7. "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network."
    Brajenovic M., Joberty G., Kuster B., Bouwmeester T., Drewes G.
    J. Biol. Chem. 279:12804-12811(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MARK4.

Entry informationi

Entry nameiKCD20_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5Y7
Secondary accession number(s): B4DZD3
, B4E2Q3, F5H3T3, Q5W105, Q69YQ7, Q8IZ55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3