Q7Z5Y6 (BMP8A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 8A
Short name=BMP-8A

Gene names

Name:

BMP8A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage development Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW growth Inferred from electronic annotation. Source: InterPro ossification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 263	244	Potential		PRO_0000227896
	Chain	264 – 402	139	Bone morphogenetic protein 8A		PRO_0000227897
Amino acid modifications
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
	Glycosylation	343	1	N-linked (GlcNAc...) Potential
	Disulfide bond	301 ↔ 367		By similarity
	Disulfide bond	330 ↔ 399		By similarity
	Disulfide bond	334 ↔ 401		By similarity
	Disulfide bond	366		Interchain By similarity
Natural variations
	Natural variant	84	1	M → V. Corresponds to variant rs4660269 [ dbSNP | Ensembl ].		VAR_059859
	Natural variant	293	1	R → H. Ref.1 Corresponds to variant rs6525 [ dbSNP | Ensembl ].		VAR_052571

Sequences

	Sequence		Length	Mass (Da)
	Q7Z5Y6 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: F50E2C06D261E31E	FASTA	402	44,798
	10 20 30 40 50 60 MAARPGPLWL LGLTLCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA VLGLPGRPRP 70 80 90 100 110 120 RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAEQRLG RADLVMSFVN MVERDRALGH 130 140 150 160 170 180 QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF 190 200 210 220 230 240 FLDLQTLRAG DEGWLVLDVT AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA 250 260 270 280 290 300 PRSQQPFVVT FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVRGSHGRQV 310 320 330 340 350 360 CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMKPN 370 380 390 400 AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog." Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-293.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 8A entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY303954 mRNA. Translation: AAP74559.1. AL365277 Genomic DNA. Translation: CAI16418.1.
IPI	IPI00376235.
RefSeq	NP_861525.2. NM_181809.3.
UniGene	Hs.472497.
3D structure databases
ProteinModelPortal	Q7Z5Y6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000327440.
PTM databases
PhosphoSite	Q7Z5Y6.
Polymorphism databases
DMDM	90111975.
Proteomic databases
PaxDb	Q7Z5Y6.
PRIDE	Q7Z5Y6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331593; ENSP00000327440; ENSG00000183682.
GeneID	353500.
KEGG	hsa:353500.
UCSC	uc001cdi.3. human.
Organism-specific databases
CTD	353500.
GeneCards	GC01P039958.
HGNC	HGNC:21650. BMP8A.
HPA	HPA044883.
neXtProt	NX_Q7Z5Y6.
PharmGKB	PA134894231.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG323541.
HOGENOM	HOG000249476.
HOVERGEN	HBG004860.
InParanoid	Q7Z5Y6.
KO	K16622.
OMA	ERPNRES.
OrthoDB	EOG4HMJ9J.
PhylomeDB	Q7Z5Y6.
Gene expression databases
Bgee	Q7Z5Y6.
CleanEx	HS_BMP8A.
Genevestigator	Q7Z5Y6.
GermOnline	ENSG00000183682. Homo sapiens.
Family and domain databases
InterPro	IPR002405. Inhibin_asu. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00669. INHIBINA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BMP8A. human.
GenomeRNAi	353500.
NextBio	99812.

Entry information

Entry name

BMP8A_HUMAN

Accession

Primary (citable) accession number: Q7Z5Y6
Secondary accession number(s): Q5T3A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.