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Q7Z5Y6

- BMP8A_HUMAN

UniProt

Q7Z5Y6 - BMP8A_HUMAN

Protein

Bone morphogenetic protein 8A

Gene

BMP8A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.By similarity1 Publication

    GO - Biological processi

    1. cartilage development Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. diet induced thermogenesis Source: UniProtKB
    4. growth Source: InterPro
    5. negative regulation of insulin secretion Source: UniProtKB
    6. ossification Source: UniProtKB-KW
    7. regulation of energy homeostasis Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 8A
    Short name:
    BMP-8A
    Gene namesi
    Name:BMP8A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21650. BMP8A.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134894231.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 263244Sequence AnalysisPRO_0000227896Add
    BLAST
    Chaini264 – 402139Bone morphogenetic protein 8APRO_0000227897Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi301 ↔ 367By similarity
    Disulfide bondi330 ↔ 399By similarity
    Disulfide bondi334 ↔ 401By similarity
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi366 – 366InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ7Z5Y6.
    PRIDEiQ7Z5Y6.

    PTM databases

    PhosphoSiteiQ7Z5Y6.

    Expressioni

    Gene expression databases

    BgeeiQ7Z5Y6.
    CleanExiHS_BMP8A.
    GenevestigatoriQ7Z5Y6.

    Organism-specific databases

    HPAiHPA044883.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi131696. 1 interaction.
    IntActiQ7Z5Y6. 1 interaction.
    MINTiMINT-7970900.
    STRINGi9606.ENSP00000327440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z5Y6.
    SMRiQ7Z5Y6. Positions 301-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG323541.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiQ7Z5Y6.
    KOiK16622.
    OMAiMVERNHA.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiQ7Z5Y6.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z5Y6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARPGPLWL LGLTLCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA    50
    VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAEQRLG 100
    RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK 150
    VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT 200
    AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT 250
    FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVRGSHGRQV 300
    CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL 350
    QSLVHLMKPN AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG 400
    CH 402
    Length:402
    Mass (Da):44,798
    Last modified:March 21, 2006 - v2
    Checksum:iF50E2C06D261E31E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841M → V.
    Corresponds to variant rs4660269 [ dbSNP | Ensembl ].
    VAR_059859
    Natural varianti293 – 2931R → H.1 Publication
    Corresponds to variant rs6525 [ dbSNP | Ensembl ].
    VAR_052571

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY303954 mRNA. Translation: AAP74559.1.
    AL365277 Genomic DNA. Translation: CAI16418.1.
    CCDSiCCDS437.1.
    RefSeqiNP_861525.2. NM_181809.3.
    UniGeneiHs.472497.

    Genome annotation databases

    EnsembliENST00000331593; ENSP00000327440; ENSG00000183682.
    GeneIDi353500.
    KEGGihsa:353500.
    UCSCiuc001cdi.3. human.

    Polymorphism databases

    DMDMi90111975.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 8A entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY303954 mRNA. Translation: AAP74559.1 .
    AL365277 Genomic DNA. Translation: CAI16418.1 .
    CCDSi CCDS437.1.
    RefSeqi NP_861525.2. NM_181809.3.
    UniGenei Hs.472497.

    3D structure databases

    ProteinModelPortali Q7Z5Y6.
    SMRi Q7Z5Y6. Positions 301-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131696. 1 interaction.
    IntActi Q7Z5Y6. 1 interaction.
    MINTi MINT-7970900.
    STRINGi 9606.ENSP00000327440.

    PTM databases

    PhosphoSitei Q7Z5Y6.

    Polymorphism databases

    DMDMi 90111975.

    Proteomic databases

    PaxDbi Q7Z5Y6.
    PRIDEi Q7Z5Y6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331593 ; ENSP00000327440 ; ENSG00000183682 .
    GeneIDi 353500.
    KEGGi hsa:353500.
    UCSCi uc001cdi.3. human.

    Organism-specific databases

    CTDi 353500.
    GeneCardsi GC01P039958.
    HGNCi HGNC:21650. BMP8A.
    HPAi HPA044883.
    neXtProti NX_Q7Z5Y6.
    PharmGKBi PA134894231.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323541.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi Q7Z5Y6.
    KOi K16622.
    OMAi MVERNHA.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi Q7Z5Y6.
    TreeFami TF316134.

    Miscellaneous databases

    ChiTaRSi BMP8A. human.
    GeneWikii Bone_morphogenetic_protein_8A.
    GenomeRNAii 353500.
    NextBioi 99812.
    PROi Q7Z5Y6.

    Gene expression databases

    Bgeei Q7Z5Y6.
    CleanExi HS_BMP8A.
    Genevestigatori Q7Z5Y6.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog."
      Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-293.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: FUNCTION.

    Entry informationi

    Entry nameiBMP8A_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z5Y6
    Secondary accession number(s): Q5T3A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Experiments with human recombinant protein (in mouse system by intracerebroventricular treatment) are reported for BMP8B but the protein is corresponding to BMP8A according sequence data provided by the supplier; related experiments with Bmp8b-/-mice show similar results.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3