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Protein

Bone morphogenetic protein 8A

Gene

BMP8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.By similarity1 Publication

GO - Molecular functioni

  1. BMP receptor binding Source: GO_Central
  2. cytokine activity Source: GO_Central
  3. transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  1. BMP signaling pathway Source: GO_Central
  2. cartilage development Source: UniProtKB-KW
  3. cell development Source: GO_Central
  4. diet induced thermogenesis Source: UniProtKB
  5. growth Source: InterPro
  6. negative regulation of insulin secretion Source: UniProtKB
  7. ossification Source: UniProtKB-KW
  8. positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  9. regulation of apoptotic process Source: GO_Central
  10. regulation of energy homeostasis Source: UniProtKB
  11. regulation of MAPK cascade Source: GO_Central
  12. SMAD protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 8A
Short name:
BMP-8A
Gene namesi
Name:BMP8A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21650. BMP8A.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894231.

Polymorphism and mutation databases

BioMutaiBMP8A.
DMDMi90111975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 263244Sequence AnalysisPRO_0000227896Add
BLAST
Chaini264 – 402139Bone morphogenetic protein 8APRO_0000227897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi301 ↔ 367By similarity
Disulfide bondi330 ↔ 399By similarity
Disulfide bondi334 ↔ 401By similarity
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi366 – 366InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z5Y6.
PRIDEiQ7Z5Y6.

PTM databases

PhosphoSiteiQ7Z5Y6.

Expressioni

Gene expression databases

BgeeiQ7Z5Y6.
CleanExiHS_BMP8A.
GenevestigatoriQ7Z5Y6.

Organism-specific databases

HPAiHPA044883.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi131696. 1 interaction.
IntActiQ7Z5Y6. 1 interaction.
MINTiMINT-7970900.
STRINGi9606.ENSP00000327440.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5Y6.
SMRiQ7Z5Y6. Positions 301-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG323541.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiQ7Z5Y6.
KOiK16622.
OMAiQMARSQN.
OrthoDBiEOG7J9VPQ.
PhylomeDBiQ7Z5Y6.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z5Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARPGPLWL LGLTLCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA
60 70 80 90 100
VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAEQRLG
110 120 130 140 150
RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK
160 170 180 190 200
VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT
210 220 230 240 250
AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT
260 270 280 290 300
FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVRGSHGRQV
310 320 330 340 350
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL
360 370 380 390 400
QSLVHLMKPN AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG

CH
Length:402
Mass (Da):44,798
Last modified:March 21, 2006 - v2
Checksum:iF50E2C06D261E31E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841M → V.
Corresponds to variant rs4660269 [ dbSNP | Ensembl ].
VAR_059859
Natural varianti293 – 2931R → H.1 Publication
Corresponds to variant rs6525 [ dbSNP | Ensembl ].
VAR_052571

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303954 mRNA. Translation: AAP74559.1.
AL365277 Genomic DNA. Translation: CAI16418.1.
CCDSiCCDS437.1.
RefSeqiNP_861525.2. NM_181809.3.
UniGeneiHs.472497.

Genome annotation databases

EnsembliENST00000331593; ENSP00000327440; ENSG00000183682.
GeneIDi353500.
KEGGihsa:353500.
UCSCiuc001cdi.3. human.

Polymorphism and mutation databases

BioMutaiBMP8A.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 8A entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303954 mRNA. Translation: AAP74559.1.
AL365277 Genomic DNA. Translation: CAI16418.1.
CCDSiCCDS437.1.
RefSeqiNP_861525.2. NM_181809.3.
UniGeneiHs.472497.

3D structure databases

ProteinModelPortaliQ7Z5Y6.
SMRiQ7Z5Y6. Positions 301-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131696. 1 interaction.
IntActiQ7Z5Y6. 1 interaction.
MINTiMINT-7970900.
STRINGi9606.ENSP00000327440.

PTM databases

PhosphoSiteiQ7Z5Y6.

Polymorphism and mutation databases

BioMutaiBMP8A.
DMDMi90111975.

Proteomic databases

PaxDbiQ7Z5Y6.
PRIDEiQ7Z5Y6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331593; ENSP00000327440; ENSG00000183682.
GeneIDi353500.
KEGGihsa:353500.
UCSCiuc001cdi.3. human.

Organism-specific databases

CTDi353500.
GeneCardsiGC01P039958.
HGNCiHGNC:21650. BMP8A.
HPAiHPA044883.
neXtProtiNX_Q7Z5Y6.
PharmGKBiPA134894231.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG323541.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiQ7Z5Y6.
KOiK16622.
OMAiQMARSQN.
OrthoDBiEOG7J9VPQ.
PhylomeDBiQ7Z5Y6.
TreeFamiTF316134.

Miscellaneous databases

ChiTaRSiBMP8A. human.
GeneWikiiBone_morphogenetic_protein_8A.
GenomeRNAii353500.
NextBioi99812.
PROiQ7Z5Y6.

Gene expression databases

BgeeiQ7Z5Y6.
CleanExiHS_BMP8A.
GenevestigatoriQ7Z5Y6.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog."
    Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-293.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: FUNCTION.

Entry informationi

Entry nameiBMP8A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5Y6
Secondary accession number(s): Q5T3A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 29, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Experiments with human recombinant protein (in mouse system by intracerebroventricular treatment) are reported for BMP8B but the protein is corresponding to BMP8A according sequence data provided by the supplier; related experiments with Bmp8b-/-mice show similar results.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.