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Q7Z5Y6 (BMP8A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 8A

Short name=BMP-8A
Gene names
Name:BMP8A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. Ref.3

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the TGF-beta family.

Caution

Experiments with human recombinant protein (in mouse system by intracerebroventricular treatment) are reported for BMP8B but the protein is corresponding to BMP8A according sequence data provided by the supplier; related experiments with Bmp8b-/-mice show similar results (Ref.3).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 263244 Potential
PRO_0000227896
Chain264 – 402139Bone morphogenetic protein 8A
PRO_0000227897

Amino acid modifications

Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation3431N-linked (GlcNAc...) Potential
Disulfide bond301 ↔ 367 By similarity
Disulfide bond330 ↔ 399 By similarity
Disulfide bond334 ↔ 401 By similarity
Disulfide bond366Interchain By similarity

Natural variations

Natural variant841M → V.
Corresponds to variant rs4660269 [ dbSNP | Ensembl ].
VAR_059859
Natural variant2931R → H. Ref.1
Corresponds to variant rs6525 [ dbSNP | Ensembl ].
VAR_052571

Sequences

Sequence LengthMass (Da)Tools
Q7Z5Y6 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: F50E2C06D261E31E

FASTA40244,798
        10         20         30         40         50         60 
MAARPGPLWL LGLTLCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA VLGLPGRPRP 

        70         80         90        100        110        120 
RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAEQRLG RADLVMSFVN MVERDRALGH 

       130        140        150        160        170        180 
QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF 

       190        200        210        220        230        240 
FLDLQTLRAG DEGWLVLDVT AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA 

       250        260        270        280        290        300 
PRSQQPFVVT FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVRGSHGRQV 

       310        320        330        340        350        360 
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMKPN 

       370        380        390        400 
AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH 

« Hide

References

« Hide 'large scale' references
[1]"Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog."
Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-293.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions."
Whittle A.J., Carobbio S., Martins L., Slawik M., Hondares E., Vazquez M.J., Morgan D., Csikasz R.I., Gallego R., Rodriguez-Cuenca S., Dale M., Virtue S., Villarroya F., Cannon B., Rahmouni K., Lopez M., Vidal-Puig A.
Cell 149:871-885(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 8A entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY303954 mRNA. Translation: AAP74559.1.
AL365277 Genomic DNA. Translation: CAI16418.1.
CCDSCCDS437.1.
RefSeqNP_861525.2. NM_181809.3.
UniGeneHs.472497.

3D structure databases

ProteinModelPortalQ7Z5Y6.
SMRQ7Z5Y6. Positions 301-402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131696. 1 interaction.
IntActQ7Z5Y6. 1 interaction.
MINTMINT-7970900.
STRING9606.ENSP00000327440.

PTM databases

PhosphoSiteQ7Z5Y6.

Polymorphism databases

DMDM90111975.

Proteomic databases

PaxDbQ7Z5Y6.
PRIDEQ7Z5Y6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331593; ENSP00000327440; ENSG00000183682.
GeneID353500.
KEGGhsa:353500.
UCSCuc001cdi.3. human.

Organism-specific databases

CTD353500.
GeneCardsGC01P039958.
HGNCHGNC:21650. BMP8A.
HPAHPA044883.
neXtProtNX_Q7Z5Y6.
PharmGKBPA134894231.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG323541.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidQ7Z5Y6.
KOK16622.
OMAMVERNHA.
OrthoDBEOG7J9VPQ.
PhylomeDBQ7Z5Y6.
TreeFamTF316134.

Gene expression databases

BgeeQ7Z5Y6.
CleanExHS_BMP8A.
GenevestigatorQ7Z5Y6.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBMP8A. human.
GeneWikiBone_morphogenetic_protein_8A.
GenomeRNAi353500.
NextBio99812.
PROQ7Z5Y6.

Entry information

Entry nameBMP8A_HUMAN
AccessionPrimary (citable) accession number: Q7Z5Y6
Secondary accession number(s): Q5T3A5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM