ID   Q7Z5W8_HUMAN            Unreviewed;       690 AA.
AC   Q7Z5W8;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   SubName: Full=ACACA protein {ECO:0000313|EMBL:AAH31485.1};
DE   Flags: Fragment;
GN   Name=ACACA {ECO:0000313|EMBL:AAH31485.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH31485.1};
RN   [1] {ECO:0000313|EMBL:AAH31485.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000313|EMBL:AAH31485.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC031485; AAH31485.1; -; mRNA.
DR   RefSeq; NP_942134.1; NM_198837.1.
DR   RefSeq; NP_942135.1; NM_198838.1.
DR   AlphaFoldDB; Q7Z5W8; -.
DR   SMR; Q7Z5W8; -.
DR   PeptideAtlas; Q7Z5W8; -.
DR   DNASU; 31; -.
DR   GeneID; 31; -.
DR   CTD; 31; -.
DR   PharmGKB; PA24421; -.
DR   OrthoDB; 911at2759; -.
DR   BioGRID-ORCS; 31; 225 hits in 1172 CRISPR screens.
DR   ChiTaRS; ACACA; human.
DR   GenomeRNAi; 31; -.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR   InterPro; IPR049076; ACCA.
DR   InterPro; IPR034733; AcCoA_carboxyl_beta.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   PANTHER; PTHR45728:SF5; ACETYL-COA CARBOXYLASE 1; 1.
DR   PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 2.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
DR   Genevisible; Q7Z5W8; HS.
PE   2: Evidence at transcript level;
FT   DOMAIN          1..258
FT                   /note="CoA carboxyltransferase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50980"
FT   DOMAIN          262..578
FT                   /note="CoA carboxyltransferase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50989"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH31485.1"
SQ   SEQUENCE   690 AA;  78272 MW;  54814516C7A58A06 CRC64;
     IGMVAWKMTF KSPEYPEGRD IIVIGNDITY RIGSFGPQED LLFLRASELA RAEGIPRIYV
     SANSGARIGL AEEIRHMFHV AWVDPEDPYK GYRYLYLTPQ DYKRVSALNS VHCEHVEDEG
     ESRYKITDII GKEEGIGPEN LRGSGMIAGE SSLAYNEIIT ISLVTCRAIG IGAYLVRLGQ
     RTIQVENSHL ILTGAGALNK VLGREVYTSN NQLGGIQIMH NNGVTHCTVC DDFEGVFTVL
     HWLSYMPKSV HSSVPLLNSK DPIDRIIEFV PTKTPYDPRW MLAGRPHPTQ KGQWLSGFFD
     YGSFSEIMQP WAQTVVVGRA RLGGIPVGVV AVETRTVELS IPADPANLDS EAKIIQQAGQ
     VWFPDSAFKT YQAIKDFNRE GLPLMVFANW RGFSGGMKDM YDQVLKFGAY IVDGLRECCQ
     PVLVYIPPQA ELRGGSWVVI DSSINPRHME MYADRESRGS VLEPEGTVEI KFRRKDLVKT
     MRRVDPVYIH LAERLGTPEL STAERKELEN KLKEREEFLI PIYHQVAVQF ADLHDTPGRM
     QEKGVISDIL DWKTSRTFFY WRLRRLLLED LVKKKIHNAN PELTDGQIQA MLRRWFVEVE
     GTVKAYVWDN NKDLAEWLEK QLTEEDGVHS VIEENIKCIS RDYVLKQIRS LVQANPEVAM
     DSIIHMTQHI SPTQRAEVIR ILSTMDSPST
//