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Q7Z5W3

- BN3D2_HUMAN

UniProt

Q7Z5W3 - BN3D2_HUMAN

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Protein
Pre-miRNA 5'-monophosphate methyltransferase
Gene
BCDIN3D
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs.1 Publication

GO - Molecular functioni

  1. O-methyltransferase activity Source: UniProtKB
  2. RNA methyltransferase activity Source: UniProtKB

GO - Biological processi

  1. RNA methylation Source: UniProtKB
  2. miRNA metabolic process Source: UniProtKB
  3. negative regulation of pre-miRNA processing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-miRNA 5'-monophosphate methyltransferase (EC:2.1.1.-)
Alternative name(s):
BCDIN3 domain-containing protein
Gene namesi
Name:BCDIN3D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:27050. BCDIN3D.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi72 – 743DVG → AVA: Abolishes methyltransferase activity. 1 Publication

Organism-specific databases

PharmGKBiPA162377410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Pre-miRNA 5'-monophosphate methyltransferase
PRO_0000289265Add
BLAST

Proteomic databases

MaxQBiQ7Z5W3.
PaxDbiQ7Z5W3.
PRIDEiQ7Z5W3.

PTM databases

PhosphoSiteiQ7Z5W3.

Expressioni

Gene expression databases

BgeeiQ7Z5W3.
CleanExiHS_BCDIN3D.
GenevestigatoriQ7Z5W3.

Organism-specific databases

HPAiHPA039911.

Interactioni

Subunit structurei

Interacts with DICER1; the interaction may be mediated by RNA.1 Publication

Protein-protein interaction databases

BioGridi126839. 3 interactions.
STRINGi9606.ENSP00000335201.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5W3.
SMRiQ7Z5W3. Positions 46-203.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 274222Bin3-type SAM
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG255867.
HOGENOMiHOG000013152.
HOVERGENiHBG057674.
InParanoidiQ7Z5W3.
OMAiCYRSAAR.
OrthoDBiEOG715Q5R.
PhylomeDBiQ7Z5W3.
TreeFamiTF324061.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR010675. Bin3.
IPR024160. BIN3_SAM-bd_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF06859. Bin3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51515. BIN3_SAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z5W3-1 [UniParc]FASTAAdd to Basket

« Hide

MAVPTELDGG SVKETAAEEE SRVLAPGAAP FGNFPHYSRF HPPEQRLRLL    50
PPELLRQLFP ESPENGPILG LDVGCNSGDL SVALYKHFLS LPDGETCSDA 100
SREFRLLCCD IDPVLVKRAE KECPFPDALT FITLDFMNQR TRKVLLSSFL 150
SQFGRSVFDI GFCMSITMWI HLNHGDHGLW EFLAHLSSLC HYLLVEPQPW 200
KCYRAAARRL RKLGLHDFDH FHSLAIRGDM PNQIVQILTQ DHGMELICCF 250
GNTSWDRSLL LFRAKQTIET HPIPESLIEK GKEKNRLSFQ KQ 292
Length:292
Mass (Da):33,200
Last modified:October 1, 2003 - v1
Checksum:i361EF0BBAAC0CCAF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti288 – 2881S → R.
Corresponds to variant rs11169172 [ dbSNP | Ensembl ].
VAR_032614

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292194 mRNA. Translation: BAF84883.1.
CH471111 Genomic DNA. Translation: EAW58101.1.
BC053560 mRNA. Translation: AAH53560.1.
CCDSiCCDS8790.1.
RefSeqiNP_859059.1. NM_181708.2.
UniGeneiHs.142736.

Genome annotation databases

EnsembliENST00000333924; ENSP00000335201; ENSG00000186666.
GeneIDi144233.
KEGGihsa:144233.
UCSCiuc001rvh.3. human.

Polymorphism databases

DMDMi74738762.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292194 mRNA. Translation: BAF84883.1 .
CH471111 Genomic DNA. Translation: EAW58101.1 .
BC053560 mRNA. Translation: AAH53560.1 .
CCDSi CCDS8790.1.
RefSeqi NP_859059.1. NM_181708.2.
UniGenei Hs.142736.

3D structure databases

ProteinModelPortali Q7Z5W3.
SMRi Q7Z5W3. Positions 46-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126839. 3 interactions.
STRINGi 9606.ENSP00000335201.

PTM databases

PhosphoSitei Q7Z5W3.

Polymorphism databases

DMDMi 74738762.

Proteomic databases

MaxQBi Q7Z5W3.
PaxDbi Q7Z5W3.
PRIDEi Q7Z5W3.

Protocols and materials databases

DNASUi 144233.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333924 ; ENSP00000335201 ; ENSG00000186666 .
GeneIDi 144233.
KEGGi hsa:144233.
UCSCi uc001rvh.3. human.

Organism-specific databases

CTDi 144233.
GeneCardsi GC12M050231.
HGNCi HGNC:27050. BCDIN3D.
HPAi HPA039911.
neXtProti NX_Q7Z5W3.
PharmGKBi PA162377410.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255867.
HOGENOMi HOG000013152.
HOVERGENi HBG057674.
InParanoidi Q7Z5W3.
OMAi CYRSAAR.
OrthoDBi EOG715Q5R.
PhylomeDBi Q7Z5W3.
TreeFami TF324061.

Miscellaneous databases

GenomeRNAii 144233.
NextBioi 84869.
PROi Q7Z5W3.

Gene expression databases

Bgeei Q7Z5W3.
CleanExi HS_BCDIN3D.
Genevestigatori Q7Z5W3.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR010675. Bin3.
IPR024160. BIN3_SAM-bd_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF06859. Bin3. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51515. BIN3_SAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. "Human RNA methyltransferase BCDIN3D regulates microRNA processing."
    Xhemalce B., Robson S.C., Kouzarides T.
    Cell 151:278-288(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH DICER1, MUTAGENESIS OF 72-ASP--GLU-74, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiBN3D2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5W3
Secondary accession number(s): A8K829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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