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Protein

Protein phosphatase 1 regulatory subunit 32

Gene

PPP1R32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 32
Gene namesi
Name:PPP1R32
Synonyms:C11orf66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28869. PPP1R32.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162148.
PharmGKBiPA144596485.

Polymorphism and mutation databases

BioMutaiPPP1R32.
DMDMi74738757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743771 – 425Protein phosphatase 1 regulatory subunit 32Add BLAST425

Proteomic databases

EPDiQ7Z5V6.
PaxDbiQ7Z5V6.
PeptideAtlasiQ7Z5V6.
PRIDEiQ7Z5V6.

PTM databases

iPTMnetiQ7Z5V6.
PhosphoSitePlusiQ7Z5V6.

Expressioni

Gene expression databases

BgeeiENSG00000162148.
CleanExiHS_C11orf66.
ExpressionAtlasiQ7Z5V6. baseline and differential.
GenevisibleiQ7Z5V6. HS.

Organism-specific databases

HPAiHPA039067.
HPA039068.

Interactioni

Subunit structurei

Interacts with PPP1CA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621363EBI-4311771,EBI-357253
PPP1CCP36873-24EBI-4311771,EBI-3964623

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128618. 6 interactors.
IntActiQ7Z5V6. 18 interactors.
STRINGi9606.ENSP00000344140.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5V6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFQ1. Eukaryota.
ENOG4110MWW. LUCA.
GeneTreeiENSGT00390000003127.
HOGENOMiHOG000007162.
HOVERGENiHBG056750.
InParanoidiQ7Z5V6.
KOiK17571.
OMAiTYNQGYF.
OrthoDBiEOG091G0E7L.
PhylomeDBiQ7Z5V6.
TreeFamiTF328734.

Family and domain databases

InterProiIPR031410. PPP1R32.
[Graphical view]
PfamiPF15691. PPP1R32. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5V6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGKLPLGVV SPYVKMSSGG YTDPLKFYAT SYCTAYGRED FKPRVGSHVG
60 70 80 90 100
TGYKSNFQPV VSCQASLEAL DNPARGEQAQ DHFQSVASQS YRPLEVPDGK
110 120 130 140 150
HPLPWSMRQT SSGYGREKPS AGPPTKEVRK VHFDTQEHGP QAITGLEPRE
160 170 180 190 200
VPLLHQQQGQ DPLERENFRH GPRFMTSEYN SKYLRDPLDQ PDFLQKKSIG
210 220 230 240 250
AKEGSGFTKQ SHQSPIVFQP PSQALPGDPA LLPGQSVTKS DFLPKTHLHG
260 270 280 290 300
DEFLPVLARG SKRETAFSRG NERILNPRVP PPCPEPSSVS HQQFQPLHRM
310 320 330 340 350
QQTNVALLGR ETVGKKEPTG FSLNNPMYVR SPCDPDRDQR YLTTYNQGYF
360 370 380 390 400
ENIPKGLDQE GWTRGGIQPQ MPGGYALSQP VSCMEATPNP MESLRHLHPH
410 420
VGRTLTSADP FYQNTPHSSR CVAHS
Length:425
Mass (Da):47,295
Last modified:October 1, 2003 - v1
Checksum:i61020C5A4F14563F
GO
Isoform 2 (identifier: Q7Z5V6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-249: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):45,123
Checksum:iFA14F2D08D1B617E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155H → R in BAB71432 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030271238T → N.Corresponds to variant rs11230707dbSNPEnsembl.1
Natural variantiVAR_030272382S → T.1 PublicationCorresponds to variant rs12787061dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022731230 – 249Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057333 mRNA. Translation: BAB71432.1.
BC043246 mRNA. Translation: AAH43246.1.
BC053995 mRNA. Translation: AAH53995.1.
CCDSiCCDS53641.1. [Q7Z5V6-2]
CCDS8008.1. [Q7Z5V6-1]
RefSeqiNP_001164224.1. NM_001170753.1. [Q7Z5V6-2]
NP_659454.2. NM_145017.2. [Q7Z5V6-1]
UniGeneiHs.729003.

Genome annotation databases

EnsembliENST00000338608; ENSP00000344140; ENSG00000162148. [Q7Z5V6-1]
ENST00000432063; ENSP00000391560; ENSG00000162148. [Q7Z5V6-2]
GeneIDi220004.
KEGGihsa:220004.
UCSCiuc001nru.3. human. [Q7Z5V6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057333 mRNA. Translation: BAB71432.1.
BC043246 mRNA. Translation: AAH43246.1.
BC053995 mRNA. Translation: AAH53995.1.
CCDSiCCDS53641.1. [Q7Z5V6-2]
CCDS8008.1. [Q7Z5V6-1]
RefSeqiNP_001164224.1. NM_001170753.1. [Q7Z5V6-2]
NP_659454.2. NM_145017.2. [Q7Z5V6-1]
UniGeneiHs.729003.

3D structure databases

ProteinModelPortaliQ7Z5V6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128618. 6 interactors.
IntActiQ7Z5V6. 18 interactors.
STRINGi9606.ENSP00000344140.

PTM databases

iPTMnetiQ7Z5V6.
PhosphoSitePlusiQ7Z5V6.

Polymorphism and mutation databases

BioMutaiPPP1R32.
DMDMi74738757.

Proteomic databases

EPDiQ7Z5V6.
PaxDbiQ7Z5V6.
PeptideAtlasiQ7Z5V6.
PRIDEiQ7Z5V6.

Protocols and materials databases

DNASUi220004.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338608; ENSP00000344140; ENSG00000162148. [Q7Z5V6-1]
ENST00000432063; ENSP00000391560; ENSG00000162148. [Q7Z5V6-2]
GeneIDi220004.
KEGGihsa:220004.
UCSCiuc001nru.3. human. [Q7Z5V6-1]

Organism-specific databases

CTDi220004.
GeneCardsiPPP1R32.
HGNCiHGNC:28869. PPP1R32.
HPAiHPA039067.
HPA039068.
neXtProtiNX_Q7Z5V6.
OpenTargetsiENSG00000162148.
PharmGKBiPA144596485.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFQ1. Eukaryota.
ENOG4110MWW. LUCA.
GeneTreeiENSGT00390000003127.
HOGENOMiHOG000007162.
HOVERGENiHBG056750.
InParanoidiQ7Z5V6.
KOiK17571.
OMAiTYNQGYF.
OrthoDBiEOG091G0E7L.
PhylomeDBiQ7Z5V6.
TreeFamiTF328734.

Miscellaneous databases

ChiTaRSiPPP1R32. human.
GenomeRNAii220004.
PROiQ7Z5V6.

Gene expression databases

BgeeiENSG00000162148.
CleanExiHS_C11orf66.
ExpressionAtlasiQ7Z5V6. baseline and differential.
GenevisibleiQ7Z5V6. HS.

Family and domain databases

InterProiIPR031410. PPP1R32.
[Graphical view]
PfamiPF15691. PPP1R32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR32_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5V6
Secondary accession number(s): Q4G0P4, Q96M77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.