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Protein

Cytoplasmic polyadenylation element-binding protein 2

Gene

CPEB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 2
Short name:
CPE-BP2
Short name:
CPE-binding protein 2
Short name:
hCPEB-2
Gene namesi
Name:CPEB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000137449.15
HGNCiHGNC:21745 CPEB2
MIMi610605 gene
neXtProtiNX_Q7Z5Q1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi132864
OpenTargetsiENSG00000137449
PharmGKBiPA134864048

Polymorphism and mutation databases

BioMutaiCPEB2
DMDMi158937340

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692591 – 589Cytoplasmic polyadenylation element-binding protein 2Add BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7Z5Q1
PeptideAtlasiQ7Z5Q1
PRIDEiQ7Z5Q1

PTM databases

iPTMnetiQ7Z5Q1
PhosphoSitePlusiQ7Z5Q1

Expressioni

Gene expression databases

BgeeiENSG00000137449
CleanExiHS_CPEB2
ExpressionAtlasiQ7Z5Q1 baseline and differential
GenevisibleiQ7Z5Q1 HS

Organism-specific databases

HPAiHPA072513

Interactioni

Subunit structurei

Interacts with PAPD4/GLD2.By similarity

Protein-protein interaction databases

BioGridi126338, 3 interactors
STRINGi9606.ENSP00000443985

Structurei

3D structure databases

ProteinModelPortaliQ7Z5Q1
SMRiQ7Z5Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 423RRM 1PROSITE-ProRule annotationAdd BLAST92
Domaini440 – 522RRM 2PROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 93Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the RRM CPEB family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0129 Eukaryota
ENOG410Y1XZ LUCA
GeneTreeiENSGT00390000012886
HOGENOMiHOG000290661
HOVERGENiHBG058010
InParanoidiQ7Z5Q1
KOiK02602
OMAiMESPNHP
OrthoDBiEOG091G0AO9
PhylomeDBiQ7Z5Q1

Family and domain databases

Gene3Di3.30.40.130, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR032296 CEBP_ZZ
IPR038446 CEBP_ZZ_sf
IPR034819 CPEB
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR12566 PTHR12566, 2 hits
PfamiView protein in Pfam
PF16366 CEBP_ZZ, 1 hit
PF16367 RRM_7, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5Q1-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPSPDSEN GFYPGLPSSM NPAFFPSFSP VSPHGCTGLS VPTSGGGGGG
60 70 80 90 100
FGGPFSATAV PPPPPPAMNI PQQQPPPPAA PQQPQSRRSP VSPQLQQQHQ
110 120 130 140 150
AAAAAFLQQR NSYNHHQPLL KQSPWSNHQS SGWGTGSMSW GAMHGRDHRR
160 170 180 190 200
TGNMGIPGTM NQISPLKKPF SGNVIAPPKF TRSTPSLTPK SWIEDNVFRT
210 220 230 240 250
DNNSNTLLPL QVRSSLQLPA WGSDSLQDSW CTAAGTSRID QDRSRMYDSL
260 270 280 290 300
NMHSLENSLI DIMRAEHDPL KGRLSYPHPG TDNLLMLNGR SSLFPIDDGL
310 320 330 340 350
LDDGHSDQVG VLNSPTCYSA HQNGERIERF SRKVFVGGLP PDIDEDEITA
360 370 380 390 400
SFRRFGPLVV DWPHKAESKS YFPPKGYAFL LFQEESSVQA LIDACIEEDG
410 420 430 440 450
KLYLCVSSPT IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP
460 470 480 490 500
LRAVELAMIM DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS
510 520 530 540 550
ARFVQLQHGD IDKRVEVKPY VLDDQMCDEC QGARCGGKFA PFFCANVTCL
560 570 580
QYYCEFCWAN IHSRAGREFH KPLVKEGADR PRQIHFRWN
Length:589
Mass (Da):64,944
Last modified:August 21, 2007 - v3
Checksum:iE0A16772D2E3091A
GO
Isoform 2 (identifier: Q7Z5Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.
     288-288: N → NARSYGRRR

Show »
Length:575
Mass (Da):64,093
Checksum:i0BC308E83DB1D799
GO
Isoform 3 (identifier: Q7Z5Q1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-241: SSLQLPAWGSDSLQDSWCTAAGTSRIDQ → M

Show »
Length:562
Mass (Da):62,112
Checksum:i269754FE66F5B647
GO
Isoform 4 (identifier: Q7Z5Q1-5) [UniParc]FASTAAdd to basket
Also known as: CPEB2b

The sequence of this isoform differs from the canonical sequence as follows:
     212-241: Missing.

Show »
Length:559
Mass (Da):61,726
Checksum:i9465D16A0203B6A9
GO
Isoform 5 (identifier: Q7Z5Q1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-241: Missing.
     288-288: N → NARSYGRRR

Show »
Length:567
Mass (Da):62,729
Checksum:i17A2D7994BFAADA6
GO
Isoform 6 (identifier: Q7Z5Q1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.
     214-241: SSLQLPAWGSDSLQDSWCTAAGTSRIDQ → M
     288-288: N → NARSYGRRR

Show »
Length:548
Mass (Da):61,261
Checksum:i2A5A0BDA3FCCDD06
GO
Isoform 7 (identifier: Q7Z5Q1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRDFGFGVLQ...GGSGGSLSAM
     214-241: SSLQLPAWGSDSLQDSWCTAAGTSRIDQ → M
     288-288: N → NARSYGRRR

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,007
Mass (Da):106,972
Checksum:iE71487A7D5AA3EE4
GO
Isoform 8 (identifier: Q7Z5Q1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRDFGFGVLQ...GGSGGSLSAM
     288-288: N → NARSYGRRR

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,034
Mass (Da):109,804
Checksum:i1802DC868AB9211C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50G → GG in AAI03942 (PubMed:15815621).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556701M → MRDFGFGVLQTAPLRSSSPG PLFCGEAYGPYAVGSVNPLP SATPFGPLSPPPLPVTGFLE AASPFSVPLGGGAGSPAAAA SSSSPFLAHQQTMQDELLLG LTQQPARPLSGAAATEKLPD HHPGGGTIAGVTHLLPSQDF KPSLHHPSSSSASSCCCCRT SSPQDFSKRQQQQLSSQKRK EFSPPHLPHPPDSKPPPPPP PLHCPGRFSPPPPPAGPLLQ PAQLAQRQQQQPPQQFSLLH QQHLSPQDFAPRQRPADLPP LPQLPPSPPAAPRRRHGGAG SPRKTPAAGEGSAAESPNAG LASSTPVNPAPGSMESPNHP LLNSPSNLLPGGALGAGAFS SLQSPDLPHPGGGGGGGGGG PPGGGGGGGSASPPPLPGFG TPWSVQTASPPPQPQQPPPT QPQQQPPPPQQPPQPQPQPP GSSATTPGGGSGGSLSAM in isoform 7 and isoform 8. Curated1
Alternative sequenceiVSP_02203043 – 64Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_022031212 – 241Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_022032214 – 241SSLQL…SRIDQ → M in isoform 3, isoform 6 and isoform 7. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_027372288N → NARSYGRRR in isoform 2, isoform 5, isoform 6, isoform 7 and isoform 8. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247744 mRNA Translation: AAP37585.1
AY255519 mRNA Translation: AAP41553.1
AC098829 Genomic DNA No translation available.
AC105289 Genomic DNA No translation available.
AC114749 Genomic DNA No translation available.
BC103939 mRNA Translation: AAI03940.2
BC103940 mRNA Translation: AAI03941.1
BC103941 mRNA Translation: AAI03942.1
BC103942 mRNA Translation: AAI03943.1
BC105925 mRNA Translation: AAI05926.1
CCDSiCCDS56325.1 [Q7Z5Q1-9]
CCDS56326.1 [Q7Z5Q1-8]
RefSeqiNP_001170852.1, NM_001177381.1 [Q7Z5Q1-8]
NP_001170853.1, NM_001177382.1 [Q7Z5Q1-9]
NP_001170854.1, NM_001177383.1
NP_001170855.1, NM_001177384.1
NP_872291.2, NM_182485.2
NP_872587.2, NM_182646.2
UniGeneiHs.656937

Genome annotation databases

EnsembliENST00000345451; ENSP00000334058; ENSG00000137449 [Q7Z5Q1-5]
ENST00000382395; ENSP00000371832; ENSG00000137449 [Q7Z5Q1-6]
ENST00000382401; ENSP00000371838; ENSG00000137449 [Q7Z5Q1-4]
ENST00000442003; ENSP00000414270; ENSG00000137449 [Q7Z5Q1-8]
ENST00000507071; ENSP00000424084; ENSG00000137449 [Q7Z5Q1-2]
ENST00000538197; ENSP00000443985; ENSG00000137449 [Q7Z5Q1-9]
ENST00000634696; ENSP00000488925; ENSG00000283087 [Q7Z5Q1-2]
ENST00000634867; ENSP00000489160; ENSG00000283087 [Q7Z5Q1-5]
ENST00000635061; ENSP00000489427; ENSG00000283087 [Q7Z5Q1-9]
ENST00000635093; ENSP00000489406; ENSG00000283087 [Q7Z5Q1-6]
ENST00000635362; ENSP00000489336; ENSG00000283087 [Q7Z5Q1-8]
ENST00000635651; ENSP00000489362; ENSG00000283087 [Q7Z5Q1-4]
GeneIDi132864
KEGGihsa:132864
UCSCiuc003gnk.2 human [Q7Z5Q1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCPEB2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5Q1
Secondary accession number(s): E7EPM3
, F5H160, Q3B8N6, Q3MI89, Q3MI90, Q3MI92, Q7Z5Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health