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Protein

Cytoplasmic polyadenylation element-binding protein 2

Gene

CPEB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 2
Short name:
CPE-BP2
Short name:
CPE-binding protein 2
Short name:
hCPEB-2
Gene namesi
Name:CPEB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:21745. CPEB2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • messenger ribonucleoprotein complex Source: UniProtKB
  • neuron projection Source: GO_Central
  • nucleus Source: UniProtKB
  • synapse Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864048.

Polymorphism and mutation databases

BioMutaiCPEB2.
DMDMi158937340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Cytoplasmic polyadenylation element-binding protein 2PRO_0000269259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z5Q1.
PaxDbiQ7Z5Q1.
PeptideAtlasiQ7Z5Q1.
PRIDEiQ7Z5Q1.

PTM databases

iPTMnetiQ7Z5Q1.
PhosphoSiteiQ7Z5Q1.

Expressioni

Gene expression databases

BgeeiQ7Z5Q1.
CleanExiHS_CPEB2.
ExpressionAtlasiQ7Z5Q1. baseline and differential.
GenevisibleiQ7Z5Q1. HS.

Interactioni

Subunit structurei

Interacts with PAPD4/GLD2.By similarity

Protein-protein interaction databases

BioGridi126338. 3 interactions.
STRINGi9606.ENSP00000443985.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5Q1.
SMRiQ7Z5Q1. Positions 320-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini332 – 42392RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini440 – 52283RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 9392Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM CPEB family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0129. Eukaryota.
ENOG410Y1XZ. LUCA.
GeneTreeiENSGT00390000012886.
HOGENOMiHOG000290661.
HOVERGENiHBG058010.
InParanoidiQ7Z5Q1.
KOiK02602.
OMAiMESPNHP.
OrthoDBiEOG7X3QR2.
PhylomeDBiQ7Z5Q1.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5Q1-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPSPDSEN GFYPGLPSSM NPAFFPSFSP VSPHGCTGLS VPTSGGGGGG
60 70 80 90 100
FGGPFSATAV PPPPPPAMNI PQQQPPPPAA PQQPQSRRSP VSPQLQQQHQ
110 120 130 140 150
AAAAAFLQQR NSYNHHQPLL KQSPWSNHQS SGWGTGSMSW GAMHGRDHRR
160 170 180 190 200
TGNMGIPGTM NQISPLKKPF SGNVIAPPKF TRSTPSLTPK SWIEDNVFRT
210 220 230 240 250
DNNSNTLLPL QVRSSLQLPA WGSDSLQDSW CTAAGTSRID QDRSRMYDSL
260 270 280 290 300
NMHSLENSLI DIMRAEHDPL KGRLSYPHPG TDNLLMLNGR SSLFPIDDGL
310 320 330 340 350
LDDGHSDQVG VLNSPTCYSA HQNGERIERF SRKVFVGGLP PDIDEDEITA
360 370 380 390 400
SFRRFGPLVV DWPHKAESKS YFPPKGYAFL LFQEESSVQA LIDACIEEDG
410 420 430 440 450
KLYLCVSSPT IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP
460 470 480 490 500
LRAVELAMIM DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS
510 520 530 540 550
ARFVQLQHGD IDKRVEVKPY VLDDQMCDEC QGARCGGKFA PFFCANVTCL
560 570 580
QYYCEFCWAN IHSRAGREFH KPLVKEGADR PRQIHFRWN
Length:589
Mass (Da):64,944
Last modified:August 21, 2007 - v3
Checksum:iE0A16772D2E3091A
GO
Isoform 2 (identifier: Q7Z5Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.
     288-288: N → NARSYGRRR

Show »
Length:575
Mass (Da):64,093
Checksum:i0BC308E83DB1D799
GO
Isoform 3 (identifier: Q7Z5Q1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-241: SSLQLPAWGSDSLQDSWCTAAGTSRIDQ → M

Show »
Length:562
Mass (Da):62,112
Checksum:i269754FE66F5B647
GO
Isoform 4 (identifier: Q7Z5Q1-5) [UniParc]FASTAAdd to basket

Also known as: CPEB2b

The sequence of this isoform differs from the canonical sequence as follows:
     212-241: Missing.

Show »
Length:559
Mass (Da):61,726
Checksum:i9465D16A0203B6A9
GO
Isoform 5 (identifier: Q7Z5Q1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-241: Missing.
     288-288: N → NARSYGRRR

Show »
Length:567
Mass (Da):62,729
Checksum:i17A2D7994BFAADA6
GO
Isoform 6 (identifier: Q7Z5Q1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.
     214-241: SSLQLPAWGSDSLQDSWCTAAGTSRIDQ → M
     288-288: N → NARSYGRRR

Show »
Length:548
Mass (Da):61,261
Checksum:i2A5A0BDA3FCCDD06
GO
Isoform 7 (identifier: Q7Z5Q1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRDFGFGVLQ...GGSGGSLSAM
     214-241: SSLQLPAWGSDSLQDSWCTAAGTSRIDQ → M
     288-288: N → NARSYGRRR

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,007
Mass (Da):106,972
Checksum:iE71487A7D5AA3EE4
GO
Isoform 8 (identifier: Q7Z5Q1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRDFGFGVLQ...GGSGGSLSAM
     288-288: N → NARSYGRRR

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,034
Mass (Da):109,804
Checksum:i1802DC868AB9211C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501G → GG in AAI03942 (PubMed:15815621).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRDFGFGVLQTAPLRSSSPG PLFCGEAYGPYAVGSVNPLP SATPFGPLSPPPLPVTGFLE AASPFSVPLGGGAGSPAAAA SSSSPFLAHQQTMQDELLLG LTQQPARPLSGAAATEKLPD HHPGGGTIAGVTHLLPSQDF KPSLHHPSSSSASSCCCCRT SSPQDFSKRQQQQLSSQKRK EFSPPHLPHPPDSKPPPPPP PLHCPGRFSPPPPPAGPLLQ PAQLAQRQQQQPPQQFSLLH QQHLSPQDFAPRQRPADLPP LPQLPPSPPAAPRRRHGGAG SPRKTPAAGEGSAAESPNAG LASSTPVNPAPGSMESPNHP LLNSPSNLLPGGALGAGAFS SLQSPDLPHPGGGGGGGGGG PPGGGGGGGSASPPPLPGFG TPWSVQTASPPPQPQQPPPT QPQQQPPPPQQPPQPQPQPP GSSATTPGGGSGGSLSAM in isoform 7 and isoform 8. CuratedVSP_055670
Alternative sequencei43 – 6422Missing in isoform 2 and isoform 6. 1 PublicationVSP_022030Add
BLAST
Alternative sequencei212 – 24130Missing in isoform 4 and isoform 5. 2 PublicationsVSP_022031Add
BLAST
Alternative sequencei214 – 24128SSLQL…SRIDQ → M in isoform 3, isoform 6 and isoform 7. 1 PublicationVSP_022032Add
BLAST
Alternative sequencei288 – 2881N → NARSYGRRR in isoform 2, isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationVSP_027372

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247744 mRNA. Translation: AAP37585.1.
AY255519 mRNA. Translation: AAP41553.1.
AC098829 Genomic DNA. No translation available.
AC105289 Genomic DNA. No translation available.
AC114749 Genomic DNA. No translation available.
BC103939 mRNA. Translation: AAI03940.2.
BC103940 mRNA. Translation: AAI03941.1.
BC103941 mRNA. Translation: AAI03942.1.
BC103942 mRNA. Translation: AAI03943.1.
BC105925 mRNA. Translation: AAI05926.1.
CCDSiCCDS56325.1. [Q7Z5Q1-9]
CCDS56326.1. [Q7Z5Q1-8]
RefSeqiNP_001170852.1. NM_001177381.1. [Q7Z5Q1-8]
NP_001170853.1. NM_001177382.1. [Q7Z5Q1-9]
NP_001170854.1. NM_001177383.1.
NP_001170855.1. NM_001177384.1.
NP_872291.2. NM_182485.2.
NP_872587.2. NM_182646.2.
UniGeneiHs.656937.

Genome annotation databases

EnsembliENST00000345451; ENSP00000334058; ENSG00000137449. [Q7Z5Q1-5]
ENST00000382395; ENSP00000371832; ENSG00000137449. [Q7Z5Q1-6]
ENST00000382401; ENSP00000371838; ENSG00000137449. [Q7Z5Q1-4]
ENST00000442003; ENSP00000414270; ENSG00000137449. [Q7Z5Q1-8]
ENST00000507071; ENSP00000424084; ENSG00000137449. [Q7Z5Q1-2]
ENST00000538197; ENSP00000443985; ENSG00000137449. [Q7Z5Q1-9]
GeneIDi132864.
KEGGihsa:132864.
UCSCiuc003gnk.2. human. [Q7Z5Q1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247744 mRNA. Translation: AAP37585.1.
AY255519 mRNA. Translation: AAP41553.1.
AC098829 Genomic DNA. No translation available.
AC105289 Genomic DNA. No translation available.
AC114749 Genomic DNA. No translation available.
BC103939 mRNA. Translation: AAI03940.2.
BC103940 mRNA. Translation: AAI03941.1.
BC103941 mRNA. Translation: AAI03942.1.
BC103942 mRNA. Translation: AAI03943.1.
BC105925 mRNA. Translation: AAI05926.1.
CCDSiCCDS56325.1. [Q7Z5Q1-9]
CCDS56326.1. [Q7Z5Q1-8]
RefSeqiNP_001170852.1. NM_001177381.1. [Q7Z5Q1-8]
NP_001170853.1. NM_001177382.1. [Q7Z5Q1-9]
NP_001170854.1. NM_001177383.1.
NP_001170855.1. NM_001177384.1.
NP_872291.2. NM_182485.2.
NP_872587.2. NM_182646.2.
UniGeneiHs.656937.

3D structure databases

ProteinModelPortaliQ7Z5Q1.
SMRiQ7Z5Q1. Positions 320-580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126338. 3 interactions.
STRINGi9606.ENSP00000443985.

PTM databases

iPTMnetiQ7Z5Q1.
PhosphoSiteiQ7Z5Q1.

Polymorphism and mutation databases

BioMutaiCPEB2.
DMDMi158937340.

Proteomic databases

MaxQBiQ7Z5Q1.
PaxDbiQ7Z5Q1.
PeptideAtlasiQ7Z5Q1.
PRIDEiQ7Z5Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345451; ENSP00000334058; ENSG00000137449. [Q7Z5Q1-5]
ENST00000382395; ENSP00000371832; ENSG00000137449. [Q7Z5Q1-6]
ENST00000382401; ENSP00000371838; ENSG00000137449. [Q7Z5Q1-4]
ENST00000442003; ENSP00000414270; ENSG00000137449. [Q7Z5Q1-8]
ENST00000507071; ENSP00000424084; ENSG00000137449. [Q7Z5Q1-2]
ENST00000538197; ENSP00000443985; ENSG00000137449. [Q7Z5Q1-9]
GeneIDi132864.
KEGGihsa:132864.
UCSCiuc003gnk.2. human. [Q7Z5Q1-2]

Organism-specific databases

CTDi132864.
GeneCardsiCPEB2.
HGNCiHGNC:21745. CPEB2.
MIMi610605. gene.
neXtProtiNX_Q7Z5Q1.
PharmGKBiPA134864048.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0129. Eukaryota.
ENOG410Y1XZ. LUCA.
GeneTreeiENSGT00390000012886.
HOGENOMiHOG000290661.
HOVERGENiHBG058010.
InParanoidiQ7Z5Q1.
KOiK02602.
OMAiMESPNHP.
OrthoDBiEOG7X3QR2.
PhylomeDBiQ7Z5Q1.

Miscellaneous databases

ChiTaRSiCPEB2. human.
GenomeRNAii132864.
PROiQ7Z5Q1.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z5Q1.
CleanExiHS_CPEB2.
ExpressionAtlasiQ7Z5Q1. baseline and differential.
GenevisibleiQ7Z5Q1. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Wu S.L., Shan Y.X., Xiao P.J.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 5 AND 6).

Entry informationi

Entry nameiCPEB2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5Q1
Secondary accession number(s): E7EPM3
, F5H160, Q3B8N6, Q3MI89, Q3MI90, Q3MI92, Q7Z5Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 21, 2007
Last modified: July 6, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.