Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7Z5P9

- MUC19_HUMAN

UniProt

Q7Z5P9 - MUC19_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mucin-19

Gene

MUC19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May function in ocular mucus homeostasis.1 Publication

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. O-glycan processing Source: Reactome
  3. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-19
Short name:
MUC-19
Gene namesi
Name:MUC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14362. MUC19.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 6254Mucin-19PRO_0000342664
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 6245By similarity
Disulfide bondi6158 ↔ 6209By similarity
Disulfide bondi6176 ↔ 6223By similarity
Disulfide bondi6185 ↔ 6239By similarity
Disulfide bondi6189 ↔ 6241By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z5P9.
PRIDEiQ7Z5P9.

PTM databases

PhosphoSiteiQ7Z5P9.

Expressioni

Tissue specificityi

Expressed corneal epithelial cells, conjunctival goblet and epithelial cells and lacrimal gland cells (at protein level). Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expressed by middle ear epithelial cells.3 Publications

Inductioni

Down-regulated in Sjoegren syndrome patients (at protein level).1 Publication

Gene expression databases

BgeeiQ7Z5P9.
CleanExiHS_MUC19.
GenevestigatoriQ7Z5P9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000395253.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5P9.
SMRiQ7Z5P9. Positions 485-584, 592-688, 948-1053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9797VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 439209VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini691 – 900210VWFD 3PROSITE-ProRule annotationAdd
BLAST
Domaini6029 – 609567VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini6097 – 615963VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini6162 – 624685CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni910 – 55094600Approximate repeats of G-V-T-G-T-T-G-P-S-AAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation
Contains 3 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiQ7Z5P9.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 2 hits.
[Graphical view]
SMARTiSM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z5P9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWDKNNKLSL TLHKQYPTCG LCGNFNSTPG QDINEHIANS KIPGDCPNAV
60 70 80 90 100
GKSYEVCEDG IQHCNKIIGT YFEKCGKVAA LSNDYKMICI DEYCQTRDKT
110 120 130 140 150
STCDTYSELS RLCASDGPGT FESWRSDSDV VCGTQRCPEQ HIYKECGPSN
160 170 180 190 200
PATCSNVAPF QDSECVSGCT CPEGYLLDDI GEKGKCVLKA ECPCESSGTV
210 220 230 240 250
YQPGEVREGP CGSQCTCQDA KWSCTEALCP GRCKVEGSSL TTFDGVKYNF
260 270 280 290 300
PGNCHFLAVH NEDWSISVEL RPCPSGQTGT CLNSVTLLLN SSVPVDKYVF
310 320 330 340 350
NSDGTVTNDK IRNQGYYYSD KIQIFNASSS YLQVETYFHV KLQIQIVPVM
360 370 380 390 400
QLYVSMPPNQ FTDTVGLCGS YNNKAEDDFM SSQNILEKTS QAFANSWEMM
410 420 430 440 450
SCPKGNPSSC ISIEKEKFAE RHCGILLDSS GPLASCHPIV NPKPYHEECK
460 470 480 490 500
KYTCTCENSQ DCLCTILGNY VKACAEKETY IVGWRTGLCE HSCPSGLVFK
510 520 530 540 550
YNVKACNSSC RSLSERDRSC DVEDVPVDGC TCPDAMYQNN EGNCVLKSQC
560 570 580 590 600
DCYINDEVMQ PGKLIHIDDN KCVCRDGILL CQIPIDLTLQ NCSGGAEYVD
610 620 630 640 650
CSDPKAQRRT NRTCSTRNIP VFDENLPCKR GCFCPEGMVR NSKGICVFPN
660 670 680 690 700
DCPCSFGGRE YDEGSVTSVG CNECTCIKGS WSCTQNECQT ICHIYGEGHV
710 720 730 740 750
RTFDGKSYSF DGLCQYSFLE DYCGHENGTF RILTESVPCC EDGLTCSRKI
760 770 780 790 800
IVAFQDQNIV LQDGKVTAVK STESKKCELN ANAYSIHTVG LYLILKFQNG
810 820 830 840 850
IIVIWDKNTR LSVILDPNWN GKVCGLCGNN NGDLKDDFTT RYSSVASGAL
860 870 880 890 900
EFGNSWKTSQ ECSDTVAQTF PCDSNPYCKA WAVRKCEILR DSTFRDCHNK
910 920 930 940 950
VDPSAYHDVC IEEACACDME GKYLGFCTAV AMYAEACSAV GVCVSWRKPN
960 970 980 990 1000
LCPVYCDYYN APGECRWHYE PCGTVTAKTC KDQLVGQKFS SLLEGCYAKC
1010 1020 1030 1040 1050
PDSAPYLDEN TMKCVSLSEC SCFYNDVIPA GGVIEDNCGR TCYCIAGQLE
1060 1070 1080 1090 1100
CSETAPTNST FAVSTTTATT ILSTGAAITL VTGGPSTAAS IPAITTSSSE
1110 1120 1130 1140 1150
TTGTTLGPLT EPFTTGITET SVPIISTSGN AGMTGVVSPT VTGASGMAGT
1160 1170 1180 1190 1200
TGGVDAATTG AASENTSERA GTPRVSGETP AVGGGSTPGE AGPGATVSGS
1210 1220 1230 1240 1250
TGVSAGSITA SPGASATSSE SSKSGTTGPS VGGKTGATSS EATSSEGMSG
1260 1270 1280 1290 1300
VTGQSLGSTA GSDSEITAKT SFTGSSPPGK LTRPSPGSPG HFSGGTTEWG
1310 1320 1330 1340 1350
NVATTGAAGE NTSGALGSTE GSVEATTSAG SGNTAGTSGT GDTGPGNTAV
1360 1370 1380 1390 1400
SGTPVVSPGA TPGAPGSSTP GEADIGNTSF GKSGKSGHDS LTVLNPAFLR
1410 1420 1430 1440 1450
RTPTVSAAST TSSPVSKHTD AASATAVTIS GSKPGTPGTP GGATSGGKIT
1460 1470 1480 1490 1500
SGWSSSGTST GASNTPGATG SSTGQTDTSG PSAKVTGNYG QSSEIPGTIK
1510 1520 1530 1540 1550
SSSDVSGTMG QSDTTSGPSV AVTRTSEQSS GVTVASEPSV GVSGTTGPLA
1560 1570 1580 1590 1600
EISGTTRPLV SGLRTTGSSA EGSGTTGPSS RESVTTRPLA EGSGTSGQSV
1610 1620 1630 1640 1650
TGSRATGLSA TELGTTVSFT GGLGTSRSSA RETRTTGPSA DGSGTTGPSV
1660 1670 1680 1690 1700
VRSGTTRLSV GVTRATESSP GVTGTTTPSA EESRTTGPSV LVTGTTGQSG
1710 1720 1730 1740 1750
QGSGTTGKSF IESGPSVVGS GTTGPTSAGL GTTAPSTRRS STTKPSVGRT
1760 1770 1780 1790 1800
GTTGQSGAES GTTEPSARVA GVTGTSAEVS GRIEPSATES STSRPLGETT
1810 1820 1830 1840 1850
GTTIPSMEGS EATGPSVIGS ETTRLSVIGS GTTGTSSGGS GATRSSGGGM
1860 1870 1880 1890 1900
GTTGQSTARS ETTGPLFGLT GTFGQSATVT GTSSNSAGVT TPEKSPGVAM
1910 1920 1930 1940 1950
TTGLLVEGSA TTQPRILESE TTESSAGVIV TSGQSARVTG ATGPSAGETG
1960 1970 1980 1990 2000
TTEPSTEGSV AAVLFVIGSE TTRPLDIGSG TTGTLSGGSS TTRSSDGTTG
2010 2020 2030 2040 2050
TTRKSTARSE TTGLSGLTGT SGQLAGVTGT SSKSAGVTVT SEKSAGVAVI
2060 2070 2080 2090 2100
TGSFVERPVT TGPPLLESET TRPSGGVTVT SGQSARVTET VGASAGVTGT
2110 2120 2130 2140 2150
TGPSTEGSGA TGPSVVGSGT TRPLAGESGT TESSAGVTGT RPSSSRESAT
2160 2170 2180 2190 2200
TGPSDEGSGT TGLSAGVTVT SGQSVRKTGT TGAPAGVTET TRPSVVKSGT
2210 2220 2230 2240 2250
TGPSVIGTRT TGTSSGGSGA TRSSGGETET TGQSAVKSGT TESFTRLTRT
2260 2270 2280 2290 2300
SGQSAGMTGT SAQSAGVALT SPFVEGLVTT GSSTVGLETT RPSAVGSGKT
2310 2320 2330 2340 2350
GPPVVKAQTT GPSAGVTVTS GQSARMTGAS GPSVGVTGTT GPASKGLGTI
2360 2370 2380 2390 2400
RPSVVGLETT ELSAEGSGTT GPPIVGETTV PSAGVTVTSG YSDRVTGATE
2410 2420 2430 2440 2450
PLAGVTGTIK PSVAGSVTTG PSVTGVETTA KTTSGGLSTT ISSVGGTGTT
2460 2470 2480 2490 2500
GQSPERSGTT GPFTGLTGTS AQSAGVTMTS IQSAGVLVTT GLNVDGLGTT
2510 2520 2530 2540 2550
GKALIGSGTT GLSAEATGTI GPSTEGLEKT GPSITGSGTT RPLVTESWTA
2560 2570 2580 2590 2600
GTSSGGHSTT SPSVRGTETT GQSAAESVTT GPVTGYTETS GPSAGVTVTP
2610 2620 2630 2640 2650
RQSPTVTQTT GSSAAVSGTT VQSLTVSGTT RPSSGQTEIT GSSVKESGTT
2660 2670 2680 2690 2700
ESSAVRSGTT GPTAGVTGTN GPSSAGVTGI TGSSPGVTGT TGSSPGVTGT
2710 2720 2730 2740 2750
TGSSARSGTS IPSVGKTGTT RTSVEESRTT RPSAGITGTN GLSAEVTGTT
2760 2770 2780 2790 2800
GPLAGVTGTT GPSAGVTRTT GLSAGETGTT GLSPGVTRTT RSSAGLTGKT
2810 2820 2830 2840 2850
GLSAGVTGKT GLSAEVTGTT RLSAGVTGTT GPSPGVTGTT GTPAGVTGTT
2860 2870 2880 2890 2900
ELSAGVTGKT GLSSEVTETT GLSYGVKRTI GLSAGSTGTS GQSAGVAGTT
2910 2920 2930 2940 2950
TLSAEVTGTT RPSAGVTGTT GLSAEVTEIT GISAVVTGTT GPSAGVTETT
2960 2970 2980 2990 3000
GSSAGVAGTT RLSAGVTGIT GLSAGVTGTT GLSTEVTGTT GPSAGATGTT
3010 3020 3030 3040 3050
GLSVGVTGIT GLSDVVTETT GSSARSGTGI PSVGETRTTS TSVEESRTTR
3060 3070 3080 3090 3100
PSAGIMGTNG LPAEVTGTTE PLAGGTGTTG ILAGVTGTTG LSAGETGKIG
3110 3120 3130 3140 3150
SSAGVTGKTG SSARVTGKTG PSAEVTGKTG LSAGVTGTTG LSPGVTGTSG
3160 3170 3180 3190 3200
LSAEVTGTTG PSAEATGLPG VSAGVTGTTG SLAGGTGTIG LSAGVTGTTG
3210 3220 3230 3240 3250
SSAGVTGTTG LSAGVTGIAG LSAGVTGITG PSAGVTGTTT VSAGVTGTTG
3260 3270 3280 3290 3300
LSAEATEITG LSAGVTGTTG LSAGVTETIR LSAGVTGTIR SSAGVTGITG
3310 3320 3330 3340 3350
LSAGVTGTTG PSAGVTGSTG LLAGVTETTG QSAKVTGTTG QSVGVTGTTR
3360 3370 3380 3390 3400
SSGGVTGITG LSAGVTGTNG LSAVTGMTGL SAEVTGTTGL SVGVTGIAGL
3410 3420 3430 3440 3450
SAGVTGITGP SAGITGTTTI SAGVTGTSGL SAEATGITGL SAGVTGKTGL
3460 3470 3480 3490 3500
SAGVTETIGL SAEATGTIGS SPGVTGTTGS STGVTGITGL SAGVTGTTGL
3510 3520 3530 3540 3550
STEVTGTTGP SAGVTRTTGL SAGVTGITGL SAIVTETTGS SARSGTSIPS
3560 3570 3580 3590 3600
VGETGTTRTS VEESRTTRPS AGITGTTGLS AGVTGTVGSS AVVTGTTGLS
3610 3620 3630 3640 3650
AGVTGTTGPS AEETGATGPS AEVTETTGPS AGVTGTGRLS AEVTGTTGPS
3660 3670 3680 3690 3700
AEVTGLPGES AEVTGTIGSP AGVTGTTQLS AVVTGITGLS AEVTGTTGLS
3710 3720 3730 3740 3750
AGVTGITGLS AEVTRTTGLS AGVTGTIGLS AGVTGTTRPS AGVTGTTGQS
3760 3770 3780 3790 3800
AEVTGTTEPS AGLTETTGSS TGVTGATGPL AGVTGTTGIS TEVTGTTGPS
3810 3820 3830 3840 3850
ARVTGTTVLS AGVTGITGLS AIVTETTGSS ARSGTSTPSV GETGTTRTSV
3860 3870 3880 3890 3900
EESRATRPSA GITGTNGQSA EVTWITGPLA GVTGTTGISA GVTGTTGLSA
3910 3920 3930 3940 3950
GVTGTIGSSA VVTGINGLSA GVTGTTGPSA EETGATGPSA EVTGTTGPSA
3960 3970 3980 3990 4000
EETGATGPSA EVTGTTGPSG GVTGTNGLSA EVTGTTGPSA EVTGLPGVSA
4010 4020 4030 4040 4050
GVTGTIGSPA AVTGTIRPSA VVTGITGLSA EVTGTTGLSA WVTGIAGLSA
4060 4070 4080 4090 4100
GVTETIGSSA GVTGTNGLSA EATGTTGPSA GVTGTTGLSA GVTGTAGLSA
4110 4120 4130 4140 4150
RVTESTGLSA GVTGTTGLSA GVTGTTGPSA GITGTNGLSA EVTGTTGPLA
4160 4170 4180 4190 4200
GVTGTIGLSA GVTGIAGLSA GVTESTGLSA GVTGTIRSSA VVTGINGLSA
4210 4220 4230 4240 4250
GVTGTTGPSA EETGATGPSA EVTGTTGPSG GVTGTSGISA EVTGTTGPSA
4260 4270 4280 4290 4300
EVTGLPGVSA GVTGTIGSPA AVTGTTRPSA VVTGISGLSA EVTGTTGLSA
4310 4320 4330 4340 4350
GVTETIGSSA GVTGTNGLSA EATETTGPSA GVTGTTGLSA GVTGTTGPSA
4360 4370 4380 4390 4400
GIAGTNGLSA GVTGTTGLSA RVTESTGLSA GVTGTIGSSA VVTETTRLSS
4410 4420 4430 4440 4450
GVTGTIGPSA EETGATGLSA EVTGTTGSLA EVTGTTGLSA GVTGTIGSSA
4460 4470 4480 4490 4500
VVTGTTGLSA GITGTNGLSA EVTGTAGPLA GVTGTTGLSA GVTGTTGLSA
4510 4520 4530 4540 4550
GVTETTGQSA GVTESTGLSP GVTGTIGSSA VVTGIKGLSA GVTGTTGPSA
4560 4570 4580 4590 4600
EETGATGPSA EVTGTTGPSG GVTGTSVLSV EVTGTTGPSA EVTGLPGVSA
4610 4620 4630 4640 4650
GLTGTIGSPA AVRGTTWPSA VVTGISGLSG EVTGTTGLSA GVTGIGGLSA
4660 4670 4680 4690 4700
GVTGTIGSSA GVTGTNALSA EATGTTGPSA GVTGTTGLSA GVTGTTGLSA
4710 4720 4730 4740 4750
GVTGTIRSSA VVTETTGLSA GVTGTTGPSA GIAGTNGLSA EVTGTTGLSA
4760 4770 4780 4790 4800
GMTGTTGLSA RVTESTGLSA GVTGTIGSSA VVTETTRLSA GVTGTIGPSA
4810 4820 4830 4840 4850
EETGATGLSA EVTRTTGSLA GVTGTTGPSA VVTGKTELSA EVTGTTELSA
4860 4870 4880 4890 4900
EVTEKTGPSA EVTGKTGLSA GVMETTGPSA EVTGTTGSSA GVTGTTGPSA
4910 4920 4930 4940 4950
GVTGTTGPSA EATGLPGVSA GVTGTIGSPA GVTGTARLSA VVTGISGLSA
4960 4970 4980 4990 5000
EVTGTTGLST GVTGIAGHSA AVTGITRPSA GVTGTTTVSA GVTGTIGLSA
5010 5020 5030 5040 5050
EATGITLPSA GVTETTGLSA GVTETIGLSA GVTGTIGSSA GVTEITGLSA
5060 5070 5080 5090 5100
GVTGTTGPSA GVTGSTVLSA GVTATTGQSV GVTGTTGPSA GVTGTTGLSA
5110 5120 5130 5140 5150
GVTGIAGLSA GVTGITGPSA GVTGTTTVSA GVTGTTGLSA EATEITGLSA
5160 5170 5180 5190 5200
GVTGTTGLSA GVTGIAGLSA GVTETIGSSA GVTGTNGLSA EATGKTGPSA
5210 5220 5230 5240 5250
GVTGTTGLSA GVTGTTGLSA GVTETIGLSA GVTGTIGSSA GVKGTTGQSA
5260 5270 5280 5290 5300
EVTGATGQSV GVTGTTRSSG GVTGITGLSA GLRGTTVSSA KAGTSIPLTG
5310 5320 5330 5340 5350
KTGTTRTSVE ESTTTGPSAG ITGTNGLSAE MTGTNELSAG VTGTIGSSAG
5360 5370 5380 5390 5400
VTGTTGLSVE ATVTTGLSAG VTGTTVPLAG VTWTPGPSAG VTGIAALSAG
5410 5420 5430 5440 5450
VTGKSGLSAG VTGKTGLSAG VTGTTGPSAE ATGKTGLSAG VTGITGPFAE
5460 5470 5480 5490 5500
VTGTTGLSAG VIGTTGSSAE VTGITGLSAG VTGKTRSSAG VTGTTGLSAK
5510 5520 5530 5540 5550
SGTSIPSAGK TGTTKTSVEE SRTTRPSAGI TGTNGLPARV TGTXXXXXXX
5560 5570 5580 5590 5600
XXXGTSGVAP GTTVAPGSFS TAATTSPGAS GVTGTGPTAE TTTFLGGSST
5610 5620 5630 5640 5650
TGAEIKSGAT TGAPGSKTGT AKVLSGTTVA SGSSNSEATT FSGITEAVTV
5660 5670 5680 5690 5700
PSKNGSMTTA LGSQLSSSQT VIPGSSGTIS HTTVAPGSSV TGTTTGASDD
5710 5720 5730 5740 5750
QVTGSKTGTT GVALSTTVAP GSSSTEATTS TGVHRTTVVG QKTGATTRGS
5760 5770 5780 5790 5800
AKQGTRSTIE ATTSFRGTGT TGSGMNTGTT GVVSGNTISP SSFNTEATSG
5810 5820 5830 5840 5850
TSERPNPGSE IGTTGIVSGT TVAPGSSNTE ATTSLGNGGT TEAGSKIVTT
5860 5870 5880 5890 5900
GITTGTTIVP GSFNTKATTS TDVGVATGVG MATGITNIIS GRSQPTGSKT
5910 5920 5930 5940 5950
GYTVTGSGTT ALPGGFRTGN TPGSTGVTSS QEGTTVVSSG ITGIPETSIS
5960 5970 5980 5990 6000
GPSKEASDKT TAPGPPTTVT ASTGVKETSE TGVQTGSTLV TAGVPTRPQV
6010 6020 6030 6040 6050
SQPETTVVAT REVETENKTE CLASLPPAPV CHGPLGEEKS PGDIWTANCH
6060 6070 6080 6090 6100
RGTCTDAKTI DCKPEECPSP PTCKTGEKLV KFQSNDTCCE IGYCEPRTCL
6110 6120 6130 6140 6150
FNNTDYEIGA SFDDPSNPCV SYSCKDTGFA AVVQDCPKQT WCAEANRIYD
6160 6170 6180 6190 6200
SKKCCYTCKN NCRSSLVNVT VIYSGCKKRV QMAKCTGECE KTAKYNHDIL
6210 6220 6230 6240 6250
LLEHSCLCCR EENYELRDIV LDCPDGSTIP YQYKHITTCS CLDICQLYTT

FMYS
Length:6,254
Mass (Da):598,155
Last modified:July 1, 2008 - v2
Checksum:i0B29670B870FBCB8
GO
Isoform 2 (identifier: Q7Z5P9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     5919-5936: GNTPGSTGVTSSQEGTTV → DSPSFPLFLICSYRGHNF
     5937-6254: Missing.

Note: No experimental confirmation available.

Show »
Length:5,936
Mass (Da):564,084
Checksum:i828E67D663F5A033
GO

Sequence cautioni

The sequence BAC04041.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331G → E.
Corresponds to variant rs7955308 [ dbSNP | Ensembl ].
VAR_056617
Natural varianti199 – 1991T → K.
Corresponds to variant rs11564170 [ dbSNP | Ensembl ].
VAR_056618
Natural varianti206 – 2061V → I.
Corresponds to variant rs7958987 [ dbSNP | Ensembl ].
VAR_056619
Natural varianti207 – 2071R → L.
Corresponds to variant rs17467284 [ dbSNP | Ensembl ].
VAR_056620
Natural varianti219 – 2191D → H.
Corresponds to variant rs11564245 [ dbSNP | Ensembl ].
VAR_056621
Natural varianti259 – 2591V → I.
Corresponds to variant rs10506156 [ dbSNP | Ensembl ].
VAR_056622
Natural varianti285 – 2851V → I.
Corresponds to variant rs28365246 [ dbSNP | Ensembl ].
VAR_056623
Natural varianti299 – 2991V → I.
Corresponds to variant rs11564125 [ dbSNP | Ensembl ].
VAR_056624
Natural varianti426 – 4261L → F.
Corresponds to variant rs12317988 [ dbSNP | Ensembl ].
VAR_056625
Natural varianti567 – 5671I → T.
Corresponds to variant rs11176635 [ dbSNP | Ensembl ].
VAR_056626
Natural varianti642 – 6421S → F.
Corresponds to variant rs4768261 [ dbSNP | Ensembl ].
VAR_056627
Natural varianti694 – 6941I → M.
Corresponds to variant rs7966110 [ dbSNP | Ensembl ].
VAR_056628
Natural varianti712 – 7121G → S.
Corresponds to variant rs4768264 [ dbSNP | Ensembl ].
VAR_056629
Natural varianti731 – 7311R → H.
Corresponds to variant rs7312154 [ dbSNP | Ensembl ].
VAR_056630
Natural varianti743 – 7431G → W.
Corresponds to variant rs12369002 [ dbSNP | Ensembl ].
VAR_056631
Natural varianti783 – 7831A → T.
Corresponds to variant rs11564141 [ dbSNP | Ensembl ].
VAR_056632
Natural varianti827 – 8271C → Y.
Corresponds to variant rs11564109 [ dbSNP | Ensembl ].
VAR_056633
Natural varianti867 – 8671A → T.
Corresponds to variant rs11176666 [ dbSNP | Ensembl ].
VAR_056634
Natural varianti909 – 9091V → A.
Corresponds to variant rs10784621 [ dbSNP | Ensembl ].
VAR_056635
Natural varianti1037 – 10371N → S.
Corresponds to variant rs17128169 [ dbSNP | Ensembl ].
VAR_056636
Natural varianti1104 – 11041T → A.
Corresponds to variant rs17128233 [ dbSNP | Ensembl ].
VAR_056637
Natural varianti1178 – 11781E → A.
Corresponds to variant rs2933353 [ dbSNP | Ensembl ].
VAR_056638
Natural varianti1186 – 11861S → R.
Corresponds to variant rs7956459 [ dbSNP | Ensembl ].
VAR_056639
Natural varianti1462 – 14621A → S.
Corresponds to variant rs1492333 [ dbSNP | Ensembl ].
VAR_056640

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei5919 – 593618GNTPG…EGTTV → DSPSFPLFLICSYRGHNF in isoform 2. 1 PublicationVSP_034521Add
BLAST
Alternative sequencei5937 – 6254318Missing in isoform 2. 1 PublicationVSP_034522Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024935 Genomic DNA. No translation available.
AC074030 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.
AY236870 mRNA. Translation: AAP41817.1.
AK093065 mRNA. Translation: BAC04041.1. Different initiation.
UniGeneiHs.632712.

Genome annotation databases

EnsembliENST00000538912; ENSP00000440762; ENSG00000205592.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024935 Genomic DNA. No translation available.
AC074030 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.
AY236870 mRNA. Translation: AAP41817.1 .
AK093065 mRNA. Translation: BAC04041.1 . Different initiation.
UniGenei Hs.632712.

3D structure databases

ProteinModelPortali Q7Z5P9.
SMRi Q7Z5P9. Positions 485-584, 592-688, 948-1053.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000395253.

PTM databases

PhosphoSitei Q7Z5P9.

Proteomic databases

PaxDbi Q7Z5P9.
PRIDEi Q7Z5P9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000538912 ; ENSP00000440762 ; ENSG00000205592 .

Organism-specific databases

GeneCardsi GC12P040788.
H-InvDB HIX0210549.
HGNCi HGNC:14362. MUC19.
MIMi 612170. gene.
neXtProti NX_Q7Z5P9.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi Q7Z5P9.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

PROi Q7Z5P9.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z5P9.
CleanExi HS_MUC19.
Genevestigatori Q7Z5P9.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 2 hits.
[Graphical view ]
SMARTi SM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues."
    Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R.
    Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5554-6254 (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5554-6254 (ISOFORM 2).
    Tissue: Testis.
  4. "Mucin gene expression in human middle ear epithelium."
    Kerschner J.E.
    Laryngoscope 117:1666-1676(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients."
    Yu D.F., Chen Y., Han J.M., Zhang H., Chen X.P., Zou W.J., Liang L.Y., Xu C.C., Liu Z.G.
    Exp. Eye Res. 86:403-411(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiMUC19_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5P9
Secondary accession number(s): Q8NA85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3