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Q7Z5P9

- MUC19_HUMAN

UniProt

Q7Z5P9 - MUC19_HUMAN

Protein

Mucin-19

Gene

MUC19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    May function in ocular mucus homeostasis.1 Publication

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. O-glycan processing Source: Reactome
    3. post-translational protein modification Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-19
    Short name:
    MUC-19
    Gene namesi
    Name:MUC19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:14362. MUC19.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi lumen Source: Reactome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 6254Mucin-19PRO_0000342664
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 6245By similarity
    Disulfide bondi6158 ↔ 6209By similarity
    Disulfide bondi6176 ↔ 6223By similarity
    Disulfide bondi6185 ↔ 6239By similarity
    Disulfide bondi6189 ↔ 6241By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ7Z5P9.
    PRIDEiQ7Z5P9.

    PTM databases

    PhosphoSiteiQ7Z5P9.

    Expressioni

    Tissue specificityi

    Expressed corneal epithelial cells, conjunctival goblet and epithelial cells and lacrimal gland cells (at protein level). Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expressed by middle ear epithelial cells.3 Publications

    Inductioni

    Down-regulated in Sjoegren syndrome patients (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ7Z5P9.
    BgeeiQ7Z5P9.
    CleanExiHS_MUC19.
    GenevestigatoriQ7Z5P9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000395253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z5P9.
    SMRiQ7Z5P9. Positions 134-203, 471-564, 591-663, 968-1031.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9797VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 439209VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini691 – 900210VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini6029 – 609567VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini6097 – 615963VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini6162 – 624685CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni910 – 55094600Approximate repeats of G-V-T-G-T-T-G-P-S-AAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 VWFC domains.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    InParanoidiQ7Z5P9.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 2 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 2 hits.
    [Graphical view]
    SMARTiSM00832. C8. 2 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 1 hit.
    SM00216. VWD. 2 hits.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 3 hits.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS50184. VWFC_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z5P9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWDKNNKLSL TLHKQYPTCG LCGNFNSTPG QDINEHIANS KIPGDCPNAV     50
    GKSYEVCEDG IQHCNKIIGT YFEKCGKVAA LSNDYKMICI DEYCQTRDKT 100
    STCDTYSELS RLCASDGPGT FESWRSDSDV VCGTQRCPEQ HIYKECGPSN 150
    PATCSNVAPF QDSECVSGCT CPEGYLLDDI GEKGKCVLKA ECPCESSGTV 200
    YQPGEVREGP CGSQCTCQDA KWSCTEALCP GRCKVEGSSL TTFDGVKYNF 250
    PGNCHFLAVH NEDWSISVEL RPCPSGQTGT CLNSVTLLLN SSVPVDKYVF 300
    NSDGTVTNDK IRNQGYYYSD KIQIFNASSS YLQVETYFHV KLQIQIVPVM 350
    QLYVSMPPNQ FTDTVGLCGS YNNKAEDDFM SSQNILEKTS QAFANSWEMM 400
    SCPKGNPSSC ISIEKEKFAE RHCGILLDSS GPLASCHPIV NPKPYHEECK 450
    KYTCTCENSQ DCLCTILGNY VKACAEKETY IVGWRTGLCE HSCPSGLVFK 500
    YNVKACNSSC RSLSERDRSC DVEDVPVDGC TCPDAMYQNN EGNCVLKSQC 550
    DCYINDEVMQ PGKLIHIDDN KCVCRDGILL CQIPIDLTLQ NCSGGAEYVD 600
    CSDPKAQRRT NRTCSTRNIP VFDENLPCKR GCFCPEGMVR NSKGICVFPN 650
    DCPCSFGGRE YDEGSVTSVG CNECTCIKGS WSCTQNECQT ICHIYGEGHV 700
    RTFDGKSYSF DGLCQYSFLE DYCGHENGTF RILTESVPCC EDGLTCSRKI 750
    IVAFQDQNIV LQDGKVTAVK STESKKCELN ANAYSIHTVG LYLILKFQNG 800
    IIVIWDKNTR LSVILDPNWN GKVCGLCGNN NGDLKDDFTT RYSSVASGAL 850
    EFGNSWKTSQ ECSDTVAQTF PCDSNPYCKA WAVRKCEILR DSTFRDCHNK 900
    VDPSAYHDVC IEEACACDME GKYLGFCTAV AMYAEACSAV GVCVSWRKPN 950
    LCPVYCDYYN APGECRWHYE PCGTVTAKTC KDQLVGQKFS SLLEGCYAKC 1000
    PDSAPYLDEN TMKCVSLSEC SCFYNDVIPA GGVIEDNCGR TCYCIAGQLE 1050
    CSETAPTNST FAVSTTTATT ILSTGAAITL VTGGPSTAAS IPAITTSSSE 1100
    TTGTTLGPLT EPFTTGITET SVPIISTSGN AGMTGVVSPT VTGASGMAGT 1150
    TGGVDAATTG AASENTSERA GTPRVSGETP AVGGGSTPGE AGPGATVSGS 1200
    TGVSAGSITA SPGASATSSE SSKSGTTGPS VGGKTGATSS EATSSEGMSG 1250
    VTGQSLGSTA GSDSEITAKT SFTGSSPPGK LTRPSPGSPG HFSGGTTEWG 1300
    NVATTGAAGE NTSGALGSTE GSVEATTSAG SGNTAGTSGT GDTGPGNTAV 1350
    SGTPVVSPGA TPGAPGSSTP GEADIGNTSF GKSGKSGHDS LTVLNPAFLR 1400
    RTPTVSAAST TSSPVSKHTD AASATAVTIS GSKPGTPGTP GGATSGGKIT 1450
    SGWSSSGTST GASNTPGATG SSTGQTDTSG PSAKVTGNYG QSSEIPGTIK 1500
    SSSDVSGTMG QSDTTSGPSV AVTRTSEQSS GVTVASEPSV GVSGTTGPLA 1550
    EISGTTRPLV SGLRTTGSSA EGSGTTGPSS RESVTTRPLA EGSGTSGQSV 1600
    TGSRATGLSA TELGTTVSFT GGLGTSRSSA RETRTTGPSA DGSGTTGPSV 1650
    VRSGTTRLSV GVTRATESSP GVTGTTTPSA EESRTTGPSV LVTGTTGQSG 1700
    QGSGTTGKSF IESGPSVVGS GTTGPTSAGL GTTAPSTRRS STTKPSVGRT 1750
    GTTGQSGAES GTTEPSARVA GVTGTSAEVS GRIEPSATES STSRPLGETT 1800
    GTTIPSMEGS EATGPSVIGS ETTRLSVIGS GTTGTSSGGS GATRSSGGGM 1850
    GTTGQSTARS ETTGPLFGLT GTFGQSATVT GTSSNSAGVT TPEKSPGVAM 1900
    TTGLLVEGSA TTQPRILESE TTESSAGVIV TSGQSARVTG ATGPSAGETG 1950
    TTEPSTEGSV AAVLFVIGSE TTRPLDIGSG TTGTLSGGSS TTRSSDGTTG 2000
    TTRKSTARSE TTGLSGLTGT SGQLAGVTGT SSKSAGVTVT SEKSAGVAVI 2050
    TGSFVERPVT TGPPLLESET TRPSGGVTVT SGQSARVTET VGASAGVTGT 2100
    TGPSTEGSGA TGPSVVGSGT TRPLAGESGT TESSAGVTGT RPSSSRESAT 2150
    TGPSDEGSGT TGLSAGVTVT SGQSVRKTGT TGAPAGVTET TRPSVVKSGT 2200
    TGPSVIGTRT TGTSSGGSGA TRSSGGETET TGQSAVKSGT TESFTRLTRT 2250
    SGQSAGMTGT SAQSAGVALT SPFVEGLVTT GSSTVGLETT RPSAVGSGKT 2300
    GPPVVKAQTT GPSAGVTVTS GQSARMTGAS GPSVGVTGTT GPASKGLGTI 2350
    RPSVVGLETT ELSAEGSGTT GPPIVGETTV PSAGVTVTSG YSDRVTGATE 2400
    PLAGVTGTIK PSVAGSVTTG PSVTGVETTA KTTSGGLSTT ISSVGGTGTT 2450
    GQSPERSGTT GPFTGLTGTS AQSAGVTMTS IQSAGVLVTT GLNVDGLGTT 2500
    GKALIGSGTT GLSAEATGTI GPSTEGLEKT GPSITGSGTT RPLVTESWTA 2550
    GTSSGGHSTT SPSVRGTETT GQSAAESVTT GPVTGYTETS GPSAGVTVTP 2600
    RQSPTVTQTT GSSAAVSGTT VQSLTVSGTT RPSSGQTEIT GSSVKESGTT 2650
    ESSAVRSGTT GPTAGVTGTN GPSSAGVTGI TGSSPGVTGT TGSSPGVTGT 2700
    TGSSARSGTS IPSVGKTGTT RTSVEESRTT RPSAGITGTN GLSAEVTGTT 2750
    GPLAGVTGTT GPSAGVTRTT GLSAGETGTT GLSPGVTRTT RSSAGLTGKT 2800
    GLSAGVTGKT GLSAEVTGTT RLSAGVTGTT GPSPGVTGTT GTPAGVTGTT 2850
    ELSAGVTGKT GLSSEVTETT GLSYGVKRTI GLSAGSTGTS GQSAGVAGTT 2900
    TLSAEVTGTT RPSAGVTGTT GLSAEVTEIT GISAVVTGTT GPSAGVTETT 2950
    GSSAGVAGTT RLSAGVTGIT GLSAGVTGTT GLSTEVTGTT GPSAGATGTT 3000
    GLSVGVTGIT GLSDVVTETT GSSARSGTGI PSVGETRTTS TSVEESRTTR 3050
    PSAGIMGTNG LPAEVTGTTE PLAGGTGTTG ILAGVTGTTG LSAGETGKIG 3100
    SSAGVTGKTG SSARVTGKTG PSAEVTGKTG LSAGVTGTTG LSPGVTGTSG 3150
    LSAEVTGTTG PSAEATGLPG VSAGVTGTTG SLAGGTGTIG LSAGVTGTTG 3200
    SSAGVTGTTG LSAGVTGIAG LSAGVTGITG PSAGVTGTTT VSAGVTGTTG 3250
    LSAEATEITG LSAGVTGTTG LSAGVTETIR LSAGVTGTIR SSAGVTGITG 3300
    LSAGVTGTTG PSAGVTGSTG LLAGVTETTG QSAKVTGTTG QSVGVTGTTR 3350
    SSGGVTGITG LSAGVTGTNG LSAVTGMTGL SAEVTGTTGL SVGVTGIAGL 3400
    SAGVTGITGP SAGITGTTTI SAGVTGTSGL SAEATGITGL SAGVTGKTGL 3450
    SAGVTETIGL SAEATGTIGS SPGVTGTTGS STGVTGITGL SAGVTGTTGL 3500
    STEVTGTTGP SAGVTRTTGL SAGVTGITGL SAIVTETTGS SARSGTSIPS 3550
    VGETGTTRTS VEESRTTRPS AGITGTTGLS AGVTGTVGSS AVVTGTTGLS 3600
    AGVTGTTGPS AEETGATGPS AEVTETTGPS AGVTGTGRLS AEVTGTTGPS 3650
    AEVTGLPGES AEVTGTIGSP AGVTGTTQLS AVVTGITGLS AEVTGTTGLS 3700
    AGVTGITGLS AEVTRTTGLS AGVTGTIGLS AGVTGTTRPS AGVTGTTGQS 3750
    AEVTGTTEPS AGLTETTGSS TGVTGATGPL AGVTGTTGIS TEVTGTTGPS 3800
    ARVTGTTVLS AGVTGITGLS AIVTETTGSS ARSGTSTPSV GETGTTRTSV 3850
    EESRATRPSA GITGTNGQSA EVTWITGPLA GVTGTTGISA GVTGTTGLSA 3900
    GVTGTIGSSA VVTGINGLSA GVTGTTGPSA EETGATGPSA EVTGTTGPSA 3950
    EETGATGPSA EVTGTTGPSG GVTGTNGLSA EVTGTTGPSA EVTGLPGVSA 4000
    GVTGTIGSPA AVTGTIRPSA VVTGITGLSA EVTGTTGLSA WVTGIAGLSA 4050
    GVTETIGSSA GVTGTNGLSA EATGTTGPSA GVTGTTGLSA GVTGTAGLSA 4100
    RVTESTGLSA GVTGTTGLSA GVTGTTGPSA GITGTNGLSA EVTGTTGPLA 4150
    GVTGTIGLSA GVTGIAGLSA GVTESTGLSA GVTGTIRSSA VVTGINGLSA 4200
    GVTGTTGPSA EETGATGPSA EVTGTTGPSG GVTGTSGISA EVTGTTGPSA 4250
    EVTGLPGVSA GVTGTIGSPA AVTGTTRPSA VVTGISGLSA EVTGTTGLSA 4300
    GVTETIGSSA GVTGTNGLSA EATETTGPSA GVTGTTGLSA GVTGTTGPSA 4350
    GIAGTNGLSA GVTGTTGLSA RVTESTGLSA GVTGTIGSSA VVTETTRLSS 4400
    GVTGTIGPSA EETGATGLSA EVTGTTGSLA EVTGTTGLSA GVTGTIGSSA 4450
    VVTGTTGLSA GITGTNGLSA EVTGTAGPLA GVTGTTGLSA GVTGTTGLSA 4500
    GVTETTGQSA GVTESTGLSP GVTGTIGSSA VVTGIKGLSA GVTGTTGPSA 4550
    EETGATGPSA EVTGTTGPSG GVTGTSVLSV EVTGTTGPSA EVTGLPGVSA 4600
    GLTGTIGSPA AVRGTTWPSA VVTGISGLSG EVTGTTGLSA GVTGIGGLSA 4650
    GVTGTIGSSA GVTGTNALSA EATGTTGPSA GVTGTTGLSA GVTGTTGLSA 4700
    GVTGTIRSSA VVTETTGLSA GVTGTTGPSA GIAGTNGLSA EVTGTTGLSA 4750
    GMTGTTGLSA RVTESTGLSA GVTGTIGSSA VVTETTRLSA GVTGTIGPSA 4800
    EETGATGLSA EVTRTTGSLA GVTGTTGPSA VVTGKTELSA EVTGTTELSA 4850
    EVTEKTGPSA EVTGKTGLSA GVMETTGPSA EVTGTTGSSA GVTGTTGPSA 4900
    GVTGTTGPSA EATGLPGVSA GVTGTIGSPA GVTGTARLSA VVTGISGLSA 4950
    EVTGTTGLST GVTGIAGHSA AVTGITRPSA GVTGTTTVSA GVTGTIGLSA 5000
    EATGITLPSA GVTETTGLSA GVTETIGLSA GVTGTIGSSA GVTEITGLSA 5050
    GVTGTTGPSA GVTGSTVLSA GVTATTGQSV GVTGTTGPSA GVTGTTGLSA 5100
    GVTGIAGLSA GVTGITGPSA GVTGTTTVSA GVTGTTGLSA EATEITGLSA 5150
    GVTGTTGLSA GVTGIAGLSA GVTETIGSSA GVTGTNGLSA EATGKTGPSA 5200
    GVTGTTGLSA GVTGTTGLSA GVTETIGLSA GVTGTIGSSA GVKGTTGQSA 5250
    EVTGATGQSV GVTGTTRSSG GVTGITGLSA GLRGTTVSSA KAGTSIPLTG 5300
    KTGTTRTSVE ESTTTGPSAG ITGTNGLSAE MTGTNELSAG VTGTIGSSAG 5350
    VTGTTGLSVE ATVTTGLSAG VTGTTVPLAG VTWTPGPSAG VTGIAALSAG 5400
    VTGKSGLSAG VTGKTGLSAG VTGTTGPSAE ATGKTGLSAG VTGITGPFAE 5450
    VTGTTGLSAG VIGTTGSSAE VTGITGLSAG VTGKTRSSAG VTGTTGLSAK 5500
    SGTSIPSAGK TGTTKTSVEE SRTTRPSAGI TGTNGLPARV TGTXXXXXXX 5550
    XXXGTSGVAP GTTVAPGSFS TAATTSPGAS GVTGTGPTAE TTTFLGGSST 5600
    TGAEIKSGAT TGAPGSKTGT AKVLSGTTVA SGSSNSEATT FSGITEAVTV 5650
    PSKNGSMTTA LGSQLSSSQT VIPGSSGTIS HTTVAPGSSV TGTTTGASDD 5700
    QVTGSKTGTT GVALSTTVAP GSSSTEATTS TGVHRTTVVG QKTGATTRGS 5750
    AKQGTRSTIE ATTSFRGTGT TGSGMNTGTT GVVSGNTISP SSFNTEATSG 5800
    TSERPNPGSE IGTTGIVSGT TVAPGSSNTE ATTSLGNGGT TEAGSKIVTT 5850
    GITTGTTIVP GSFNTKATTS TDVGVATGVG MATGITNIIS GRSQPTGSKT 5900
    GYTVTGSGTT ALPGGFRTGN TPGSTGVTSS QEGTTVVSSG ITGIPETSIS 5950
    GPSKEASDKT TAPGPPTTVT ASTGVKETSE TGVQTGSTLV TAGVPTRPQV 6000
    SQPETTVVAT REVETENKTE CLASLPPAPV CHGPLGEEKS PGDIWTANCH 6050
    RGTCTDAKTI DCKPEECPSP PTCKTGEKLV KFQSNDTCCE IGYCEPRTCL 6100
    FNNTDYEIGA SFDDPSNPCV SYSCKDTGFA AVVQDCPKQT WCAEANRIYD 6150
    SKKCCYTCKN NCRSSLVNVT VIYSGCKKRV QMAKCTGECE KTAKYNHDIL 6200
    LLEHSCLCCR EENYELRDIV LDCPDGSTIP YQYKHITTCS CLDICQLYTT 6250
    FMYS 6254
    Length:6,254
    Mass (Da):598,155
    Last modified:July 1, 2008 - v2
    Checksum:i0B29670B870FBCB8
    GO
    Isoform 2 (identifier: Q7Z5P9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         5919-5936: GNTPGSTGVTSSQEGTTV → DSPSFPLFLICSYRGHNF
         5937-6254: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:5,936
    Mass (Da):564,084
    Checksum:i828E67D663F5A033
    GO

    Sequence cautioni

    The sequence BAC04041.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331G → E.
    Corresponds to variant rs7955308 [ dbSNP | Ensembl ].
    VAR_056617
    Natural varianti199 – 1991T → K.
    Corresponds to variant rs11564170 [ dbSNP | Ensembl ].
    VAR_056618
    Natural varianti206 – 2061V → I.
    Corresponds to variant rs7958987 [ dbSNP | Ensembl ].
    VAR_056619
    Natural varianti207 – 2071R → L.
    Corresponds to variant rs17467284 [ dbSNP | Ensembl ].
    VAR_056620
    Natural varianti219 – 2191D → H.
    Corresponds to variant rs11564245 [ dbSNP | Ensembl ].
    VAR_056621
    Natural varianti259 – 2591V → I.
    Corresponds to variant rs10506156 [ dbSNP | Ensembl ].
    VAR_056622
    Natural varianti285 – 2851V → I.
    Corresponds to variant rs28365246 [ dbSNP | Ensembl ].
    VAR_056623
    Natural varianti299 – 2991V → I.
    Corresponds to variant rs11564125 [ dbSNP | Ensembl ].
    VAR_056624
    Natural varianti426 – 4261L → F.
    Corresponds to variant rs12317988 [ dbSNP | Ensembl ].
    VAR_056625
    Natural varianti567 – 5671I → T.
    Corresponds to variant rs11176635 [ dbSNP | Ensembl ].
    VAR_056626
    Natural varianti642 – 6421S → F.
    Corresponds to variant rs4768261 [ dbSNP | Ensembl ].
    VAR_056627
    Natural varianti694 – 6941I → M.
    Corresponds to variant rs7966110 [ dbSNP | Ensembl ].
    VAR_056628
    Natural varianti712 – 7121G → S.
    Corresponds to variant rs4768264 [ dbSNP | Ensembl ].
    VAR_056629
    Natural varianti731 – 7311R → H.
    Corresponds to variant rs7312154 [ dbSNP | Ensembl ].
    VAR_056630
    Natural varianti743 – 7431G → W.
    Corresponds to variant rs12369002 [ dbSNP | Ensembl ].
    VAR_056631
    Natural varianti783 – 7831A → T.
    Corresponds to variant rs11564141 [ dbSNP | Ensembl ].
    VAR_056632
    Natural varianti827 – 8271C → Y.
    Corresponds to variant rs11564109 [ dbSNP | Ensembl ].
    VAR_056633
    Natural varianti867 – 8671A → T.
    Corresponds to variant rs11176666 [ dbSNP | Ensembl ].
    VAR_056634
    Natural varianti909 – 9091V → A.
    Corresponds to variant rs10784621 [ dbSNP | Ensembl ].
    VAR_056635
    Natural varianti1037 – 10371N → S.
    Corresponds to variant rs17128169 [ dbSNP | Ensembl ].
    VAR_056636
    Natural varianti1104 – 11041T → A.
    Corresponds to variant rs17128233 [ dbSNP | Ensembl ].
    VAR_056637
    Natural varianti1178 – 11781E → A.
    Corresponds to variant rs2933353 [ dbSNP | Ensembl ].
    VAR_056638
    Natural varianti1186 – 11861S → R.
    Corresponds to variant rs7956459 [ dbSNP | Ensembl ].
    VAR_056639
    Natural varianti1462 – 14621A → S.
    Corresponds to variant rs1492333 [ dbSNP | Ensembl ].
    VAR_056640

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei5919 – 593618GNTPG…EGTTV → DSPSFPLFLICSYRGHNF in isoform 2. 1 PublicationVSP_034521Add
    BLAST
    Alternative sequencei5937 – 6254318Missing in isoform 2. 1 PublicationVSP_034522Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024935 Genomic DNA. No translation available.
    AC074030 Genomic DNA. No translation available.
    AC107023 Genomic DNA. No translation available.
    AY236870 mRNA. Translation: AAP41817.1.
    AK093065 mRNA. Translation: BAC04041.1. Different initiation.
    UniGeneiHs.632712.

    Genome annotation databases

    EnsembliENST00000538912; ENSP00000440762; ENSG00000205592.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Mucin database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024935 Genomic DNA. No translation available.
    AC074030 Genomic DNA. No translation available.
    AC107023 Genomic DNA. No translation available.
    AY236870 mRNA. Translation: AAP41817.1 .
    AK093065 mRNA. Translation: BAC04041.1 . Different initiation.
    UniGenei Hs.632712.

    3D structure databases

    ProteinModelPortali Q7Z5P9.
    SMRi Q7Z5P9. Positions 134-203, 471-564, 591-663, 968-1031.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000395253.

    PTM databases

    PhosphoSitei Q7Z5P9.

    Proteomic databases

    PaxDbi Q7Z5P9.
    PRIDEi Q7Z5P9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000538912 ; ENSP00000440762 ; ENSG00000205592 .

    Organism-specific databases

    GeneCardsi GC12P040788.
    H-InvDB HIX0210549.
    HGNCi HGNC:14362. MUC19.
    MIMi 612170. gene.
    neXtProti NX_Q7Z5P9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    InParanoidi Q7Z5P9.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    PROi Q7Z5P9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z5P9.
    Bgeei Q7Z5P9.
    CleanExi HS_MUC19.
    Genevestigatori Q7Z5P9.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 2 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 2 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 2 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 1 hit.
    SM00216. VWD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 3 hits.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS50184. VWFC_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues."
      Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R.
      Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5554-6254 (ISOFORM 1), TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5554-6254 (ISOFORM 2).
      Tissue: Testis.
    4. "Mucin gene expression in human middle ear epithelium."
      Kerschner J.E.
      Laryngoscope 117:1666-1676(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients."
      Yu D.F., Chen Y., Han J.M., Zhang H., Chen X.P., Zou W.J., Liang L.Y., Xu C.C., Liu Z.G.
      Exp. Eye Res. 86:403-411(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiMUC19_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z5P9
    Secondary accession number(s): Q8NA85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3