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Q7Z5P9

- MUC19_HUMAN

UniProt

Q7Z5P9 - MUC19_HUMAN

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Protein

Mucin-19

Gene
MUC19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May function in ocular mucus homeostasis.1 Publication

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. O-glycan processing Source: Reactome
  3. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-19
Short name:
MUC-19
Gene namesi
Name:MUC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14362. MUC19.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 6254Mucin-19PRO_0000342664
Signal peptidei1 – ? Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 6245 By similarity
Disulfide bondi6158 ↔ 6209 By similarity
Disulfide bondi6176 ↔ 6223 By similarity
Disulfide bondi6185 ↔ 6239 By similarity
Disulfide bondi6189 ↔ 6241 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z5P9.
PRIDEiQ7Z5P9.

PTM databases

PhosphoSiteiQ7Z5P9.

Expressioni

Tissue specificityi

Expressed corneal epithelial cells, conjunctival goblet and epithelial cells and lacrimal gland cells (at protein level). Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expressed by middle ear epithelial cells.3 Publications

Inductioni

Down-regulated in Sjoegren syndrome patients (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ7Z5P9.
BgeeiQ7Z5P9.
CleanExiHS_MUC19.
GenevestigatoriQ7Z5P9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000395253.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5P9.
SMRiQ7Z5P9. Positions 134-203, 471-564, 591-663, 968-1031.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9797VWFD 1Add
BLAST
Domaini231 – 439209VWFD 2Add
BLAST
Domaini691 – 900210VWFD 3Add
BLAST
Domaini6029 – 609567VWFC 1Add
BLAST
Domaini6097 – 615963VWFC 2Add
BLAST
Domaini6162 – 624685CTCKAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni910 – 55094600Approximate repeats of G-V-T-G-T-T-G-P-S-AAdd
BLAST

Sequence similaritiesi

Contains 2 VWFC domains.
Contains 3 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiQ7Z5P9.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 2 hits.
[Graphical view]
SMARTiSM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z5P9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWDKNNKLSL TLHKQYPTCG LCGNFNSTPG QDINEHIANS KIPGDCPNAV     50
GKSYEVCEDG IQHCNKIIGT YFEKCGKVAA LSNDYKMICI DEYCQTRDKT 100
STCDTYSELS RLCASDGPGT FESWRSDSDV VCGTQRCPEQ HIYKECGPSN 150
PATCSNVAPF QDSECVSGCT CPEGYLLDDI GEKGKCVLKA ECPCESSGTV 200
YQPGEVREGP CGSQCTCQDA KWSCTEALCP GRCKVEGSSL TTFDGVKYNF 250
PGNCHFLAVH NEDWSISVEL RPCPSGQTGT CLNSVTLLLN SSVPVDKYVF 300
NSDGTVTNDK IRNQGYYYSD KIQIFNASSS YLQVETYFHV KLQIQIVPVM 350
QLYVSMPPNQ FTDTVGLCGS YNNKAEDDFM SSQNILEKTS QAFANSWEMM 400
SCPKGNPSSC ISIEKEKFAE RHCGILLDSS GPLASCHPIV NPKPYHEECK 450
KYTCTCENSQ DCLCTILGNY VKACAEKETY IVGWRTGLCE HSCPSGLVFK 500
YNVKACNSSC RSLSERDRSC DVEDVPVDGC TCPDAMYQNN EGNCVLKSQC 550
DCYINDEVMQ PGKLIHIDDN KCVCRDGILL CQIPIDLTLQ NCSGGAEYVD 600
CSDPKAQRRT NRTCSTRNIP VFDENLPCKR GCFCPEGMVR NSKGICVFPN 650
DCPCSFGGRE YDEGSVTSVG CNECTCIKGS WSCTQNECQT ICHIYGEGHV 700
RTFDGKSYSF DGLCQYSFLE DYCGHENGTF RILTESVPCC EDGLTCSRKI 750
IVAFQDQNIV LQDGKVTAVK STESKKCELN ANAYSIHTVG LYLILKFQNG 800
IIVIWDKNTR LSVILDPNWN GKVCGLCGNN NGDLKDDFTT RYSSVASGAL 850
EFGNSWKTSQ ECSDTVAQTF PCDSNPYCKA WAVRKCEILR DSTFRDCHNK 900
VDPSAYHDVC IEEACACDME GKYLGFCTAV AMYAEACSAV GVCVSWRKPN 950
LCPVYCDYYN APGECRWHYE PCGTVTAKTC KDQLVGQKFS SLLEGCYAKC 1000
PDSAPYLDEN TMKCVSLSEC SCFYNDVIPA GGVIEDNCGR TCYCIAGQLE 1050
CSETAPTNST FAVSTTTATT ILSTGAAITL VTGGPSTAAS IPAITTSSSE 1100
TTGTTLGPLT EPFTTGITET SVPIISTSGN AGMTGVVSPT VTGASGMAGT 1150
TGGVDAATTG AASENTSERA GTPRVSGETP AVGGGSTPGE AGPGATVSGS 1200
TGVSAGSITA SPGASATSSE SSKSGTTGPS VGGKTGATSS EATSSEGMSG 1250
VTGQSLGSTA GSDSEITAKT SFTGSSPPGK LTRPSPGSPG HFSGGTTEWG 1300
NVATTGAAGE NTSGALGSTE GSVEATTSAG SGNTAGTSGT GDTGPGNTAV 1350
SGTPVVSPGA TPGAPGSSTP GEADIGNTSF GKSGKSGHDS LTVLNPAFLR 1400
RTPTVSAAST TSSPVSKHTD AASATAVTIS GSKPGTPGTP GGATSGGKIT 1450
SGWSSSGTST GASNTPGATG SSTGQTDTSG PSAKVTGNYG QSSEIPGTIK 1500
SSSDVSGTMG QSDTTSGPSV AVTRTSEQSS GVTVASEPSV GVSGTTGPLA 1550
EISGTTRPLV SGLRTTGSSA EGSGTTGPSS RESVTTRPLA EGSGTSGQSV 1600
TGSRATGLSA TELGTTVSFT GGLGTSRSSA RETRTTGPSA DGSGTTGPSV 1650
VRSGTTRLSV GVTRATESSP GVTGTTTPSA EESRTTGPSV LVTGTTGQSG 1700
QGSGTTGKSF IESGPSVVGS GTTGPTSAGL GTTAPSTRRS STTKPSVGRT 1750
GTTGQSGAES GTTEPSARVA GVTGTSAEVS GRIEPSATES STSRPLGETT 1800
GTTIPSMEGS EATGPSVIGS ETTRLSVIGS GTTGTSSGGS GATRSSGGGM 1850
GTTGQSTARS ETTGPLFGLT GTFGQSATVT GTSSNSAGVT TPEKSPGVAM 1900
TTGLLVEGSA TTQPRILESE TTESSAGVIV TSGQSARVTG ATGPSAGETG 1950
TTEPSTEGSV AAVLFVIGSE TTRPLDIGSG TTGTLSGGSS TTRSSDGTTG 2000
TTRKSTARSE TTGLSGLTGT SGQLAGVTGT SSKSAGVTVT SEKSAGVAVI 2050
TGSFVERPVT TGPPLLESET TRPSGGVTVT SGQSARVTET VGASAGVTGT 2100
TGPSTEGSGA TGPSVVGSGT TRPLAGESGT TESSAGVTGT RPSSSRESAT 2150
TGPSDEGSGT TGLSAGVTVT SGQSVRKTGT TGAPAGVTET TRPSVVKSGT 2200
TGPSVIGTRT TGTSSGGSGA TRSSGGETET TGQSAVKSGT TESFTRLTRT 2250
SGQSAGMTGT SAQSAGVALT SPFVEGLVTT GSSTVGLETT RPSAVGSGKT 2300
GPPVVKAQTT GPSAGVTVTS GQSARMTGAS GPSVGVTGTT GPASKGLGTI 2350
RPSVVGLETT ELSAEGSGTT GPPIVGETTV PSAGVTVTSG YSDRVTGATE 2400
PLAGVTGTIK PSVAGSVTTG PSVTGVETTA KTTSGGLSTT ISSVGGTGTT 2450
GQSPERSGTT GPFTGLTGTS AQSAGVTMTS IQSAGVLVTT GLNVDGLGTT 2500
GKALIGSGTT GLSAEATGTI GPSTEGLEKT GPSITGSGTT RPLVTESWTA 2550
GTSSGGHSTT SPSVRGTETT GQSAAESVTT GPVTGYTETS GPSAGVTVTP 2600
RQSPTVTQTT GSSAAVSGTT VQSLTVSGTT RPSSGQTEIT GSSVKESGTT 2650
ESSAVRSGTT GPTAGVTGTN GPSSAGVTGI TGSSPGVTGT TGSSPGVTGT 2700
TGSSARSGTS IPSVGKTGTT RTSVEESRTT RPSAGITGTN GLSAEVTGTT 2750
GPLAGVTGTT GPSAGVTRTT GLSAGETGTT GLSPGVTRTT RSSAGLTGKT 2800
GLSAGVTGKT GLSAEVTGTT RLSAGVTGTT GPSPGVTGTT GTPAGVTGTT 2850
ELSAGVTGKT GLSSEVTETT GLSYGVKRTI GLSAGSTGTS GQSAGVAGTT 2900
TLSAEVTGTT RPSAGVTGTT GLSAEVTEIT GISAVVTGTT GPSAGVTETT 2950
GSSAGVAGTT RLSAGVTGIT GLSAGVTGTT GLSTEVTGTT GPSAGATGTT 3000
GLSVGVTGIT GLSDVVTETT GSSARSGTGI PSVGETRTTS TSVEESRTTR 3050
PSAGIMGTNG LPAEVTGTTE PLAGGTGTTG ILAGVTGTTG LSAGETGKIG 3100
SSAGVTGKTG SSARVTGKTG PSAEVTGKTG LSAGVTGTTG LSPGVTGTSG 3150
LSAEVTGTTG PSAEATGLPG VSAGVTGTTG SLAGGTGTIG LSAGVTGTTG 3200
SSAGVTGTTG LSAGVTGIAG LSAGVTGITG PSAGVTGTTT VSAGVTGTTG 3250
LSAEATEITG LSAGVTGTTG LSAGVTETIR LSAGVTGTIR SSAGVTGITG 3300
LSAGVTGTTG PSAGVTGSTG LLAGVTETTG QSAKVTGTTG QSVGVTGTTR 3350
SSGGVTGITG LSAGVTGTNG LSAVTGMTGL SAEVTGTTGL SVGVTGIAGL 3400
SAGVTGITGP SAGITGTTTI SAGVTGTSGL SAEATGITGL SAGVTGKTGL 3450
SAGVTETIGL SAEATGTIGS SPGVTGTTGS STGVTGITGL SAGVTGTTGL 3500
STEVTGTTGP SAGVTRTTGL SAGVTGITGL SAIVTETTGS SARSGTSIPS 3550
VGETGTTRTS VEESRTTRPS AGITGTTGLS AGVTGTVGSS AVVTGTTGLS 3600
AGVTGTTGPS AEETGATGPS AEVTETTGPS AGVTGTGRLS AEVTGTTGPS 3650
AEVTGLPGES AEVTGTIGSP AGVTGTTQLS AVVTGITGLS AEVTGTTGLS 3700
AGVTGITGLS AEVTRTTGLS AGVTGTIGLS AGVTGTTRPS AGVTGTTGQS 3750
AEVTGTTEPS AGLTETTGSS TGVTGATGPL AGVTGTTGIS TEVTGTTGPS 3800
ARVTGTTVLS AGVTGITGLS AIVTETTGSS ARSGTSTPSV GETGTTRTSV 3850
EESRATRPSA GITGTNGQSA EVTWITGPLA GVTGTTGISA GVTGTTGLSA 3900
GVTGTIGSSA VVTGINGLSA GVTGTTGPSA EETGATGPSA EVTGTTGPSA 3950
EETGATGPSA EVTGTTGPSG GVTGTNGLSA EVTGTTGPSA EVTGLPGVSA 4000
GVTGTIGSPA AVTGTIRPSA VVTGITGLSA EVTGTTGLSA WVTGIAGLSA 4050
GVTETIGSSA GVTGTNGLSA EATGTTGPSA GVTGTTGLSA GVTGTAGLSA 4100
RVTESTGLSA GVTGTTGLSA GVTGTTGPSA GITGTNGLSA EVTGTTGPLA 4150
GVTGTIGLSA GVTGIAGLSA GVTESTGLSA GVTGTIRSSA VVTGINGLSA 4200
GVTGTTGPSA EETGATGPSA EVTGTTGPSG GVTGTSGISA EVTGTTGPSA 4250
EVTGLPGVSA GVTGTIGSPA AVTGTTRPSA VVTGISGLSA EVTGTTGLSA 4300
GVTETIGSSA GVTGTNGLSA EATETTGPSA GVTGTTGLSA GVTGTTGPSA 4350
GIAGTNGLSA GVTGTTGLSA RVTESTGLSA GVTGTIGSSA VVTETTRLSS 4400
GVTGTIGPSA EETGATGLSA EVTGTTGSLA EVTGTTGLSA GVTGTIGSSA 4450
VVTGTTGLSA GITGTNGLSA EVTGTAGPLA GVTGTTGLSA GVTGTTGLSA 4500
GVTETTGQSA GVTESTGLSP GVTGTIGSSA VVTGIKGLSA GVTGTTGPSA 4550
EETGATGPSA EVTGTTGPSG GVTGTSVLSV EVTGTTGPSA EVTGLPGVSA 4600
GLTGTIGSPA AVRGTTWPSA VVTGISGLSG EVTGTTGLSA GVTGIGGLSA 4650
GVTGTIGSSA GVTGTNALSA EATGTTGPSA GVTGTTGLSA GVTGTTGLSA 4700
GVTGTIRSSA VVTETTGLSA GVTGTTGPSA GIAGTNGLSA EVTGTTGLSA 4750
GMTGTTGLSA RVTESTGLSA GVTGTIGSSA VVTETTRLSA GVTGTIGPSA 4800
EETGATGLSA EVTRTTGSLA GVTGTTGPSA VVTGKTELSA EVTGTTELSA 4850
EVTEKTGPSA EVTGKTGLSA GVMETTGPSA EVTGTTGSSA GVTGTTGPSA 4900
GVTGTTGPSA EATGLPGVSA GVTGTIGSPA GVTGTARLSA VVTGISGLSA 4950
EVTGTTGLST GVTGIAGHSA AVTGITRPSA GVTGTTTVSA GVTGTIGLSA 5000
EATGITLPSA GVTETTGLSA GVTETIGLSA GVTGTIGSSA GVTEITGLSA 5050
GVTGTTGPSA GVTGSTVLSA GVTATTGQSV GVTGTTGPSA GVTGTTGLSA 5100
GVTGIAGLSA GVTGITGPSA GVTGTTTVSA GVTGTTGLSA EATEITGLSA 5150
GVTGTTGLSA GVTGIAGLSA GVTETIGSSA GVTGTNGLSA EATGKTGPSA 5200
GVTGTTGLSA GVTGTTGLSA GVTETIGLSA GVTGTIGSSA GVKGTTGQSA 5250
EVTGATGQSV GVTGTTRSSG GVTGITGLSA GLRGTTVSSA KAGTSIPLTG 5300
KTGTTRTSVE ESTTTGPSAG ITGTNGLSAE MTGTNELSAG VTGTIGSSAG 5350
VTGTTGLSVE ATVTTGLSAG VTGTTVPLAG VTWTPGPSAG VTGIAALSAG 5400
VTGKSGLSAG VTGKTGLSAG VTGTTGPSAE ATGKTGLSAG VTGITGPFAE 5450
VTGTTGLSAG VIGTTGSSAE VTGITGLSAG VTGKTRSSAG VTGTTGLSAK 5500
SGTSIPSAGK TGTTKTSVEE SRTTRPSAGI TGTNGLPARV TGTXXXXXXX 5550
XXXGTSGVAP GTTVAPGSFS TAATTSPGAS GVTGTGPTAE TTTFLGGSST 5600
TGAEIKSGAT TGAPGSKTGT AKVLSGTTVA SGSSNSEATT FSGITEAVTV 5650
PSKNGSMTTA LGSQLSSSQT VIPGSSGTIS HTTVAPGSSV TGTTTGASDD 5700
QVTGSKTGTT GVALSTTVAP GSSSTEATTS TGVHRTTVVG QKTGATTRGS 5750
AKQGTRSTIE ATTSFRGTGT TGSGMNTGTT GVVSGNTISP SSFNTEATSG 5800
TSERPNPGSE IGTTGIVSGT TVAPGSSNTE ATTSLGNGGT TEAGSKIVTT 5850
GITTGTTIVP GSFNTKATTS TDVGVATGVG MATGITNIIS GRSQPTGSKT 5900
GYTVTGSGTT ALPGGFRTGN TPGSTGVTSS QEGTTVVSSG ITGIPETSIS 5950
GPSKEASDKT TAPGPPTTVT ASTGVKETSE TGVQTGSTLV TAGVPTRPQV 6000
SQPETTVVAT REVETENKTE CLASLPPAPV CHGPLGEEKS PGDIWTANCH 6050
RGTCTDAKTI DCKPEECPSP PTCKTGEKLV KFQSNDTCCE IGYCEPRTCL 6100
FNNTDYEIGA SFDDPSNPCV SYSCKDTGFA AVVQDCPKQT WCAEANRIYD 6150
SKKCCYTCKN NCRSSLVNVT VIYSGCKKRV QMAKCTGECE KTAKYNHDIL 6200
LLEHSCLCCR EENYELRDIV LDCPDGSTIP YQYKHITTCS CLDICQLYTT 6250
FMYS 6254
Length:6,254
Mass (Da):598,155
Last modified:July 1, 2008 - v2
Checksum:i0B29670B870FBCB8
GO
Isoform 2 (identifier: Q7Z5P9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     5919-5936: GNTPGSTGVTSSQEGTTV → DSPSFPLFLICSYRGHNF
     5937-6254: Missing.

Note: No experimental confirmation available.

Show »
Length:5,936
Mass (Da):564,084
Checksum:i828E67D663F5A033
GO

Sequence cautioni

The sequence BAC04041.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331G → E.
Corresponds to variant rs7955308 [ dbSNP | Ensembl ].
VAR_056617
Natural varianti199 – 1991T → K.
Corresponds to variant rs11564170 [ dbSNP | Ensembl ].
VAR_056618
Natural varianti206 – 2061V → I.
Corresponds to variant rs7958987 [ dbSNP | Ensembl ].
VAR_056619
Natural varianti207 – 2071R → L.
Corresponds to variant rs17467284 [ dbSNP | Ensembl ].
VAR_056620
Natural varianti219 – 2191D → H.
Corresponds to variant rs11564245 [ dbSNP | Ensembl ].
VAR_056621
Natural varianti259 – 2591V → I.
Corresponds to variant rs10506156 [ dbSNP | Ensembl ].
VAR_056622
Natural varianti285 – 2851V → I.
Corresponds to variant rs28365246 [ dbSNP | Ensembl ].
VAR_056623
Natural varianti299 – 2991V → I.
Corresponds to variant rs11564125 [ dbSNP | Ensembl ].
VAR_056624
Natural varianti426 – 4261L → F.
Corresponds to variant rs12317988 [ dbSNP | Ensembl ].
VAR_056625
Natural varianti567 – 5671I → T.
Corresponds to variant rs11176635 [ dbSNP | Ensembl ].
VAR_056626
Natural varianti642 – 6421S → F.
Corresponds to variant rs4768261 [ dbSNP | Ensembl ].
VAR_056627
Natural varianti694 – 6941I → M.
Corresponds to variant rs7966110 [ dbSNP | Ensembl ].
VAR_056628
Natural varianti712 – 7121G → S.
Corresponds to variant rs4768264 [ dbSNP | Ensembl ].
VAR_056629
Natural varianti731 – 7311R → H.
Corresponds to variant rs7312154 [ dbSNP | Ensembl ].
VAR_056630
Natural varianti743 – 7431G → W.
Corresponds to variant rs12369002 [ dbSNP | Ensembl ].
VAR_056631
Natural varianti783 – 7831A → T.
Corresponds to variant rs11564141 [ dbSNP | Ensembl ].
VAR_056632
Natural varianti827 – 8271C → Y.
Corresponds to variant rs11564109 [ dbSNP | Ensembl ].
VAR_056633
Natural varianti867 – 8671A → T.
Corresponds to variant rs11176666 [ dbSNP | Ensembl ].
VAR_056634
Natural varianti909 – 9091V → A.
Corresponds to variant rs10784621 [ dbSNP | Ensembl ].
VAR_056635
Natural varianti1037 – 10371N → S.
Corresponds to variant rs17128169 [ dbSNP | Ensembl ].
VAR_056636
Natural varianti1104 – 11041T → A.
Corresponds to variant rs17128233 [ dbSNP | Ensembl ].
VAR_056637
Natural varianti1178 – 11781E → A.
Corresponds to variant rs2933353 [ dbSNP | Ensembl ].
VAR_056638
Natural varianti1186 – 11861S → R.
Corresponds to variant rs7956459 [ dbSNP | Ensembl ].
VAR_056639
Natural varianti1462 – 14621A → S.
Corresponds to variant rs1492333 [ dbSNP | Ensembl ].
VAR_056640

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei5919 – 593618GNTPG…EGTTV → DSPSFPLFLICSYRGHNF in isoform 2. VSP_034521Add
BLAST
Alternative sequencei5937 – 6254318Missing in isoform 2. VSP_034522Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC024935 Genomic DNA. No translation available.
AC074030 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.
AY236870 mRNA. Translation: AAP41817.1.
AK093065 mRNA. Translation: BAC04041.1. Different initiation.
UniGeneiHs.632712.

Genome annotation databases

EnsembliENST00000538912; ENSP00000440762; ENSG00000205592.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC024935 Genomic DNA. No translation available.
AC074030 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.
AY236870 mRNA. Translation: AAP41817.1 .
AK093065 mRNA. Translation: BAC04041.1 . Different initiation.
UniGenei Hs.632712.

3D structure databases

ProteinModelPortali Q7Z5P9.
SMRi Q7Z5P9. Positions 134-203, 471-564, 591-663, 968-1031.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000395253.

PTM databases

PhosphoSitei Q7Z5P9.

Proteomic databases

PaxDbi Q7Z5P9.
PRIDEi Q7Z5P9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000538912 ; ENSP00000440762 ; ENSG00000205592 .

Organism-specific databases

GeneCardsi GC12P040788.
H-InvDB HIX0210549.
HGNCi HGNC:14362. MUC19.
MIMi 612170. gene.
neXtProti NX_Q7Z5P9.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi Q7Z5P9.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

PROi Q7Z5P9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7Z5P9.
Bgeei Q7Z5P9.
CleanExi HS_MUC19.
Genevestigatori Q7Z5P9.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 2 hits.
[Graphical view ]
SMARTi SM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues."
    Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R.
    Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5554-6254 (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5554-6254 (ISOFORM 2).
    Tissue: Testis.
  4. "Mucin gene expression in human middle ear epithelium."
    Kerschner J.E.
    Laryngoscope 117:1666-1676(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients."
    Yu D.F., Chen Y., Han J.M., Zhang H., Chen X.P., Zou W.J., Liang L.Y., Xu C.C., Liu Z.G.
    Exp. Eye Res. 86:403-411(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiMUC19_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5P9
Secondary accession number(s): Q8NA85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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