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Q7Z5P9 (MUC19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-19

Short name=MUC-19
Gene names
Name:MUC19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length6254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function in ocular mucus homeostasis. Ref.5

Subcellular location

Secreted Potential.

Tissue specificity

Expressed corneal epithelial cells, conjunctival goblet and epithelial cells and lacrimal gland cells (at protein level). Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expressed by middle ear epithelial cells. Ref.2 Ref.4 Ref.5

Induction

Down-regulated in Sjoegren syndrome patients (at protein level). Ref.5

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 VWFC domains.

Contains 3 VWFD domains.

Sequence caution

The sequence BAC04041.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processO-glycan processing

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

post-translational protein modification

Traceable author statement. Source: Reactome

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z5P9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z5P9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     5919-5936: GNTPGSTGVTSSQEGTTV → DSPSFPLFLICSYRGHNF
     5937-6254: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Chain? – 6254Mucin-19PRO_0000342664

Regions

Domain1 – 9797VWFD 1
Domain231 – 439209VWFD 2
Domain691 – 900210VWFD 3
Domain6029 – 609567VWFC 1
Domain6097 – 615963VWFC 2
Domain6162 – 624685CTCK
Region910 – 55094600Approximate repeats of G-V-T-G-T-T-G-P-S-A

Amino acid modifications

Disulfide bond6158 ↔ 6209 By similarity
Disulfide bond6176 ↔ 6223 By similarity
Disulfide bond6185 ↔ 6239 By similarity
Disulfide bond6189 ↔ 6241 By similarity
Disulfide bond? ↔ 6245 By similarity

Natural variations

Alternative sequence5919 – 593618GNTPG…EGTTV → DSPSFPLFLICSYRGHNF in isoform 2.
VSP_034521
Alternative sequence5937 – 6254318Missing in isoform 2.
VSP_034522
Natural variant1331G → E.
Corresponds to variant rs7955308 [ dbSNP | Ensembl ].
VAR_056617
Natural variant1991T → K.
Corresponds to variant rs11564170 [ dbSNP | Ensembl ].
VAR_056618
Natural variant2061V → I.
Corresponds to variant rs7958987 [ dbSNP | Ensembl ].
VAR_056619
Natural variant2071R → L.
Corresponds to variant rs17467284 [ dbSNP | Ensembl ].
VAR_056620
Natural variant2191D → H.
Corresponds to variant rs11564245 [ dbSNP | Ensembl ].
VAR_056621
Natural variant2591V → I.
Corresponds to variant rs10506156 [ dbSNP | Ensembl ].
VAR_056622
Natural variant2851V → I.
Corresponds to variant rs28365246 [ dbSNP | Ensembl ].
VAR_056623
Natural variant2991V → I.
Corresponds to variant rs11564125 [ dbSNP | Ensembl ].
VAR_056624
Natural variant4261L → F.
Corresponds to variant rs12317988 [ dbSNP | Ensembl ].
VAR_056625
Natural variant5671I → T.
Corresponds to variant rs11176635 [ dbSNP | Ensembl ].
VAR_056626
Natural variant6421S → F.
Corresponds to variant rs4768261 [ dbSNP | Ensembl ].
VAR_056627
Natural variant6941I → M.
Corresponds to variant rs7966110 [ dbSNP | Ensembl ].
VAR_056628
Natural variant7121G → S.
Corresponds to variant rs4768264 [ dbSNP | Ensembl ].
VAR_056629
Natural variant7311R → H.
Corresponds to variant rs7312154 [ dbSNP | Ensembl ].
VAR_056630
Natural variant7431G → W.
Corresponds to variant rs12369002 [ dbSNP | Ensembl ].
VAR_056631
Natural variant7831A → T.
Corresponds to variant rs11564141 [ dbSNP | Ensembl ].
VAR_056632
Natural variant8271C → Y.
Corresponds to variant rs11564109 [ dbSNP | Ensembl ].
VAR_056633
Natural variant8671A → T.
Corresponds to variant rs11176666 [ dbSNP | Ensembl ].
VAR_056634
Natural variant9091V → A.
Corresponds to variant rs10784621 [ dbSNP | Ensembl ].
VAR_056635
Natural variant10371N → S.
Corresponds to variant rs17128169 [ dbSNP | Ensembl ].
VAR_056636
Natural variant11041T → A.
Corresponds to variant rs17128233 [ dbSNP | Ensembl ].
VAR_056637
Natural variant11781E → A.
Corresponds to variant rs2933353 [ dbSNP | Ensembl ].
VAR_056638
Natural variant11861S → R.
Corresponds to variant rs7956459 [ dbSNP | Ensembl ].
VAR_056639
Natural variant14621A → S.
Corresponds to variant rs1492333 [ dbSNP | Ensembl ].
VAR_056640

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 2008. Version 2.
Checksum: 0B29670B870FBCB8

FASTA6,254598,155
        10         20         30         40         50         60 
MWDKNNKLSL TLHKQYPTCG LCGNFNSTPG QDINEHIANS KIPGDCPNAV GKSYEVCEDG 

        70         80         90        100        110        120 
IQHCNKIIGT YFEKCGKVAA LSNDYKMICI DEYCQTRDKT STCDTYSELS RLCASDGPGT 

       130        140        150        160        170        180 
FESWRSDSDV VCGTQRCPEQ HIYKECGPSN PATCSNVAPF QDSECVSGCT CPEGYLLDDI 

       190        200        210        220        230        240 
GEKGKCVLKA ECPCESSGTV YQPGEVREGP CGSQCTCQDA KWSCTEALCP GRCKVEGSSL 

       250        260        270        280        290        300 
TTFDGVKYNF PGNCHFLAVH NEDWSISVEL RPCPSGQTGT CLNSVTLLLN SSVPVDKYVF 

       310        320        330        340        350        360 
NSDGTVTNDK IRNQGYYYSD KIQIFNASSS YLQVETYFHV KLQIQIVPVM QLYVSMPPNQ 

       370        380        390        400        410        420 
FTDTVGLCGS YNNKAEDDFM SSQNILEKTS QAFANSWEMM SCPKGNPSSC ISIEKEKFAE 

       430        440        450        460        470        480 
RHCGILLDSS GPLASCHPIV NPKPYHEECK KYTCTCENSQ DCLCTILGNY VKACAEKETY 

       490        500        510        520        530        540 
IVGWRTGLCE HSCPSGLVFK YNVKACNSSC RSLSERDRSC DVEDVPVDGC TCPDAMYQNN 

       550        560        570        580        590        600 
EGNCVLKSQC DCYINDEVMQ PGKLIHIDDN KCVCRDGILL CQIPIDLTLQ NCSGGAEYVD 

       610        620        630        640        650        660 
CSDPKAQRRT NRTCSTRNIP VFDENLPCKR GCFCPEGMVR NSKGICVFPN DCPCSFGGRE 

       670        680        690        700        710        720 
YDEGSVTSVG CNECTCIKGS WSCTQNECQT ICHIYGEGHV RTFDGKSYSF DGLCQYSFLE 

       730        740        750        760        770        780 
DYCGHENGTF RILTESVPCC EDGLTCSRKI IVAFQDQNIV LQDGKVTAVK STESKKCELN 

       790        800        810        820        830        840 
ANAYSIHTVG LYLILKFQNG IIVIWDKNTR LSVILDPNWN GKVCGLCGNN NGDLKDDFTT 

       850        860        870        880        890        900 
RYSSVASGAL EFGNSWKTSQ ECSDTVAQTF PCDSNPYCKA WAVRKCEILR DSTFRDCHNK 

       910        920        930        940        950        960 
VDPSAYHDVC IEEACACDME GKYLGFCTAV AMYAEACSAV GVCVSWRKPN LCPVYCDYYN 

       970        980        990       1000       1010       1020 
APGECRWHYE PCGTVTAKTC KDQLVGQKFS SLLEGCYAKC PDSAPYLDEN TMKCVSLSEC 

      1030       1040       1050       1060       1070       1080 
SCFYNDVIPA GGVIEDNCGR TCYCIAGQLE CSETAPTNST FAVSTTTATT ILSTGAAITL 

      1090       1100       1110       1120       1130       1140 
VTGGPSTAAS IPAITTSSSE TTGTTLGPLT EPFTTGITET SVPIISTSGN AGMTGVVSPT 

      1150       1160       1170       1180       1190       1200 
VTGASGMAGT TGGVDAATTG AASENTSERA GTPRVSGETP AVGGGSTPGE AGPGATVSGS 

      1210       1220       1230       1240       1250       1260 
TGVSAGSITA SPGASATSSE SSKSGTTGPS VGGKTGATSS EATSSEGMSG VTGQSLGSTA 

      1270       1280       1290       1300       1310       1320 
GSDSEITAKT SFTGSSPPGK LTRPSPGSPG HFSGGTTEWG NVATTGAAGE NTSGALGSTE 

      1330       1340       1350       1360       1370       1380 
GSVEATTSAG SGNTAGTSGT GDTGPGNTAV SGTPVVSPGA TPGAPGSSTP GEADIGNTSF 

      1390       1400       1410       1420       1430       1440 
GKSGKSGHDS LTVLNPAFLR RTPTVSAAST TSSPVSKHTD AASATAVTIS GSKPGTPGTP 

      1450       1460       1470       1480       1490       1500 
GGATSGGKIT SGWSSSGTST GASNTPGATG SSTGQTDTSG PSAKVTGNYG QSSEIPGTIK 

      1510       1520       1530       1540       1550       1560 
SSSDVSGTMG QSDTTSGPSV AVTRTSEQSS GVTVASEPSV GVSGTTGPLA EISGTTRPLV 

      1570       1580       1590       1600       1610       1620 
SGLRTTGSSA EGSGTTGPSS RESVTTRPLA EGSGTSGQSV TGSRATGLSA TELGTTVSFT 

      1630       1640       1650       1660       1670       1680 
GGLGTSRSSA RETRTTGPSA DGSGTTGPSV VRSGTTRLSV GVTRATESSP GVTGTTTPSA 

      1690       1700       1710       1720       1730       1740 
EESRTTGPSV LVTGTTGQSG QGSGTTGKSF IESGPSVVGS GTTGPTSAGL GTTAPSTRRS 

      1750       1760       1770       1780       1790       1800 
STTKPSVGRT GTTGQSGAES GTTEPSARVA GVTGTSAEVS GRIEPSATES STSRPLGETT 

      1810       1820       1830       1840       1850       1860 
GTTIPSMEGS EATGPSVIGS ETTRLSVIGS GTTGTSSGGS GATRSSGGGM GTTGQSTARS 

      1870       1880       1890       1900       1910       1920 
ETTGPLFGLT GTFGQSATVT GTSSNSAGVT TPEKSPGVAM TTGLLVEGSA TTQPRILESE 

      1930       1940       1950       1960       1970       1980 
TTESSAGVIV TSGQSARVTG ATGPSAGETG TTEPSTEGSV AAVLFVIGSE TTRPLDIGSG 

      1990       2000       2010       2020       2030       2040 
TTGTLSGGSS TTRSSDGTTG TTRKSTARSE TTGLSGLTGT SGQLAGVTGT SSKSAGVTVT 

      2050       2060       2070       2080       2090       2100 
SEKSAGVAVI TGSFVERPVT TGPPLLESET TRPSGGVTVT SGQSARVTET VGASAGVTGT 

      2110       2120       2130       2140       2150       2160 
TGPSTEGSGA TGPSVVGSGT TRPLAGESGT TESSAGVTGT RPSSSRESAT TGPSDEGSGT 

      2170       2180       2190       2200       2210       2220 
TGLSAGVTVT SGQSVRKTGT TGAPAGVTET TRPSVVKSGT TGPSVIGTRT TGTSSGGSGA 

      2230       2240       2250       2260       2270       2280 
TRSSGGETET TGQSAVKSGT TESFTRLTRT SGQSAGMTGT SAQSAGVALT SPFVEGLVTT 

      2290       2300       2310       2320       2330       2340 
GSSTVGLETT RPSAVGSGKT GPPVVKAQTT GPSAGVTVTS GQSARMTGAS GPSVGVTGTT 

      2350       2360       2370       2380       2390       2400 
GPASKGLGTI RPSVVGLETT ELSAEGSGTT GPPIVGETTV PSAGVTVTSG YSDRVTGATE 

      2410       2420       2430       2440       2450       2460 
PLAGVTGTIK PSVAGSVTTG PSVTGVETTA KTTSGGLSTT ISSVGGTGTT GQSPERSGTT 

      2470       2480       2490       2500       2510       2520 
GPFTGLTGTS AQSAGVTMTS IQSAGVLVTT GLNVDGLGTT GKALIGSGTT GLSAEATGTI 

      2530       2540       2550       2560       2570       2580 
GPSTEGLEKT GPSITGSGTT RPLVTESWTA GTSSGGHSTT SPSVRGTETT GQSAAESVTT 

      2590       2600       2610       2620       2630       2640 
GPVTGYTETS GPSAGVTVTP RQSPTVTQTT GSSAAVSGTT VQSLTVSGTT RPSSGQTEIT 

      2650       2660       2670       2680       2690       2700 
GSSVKESGTT ESSAVRSGTT GPTAGVTGTN GPSSAGVTGI TGSSPGVTGT TGSSPGVTGT 

      2710       2720       2730       2740       2750       2760 
TGSSARSGTS IPSVGKTGTT RTSVEESRTT RPSAGITGTN GLSAEVTGTT GPLAGVTGTT 

      2770       2780       2790       2800       2810       2820 
GPSAGVTRTT GLSAGETGTT GLSPGVTRTT RSSAGLTGKT GLSAGVTGKT GLSAEVTGTT 

      2830       2840       2850       2860       2870       2880 
RLSAGVTGTT GPSPGVTGTT GTPAGVTGTT ELSAGVTGKT GLSSEVTETT GLSYGVKRTI 

      2890       2900       2910       2920       2930       2940 
GLSAGSTGTS GQSAGVAGTT TLSAEVTGTT RPSAGVTGTT GLSAEVTEIT GISAVVTGTT 

      2950       2960       2970       2980       2990       3000 
GPSAGVTETT GSSAGVAGTT RLSAGVTGIT GLSAGVTGTT GLSTEVTGTT GPSAGATGTT 

      3010       3020       3030       3040       3050       3060 
GLSVGVTGIT GLSDVVTETT GSSARSGTGI PSVGETRTTS TSVEESRTTR PSAGIMGTNG 

      3070       3080       3090       3100       3110       3120 
LPAEVTGTTE PLAGGTGTTG ILAGVTGTTG LSAGETGKIG SSAGVTGKTG SSARVTGKTG 

      3130       3140       3150       3160       3170       3180 
PSAEVTGKTG LSAGVTGTTG LSPGVTGTSG LSAEVTGTTG PSAEATGLPG VSAGVTGTTG 

      3190       3200       3210       3220       3230       3240 
SLAGGTGTIG LSAGVTGTTG SSAGVTGTTG LSAGVTGIAG LSAGVTGITG PSAGVTGTTT 

      3250       3260       3270       3280       3290       3300 
VSAGVTGTTG LSAEATEITG LSAGVTGTTG LSAGVTETIR LSAGVTGTIR SSAGVTGITG 

      3310       3320       3330       3340       3350       3360 
LSAGVTGTTG PSAGVTGSTG LLAGVTETTG QSAKVTGTTG QSVGVTGTTR SSGGVTGITG 

      3370       3380       3390       3400       3410       3420 
LSAGVTGTNG LSAVTGMTGL SAEVTGTTGL SVGVTGIAGL SAGVTGITGP SAGITGTTTI 

      3430       3440       3450       3460       3470       3480 
SAGVTGTSGL SAEATGITGL SAGVTGKTGL SAGVTETIGL SAEATGTIGS SPGVTGTTGS 

      3490       3500       3510       3520       3530       3540 
STGVTGITGL SAGVTGTTGL STEVTGTTGP SAGVTRTTGL SAGVTGITGL SAIVTETTGS 

      3550       3560       3570       3580       3590       3600 
SARSGTSIPS VGETGTTRTS VEESRTTRPS AGITGTTGLS AGVTGTVGSS AVVTGTTGLS 

      3610       3620       3630       3640       3650       3660 
AGVTGTTGPS AEETGATGPS AEVTETTGPS AGVTGTGRLS AEVTGTTGPS AEVTGLPGES 

      3670       3680       3690       3700       3710       3720 
AEVTGTIGSP AGVTGTTQLS AVVTGITGLS AEVTGTTGLS AGVTGITGLS AEVTRTTGLS 

      3730       3740       3750       3760       3770       3780 
AGVTGTIGLS AGVTGTTRPS AGVTGTTGQS AEVTGTTEPS AGLTETTGSS TGVTGATGPL 

      3790       3800       3810       3820       3830       3840 
AGVTGTTGIS TEVTGTTGPS ARVTGTTVLS AGVTGITGLS AIVTETTGSS ARSGTSTPSV 

      3850       3860       3870       3880       3890       3900 
GETGTTRTSV EESRATRPSA GITGTNGQSA EVTWITGPLA GVTGTTGISA GVTGTTGLSA 

      3910       3920       3930       3940       3950       3960 
GVTGTIGSSA VVTGINGLSA GVTGTTGPSA EETGATGPSA EVTGTTGPSA EETGATGPSA 

      3970       3980       3990       4000       4010       4020 
EVTGTTGPSG GVTGTNGLSA EVTGTTGPSA EVTGLPGVSA GVTGTIGSPA AVTGTIRPSA 

      4030       4040       4050       4060       4070       4080 
VVTGITGLSA EVTGTTGLSA WVTGIAGLSA GVTETIGSSA GVTGTNGLSA EATGTTGPSA 

      4090       4100       4110       4120       4130       4140 
GVTGTTGLSA GVTGTAGLSA RVTESTGLSA GVTGTTGLSA GVTGTTGPSA GITGTNGLSA 

      4150       4160       4170       4180       4190       4200 
EVTGTTGPLA GVTGTIGLSA GVTGIAGLSA GVTESTGLSA GVTGTIRSSA VVTGINGLSA 

      4210       4220       4230       4240       4250       4260 
GVTGTTGPSA EETGATGPSA EVTGTTGPSG GVTGTSGISA EVTGTTGPSA EVTGLPGVSA 

      4270       4280       4290       4300       4310       4320 
GVTGTIGSPA AVTGTTRPSA VVTGISGLSA EVTGTTGLSA GVTETIGSSA GVTGTNGLSA 

      4330       4340       4350       4360       4370       4380 
EATETTGPSA GVTGTTGLSA GVTGTTGPSA GIAGTNGLSA GVTGTTGLSA RVTESTGLSA 

      4390       4400       4410       4420       4430       4440 
GVTGTIGSSA VVTETTRLSS GVTGTIGPSA EETGATGLSA EVTGTTGSLA EVTGTTGLSA 

      4450       4460       4470       4480       4490       4500 
GVTGTIGSSA VVTGTTGLSA GITGTNGLSA EVTGTAGPLA GVTGTTGLSA GVTGTTGLSA 

      4510       4520       4530       4540       4550       4560 
GVTETTGQSA GVTESTGLSP GVTGTIGSSA VVTGIKGLSA GVTGTTGPSA EETGATGPSA 

      4570       4580       4590       4600       4610       4620 
EVTGTTGPSG GVTGTSVLSV EVTGTTGPSA EVTGLPGVSA GLTGTIGSPA AVRGTTWPSA 

      4630       4640       4650       4660       4670       4680 
VVTGISGLSG EVTGTTGLSA GVTGIGGLSA GVTGTIGSSA GVTGTNALSA EATGTTGPSA 

      4690       4700       4710       4720       4730       4740 
GVTGTTGLSA GVTGTTGLSA GVTGTIRSSA VVTETTGLSA GVTGTTGPSA GIAGTNGLSA 

      4750       4760       4770       4780       4790       4800 
EVTGTTGLSA GMTGTTGLSA RVTESTGLSA GVTGTIGSSA VVTETTRLSA GVTGTIGPSA 

      4810       4820       4830       4840       4850       4860 
EETGATGLSA EVTRTTGSLA GVTGTTGPSA VVTGKTELSA EVTGTTELSA EVTEKTGPSA 

      4870       4880       4890       4900       4910       4920 
EVTGKTGLSA GVMETTGPSA EVTGTTGSSA GVTGTTGPSA GVTGTTGPSA EATGLPGVSA 

      4930       4940       4950       4960       4970       4980 
GVTGTIGSPA GVTGTARLSA VVTGISGLSA EVTGTTGLST GVTGIAGHSA AVTGITRPSA 

      4990       5000       5010       5020       5030       5040 
GVTGTTTVSA GVTGTIGLSA EATGITLPSA GVTETTGLSA GVTETIGLSA GVTGTIGSSA 

      5050       5060       5070       5080       5090       5100 
GVTEITGLSA GVTGTTGPSA GVTGSTVLSA GVTATTGQSV GVTGTTGPSA GVTGTTGLSA 

      5110       5120       5130       5140       5150       5160 
GVTGIAGLSA GVTGITGPSA GVTGTTTVSA GVTGTTGLSA EATEITGLSA GVTGTTGLSA 

      5170       5180       5190       5200       5210       5220 
GVTGIAGLSA GVTETIGSSA GVTGTNGLSA EATGKTGPSA GVTGTTGLSA GVTGTTGLSA 

      5230       5240       5250       5260       5270       5280 
GVTETIGLSA GVTGTIGSSA GVKGTTGQSA EVTGATGQSV GVTGTTRSSG GVTGITGLSA 

      5290       5300       5310       5320       5330       5340 
GLRGTTVSSA KAGTSIPLTG KTGTTRTSVE ESTTTGPSAG ITGTNGLSAE MTGTNELSAG 

      5350       5360       5370       5380       5390       5400 
VTGTIGSSAG VTGTTGLSVE ATVTTGLSAG VTGTTVPLAG VTWTPGPSAG VTGIAALSAG 

      5410       5420       5430       5440       5450       5460 
VTGKSGLSAG VTGKTGLSAG VTGTTGPSAE ATGKTGLSAG VTGITGPFAE VTGTTGLSAG 

      5470       5480       5490       5500       5510       5520 
VIGTTGSSAE VTGITGLSAG VTGKTRSSAG VTGTTGLSAK SGTSIPSAGK TGTTKTSVEE 

      5530       5540       5550       5560       5570       5580 
SRTTRPSAGI TGTNGLPARV TGTXXXXXXX XXXGTSGVAP GTTVAPGSFS TAATTSPGAS 

      5590       5600       5610       5620       5630       5640 
GVTGTGPTAE TTTFLGGSST TGAEIKSGAT TGAPGSKTGT AKVLSGTTVA SGSSNSEATT 

      5650       5660       5670       5680       5690       5700 
FSGITEAVTV PSKNGSMTTA LGSQLSSSQT VIPGSSGTIS HTTVAPGSSV TGTTTGASDD 

      5710       5720       5730       5740       5750       5760 
QVTGSKTGTT GVALSTTVAP GSSSTEATTS TGVHRTTVVG QKTGATTRGS AKQGTRSTIE 

      5770       5780       5790       5800       5810       5820 
ATTSFRGTGT TGSGMNTGTT GVVSGNTISP SSFNTEATSG TSERPNPGSE IGTTGIVSGT 

      5830       5840       5850       5860       5870       5880 
TVAPGSSNTE ATTSLGNGGT TEAGSKIVTT GITTGTTIVP GSFNTKATTS TDVGVATGVG 

      5890       5900       5910       5920       5930       5940 
MATGITNIIS GRSQPTGSKT GYTVTGSGTT ALPGGFRTGN TPGSTGVTSS QEGTTVVSSG 

      5950       5960       5970       5980       5990       6000 
ITGIPETSIS GPSKEASDKT TAPGPPTTVT ASTGVKETSE TGVQTGSTLV TAGVPTRPQV 

      6010       6020       6030       6040       6050       6060 
SQPETTVVAT REVETENKTE CLASLPPAPV CHGPLGEEKS PGDIWTANCH RGTCTDAKTI 

      6070       6080       6090       6100       6110       6120 
DCKPEECPSP PTCKTGEKLV KFQSNDTCCE IGYCEPRTCL FNNTDYEIGA SFDDPSNPCV 

      6130       6140       6150       6160       6170       6180 
SYSCKDTGFA AVVQDCPKQT WCAEANRIYD SKKCCYTCKN NCRSSLVNVT VIYSGCKKRV 

      6190       6200       6210       6220       6230       6240 
QMAKCTGECE KTAKYNHDIL LLEHSCLCCR EENYELRDIV LDCPDGSTIP YQYKHITTCS 

      6250 
CLDICQLYTT FMYS 

« Hide

Isoform 2 [UniParc].

Checksum: 828E67D663F5A033
Show »

FASTA5,936564,084

References

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[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues."
Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R.
Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5554-6254 (ISOFORM 1), TISSUE SPECIFICITY.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5554-6254 (ISOFORM 2).
Tissue: Testis.
[4]"Mucin gene expression in human middle ear epithelium."
Kerschner J.E.
Laryngoscope 117:1666-1676(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients."
Yu D.F., Chen Y., Han J.M., Zhang H., Chen X.P., Zou W.J., Liang L.Y., Xu C.C., Liu Z.G.
Exp. Eye Res. 86:403-411(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC024935 Genomic DNA. No translation available.
AC074030 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.
AY236870 mRNA. Translation: AAP41817.1.
AK093065 mRNA. Translation: BAC04041.1. Different initiation.
UniGeneHs.632712.

3D structure databases

ProteinModelPortalQ7Z5P9.
SMRQ7Z5P9. Positions 134-203, 471-564, 591-663, 968-1031.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000395253.

PTM databases

PhosphoSiteQ7Z5P9.

Proteomic databases

PaxDbQ7Z5P9.
PRIDEQ7Z5P9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000538912; ENSP00000440762; ENSG00000205592.

Organism-specific databases

GeneCardsGC12P040788.
H-InvDBHIX0210549.
HGNCHGNC:14362. MUC19.
MIM612170. gene.
neXtProtNX_Q7Z5P9.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
InParanoidQ7Z5P9.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ7Z5P9.
BgeeQ7Z5P9.
CleanExHS_MUC19.
GenevestigatorQ7Z5P9.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF08742. C8. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 2 hits.
[Graphical view]
SMARTSM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view]
SUPFAMSSF57567. SSF57567. 3 hits.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ7Z5P9.
SOURCESearch...

Entry information

Entry nameMUC19_HUMAN
AccessionPrimary (citable) accession number: Q7Z5P9
Secondary accession number(s): Q8NA85
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM