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Protein

17-beta-hydroxysteroid dehydrogenase 13

Gene

HSD17B13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172SubstrateBy similarity1
Active sitei185Proton acceptorBy similarity1
Binding sitei189NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 67NADBy similarityAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • positive regulation of lipid biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-HSA-73923. Lipid digestion, mobilization, and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 13 (EC:1.1.-.-)
Short name:
17-beta-HSD 13
Alternative name(s):
Short chain dehydrogenase/reductase family 16C member 3
Short-chain dehydrogenase/reductase 9
Gene namesi
Name:HSD17B13
Synonyms:SCDR9, SDR16C3
ORF Names:HMFN0376, UNQ497/PRO1014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:18685. HSD17B13.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • lipid particle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi345275.
OpenTargetsiENSG00000170509.
PharmGKBiPA38634.

Polymorphism and mutation databases

BioMutaiHSD17B13.
DMDMi74750138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000004258320 – 30017-beta-hydroxysteroid dehydrogenase 13Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z5P4.
PaxDbiQ7Z5P4.
PeptideAtlasiQ7Z5P4.
PRIDEiQ7Z5P4.

PTM databases

iPTMnetiQ7Z5P4.
PhosphoSitePlusiQ7Z5P4.

Expressioni

Tissue specificityi

Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.1 Publication

Gene expression databases

BgeeiENSG00000170509.
CleanExiHS_HSD17B13.

Organism-specific databases

HPAiHPA029125.

Interactioni

Protein-protein interaction databases

BioGridi131346. 3 interactors.
STRINGi9606.ENSP00000333300.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5P4.
SMRiQ7Z5P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ7Z5P4.
OMAiCGHEGIP.
OrthoDBiEOG091G0825.
PhylomeDBiQ7Z5P4.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q7Z5P4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR
60 70 80 90 100
QTTYEFAKRQ SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI
110 120 130 140 150
YRSLNQVKKE VGDVTIVVNN AGTVYPADLL STKDEEITKT FEVNILGHFW
160 170 180 190 200
ITKALLPSMM ERNHGHIVTV ASVCGHEGIP YLIPYCSSKF AAVGFHRGLT
210 220 230 240 250
SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD EVVRSLIDGI
260 270 280 290 300
LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK
Length:300
Mass (Da):33,655
Last modified:October 1, 2003 - v1
Checksum:i5B85778554265DFE
GO
Isoform 1 (identifier: Q7Z5P4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-106: Missing.

Show »
Length:264
Mass (Da):29,605
Checksum:iE18D65C68306E3B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260P → S in AAO72313 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01586071 – 106Missing in isoform 1. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186249 mRNA. Translation: AAO72313.1.
AY186250 mRNA. Translation: AAO72314.1.
AY268355 mRNA. Translation: AAP42289.1.
AY358575 mRNA. Translation: AAQ88938.1.
AB073347 mRNA. Translation: BAD38632.1.
AK292784 mRNA. Translation: BAF85473.1.
CH471057 Genomic DNA. Translation: EAX05986.1.
BC112303 mRNA. Translation: AAI12304.1.
BC112305 mRNA. Translation: AAI12306.1.
CCDSiCCDS3618.1. [Q7Z5P4-1]
CCDS47097.1. [Q7Z5P4-2]
RefSeqiNP_001129702.1. NM_001136230.2. [Q7Z5P4-2]
NP_835236.2. NM_178135.4. [Q7Z5P4-1]
UniGeneiHs.284414.

Genome annotation databases

EnsembliENST00000302219; ENSP00000305438; ENSG00000170509. [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509. [Q7Z5P4-1]
GeneIDi345275.
KEGGihsa:345275.
UCSCiuc003hqo.3. human. [Q7Z5P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186249 mRNA. Translation: AAO72313.1.
AY186250 mRNA. Translation: AAO72314.1.
AY268355 mRNA. Translation: AAP42289.1.
AY358575 mRNA. Translation: AAQ88938.1.
AB073347 mRNA. Translation: BAD38632.1.
AK292784 mRNA. Translation: BAF85473.1.
CH471057 Genomic DNA. Translation: EAX05986.1.
BC112303 mRNA. Translation: AAI12304.1.
BC112305 mRNA. Translation: AAI12306.1.
CCDSiCCDS3618.1. [Q7Z5P4-1]
CCDS47097.1. [Q7Z5P4-2]
RefSeqiNP_001129702.1. NM_001136230.2. [Q7Z5P4-2]
NP_835236.2. NM_178135.4. [Q7Z5P4-1]
UniGeneiHs.284414.

3D structure databases

ProteinModelPortaliQ7Z5P4.
SMRiQ7Z5P4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131346. 3 interactors.
STRINGi9606.ENSP00000333300.

PTM databases

iPTMnetiQ7Z5P4.
PhosphoSitePlusiQ7Z5P4.

Polymorphism and mutation databases

BioMutaiHSD17B13.
DMDMi74750138.

Proteomic databases

MaxQBiQ7Z5P4.
PaxDbiQ7Z5P4.
PeptideAtlasiQ7Z5P4.
PRIDEiQ7Z5P4.

Protocols and materials databases

DNASUi345275.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302219; ENSP00000305438; ENSG00000170509. [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509. [Q7Z5P4-1]
GeneIDi345275.
KEGGihsa:345275.
UCSCiuc003hqo.3. human. [Q7Z5P4-1]

Organism-specific databases

CTDi345275.
DisGeNETi345275.
GeneCardsiHSD17B13.
HGNCiHGNC:18685. HSD17B13.
HPAiHPA029125.
MIMi612127. gene.
neXtProtiNX_Q7Z5P4.
OpenTargetsiENSG00000170509.
PharmGKBiPA38634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ7Z5P4.
OMAiCGHEGIP.
OrthoDBiEOG091G0825.
PhylomeDBiQ7Z5P4.
TreeFamiTF312837.

Enzyme and pathway databases

ReactomeiR-HSA-73923. Lipid digestion, mobilization, and transport.

Miscellaneous databases

GenomeRNAii345275.
PROiQ7Z5P4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170509.
CleanExiHS_HSD17B13.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHB13_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5P4
Secondary accession number(s): A8K9R9
, Q2M1L5, Q86W22, Q86W23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.