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Protein

17-beta-hydroxysteroid dehydrogenase 13

Gene

HSD17B13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei172 – 1721SubstrateBy similarity
Active sitei185 – 1851Proton acceptorBy similarity
Binding sitei189 – 1891NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 6728NADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of lipid biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 13 (EC:1.1.-.-)
Short name:
17-beta-HSD 13
Alternative name(s):
Short chain dehydrogenase/reductase family 16C member 3
Short-chain dehydrogenase/reductase 9
Gene namesi
Name:HSD17B13
Synonyms:SCDR9, SDR16C3
ORF Names:HMFN0376, UNQ497/PRO1014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:18685. HSD17B13.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • lipid particle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38634.

Polymorphism and mutation databases

BioMutaiHSD17B13.
DMDMi74750138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 30028117-beta-hydroxysteroid dehydrogenase 13PRO_0000042583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z5P4.
MaxQBiQ7Z5P4.
PaxDbiQ7Z5P4.
PeptideAtlasiQ7Z5P4.
PRIDEiQ7Z5P4.

PTM databases

iPTMnetiQ7Z5P4.
PhosphoSiteiQ7Z5P4.

Expressioni

Tissue specificityi

Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.1 Publication

Gene expression databases

BgeeiQ7Z5P4.
CleanExiHS_HSD17B13.

Organism-specific databases

HPAiHPA029125.

Interactioni

Protein-protein interaction databases

BioGridi131346. 3 interactions.
STRINGi9606.ENSP00000333300.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5P4.
SMRiQ7Z5P4. Positions 30-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ7Z5P4.
OMAiCGHEGIP.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ7Z5P4.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q7Z5P4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR
60 70 80 90 100
QTTYEFAKRQ SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI
110 120 130 140 150
YRSLNQVKKE VGDVTIVVNN AGTVYPADLL STKDEEITKT FEVNILGHFW
160 170 180 190 200
ITKALLPSMM ERNHGHIVTV ASVCGHEGIP YLIPYCSSKF AAVGFHRGLT
210 220 230 240 250
SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD EVVRSLIDGI
260 270 280 290 300
LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK
Length:300
Mass (Da):33,655
Last modified:October 1, 2003 - v1
Checksum:i5B85778554265DFE
GO
Isoform 1 (identifier: Q7Z5P4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-106: Missing.

Show »
Length:264
Mass (Da):29,605
Checksum:iE18D65C68306E3B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti260 – 2601P → S in AAO72313 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei71 – 10636Missing in isoform 1. 2 PublicationsVSP_015860Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186249 mRNA. Translation: AAO72313.1.
AY186250 mRNA. Translation: AAO72314.1.
AY268355 mRNA. Translation: AAP42289.1.
AY358575 mRNA. Translation: AAQ88938.1.
AB073347 mRNA. Translation: BAD38632.1.
AK292784 mRNA. Translation: BAF85473.1.
CH471057 Genomic DNA. Translation: EAX05986.1.
BC112303 mRNA. Translation: AAI12304.1.
BC112305 mRNA. Translation: AAI12306.1.
CCDSiCCDS3618.1. [Q7Z5P4-1]
CCDS47097.1. [Q7Z5P4-2]
RefSeqiNP_001129702.1. NM_001136230.2. [Q7Z5P4-2]
NP_835236.2. NM_178135.4. [Q7Z5P4-1]
UniGeneiHs.284414.

Genome annotation databases

EnsembliENST00000302219; ENSP00000305438; ENSG00000170509. [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509. [Q7Z5P4-1]
GeneIDi345275.
KEGGihsa:345275.
UCSCiuc003hqo.3. human. [Q7Z5P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186249 mRNA. Translation: AAO72313.1.
AY186250 mRNA. Translation: AAO72314.1.
AY268355 mRNA. Translation: AAP42289.1.
AY358575 mRNA. Translation: AAQ88938.1.
AB073347 mRNA. Translation: BAD38632.1.
AK292784 mRNA. Translation: BAF85473.1.
CH471057 Genomic DNA. Translation: EAX05986.1.
BC112303 mRNA. Translation: AAI12304.1.
BC112305 mRNA. Translation: AAI12306.1.
CCDSiCCDS3618.1. [Q7Z5P4-1]
CCDS47097.1. [Q7Z5P4-2]
RefSeqiNP_001129702.1. NM_001136230.2. [Q7Z5P4-2]
NP_835236.2. NM_178135.4. [Q7Z5P4-1]
UniGeneiHs.284414.

3D structure databases

ProteinModelPortaliQ7Z5P4.
SMRiQ7Z5P4. Positions 30-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131346. 3 interactions.
STRINGi9606.ENSP00000333300.

PTM databases

iPTMnetiQ7Z5P4.
PhosphoSiteiQ7Z5P4.

Polymorphism and mutation databases

BioMutaiHSD17B13.
DMDMi74750138.

Proteomic databases

EPDiQ7Z5P4.
MaxQBiQ7Z5P4.
PaxDbiQ7Z5P4.
PeptideAtlasiQ7Z5P4.
PRIDEiQ7Z5P4.

Protocols and materials databases

DNASUi345275.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302219; ENSP00000305438; ENSG00000170509. [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509. [Q7Z5P4-1]
GeneIDi345275.
KEGGihsa:345275.
UCSCiuc003hqo.3. human. [Q7Z5P4-1]

Organism-specific databases

CTDi345275.
GeneCardsiHSD17B13.
HGNCiHGNC:18685. HSD17B13.
HPAiHPA029125.
MIMi612127. gene.
neXtProtiNX_Q7Z5P4.
PharmGKBiPA38634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ7Z5P4.
OMAiCGHEGIP.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ7Z5P4.
TreeFamiTF312837.

Miscellaneous databases

GenomeRNAii345275.
PROiQ7Z5P4.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z5P4.
CleanExiHS_HSD17B13.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of a novel and tissue specific 17-beta hydroxysteroid dehydrogenase."
    Zhong H., Wang R.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9."
    Liu S., Huang C., Li D., Ren W., Zhang H., Qi M., Li X., Yu L.
    Acta Biochim. Pol. 54:213-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hepatoblastoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDHB13_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5P4
Secondary accession number(s): A8K9R9
, Q2M1L5, Q86W22, Q86W23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.