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Protein

Protein sidekick-1

Gene

SDK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sidekick-11 Publication
Gene namesi
Name:SDK11 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19307. SDK1.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Cell junctionsynapse By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 2009ExtracellularSequence analysis
Transmembranei2010 – 203021HelicalSequence analysisAdd
BLAST
Topological domaini2031 – 2213183CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957188.

Polymorphism and mutation databases

BioMutaiSDK1.
DMDMi296452965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 2213Protein sidekick-1PRO_0000226975
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi126 ↔ 169PROSITE-ProRule annotation
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence analysis
Disulfide bondi315 ↔ 362PROSITE-ProRule annotation
Disulfide bondi408 ↔ 458PROSITE-ProRule annotation
Disulfide bondi501 ↔ 553PROSITE-ProRule annotation
Glycosylationi550 – 5501N-linked (GlcNAc...)Sequence analysis
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi595 ↔ 647PROSITE-ProRule annotation
Glycosylationi655 – 6551N-linked (GlcNAc...)Sequence analysis
Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence analysis
Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence analysis
Glycosylationi821 – 8211N-linked (GlcNAc...)Sequence analysis
Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence analysis
Glycosylationi1015 – 10151N-linked (GlcNAc...)Sequence analysis
Glycosylationi1024 – 10241N-linked (GlcNAc...)Sequence analysis
Glycosylationi1282 – 12821N-linked (GlcNAc...)Sequence analysis
Glycosylationi1333 – 13331N-linked (GlcNAc...)Sequence analysis
Glycosylationi1654 – 16541N-linked (GlcNAc...)Sequence analysis
Glycosylationi1748 – 17481N-linked (GlcNAc...)Sequence analysis
Glycosylationi1767 – 17671N-linked (GlcNAc...)Sequence analysis
Glycosylationi1819 – 18191N-linked (GlcNAc...)Sequence analysis
Glycosylationi1893 – 18931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z5N4.
PeptideAtlasiQ7Z5N4.
PRIDEiQ7Z5N4.

PTM databases

iPTMnetiQ7Z5N4.
PhosphoSiteiQ7Z5N4.

Expressioni

Tissue specificityi

Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells (PubMed:15213259).1 Publication

Gene expression databases

BgeeiQ7Z5N4.
CleanExiHS_SDK1.
ExpressionAtlasiQ7Z5N4. baseline and differential.
GenevisibleiQ7Z5N4. HS.

Organism-specific databases

HPAiHPA011392.

Interactioni

Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128768. 6 interactions.
IntActiQ7Z5N4. 2 interactions.
MINTiMINT-1182578.
STRINGi9606.ENSP00000385899.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5N4.
SMRiQ7Z5N4. Positions 955-1173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 18683Ig-like C2-type 1Add
BLAST
Domaini191 – 27787Ig-like C2-type 2Add
BLAST
Domaini293 – 37886Ig-like C2-type 3Add
BLAST
Domaini386 – 47691Ig-like C2-type 4Add
BLAST
Domaini480 – 56990Ig-like C2-type 5Add
BLAST
Domaini574 – 66390Ig-like C2-type 6Add
BLAST
Domaini670 – 76697Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini771 – 86797Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini872 – 97099Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini974 – 106895Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini1072 – 1171100Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini1176 – 127499Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini1279 – 137698Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1380 – 147495Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1479 – 157698Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini1581 – 1699119Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1704 – 180097Fibronectin type-III 11PROSITE-ProRule annotationAdd
BLAST
Domaini1804 – 189996Fibronectin type-III 12PROSITE-ProRule annotationAdd
BLAST
Domaini1902 – 200099Fibronectin type-III 13PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2207 – 22137PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 5840Pro-richAdd
BLAST

Domaini

Ig-like C2-type domains 1 and 2 mediate homophilic interactions.By similarity

Sequence similaritiesi

Belongs to the sidekick family.Curated
Contains 13 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410ZHW1. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231052.
HOVERGENiHBG080083.
InParanoidiQ7Z5N4.
KOiK16353.
OMAiLRYVWKK.
OrthoDBiEOG7MPRCZ.
PhylomeDBiQ7Z5N4.
TreeFamiTF316846.

Family and domain databases

Gene3Di2.60.40.10. 19 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 13 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 13 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 7 hits.
PROSITEiPS50853. FN3. 13 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5N4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGARPSAA GGGGGGAEPP ERAGPGRPRG SPPGRARPSL APRPGPEPSR
60 70 80 90 100
PRAAPETSGG DTAGAGRCGG RRAAKLGPGR RGWWALLALQ LHLLRALAQD
110 120 130 140 150
DVAPYFKTEP GLPQIHLEGN RLVLTCLAEG SWPLEFKWMR DDSELTTYSS
160 170 180 190 200
EYKYIIPSLQ KLDAGFYRCV VRNRMGALLQ RKSEVQVAYM GSFMDTDQRK
210 220 230 240 250
TVSQGRAAIL NLLPITSYPR PQVTWFREGH KIIPSNRIAI TLENQLVILA
260 270 280 290 300
TTTSDAGAYY VQAVNEKNGE NKTSPFIHLS IARDVGTPET MAPTIVVPPG
310 320 330 340 350
NRSVVAGSSE TTLECIASAR PVEDLSVTWK RNGVRITSGL HSFGRRLTIS
360 370 380 390 400
NPTSADTGPY VCEAALPGSA FEPARATAFL FIIEPPYFTA EPESRISAEV
410 420 430 440 450
EETVDIGCQA MGVPLPTLQW YKDAISISRL QNPRYKVLAS GGLRIQKLRP
460 470 480 490 500
EDSGIFQCFA SNEGGEIQTH TYLDVTNIAP VFTQRPVDTT VTDGMTAILR
510 520 530 540 550
CEVSGAPKPA ITWKRENHIL ASGSVRIPRF MLLESGGLQI APVFIQDAGN
560 570 580 590 600
YTCYAANTEG SLNASATLTV WNRTSIVHPP EDHVVIKGTT ATLHCGATHD
610 620 630 640 650
PRVSLRYVWK KDNVALTPSS TSRIVVEKDG SLLISQTWSG DIGDYSCEIV
660 670 680 690 700
SEGGNDSRMA RLEVIELPHS PQNLLVSPNS SHSHAVVLSW VRPFDGNSPI
710 720 730 740 750
LYYIVELSEN NSPWKVHLSN VGPEMTGVTV SGLTPARTYQ FRVCAVNEVG
760 770 780 790 800
RGQYSAETSR LMLPEEPPSA PPKNIVASGR TNQSIMVQWQ PPPETEHNGV
810 820 830 840 850
LRGYILRYRL AGLPGEYQQR NITSPEVNYC LVTDLIIWTQ YEIQVAAYNG
860 870 880 890 900
AGLGVFSRAV TEYTLQGVPT APPQNVQTEA VNSTTIQFLW NPPPQQFING
910 920 930 940 950
INQGYKLLAW PADAPEAVTV VTIAPDFHGV HHGHITNLKK FTAYFTSVLC
960 970 980 990 1000
FTTPGDGPPS TPQLVWTQED KPGAVGHLSF TEILDTSLKV SWQEPLEKNG
1010 1020 1030 1040 1050
IITGYQISWE VYGRNDSRLT HTLNSTTHEY KIQGLSSLTT YTIDVAAVTA
1060 1070 1080 1090 1100
VGTGLVTSST ISSGVPPDLP GAPSNLVISN ISPRSATLQF RPGYDGKTSI
1110 1120 1130 1140 1150
SRWIVEGQVG AIGDEEEWVT LYEEENEPDA QMLEIPNLTP YTHYRFRMKQ
1160 1170 1180 1190 1200
VNIVGPSPYS PSSRVIQTLQ APPDVAPTSV TVRTASETSL RLRWVPLPDS
1210 1220 1230 1240 1250
QYNGNPESVG YRIKYWRSDL QSSAVAQVVS DRLEREFTIE ELEEWMEYEL
1260 1270 1280 1290 1300
QMQAFNAVGA GPWSEVVRGR TRESVPSAAP ENVSAEAVSS TQILLTWTSV
1310 1320 1330 1340 1350
PEQDQNGLIL GYKILFRAKD LDPEPRSHIV RGNHTQSALL AGLRKFVLYE
1360 1370 1380 1390 1400
LQVLAFTRIG NGVPSTPLIL ERTKDDAPGP PVRLVFPEVR LTSVRIVWQP
1410 1420 1430 1440 1450
PEEPNGIILG YQIAYRLASS SPHTFTTVEV GATVRQFTAT DLAPESAYIF
1460 1470 1480 1490 1500
RLSAKTRQGW GEPLEATVIT TEKRERPAPP RELLVPQAEV TARSLRLQWV
1510 1520 1530 1540 1550
PGSDGASPIR YFTMQVRELP RGEWQTYSSS ISHEATACVV DRLRPFTSYK
1560 1570 1580 1590 1600
LRLKATNDIG DSDFSSETEA VTTLQDVPGE PPGSVSATPH TTSSVLIQWQ
1610 1620 1630 1640 1650
PPRDESLNGL LQGYRIYYRE LEYEAGSGTE AKTLKNPIAL HAELTAQSSF
1660 1670 1680 1690 1700
KTVNSSSTST MCELTHLKKY RRYEVIMTAY NIIGESPASA PVEVFVGEAA
1710 1720 1730 1740 1750
PAMAPQNVQV TPLTASQLEV TWDPPPPESQ NGNIQGYKIY YWEADSQNET
1760 1770 1780 1790 1800
EKMKVLFLPE PVVRLKNLTS HTKYLVSISA FNAAGDGPKS DPQQGRTHQA
1810 1820 1830 1840 1850
APGAPSFLAF SEITSTTLNV SWGEPAAANG ILQGYRVVYE PLAPVQGVSK
1860 1870 1880 1890 1900
VVTVEVRGNW QRWLKVRDLT KGVTYFFRVQ ARTITYGPEL QANITAGPAE
1910 1920 1930 1940 1950
GSPGSPRDVL VTKSASELTL QWTEGHSGDT PTTGYVIEAR PSDEGLWDMF
1960 1970 1980 1990 2000
VKDIPRSATS YTLSLDKLRQ GVTYEFRVVA VNEAGYGEPS NPSTAVSAQV
2010 2020 2030 2040 2050
EAPFYEEWWF LLVMALSSLI VILLVVFALV LHGQNKKYKN CSTGKGISTM
2060 2070 2080 2090 2100
EESVTLDNGG FAALELSSRH LNVKSTFSKK NGTRSPPRPS PGGLHYSDED
2110 2120 2130 2140 2150
ICNKYNGAVL TESVSLKEKS ADASESEATD SDYEDALPKH SFVNHYMSDP
2160 2170 2180 2190 2200
TYYNSWKRRA QGRAPAPHRY EAVAGSEAGA QLHPVITTQS AGGVYTPAGP
2210
GARTPLTGFS SFV
Length:2,213
Mass (Da):242,112
Last modified:May 18, 2010 - v3
Checksum:i7475FB659695F2C5
GO
Isoform 2 (identifier: Q7Z5N4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1940: Missing.
     1941-1942: PS → ME

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):29,746
Checksum:i6BB44219DE5BDE8A
GO
Isoform 3 (identifier: Q7Z5N4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1643-1662: Missing.

Note: No experimental confirmation available.
Show »
Length:2,193
Mass (Da):240,021
Checksum:i7465B64D75DF88BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581S → P in AAP75619 (Ref. 1) Curated
Sequence conflicti58 – 581S → P in BAB71066 (PubMed:14702039).Curated
Sequence conflicti346 – 3461R → H in AAP75619 (Ref. 1) Curated
Sequence conflicti346 – 3461R → H in BAB71066 (PubMed:14702039).Curated
Sequence conflicti711 – 7111N → S in AAP75619 (Ref. 1) Curated
Sequence conflicti711 – 7111N → S in BAB71066 (PubMed:14702039).Curated
Sequence conflicti1666 – 16661H → D in BAB84909 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1016 – 10161D → N.1 Publication
Corresponds to variant rs11978101 [ dbSNP | Ensembl ].
VAR_025529
Natural varianti1641 – 16411H → R.1 Publication
Corresponds to variant rs671694 [ dbSNP | Ensembl ].
VAR_025530

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 19401940Missing in isoform 2. 1 PublicationVSP_017517Add
BLAST
Alternative sequencei1643 – 166220Missing in isoform 3. 1 PublicationVSP_017518Add
BLAST
Alternative sequencei1941 – 19422PS → ME in isoform 2. 1 PublicationVSP_017519

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY310398 mRNA. Translation: AAP75619.1.
AK055987 mRNA. Translation: BAB71066.1.
AC004935 Genomic DNA. No translation available.
AC004984 Genomic DNA. No translation available.
AC011284 Genomic DNA. No translation available.
AC015968 Genomic DNA. No translation available.
AC069286 Genomic DNA. No translation available.
AC073316 Genomic DNA. No translation available.
AC073550 Genomic DNA. No translation available.
AC079231 Genomic DNA. No translation available.
AC092427 Genomic DNA. No translation available.
AK074077 mRNA. Translation: BAB84903.1.
AK074083 mRNA. Translation: BAB84909.1.
CCDSiCCDS34590.1. [Q7Z5N4-1]
RefSeqiNP_689957.3. NM_152744.3. [Q7Z5N4-1]
UniGeneiHs.653013.

Genome annotation databases

EnsembliENST00000404826; ENSP00000385899; ENSG00000146555. [Q7Z5N4-1]
GeneIDi221935.
KEGGihsa:221935.
UCSCiuc003smx.4. human. [Q7Z5N4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY310398 mRNA. Translation: AAP75619.1.
AK055987 mRNA. Translation: BAB71066.1.
AC004935 Genomic DNA. No translation available.
AC004984 Genomic DNA. No translation available.
AC011284 Genomic DNA. No translation available.
AC015968 Genomic DNA. No translation available.
AC069286 Genomic DNA. No translation available.
AC073316 Genomic DNA. No translation available.
AC073550 Genomic DNA. No translation available.
AC079231 Genomic DNA. No translation available.
AC092427 Genomic DNA. No translation available.
AK074077 mRNA. Translation: BAB84903.1.
AK074083 mRNA. Translation: BAB84909.1.
CCDSiCCDS34590.1. [Q7Z5N4-1]
RefSeqiNP_689957.3. NM_152744.3. [Q7Z5N4-1]
UniGeneiHs.653013.

3D structure databases

ProteinModelPortaliQ7Z5N4.
SMRiQ7Z5N4. Positions 955-1173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128768. 6 interactions.
IntActiQ7Z5N4. 2 interactions.
MINTiMINT-1182578.
STRINGi9606.ENSP00000385899.

PTM databases

iPTMnetiQ7Z5N4.
PhosphoSiteiQ7Z5N4.

Polymorphism and mutation databases

BioMutaiSDK1.
DMDMi296452965.

Proteomic databases

PaxDbiQ7Z5N4.
PeptideAtlasiQ7Z5N4.
PRIDEiQ7Z5N4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404826; ENSP00000385899; ENSG00000146555. [Q7Z5N4-1]
GeneIDi221935.
KEGGihsa:221935.
UCSCiuc003smx.4. human. [Q7Z5N4-1]

Organism-specific databases

CTDi221935.
GeneCardsiSDK1.
H-InvDBHIX0006441.
HGNCiHGNC:19307. SDK1.
HPAiHPA011392.
MIMi607216. gene.
neXtProtiNX_Q7Z5N4.
PharmGKBiPA134957188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410ZHW1. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231052.
HOVERGENiHBG080083.
InParanoidiQ7Z5N4.
KOiK16353.
OMAiLRYVWKK.
OrthoDBiEOG7MPRCZ.
PhylomeDBiQ7Z5N4.
TreeFamiTF316846.

Miscellaneous databases

ChiTaRSiSDK1. human.
GenomeRNAii221935.
PROiQ7Z5N4.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z5N4.
CleanExiHS_SDK1.
ExpressionAtlasiQ7Z5N4. baseline and differential.
GenevisibleiQ7Z5N4. HS.

Family and domain databases

Gene3Di2.60.40.10. 19 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 13 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 13 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 7 hits.
PROSITEiPS50853. FN3. 13 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of human sidekick homolog 1."
    Bonner T.I.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-2213 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1642-2213 (ISOFORM 1), VARIANTS ASN-1016 AND ARG-1641.
    Tissue: Spleen.
  5. "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy."
    Kaufman L., Hayashi K., Ross M.J., Ross M.D., Klotman P.E.
    J. Am. Soc. Nephrol. 15:1721-1730(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSDK1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5N4
Secondary accession number(s): Q8TEN9, Q8TEP5, Q96N44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.