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Q7Z5L9

- I2BP2_HUMAN

UniProt

Q7Z5L9 - I2BP2_HUMAN

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Protein

Interferon regulatory factor 2-binding protein 2

Gene
IRF2BP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri506 – 55348RING-type; degenerateAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein 2
Short name:
IRF-2-binding protein 2
Short name:
IRF-2BP2
Gene namesi
Name:IRF2BP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:21729. IRF2BP2.

Subcellular locationi

Cytoplasm. Nucleus 3 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134947294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 587586Interferon regulatory factor 2-binding protein 2PRO_0000328734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei175 – 1751Phosphoserine2 Publications
Modified residuei240 – 2401Phosphoserine By similarity
Modified residuei360 – 3601Phosphoserine4 Publications
Modified residuei455 – 4551Phosphoserine1 Publication
Modified residuei457 – 4571Phosphoserine3 Publications
Modified residuei460 – 4601Phosphoserine3 Publications

Post-translational modificationi

Phosphorylation at Ser-360 is required for nuclear targeting.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ7Z5L9.
PaxDbiQ7Z5L9.
PRIDEiQ7Z5L9.

PTM databases

PhosphoSiteiQ7Z5L9.

Expressioni

Gene expression databases

ArrayExpressiQ7Z5L9.
BgeeiQ7Z5L9.
CleanExiHS_IRF2BP2.
GenevestigatoriQ7Z5L9.

Organism-specific databases

HPAiHPA027815.

Interactioni

Subunit structurei

Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4.2 Publications

Protein-protein interaction databases

BioGridi131797. 13 interactions.
IntActiQ7Z5L9. 2 interactions.
STRINGi9606.ENSP00000355568.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5L9.
SMRiQ7Z5L9. Positions 498-577.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni506 – 55045Cys-richAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi354 – 3618Nuclear localization signal1 Publication

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 20097Pro-richAdd
BLAST

Domaini

The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2.

Sequence similaritiesi

Belongs to the IRF2BP family.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri506 – 55348RING-type; degenerateAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG325224.
HOVERGENiHBG108364.
InParanoidiQ7Z5L9.
OMAiSIPLCCT.
OrthoDBiEOG7673CH.
PhylomeDBiQ7Z5L9.
TreeFamiTF317075.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z5L9-1) [UniParc]FASTAAdd to Basket

Also known as: IRF-2BP2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE    50
FVIETARQLK RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG 100
HGGPEAAPRA PQALERYPLA AAAERPPRLG SDFGSSRPAA SLAQPPTPQP 150
PPVNGILVPN GFSKLEEPPE LNRQSPNPRR GHAVPPTLVP LMNGSATPLP 200
TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS VSSSAAVEHE 250
QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN 300
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV 350
ARTARKRKPS PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP 400
PPPTASPHSN RTTPPEAAQN GQSPMAALIL VADNAGGSHA SKDANQVHST 450
TRRNSNSPPS PSSMNQRRLG PREVGGQGAG NTGGLEPVHP ASLPDSSLAT 500
SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ QGASGEVYCP 550
SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS 587
Length:587
Mass (Da):61,025
Last modified:May 5, 2009 - v2
Checksum:i2B36B7EE2C3B96A6
GO
Isoform 2 (identifier: Q7Z5L9-2) [UniParc]FASTAAdd to Basket

Also known as: IRF-2BP2B

The sequence of this isoform differs from the canonical sequence as follows:
     333-348: Missing.

Show »
Length:571
Mass (Da):59,481
Checksum:iCE45834F631B6E86
GO
Isoform 3 (identifier: Q7Z5L9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:163
Mass (Da):17,139
Checksum:i9929F96A8CD66921
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541A → V.
Corresponds to variant rs11502 [ dbSNP | Ensembl ].
VAR_042503

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 424424Missing in isoform 3. VSP_032769Add
BLAST
Alternative sequencei333 – 34816Missing in isoform 2. VSP_032770Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771N → K in AAP78944. 1 Publication
Sequence conflicti177 – 1771N → K in AAP78945. 1 Publication
Sequence conflicti183 – 1831A → T in AAP78944. 1 Publication
Sequence conflicti183 – 1831A → T in AAP78945. 1 Publication
Sequence conflicti246 – 2461A → T in AAP78944. 1 Publication
Sequence conflicti246 – 2461A → T in AAP78945. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY278023 mRNA. Translation: AAP78944.1.
AY278024 mRNA. Translation: AAP78945.1.
AL160408 Genomic DNA. Translation: CAI22767.1.
AL160408 Genomic DNA. Translation: CAI22768.1.
BC020516 mRNA. Translation: AAH20516.1.
BC065759 mRNA. Translation: AAH65759.1.
CCDSiCCDS1602.1. [Q7Z5L9-1]
CCDS41475.1. [Q7Z5L9-2]
RefSeqiNP_001070865.1. NM_001077397.1. [Q7Z5L9-2]
NP_892017.2. NM_182972.2. [Q7Z5L9-1]
UniGeneiHs.350268.

Genome annotation databases

EnsembliENST00000366609; ENSP00000355568; ENSG00000168264. [Q7Z5L9-1]
ENST00000366610; ENSP00000355569; ENSG00000168264. [Q7Z5L9-2]
GeneIDi359948.
KEGGihsa:359948.
UCSCiuc001hwf.3. human. [Q7Z5L9-2]
uc001hwg.3. human. [Q7Z5L9-1]

Polymorphism databases

DMDMi229462882.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY278023 mRNA. Translation: AAP78944.1 .
AY278024 mRNA. Translation: AAP78945.1 .
AL160408 Genomic DNA. Translation: CAI22767.1 .
AL160408 Genomic DNA. Translation: CAI22768.1 .
BC020516 mRNA. Translation: AAH20516.1 .
BC065759 mRNA. Translation: AAH65759.1 .
CCDSi CCDS1602.1. [Q7Z5L9-1 ]
CCDS41475.1. [Q7Z5L9-2 ]
RefSeqi NP_001070865.1. NM_001077397.1. [Q7Z5L9-2 ]
NP_892017.2. NM_182972.2. [Q7Z5L9-1 ]
UniGenei Hs.350268.

3D structure databases

ProteinModelPortali Q7Z5L9.
SMRi Q7Z5L9. Positions 498-577.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131797. 13 interactions.
IntActi Q7Z5L9. 2 interactions.
STRINGi 9606.ENSP00000355568.

PTM databases

PhosphoSitei Q7Z5L9.

Polymorphism databases

DMDMi 229462882.

Proteomic databases

MaxQBi Q7Z5L9.
PaxDbi Q7Z5L9.
PRIDEi Q7Z5L9.

Protocols and materials databases

DNASUi 359948.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366609 ; ENSP00000355568 ; ENSG00000168264 . [Q7Z5L9-1 ]
ENST00000366610 ; ENSP00000355569 ; ENSG00000168264 . [Q7Z5L9-2 ]
GeneIDi 359948.
KEGGi hsa:359948.
UCSCi uc001hwf.3. human. [Q7Z5L9-2 ]
uc001hwg.3. human. [Q7Z5L9-1 ]

Organism-specific databases

CTDi 359948.
GeneCardsi GC01M234740.
H-InvDB HIX0023152.
HGNCi HGNC:21729. IRF2BP2.
HPAi HPA027815.
MIMi 615332. gene.
neXtProti NX_Q7Z5L9.
PharmGKBi PA134947294.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325224.
HOVERGENi HBG108364.
InParanoidi Q7Z5L9.
OMAi SIPLCCT.
OrthoDBi EOG7673CH.
PhylomeDBi Q7Z5L9.
TreeFami TF317075.

Miscellaneous databases

ChiTaRSi IRF2BP2. human.
GenomeRNAii 359948.
NextBioi 99975.
PROi Q7Z5L9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7Z5L9.
Bgeei Q7Z5L9.
CleanExi HS_IRF2BP2.
Genevestigatori Q7Z5L9.

Family and domain databases

InterProi IPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view ]
Pfami PF11261. IRF-2BP1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel co-repressor molecules for interferon regulatory factor-2."
    Childs K.S., Goodbourn S.
    Nucleic Acids Res. 31:3016-3026(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INTERACTION WITH IRF2, SUBCELLULAR LOCATION.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 362-587 (ISOFORMS 1/2).
    Tissue: Lung.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455; SER-457 AND SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression."
    Teng A.C., Kuraitis D., Deeke S.A., Ahmadi A., Dugan S.G., Cheng B.L., Crowson M.G., Burgon P.G., Suuronen E.J., Chen H.H., Stewart A.F.
    FASEB J. 24:4825-4834(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VGLL4, SUBCELLULAR LOCATION.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175; SER-360; SER-457 AND SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity."
    Carneiro F.R., Ramalho-Oliveira R., Mognol G.P., Viola J.P.
    Mol. Cell. Biol. 31:2889-2901(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2."
    Teng A.C., Al-Montashiri N.A., Cheng B.L., Lou P., Ozmizrak P., Chen H.H., Stewart A.F.
    PLoS ONE 6:E24100-E24100(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, PHOSPHORYLATION AT SER-360.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457 AND SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiI2BP2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5L9
Secondary accession number(s): B1AM35
, B1AM36, Q6P083, Q7Z5L8, Q8N351, Q8WUH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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