Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon regulatory factor 2-binding protein 2

Gene

IRF2BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri506 – 553RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ7Z5L9

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein 2
Short name:
IRF-2-binding protein 2
Short name:
IRF-2BP2
Gene namesi
Name:IRF2BP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000168264.10
HGNCiHGNC:21729 IRF2BP2
MIMi615332 gene
neXtProtiNX_Q7Z5L9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi359948
MalaCardsiIRF2BP2
OpenTargetsiENSG00000168264
PharmGKBiPA134947294

Polymorphism and mutation databases

BioMutaiIRF2BP2
DMDMi229462882

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003287342 – 587Interferon regulatory factor 2-binding protein 2Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei240PhosphoserineBy similarity1
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei318PhosphoserineCombined sources1
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei360PhosphoserineCombined sources1 Publication1
Modified residuei406PhosphoserineBy similarity1
Modified residuei423PhosphoserineBy similarity1
Modified residuei455PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Isoform 2 (identifier: Q7Z5L9-2)
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylation at Ser-360 is required for nuclear targeting.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7Z5L9
MaxQBiQ7Z5L9
PaxDbiQ7Z5L9
PeptideAtlasiQ7Z5L9
PRIDEiQ7Z5L9
TopDownProteomicsiQ7Z5L9-2 [Q7Z5L9-2]
Q7Z5L9-3 [Q7Z5L9-3]

PTM databases

iPTMnetiQ7Z5L9
PhosphoSitePlusiQ7Z5L9

Expressioni

Gene expression databases

BgeeiENSG00000168264
CleanExiHS_IRF2BP2
GenevisibleiQ7Z5L9 HS

Organism-specific databases

HPAiHPA027815
HPA062269

Interactioni

Subunit structurei

Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4.2 Publications

Protein-protein interaction databases

BioGridi131797, 30 interactors
CORUMiQ7Z5L9
IntActiQ7Z5L9, 3 interactors
STRINGi9606.ENSP00000355568

Structurei

3D structure databases

ProteinModelPortaliQ7Z5L9
SMRiQ7Z5L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni506 – 550Cys-richAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi354 – 361Nuclear localization signal1 Publication8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 200Pro-richAdd BLAST97

Domaini

The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2.

Sequence similaritiesi

Belongs to the IRF2BP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri506 – 553RING-type; degenerateAdd BLAST48

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPPD Eukaryota
ENOG4110EVD LUCA
GeneTreeiENSGT00390000005089
HOVERGENiHBG108364
InParanoidiQ7Z5L9
KOiK22383
OMAiEHNGGAN
OrthoDBiEOG091G040R
PhylomeDBiQ7Z5L9
TreeFamiTF317075

Family and domain databases

InterProiView protein in InterPro
IPR022750 Interferon_reg_fac2-bd1_2_Znf
PfamiView protein in Pfam
PF11261 IRF-2BP1_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5L9-1) [UniParc]FASTAAdd to basket
Also known as: IRF-2BP2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE
60 70 80 90 100
FVIETARQLK RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG
110 120 130 140 150
HGGPEAAPRA PQALERYPLA AAAERPPRLG SDFGSSRPAA SLAQPPTPQP
160 170 180 190 200
PPVNGILVPN GFSKLEEPPE LNRQSPNPRR GHAVPPTLVP LMNGSATPLP
210 220 230 240 250
TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS VSSSAAVEHE
260 270 280 290 300
QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN
310 320 330 340 350
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV
360 370 380 390 400
ARTARKRKPS PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP
410 420 430 440 450
PPPTASPHSN RTTPPEAAQN GQSPMAALIL VADNAGGSHA SKDANQVHST
460 470 480 490 500
TRRNSNSPPS PSSMNQRRLG PREVGGQGAG NTGGLEPVHP ASLPDSSLAT
510 520 530 540 550
SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ QGASGEVYCP
560 570 580
SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS
Length:587
Mass (Da):61,025
Last modified:May 5, 2009 - v2
Checksum:i2B36B7EE2C3B96A6
GO
Isoform 2 (identifier: Q7Z5L9-2) [UniParc]FASTAAdd to basket
Also known as: IRF-2BP2B

The sequence of this isoform differs from the canonical sequence as follows:
     333-348: Missing.

Show »
Length:571
Mass (Da):59,481
Checksum:iCE45834F631B6E86
GO
Isoform 3 (identifier: Q7Z5L9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:163
Mass (Da):17,139
Checksum:i9929F96A8CD66921
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177N → K in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti177N → K in AAP78945 (PubMed:12799427).Curated1
Sequence conflicti183A → T in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti183A → T in AAP78945 (PubMed:12799427).Curated1
Sequence conflicti246A → T in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti246A → T in AAP78945 (PubMed:12799427).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042503254A → V. Corresponds to variant dbSNP:rs11502Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0327691 – 424Missing in isoform 3. 1 PublicationAdd BLAST424
Alternative sequenceiVSP_032770333 – 348Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278023 mRNA Translation: AAP78944.1
AY278024 mRNA Translation: AAP78945.1
AL160408 Genomic DNA No translation available.
BC020516 mRNA Translation: AAH20516.1
BC065759 mRNA Translation: AAH65759.1
CCDSiCCDS1602.1 [Q7Z5L9-1]
CCDS41475.1 [Q7Z5L9-2]
RefSeqiNP_001070865.1, NM_001077397.1 [Q7Z5L9-2]
NP_892017.2, NM_182972.2 [Q7Z5L9-1]
UniGeneiHs.350268

Genome annotation databases

EnsembliENST00000366609; ENSP00000355568; ENSG00000168264 [Q7Z5L9-1]
ENST00000366610; ENSP00000355569; ENSG00000168264 [Q7Z5L9-2]
GeneIDi359948
KEGGihsa:359948
UCSCiuc001hwf.3 human [Q7Z5L9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiI2BP2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5L9
Secondary accession number(s): B1AM35
, B1AM36, Q6P083, Q7Z5L8, Q8N351, Q8WUH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health