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Protein

Interferon regulatory factor 2-binding protein 2

Gene

IRF2BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri506 – 553RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ7Z5L9.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein 2
Short name:
IRF-2-binding protein 2
Short name:
IRF-2BP2
Gene namesi
Name:IRF2BP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21729. IRF2BP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi359948.
OpenTargetsiENSG00000168264.
PharmGKBiPA134947294.

Polymorphism and mutation databases

BioMutaiIRF2BP2.
DMDMi229462882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003287342 – 587Interferon regulatory factor 2-binding protein 2Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei240PhosphoserineBy similarity1
Modified residuei318PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1 Publication1
Modified residuei406PhosphoserineBy similarity1
Modified residuei423PhosphoserineBy similarity1
Modified residuei455PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Isoform 2 (identifier: Q7Z5L9-2)
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylation at Ser-360 is required for nuclear targeting.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7Z5L9.
MaxQBiQ7Z5L9.
PaxDbiQ7Z5L9.
PeptideAtlasiQ7Z5L9.
PRIDEiQ7Z5L9.
TopDownProteomicsiQ7Z5L9-2. [Q7Z5L9-2]
Q7Z5L9-3. [Q7Z5L9-3]

PTM databases

iPTMnetiQ7Z5L9.
PhosphoSitePlusiQ7Z5L9.

Expressioni

Gene expression databases

BgeeiENSG00000168264.
CleanExiHS_IRF2BP2.
GenevisibleiQ7Z5L9. HS.

Organism-specific databases

HPAiHPA027815.

Interactioni

Subunit structurei

Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4.2 Publications

Protein-protein interaction databases

BioGridi131797. 19 interactors.
IntActiQ7Z5L9. 3 interactors.
STRINGi9606.ENSP00000355568.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5L9.
SMRiQ7Z5L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni506 – 550Cys-richAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi354 – 361Nuclear localization signal1 Publication8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 200Pro-richAdd BLAST97

Domaini

The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2.

Sequence similaritiesi

Belongs to the IRF2BP family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri506 – 553RING-type; degenerateAdd BLAST48

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPPD. Eukaryota.
ENOG4110EVD. LUCA.
GeneTreeiENSGT00390000005089.
HOVERGENiHBG108364.
InParanoidiQ7Z5L9.
OMAiSESHKNR.
OrthoDBiEOG091G040R.
PhylomeDBiQ7Z5L9.
TreeFamiTF317075.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5L9-1) [UniParc]FASTAAdd to basket
Also known as: IRF-2BP2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE
60 70 80 90 100
FVIETARQLK RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG
110 120 130 140 150
HGGPEAAPRA PQALERYPLA AAAERPPRLG SDFGSSRPAA SLAQPPTPQP
160 170 180 190 200
PPVNGILVPN GFSKLEEPPE LNRQSPNPRR GHAVPPTLVP LMNGSATPLP
210 220 230 240 250
TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS VSSSAAVEHE
260 270 280 290 300
QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN
310 320 330 340 350
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV
360 370 380 390 400
ARTARKRKPS PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP
410 420 430 440 450
PPPTASPHSN RTTPPEAAQN GQSPMAALIL VADNAGGSHA SKDANQVHST
460 470 480 490 500
TRRNSNSPPS PSSMNQRRLG PREVGGQGAG NTGGLEPVHP ASLPDSSLAT
510 520 530 540 550
SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ QGASGEVYCP
560 570 580
SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS
Length:587
Mass (Da):61,025
Last modified:May 5, 2009 - v2
Checksum:i2B36B7EE2C3B96A6
GO
Isoform 2 (identifier: Q7Z5L9-2) [UniParc]FASTAAdd to basket
Also known as: IRF-2BP2B

The sequence of this isoform differs from the canonical sequence as follows:
     333-348: Missing.

Show »
Length:571
Mass (Da):59,481
Checksum:iCE45834F631B6E86
GO
Isoform 3 (identifier: Q7Z5L9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:163
Mass (Da):17,139
Checksum:i9929F96A8CD66921
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177N → K in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti177N → K in AAP78945 (PubMed:12799427).Curated1
Sequence conflicti183A → T in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti183A → T in AAP78945 (PubMed:12799427).Curated1
Sequence conflicti246A → T in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti246A → T in AAP78945 (PubMed:12799427).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042503254A → V.Corresponds to variant rs11502dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0327691 – 424Missing in isoform 3. 1 PublicationAdd BLAST424
Alternative sequenceiVSP_032770333 – 348Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278023 mRNA. Translation: AAP78944.1.
AY278024 mRNA. Translation: AAP78945.1.
AL160408 Genomic DNA. Translation: CAI22767.1.
AL160408 Genomic DNA. Translation: CAI22768.1.
BC020516 mRNA. Translation: AAH20516.1.
BC065759 mRNA. Translation: AAH65759.1.
CCDSiCCDS1602.1. [Q7Z5L9-1]
CCDS41475.1. [Q7Z5L9-2]
RefSeqiNP_001070865.1. NM_001077397.1. [Q7Z5L9-2]
NP_892017.2. NM_182972.2. [Q7Z5L9-1]
UniGeneiHs.350268.

Genome annotation databases

EnsembliENST00000366609; ENSP00000355568; ENSG00000168264. [Q7Z5L9-1]
ENST00000366610; ENSP00000355569; ENSG00000168264. [Q7Z5L9-2]
GeneIDi359948.
KEGGihsa:359948.
UCSCiuc001hwf.3. human. [Q7Z5L9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278023 mRNA. Translation: AAP78944.1.
AY278024 mRNA. Translation: AAP78945.1.
AL160408 Genomic DNA. Translation: CAI22767.1.
AL160408 Genomic DNA. Translation: CAI22768.1.
BC020516 mRNA. Translation: AAH20516.1.
BC065759 mRNA. Translation: AAH65759.1.
CCDSiCCDS1602.1. [Q7Z5L9-1]
CCDS41475.1. [Q7Z5L9-2]
RefSeqiNP_001070865.1. NM_001077397.1. [Q7Z5L9-2]
NP_892017.2. NM_182972.2. [Q7Z5L9-1]
UniGeneiHs.350268.

3D structure databases

ProteinModelPortaliQ7Z5L9.
SMRiQ7Z5L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131797. 19 interactors.
IntActiQ7Z5L9. 3 interactors.
STRINGi9606.ENSP00000355568.

PTM databases

iPTMnetiQ7Z5L9.
PhosphoSitePlusiQ7Z5L9.

Polymorphism and mutation databases

BioMutaiIRF2BP2.
DMDMi229462882.

Proteomic databases

EPDiQ7Z5L9.
MaxQBiQ7Z5L9.
PaxDbiQ7Z5L9.
PeptideAtlasiQ7Z5L9.
PRIDEiQ7Z5L9.
TopDownProteomicsiQ7Z5L9-2. [Q7Z5L9-2]
Q7Z5L9-3. [Q7Z5L9-3]

Protocols and materials databases

DNASUi359948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366609; ENSP00000355568; ENSG00000168264. [Q7Z5L9-1]
ENST00000366610; ENSP00000355569; ENSG00000168264. [Q7Z5L9-2]
GeneIDi359948.
KEGGihsa:359948.
UCSCiuc001hwf.3. human. [Q7Z5L9-1]

Organism-specific databases

CTDi359948.
DisGeNETi359948.
GeneCardsiIRF2BP2.
H-InvDBHIX0023152.
HGNCiHGNC:21729. IRF2BP2.
HPAiHPA027815.
MIMi615332. gene.
neXtProtiNX_Q7Z5L9.
OpenTargetsiENSG00000168264.
PharmGKBiPA134947294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPPD. Eukaryota.
ENOG4110EVD. LUCA.
GeneTreeiENSGT00390000005089.
HOVERGENiHBG108364.
InParanoidiQ7Z5L9.
OMAiSESHKNR.
OrthoDBiEOG091G040R.
PhylomeDBiQ7Z5L9.
TreeFamiTF317075.

Enzyme and pathway databases

SIGNORiQ7Z5L9.

Miscellaneous databases

ChiTaRSiIRF2BP2. human.
GenomeRNAii359948.
PROiQ7Z5L9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168264.
CleanExiHS_IRF2BP2.
GenevisibleiQ7Z5L9. HS.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI2BP2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5L9
Secondary accession number(s): B1AM35
, B1AM36, Q6P083, Q7Z5L8, Q8N351, Q8WUH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.