ID   C1QL2_HUMAN             Reviewed;         287 AA.
AC   Q7Z5L3;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Complement C1q-like protein 2;
DE   AltName: Full=C1q and tumor necrosis factor-related protein 10;
DE            Short=C1q/TNF-related protein 10;
DE   Flags: Precursor;
GN   Name=C1QL2; Synonyms=CTRP10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ding P., Han W., Wang Y., Rui M., Song Q., Zhang Y., Ma D.;
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- FUNCTION: May regulate the number of excitatory synapses that are
CC       formed on hippocampus neurons. Has no effect on inhibitory synapses (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms homotrimers which can further assemble to form higher-
CC       order oligomeric complexes. Interacts with ADGRB3. May interact with
CC       ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are
CC       coexpressed; this interaction does not occur after secretion.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; AF525315; AAP80787.1; -; mRNA.
DR   EMBL; AC016673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS42737.1; -.
DR   RefSeq; NP_872334.2; NM_182528.3.
DR   AlphaFoldDB; Q7Z5L3; -.
DR   SMR; Q7Z5L3; -.
DR   BioGRID; 127912; 1.
DR   STRING; 9606.ENSP00000272520; -.
DR   TCDB; 8.A.94.1.6; the adiponectin (adiponectin) family.
DR   BioMuta; C1QL2; -.
DR   DMDM; 296434414; -.
DR   MassIVE; Q7Z5L3; -.
DR   PaxDb; 9606-ENSP00000272520; -.
DR   PeptideAtlas; Q7Z5L3; -.
DR   ProteomicsDB; 69319; -.
DR   Antibodypedia; 58204; 124 antibodies from 21 providers.
DR   DNASU; 165257; -.
DR   Ensembl; ENST00000272520.4; ENSP00000272520.3; ENSG00000144119.4.
DR   GeneID; 165257; -.
DR   KEGG; hsa:165257; -.
DR   MANE-Select; ENST00000272520.4; ENSP00000272520.3; NM_182528.4; NP_872334.2.
DR   UCSC; uc002tlo.3; human.
DR   AGR; HGNC:24181; -.
DR   CTD; 165257; -.
DR   DisGeNET; 165257; -.
DR   GeneCards; C1QL2; -.
DR   HGNC; HGNC:24181; C1QL2.
DR   HPA; ENSG00000144119; Tissue enriched (brain).
DR   MIM; 614330; gene.
DR   neXtProt; NX_Q7Z5L3; -.
DR   OpenTargets; ENSG00000144119; -.
DR   PharmGKB; PA134915960; -.
DR   VEuPathDB; HostDB:ENSG00000144119; -.
DR   eggNOG; ENOG502QUZ7; Eukaryota.
DR   GeneTree; ENSGT00940000156913; -.
DR   HOGENOM; CLU_001074_3_1_1; -.
DR   InParanoid; Q7Z5L3; -.
DR   OMA; GHYEMMG; -.
DR   OrthoDB; 4210331at2759; -.
DR   PhylomeDB; Q7Z5L3; -.
DR   TreeFam; TF329591; -.
DR   PathwayCommons; Q7Z5L3; -.
DR   SignaLink; Q7Z5L3; -.
DR   BioGRID-ORCS; 165257; 12 hits in 1136 CRISPR screens.
DR   GenomeRNAi; 165257; -.
DR   Pharos; Q7Z5L3; Tdark.
DR   PRO; PR:Q7Z5L3; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q7Z5L3; Protein.
DR   Bgee; ENSG00000144119; Expressed in temporal lobe and 39 other cell types or tissues.
DR   ExpressionAtlas; Q7Z5L3; baseline and differential.
DR   GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; IEA:Ensembl.
DR   GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
DR   GO; GO:0097107; P:postsynaptic density assembly; IEA:Ensembl.
DR   GO; GO:0090128; P:regulation of synapse maturation; IEA:Ensembl.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR22923; CEREBELLIN-RELATED; 1.
DR   PANTHER; PTHR22923:SF69; COMPLEMENT C1Q-LIKE PROTEIN 2; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   2: Evidence at transcript level;
KW   Collagen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..287
FT                   /note="Complement C1q-like protein 2"
FT                   /id="PRO_0000274335"
FT   DOMAIN          76..118
FT                   /note="Collagen-like"
FT   DOMAIN          154..287
FT                   /note="C1q"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT   REGION          42..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..105
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        33..34
FT                   /note="CD -> WE (in Ref. 1; AAP80787)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        50..51
FT                   /note="QP -> HN (in Ref. 1; AAP80787)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   287 AA;  29468 MW;  F9F08EBF68F3C460 CRC64;
     MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ PPGPSTAALE
     VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG PRGPPGEKGD SGRPGLPGLQ
     LTAGTASGVG VVGGGAGVGG DSEGEVTSAL SATFSGPKIA FYVGLKSPHE GYEVLKFDDV
     VTNLGNHYDP TTGKFSCQVR GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ
     NYDYASNSVV LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD
//