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Protein

Complement C1q-like protein 2

Gene

C1QL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q-like protein 2
Alternative name(s):
C1q and tumor necrosis factor-related protein 10
Short name:
C1q/TNF-related protein 10
Gene namesi
Name:C1QL2
Synonyms:CTRP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24181. C1QL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915960.

Polymorphism and mutation databases

BioMutaiC1QL2.
DMDMi296434414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 287266Complement C1q-like protein 2PRO_0000274335Add
BLAST

Proteomic databases

PaxDbiQ7Z5L3.
PRIDEiQ7Z5L3.

Expressioni

Gene expression databases

BgeeiQ7Z5L3.
CleanExiHS_C1QL2.

Organism-specific databases

HPAiHPA057934.

Interactioni

Subunit structurei

Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with BAI3. May interact with FAM132B. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7Z5L3.
SMRiQ7Z5L3. Positions 119-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 11843Collagen-likeAdd
BLAST
Domaini154 – 287134C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG87981.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ7Z5L3.
OMAiPFIQGPK.
OrthoDBiEOG757CZJ.
PhylomeDBiQ7Z5L3.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z5L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ
60 70 80 90 100
PPGPSTAALE VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG
110 120 130 140 150
PRGPPGEKGD SGRPGLPGLQ LTAGTASGVG VVGGGAGVGG DSEGEVTSAL
160 170 180 190 200
SATFSGPKIA FYVGLKSPHE GYEVLKFDDV VTNLGNHYDP TTGKFSCQVR
210 220 230 240 250
GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ NYDYASNSVV
260 270 280
LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD
Length:287
Mass (Da):29,468
Last modified:May 18, 2010 - v2
Checksum:iF9F08EBF68F3C460
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 342CD → WE in AAP80787 (Ref. 1) Curated
Sequence conflicti50 – 512QP → HN in AAP80787 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525315 mRNA. Translation: AAP80787.1.
AC016673 Genomic DNA. No translation available.
CCDSiCCDS42737.1.
RefSeqiNP_872334.2. NM_182528.3.
UniGeneiHs.433493.

Genome annotation databases

EnsembliENST00000272520; ENSP00000272520; ENSG00000144119.
GeneIDi165257.
KEGGihsa:165257.
UCSCiuc002tlo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525315 mRNA. Translation: AAP80787.1.
AC016673 Genomic DNA. No translation available.
CCDSiCCDS42737.1.
RefSeqiNP_872334.2. NM_182528.3.
UniGeneiHs.433493.

3D structure databases

ProteinModelPortaliQ7Z5L3.
SMRiQ7Z5L3. Positions 119-287.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiC1QL2.
DMDMi296434414.

Proteomic databases

PaxDbiQ7Z5L3.
PRIDEiQ7Z5L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272520; ENSP00000272520; ENSG00000144119.
GeneIDi165257.
KEGGihsa:165257.
UCSCiuc002tlo.2. human.

Organism-specific databases

CTDi165257.
GeneCardsiGC02M119914.
HGNCiHGNC:24181. C1QL2.
HPAiHPA057934.
MIMi614330. gene.
neXtProtiNX_Q7Z5L3.
PharmGKBiPA134915960.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87981.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ7Z5L3.
OMAiPFIQGPK.
OrthoDBiEOG757CZJ.
PhylomeDBiQ7Z5L3.
TreeFamiTF329591.

Miscellaneous databases

GenomeRNAii165257.
NextBioi88536.
PROiQ7Z5L3.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z5L3.
CleanExiHS_C1QL2.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ding P., Han W., Wang Y., Rui M., Song Q., Zhang Y., Ma D.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiC1QL2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.