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Q7Z5L3 (C1QL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C1q-like protein 2
Alternative name(s):
C1q and tumor necrosis factor-related protein 10
Short name=C1q/TNF-related protein 10
Gene names
Name:C1QL2
Synonyms:CTRP10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.

Subunit structure

Forms homotrimers which can further assemble to form higher-order oligomeric complexes By similarity. Interacts with BAI3 By similarity. May interact with FAM132B By similarity. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainCollagen
Signal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein oligomerization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 287266Complement C1q-like protein 2
PRO_0000274335

Regions

Domain76 – 11843Collagen-like
Domain154 – 287134C1q

Experimental info

Sequence conflict33 – 342CD → WE in AAP80787. Ref.1
Sequence conflict50 – 512QP → HN in AAP80787. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z5L3 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: F9F08EBF68F3C460

FASTA28729,468
        10         20         30         40         50         60 
MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ PPGPSTAALE 

        70         80         90        100        110        120 
VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG PRGPPGEKGD SGRPGLPGLQ 

       130        140        150        160        170        180 
LTAGTASGVG VVGGGAGVGG DSEGEVTSAL SATFSGPKIA FYVGLKSPHE GYEVLKFDDV 

       190        200        210        220        230        240 
VTNLGNHYDP TTGKFSCQVR GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ 

       250        260        270        280 
NYDYASNSVV LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD 

« Hide

References

« Hide 'large scale' references
[1]Ding P., Han W., Wang Y., Rui M., Song Q., Zhang Y., Ma D.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF525315 mRNA. Translation: AAP80787.1.
AC016673 Genomic DNA. No translation available.
RefSeqNP_872334.2. NM_182528.3.
UniGeneHs.433493.

3D structure databases

ProteinModelPortalQ7Z5L3.
SMRQ7Z5L3. Positions 119-287.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM296434414.

Proteomic databases

PaxDbQ7Z5L3.
PRIDEQ7Z5L3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272520; ENSP00000272520; ENSG00000144119.
GeneID165257.
KEGGhsa:165257.
UCSCuc002tlo.2. human.

Organism-specific databases

CTD165257.
GeneCardsGC02M119914.
HGNCHGNC:24181. C1QL2.
HPAHPA057934.
MIM614330. gene.
neXtProtNX_Q7Z5L3.
PharmGKBPA134915960.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87981.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidQ7Z5L3.
OMAPFIQGPK.
OrthoDBEOG757CZJ.
PhylomeDBQ7Z5L3.
TreeFamTF329591.

Gene expression databases

BgeeQ7Z5L3.
CleanExHS_C1QL2.
GenevestigatorQ7Z5L3.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi165257.
NextBio88536.
PROQ7Z5L3.
SOURCESearch...

Entry information

Entry nameC1QL2_HUMAN
AccessionPrimary (citable) accession number: Q7Z5L3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM