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Protein

Complement C1q-like protein 2

Gene

C1QL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q-like protein 2
Alternative name(s):
C1q and tumor necrosis factor-related protein 10
Short name:
C1q/TNF-related protein 10
Gene namesi
Name:C1QL2
Synonyms:CTRP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144119.3
HGNCiHGNC:24181 C1QL2
MIMi614330 gene
neXtProtiNX_Q7Z5L3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144119
PharmGKBiPA134915960

Polymorphism and mutation databases

BioMutaiC1QL2
DMDMi296434414

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000027433522 – 287Complement C1q-like protein 2Add BLAST266

Proteomic databases

PaxDbiQ7Z5L3
PeptideAtlasiQ7Z5L3
PRIDEiQ7Z5L3
ProteomicsDBi69319

Expressioni

Gene expression databases

BgeeiENSG00000144119
CleanExiHS_C1QL2

Organism-specific databases

HPAiHPA057934

Interactioni

Subunit structurei

Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with ADGRB3. May interact with ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ7Z5L3
SMRiQ7Z5L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 118Collagen-likeAdd BLAST43
Domaini154 – 287C1qPROSITE-ProRule annotationAdd BLAST134

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKWQ Eukaryota
ENOG410YP3F LUCA
GeneTreeiENSGT00760000119052
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiQ7Z5L3
OMAiMICDPYS
OrthoDBiEOG091G0UOF
PhylomeDBiQ7Z5L3
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z5L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ
60 70 80 90 100
PPGPSTAALE VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG
110 120 130 140 150
PRGPPGEKGD SGRPGLPGLQ LTAGTASGVG VVGGGAGVGG DSEGEVTSAL
160 170 180 190 200
SATFSGPKIA FYVGLKSPHE GYEVLKFDDV VTNLGNHYDP TTGKFSCQVR
210 220 230 240 250
GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ NYDYASNSVV
260 270 280
LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD
Length:287
Mass (Da):29,468
Last modified:May 18, 2010 - v2
Checksum:iF9F08EBF68F3C460
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 34CD → WE in AAP80787 (Ref. 1) Curated2
Sequence conflicti50 – 51QP → HN in AAP80787 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525315 mRNA Translation: AAP80787.1
AC016673 Genomic DNA No translation available.
CCDSiCCDS42737.1
RefSeqiNP_872334.2, NM_182528.3
UniGeneiHs.433493

Genome annotation databases

EnsembliENST00000272520; ENSP00000272520; ENSG00000144119
GeneIDi165257
KEGGihsa:165257
UCSCiuc002tlo.3 human

Similar proteinsi

Entry informationi

Entry nameiC1QL2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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