Q7Z5L3 (C1QL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complement C1q-like protein 2

Gene names

Name:	C1QL2
Synonyms:	CTRP10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.
Subunit structure	Forms homotrimers which can further assemble to form higher-order oligomeric complexes By similarity. Interacts with BAI3 By similarity. May interact with FAM132B By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Contains 1 C1q domain. Contains 1 collagen-like domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Collagen Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein oligomerization Inferred from electronic annotation. Source: Compara
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 287	266	Complement C1q-like protein 2		PRO_0000274335
Regions
	Domain	76 – 118	43	Collagen-like
	Domain	154 – 287	134	C1q
Experimental info
	Sequence conflict	33 – 34	2	CD → WE in AAP80787. Ref.1
	Sequence conflict	50 – 51	2	QP → HN in AAP80787. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z5L3 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: F9F08EBF68F3C460	FASTA	287	29,468
	10 20 30 40 50 60 MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ PPGPSTAALE 70 80 90 100 110 120 VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG PRGPPGEKGD SGRPGLPGLQ 130 140 150 160 170 180 LTAGTASGVG VVGGGAGVGG DSEGEVTSAL SATFSGPKIA FYVGLKSPHE GYEVLKFDDV 190 200 210 220 230 240 VTNLGNHYDP TTGKFSCQVR GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ 250 260 270 280 NYDYASNSVV LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ding P., Han W., Wang Y., Rui M., Song Q., Zhang Y., Ma D. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF525315 mRNA. Translation: AAP80787.1. AC016673 Genomic DNA. No translation available.
IPI	IPI00376197.
RefSeq	NP_872334.2. NM_182528.3.
UniGene	Hs.433493.
3D structure databases
HSSP	HSSP built from PDB template 1C28 based on UniProtKB Q60994.
ProteinModelPortal	Q7Z5L3.
SMR	Q7Z5L3. Positions 119-287.
ModBase	Search...
Polymorphism databases
DMDM	296434414.
Proteomic databases
PaxDb	Q7Z5L3.
PRIDE	Q7Z5L3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272520; ENSP00000272520; ENSG00000144119.
GeneID	165257.
KEGG	hsa:165257.
UCSC	uc002tlo.2. human.
Organism-specific databases
CTD	165257.
GeneCards	GC02M119914.
HGNC	HGNC:24181. C1QL2.
MIM	614330. gene.
neXtProt	NX_Q7Z5L3.
PharmGKB	PA134915960.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87981.
HOGENOM	HOG000085653.
HOVERGEN	HBG108220.
InParanoid	Q7Z5L3.
OMA	PFIQGPK.
OrthoDB	EOG4R23VZ.
PhylomeDB	Q7Z5L3.
Gene expression databases
Bgee	Q7Z5L3.
CleanEx	HS_C1QL2.
Genevestigator	Q7Z5L3.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	165257.
NextBio	88536.
SOURCE	Search...

Entry information

Entry name

C1QL2_HUMAN

Accession

Primary (citable) accession number: Q7Z5L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.