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Q7Z5L3

- C1QL2_HUMAN

UniProt

Q7Z5L3 - C1QL2_HUMAN

Protein

Complement C1q-like protein 2

Gene

C1QL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.By similarity

    GO - Biological processi

    1. protein oligomerization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C1q-like protein 2
    Alternative name(s):
    C1q and tumor necrosis factor-related protein 10
    Short name:
    C1q/TNF-related protein 10
    Gene namesi
    Name:C1QL2
    Synonyms:CTRP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:24181. C1QL2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134915960.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 287266Complement C1q-like protein 2PRO_0000274335Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z5L3.
    PRIDEiQ7Z5L3.

    Expressioni

    Gene expression databases

    BgeeiQ7Z5L3.
    CleanExiHS_C1QL2.
    GenevestigatoriQ7Z5L3.

    Organism-specific databases

    HPAiHPA057934.

    Interactioni

    Subunit structurei

    Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with BAI3. May interact with FAM132B. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z5L3.
    SMRiQ7Z5L3. Positions 119-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini76 – 11843Collagen-likeAdd
    BLAST
    Domaini154 – 287134C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG87981.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiQ7Z5L3.
    OMAiICDPYTA.
    OrthoDBiEOG757CZJ.
    PhylomeDBiQ7Z5L3.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z5L3-1 [UniParc]FASTAAdd to Basket

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    MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ    50
    PPGPSTAALE VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG 100
    PRGPPGEKGD SGRPGLPGLQ LTAGTASGVG VVGGGAGVGG DSEGEVTSAL 150
    SATFSGPKIA FYVGLKSPHE GYEVLKFDDV VTNLGNHYDP TTGKFSCQVR 200
    GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ NYDYASNSVV 250
    LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD 287
    Length:287
    Mass (Da):29,468
    Last modified:May 18, 2010 - v2
    Checksum:iF9F08EBF68F3C460
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 342CD → WE in AAP80787. 1 PublicationCurated
    Sequence conflicti50 – 512QP → HN in AAP80787. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF525315 mRNA. Translation: AAP80787.1.
    AC016673 Genomic DNA. No translation available.
    CCDSiCCDS42737.1.
    RefSeqiNP_872334.2. NM_182528.3.
    UniGeneiHs.433493.

    Genome annotation databases

    EnsembliENST00000272520; ENSP00000272520; ENSG00000144119.
    GeneIDi165257.
    KEGGihsa:165257.
    UCSCiuc002tlo.2. human.

    Polymorphism databases

    DMDMi296434414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF525315 mRNA. Translation: AAP80787.1 .
    AC016673 Genomic DNA. No translation available.
    CCDSi CCDS42737.1.
    RefSeqi NP_872334.2. NM_182528.3.
    UniGenei Hs.433493.

    3D structure databases

    ProteinModelPortali Q7Z5L3.
    SMRi Q7Z5L3. Positions 119-287.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 296434414.

    Proteomic databases

    PaxDbi Q7Z5L3.
    PRIDEi Q7Z5L3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272520 ; ENSP00000272520 ; ENSG00000144119 .
    GeneIDi 165257.
    KEGGi hsa:165257.
    UCSCi uc002tlo.2. human.

    Organism-specific databases

    CTDi 165257.
    GeneCardsi GC02M119914.
    HGNCi HGNC:24181. C1QL2.
    HPAi HPA057934.
    MIMi 614330. gene.
    neXtProti NX_Q7Z5L3.
    PharmGKBi PA134915960.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87981.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi Q7Z5L3.
    OMAi ICDPYTA.
    OrthoDBi EOG757CZJ.
    PhylomeDBi Q7Z5L3.
    TreeFami TF329591.

    Miscellaneous databases

    GenomeRNAii 165257.
    NextBioi 88536.
    PROi Q7Z5L3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7Z5L3.
    CleanExi HS_C1QL2.
    Genevestigatori Q7Z5L3.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ding P., Han W., Wang Y., Rui M., Song Q., Zhang Y., Ma D.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiC1QL2_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z5L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3