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Protein

Complement C1q-like protein 2

Gene

C1QL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q-like protein 2
Alternative name(s):
C1q and tumor necrosis factor-related protein 10
Short name:
C1q/TNF-related protein 10
Gene namesi
Name:C1QL2
Synonyms:CTRP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144119.3.
HGNCiHGNC:24181. C1QL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144119.
PharmGKBiPA134915960.

Polymorphism and mutation databases

BioMutaiC1QL2.
DMDMi296434414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000027433522 – 287Complement C1q-like protein 2Add BLAST266

Proteomic databases

PaxDbiQ7Z5L3.
PeptideAtlasiQ7Z5L3.
PRIDEiQ7Z5L3.

Expressioni

Gene expression databases

BgeeiENSG00000144119.
CleanExiHS_C1QL2.

Organism-specific databases

HPAiHPA057934.

Interactioni

Subunit structurei

Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with ADGRB3. May interact with ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ7Z5L3.
SMRiQ7Z5L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 118Collagen-likeAdd BLAST43
Domaini154 – 287C1qPROSITE-ProRule annotationAdd BLAST134

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKWQ. Eukaryota.
ENOG410YP3F. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ7Z5L3.
OMAiMICDPYS.
OrthoDBiEOG091G0UOF.
PhylomeDBiQ7Z5L3.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z5L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ
60 70 80 90 100
PPGPSTAALE VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG
110 120 130 140 150
PRGPPGEKGD SGRPGLPGLQ LTAGTASGVG VVGGGAGVGG DSEGEVTSAL
160 170 180 190 200
SATFSGPKIA FYVGLKSPHE GYEVLKFDDV VTNLGNHYDP TTGKFSCQVR
210 220 230 240 250
GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ NYDYASNSVV
260 270 280
LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD
Length:287
Mass (Da):29,468
Last modified:May 18, 2010 - v2
Checksum:iF9F08EBF68F3C460
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 34CD → WE in AAP80787 (Ref. 1) Curated2
Sequence conflicti50 – 51QP → HN in AAP80787 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525315 mRNA. Translation: AAP80787.1.
AC016673 Genomic DNA. No translation available.
CCDSiCCDS42737.1.
RefSeqiNP_872334.2. NM_182528.3.
UniGeneiHs.433493.

Genome annotation databases

EnsembliENST00000272520; ENSP00000272520; ENSG00000144119.
GeneIDi165257.
KEGGihsa:165257.
UCSCiuc002tlo.3. human.

Similar proteinsi

Entry informationi

Entry nameiC1QL2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot