Q7Z5L2 (GIDRP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Growth inhibition and differentiation-related protein 88

Alternative name(s):
Putative mitochondrial space protein 32.1

Gene names

Name:	GIDRP88
Synonyms:	C10orf28

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	792 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in placenta.
Sequence caution	The sequence AAC05748.1 differs from that shown. Reason: Frameshift at position 304. The sequence BAC04364.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z5L2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z5L2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     595-608: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q7Z5L2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-608: Missing.
     609-609: E → M

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 792	792	Growth inhibition and differentiation-related protein 88		PRO_0000087487
Natural variations
	Alternative sequence	1 – 608	608	Missing in isoform 3.		VSP_014919
	Alternative sequence	595 – 608	14	Missing in isoform 2.		VSP_014920
	Alternative sequence	609	1	E → M in isoform 3.		VSP_014921
	Natural variant	113	1	S → P. Corresponds to variant rs12775148 [ dbSNP | Ensembl ].		VAR_056898
	Natural variant	238	1	K → N. Corresponds to variant rs7922159 [ dbSNP | Ensembl ].		VAR_056899
	Natural variant	261	1	S → G. Corresponds to variant rs35373035 [ dbSNP | Ensembl ].		VAR_056900
	Natural variant	535	1	D → A. Corresponds to variant rs34494334 [ dbSNP | Ensembl ].		VAR_056901
	Natural variant	546	1	P → S. Corresponds to variant rs35122894 [ dbSNP | Ensembl ].		VAR_061652
	Natural variant	566	1	H → R. Ref.5 Corresponds to variant rs11189513 [ dbSNP | Ensembl ].		VAR_023092
	Natural variant	656	1	H → R. Ref.1 Ref.3 Ref.5 Corresponds to variant rs1952061 [ dbSNP | Ensembl ].		VAR_023093
Experimental info
	Sequence conflict	212	1	K → E in AAP80788. Ref.1
	Sequence conflict	438	1	S → G in AAP80788. Ref.1
	Sequence conflict	609	1	E → K in AAP80788. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 2, 2005. Version 2. Checksum: FE06B6166C856056	FASTA	792	87,884
	10 20 30 40 50 60 MQQESERCRV RARRPDMALY VPKARRGAVL LKTGDEEESC GSPNSVVKEK QKESSLSQKE 70 80 90 100 110 120 VFKDKPEARR LNINPDRKEH NCREEKKSST KLRMDTCLQK TNRVCSKRGT TESKEVLSQG 130 140 150 160 170 180 QQQGAPNAGV ITNAPLQRHF KPKKVECLEV ETTDVTGHER ILLSQACLEI SEAQVPSKPF 190 200 210 220 230 240 QNVEFCDFSR HEPDGEAFED KDLEGRIETD TKVLEILYEF PRVFSSVMKP ENMIVPIKLS 250 260 270 280 290 300 SDSEIVQQSM QTSDGILNPS SGGITTTSVP GSPDGVFDQT CVDFEVESVG GIANSTGFIL 310 320 330 340 350 360 DQKDTDSIPA TMGHISLSES TNDTVSPVMI RECEKNDSTA DELHVKHEPP DTAVLAHETH 370 380 390 400 410 420 RDSGFKNVGD ITNKACMMDT TGMSCSDHVT VDSPYVVAVR IADETSINTR SFSKFVGMSA 430 440 450 460 470 480 DATPLHVARS GNDTEDFSNP SACSDIYGES ISSHFTESTG KLIESLSDCA SSLPIKKIAG 490 500 510 520 530 540 SNYNTFLDSE LSMLNGTKVL SDSAVGIDLG STGDTTEALH ELRTAEEFKT EEQDDSGSIE 550 560 570 580 590 600 FGVSFPDRES SSMETSIEPK ATETSHTEGI TAIEESWESM FNDDGDCLDP RLLQEGILMH 610 620 630 640 650 660 IKPENHCSEL SGNTKSRESI QEPRSDYYNH EVPDIDLSDC EFPHVIEIYD FPQEFHTEDL 670 680 690 700 710 720 LRVFCSYQKK GFDIKWVDDT HALGVFSSPI TARDALGIKH TMVKIRPLSQ ATRAAKAKAR 730 740 750 760 770 780 AYAEFLQPAK ERPETSAALA RRLVISALGV RSKQSKTERE AELKKLQEAR ERKRLEAKQR 790 EDIWEGRDQS TV
	Isoform 2 [UniParc]. Checksum: 589AFE95BF9898DA	FASTA	778	86,294
	10 20 30 40 50 60 MQQESERCRV RARRPDMALY VPKARRGAVL LKTGDEEESC GSPNSVVKEK QKESSLSQKE 70 80 90 100 110 120 VFKDKPEARR LNINPDRKEH NCREEKKSST KLRMDTCLQK TNRVCSKRGT TESKEVLSQG 130 140 150 160 170 180 QQQGAPNAGV ITNAPLQRHF KPKKVECLEV ETTDVTGHER ILLSQACLEI SEAQVPSKPF 190 200 210 220 230 240 QNVEFCDFSR HEPDGEAFED KDLEGRIETD TKVLEILYEF PRVFSSVMKP ENMIVPIKLS 250 260 270 280 290 300 SDSEIVQQSM QTSDGILNPS SGGITTTSVP GSPDGVFDQT CVDFEVESVG GIANSTGFIL 310 320 330 340 350 360 DQKDTDSIPA TMGHISLSES TNDTVSPVMI RECEKNDSTA DELHVKHEPP DTAVLAHETH 370 380 390 400 410 420 RDSGFKNVGD ITNKACMMDT TGMSCSDHVT VDSPYVVAVR IADETSINTR SFSKFVGMSA 430 440 450 460 470 480 DATPLHVARS GNDTEDFSNP SACSDIYGES ISSHFTESTG KLIESLSDCA SSLPIKKIAG 490 500 510 520 530 540 SNYNTFLDSE LSMLNGTKVL SDSAVGIDLG STGDTTEALH ELRTAEEFKT EEQDDSGSIE 550 560 570 580 590 600 FGVSFPDRES SSMETSIEPK ATETSHTEGI TAIEESWESM FNDDGDCLDP RLLQELSGNT 610 620 630 640 650 660 KSRESIQEPR SDYYNHEVPD IDLSDCEFPH VIEIYDFPQE FHTEDLLRVF CSYQKKGFDI 670 680 690 700 710 720 KWVDDTHALG VFSSPITARD ALGIKHTMVK IRPLSQATRA AKAKARAYAE FLQPAKERPE 730 740 750 760 770 TSAALARRLV ISALGVRSKQ SKTEREAELK KLQEARERKR LEAKQREDIW EGRDQSTV
	Isoform 3 [UniParc]. Checksum: CB2D2DB4C017E016	FASTA	184	21,191
	10 20 30 40 50 60 MLSGNTKSRE SIQEPRSDYY NHEVPDIDLS DCEFPHVIEI YDFPQEFHTE DLLRVFCSYQ 70 80 90 100 110 120 KKGFDIKWVD DTHALGVFSS PITARDALGI KHTMVKIRPL SQATRAAKAK ARAYAEFLQP 130 140 150 160 170 180 AKERPETSAA LARRLVISAL GVRSKQSKTE REAELKKLQE ARERKRLEAK QREDIWEGRD QSTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel gene GIDRP88, encoding a growth inhibition and differentiation related protein." Yan J., Zhang J., Peng X., Luo D., Deng Y., Bao L., Liu Z., Li B., Gao X. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-656.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT ARG-656. Tissue: Ovary.
[4]	"The development of a genetic profile of placental gene expression during the first trimester of pregnancy: a potential tool for identifying novel secreted markers." Page N.M., Butlin D.J., Manyonda I., Lowry P.J. Fetal Diagn. Ther. 15:237-245(2000) [PubMed: 10867487] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-362 (ISOFORM 1). Tissue: Placenta.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-792 (ISOFORM 2), VARIANTS ARG-566 AND ARG-656. Tissue: Cerebellum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF525304 mRNA. Translation: AAP80788.1. AL139241 Genomic DNA. Translation: CAH72818.1. AL139241, AL355301 Genomic DNA. Translation: CAH72820.1. AL355301, AL139241 Genomic DNA. Translation: CAI16099.1. BC047908 mRNA. Translation: AAH47908.1. AF050198 mRNA. Translation: AAC05748.1. Frameshift. AK094479 mRNA. Translation: BAC04364.1. Different initiation.
IPI	IPI00376196. IPI00384840. IPI01010355.
UniGene	Hs.419800.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7Z5L2.
PTM databases
PhosphoSite	Q7Z5L2.
Polymorphism databases
DMDM	71648680.
Proteomic databases
PRIDE	Q7Z5L2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314594; ENSP00000314018; ENSG00000166024.
UCSC	uc001kow.2. human. uc001kox.2. human. uc009xvy.1. human.
Organism-specific databases
GeneCards	GC10P099905.
H-InvDB	HIX0009103.
HGNC	HGNC:23512. C10orf28.
HPA	HPA037367.
neXtProt	NX_Q7Z5L2.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15673.
GeneTree	ENSGT00530000063711.
HOGENOM	HBG125793.
HOVERGEN	HBG057491.
InParanoid	Q7Z5L2.
Gene expression databases
ArrayExpress	Q7Z5L2.
Bgee	Q7Z5L2.
CleanEx	HS_C10orf28.
Genevestigator	Q7Z5L2.
GermOnline	ENSG00000166024. Homo sapiens.
Family and domain databases
InterPro	IPR012677. Nucleotide-bd_a/b_plait. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GIDRP_HUMAN

Accession

Primary (citable) accession number: Q7Z5L2
Secondary accession number(s): O60598 , Q5W0B4, Q5W0B5, Q86VT9, Q8N9H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.