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Protein

Vitelline membrane outer layer protein 1 homolog

Gene

VMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Vitelline membrane outer layer protein 1 homolog
Gene namesi
Name:VMO1
ORF Names:UNQ6350/PRO21055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30387. VMO1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670619.

Polymorphism and mutation databases

BioMutaiVMO1.
DMDMi60390935.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 202178Vitelline membrane outer layer protein 1 homologPRO_0000036407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 86By similarity
Disulfide bondi114 ↔ 146By similarity
Disulfide bondi169 ↔ 199By similarity
Disulfide bondi174 ↔ 200By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z5L0.
PRIDEiQ7Z5L0.

Expressioni

Gene expression databases

BgeeiQ7Z5L0.
CleanExiHS_VMO1.
GenevisibleiQ7Z5L0. HS.

Organism-specific databases

HPAiHPA023038.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328397.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5L0.
SMRiQ7Z5L0. Positions 32-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMO1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ9K. Eukaryota.
ENOG4111VSS. LUCA.
GeneTreeiENSGT00390000009313.
HOGENOMiHOG000234360.
HOVERGENiHBG017336.
InParanoidiQ7Z5L0.
OMAiRFRCSDG.
OrthoDBiEOG73FQP2.
PhylomeDBiQ7Z5L0.
TreeFamiTF315374.

Family and domain databases

Gene3Di2.100.10.20. 1 hit.
InterProiIPR005515. VOMI.
[Graphical view]
PANTHERiPTHR18841. PTHR18841. 1 hit.
PfamiPF03762. VOMI. 1 hit.
[Graphical view]
SUPFAMiSSF51092. SSF51092. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5L0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERGAGAKLL PLLLLLRATG FTCAQTDGRN GYTAVIEVTS GGPWGDWAWP
60 70 80 90 100
EMCPDGFFAS GFSLKVEPPQ GIPGDDTALN GIRLHCARGN VLGNTHVVES
110 120 130 140 150
QSGSWGEWSE PLWCRGGAYL VAFSLRVEAP TTLGDNTAAN NVRFRCSDGE
160 170 180 190 200
ELQGPGLSWG DFGDWSDHCP KGACGLQTKI QGPRGLGDDT ALNDARLFCC

RS
Length:202
Mass (Da):21,534
Last modified:October 1, 2003 - v1
Checksum:i5C62A561693EE086
GO
Isoform 2 (identifier: Q7Z5L0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-70: VEPPQ → LGRME
     71-202: Missing.

Note: No experimental confirmation available.
Show »
Length:70
Mass (Da):7,524
Checksum:i0EBAE8707DAF06E4
GO
Isoform 3 (identifier: Q7Z5L0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-202: VESQSGSWGE...NDARLFCCRS → LGRME

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):10,827
Checksum:iC22AA2DCD011487A
GO
Isoform 4 (identifier: Q7Z5L0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-202: SWGEWSEPLW...NDARLFCCRS → RWGAGVEDPLG

Note: No experimental confirmation available.
Show »
Length:114
Mass (Da):11,966
Checksum:i871095AA868FA8FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261T → A.2 Publications
Corresponds to variant rs4790706 [ dbSNP | Ensembl ].
VAR_053736
Natural varianti77 – 771T → S.
Corresponds to variant rs2279961 [ dbSNP | Ensembl ].
VAR_034584

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei66 – 705VEPPQ → LGRME in isoform 2. 1 PublicationVSP_045706
Alternative sequencei71 – 202132Missing in isoform 2. 1 PublicationVSP_045707Add
BLAST
Alternative sequencei98 – 202105VESQS…FCCRS → LGRME in isoform 3. 1 PublicationVSP_045708Add
BLAST
Alternative sequencei104 – 20299SWGEW…FCCRS → RWGAGVEDPLG in isoform 4. 1 PublicationVSP_047219Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521892 mRNA. Translation: AAP80865.1.
BE669879 mRNA. No translation available.
AY359099 mRNA. Translation: AAQ89457.1.
CD367473 Genomic DNA. No translation available.
AC233723 Genomic DNA. No translation available.
BC038467 mRNA. Translation: AAH38467.1.
BC104195 mRNA. Translation: AAI04196.1.
CCDSiCCDS11055.1. [Q7Z5L0-1]
CCDS45585.1. [Q7Z5L0-2]
CCDS45586.1. [Q7Z5L0-3]
CCDS45587.1. [Q7Z5L0-4]
RefSeqiNP_001138411.1. NM_001144939.1. [Q7Z5L0-4]
NP_001138412.1. NM_001144940.1. [Q7Z5L0-3]
NP_001138413.1. NM_001144941.1. [Q7Z5L0-2]
NP_872372.1. NM_182566.2. [Q7Z5L0-1]
UniGeneiHs.122561.

Genome annotation databases

EnsembliENST00000328739; ENSP00000328397; ENSG00000182853. [Q7Z5L0-1]
ENST00000354194; ENSP00000346133; ENSG00000182853. [Q7Z5L0-2]
ENST00000416307; ENSP00000390450; ENSG00000182853. [Q7Z5L0-3]
ENST00000441199; ENSP00000408166; ENSG00000182853. [Q7Z5L0-4]
GeneIDi284013.
KEGGihsa:284013.
UCSCiuc002fyx.4. human. [Q7Z5L0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521892 mRNA. Translation: AAP80865.1.
BE669879 mRNA. No translation available.
AY359099 mRNA. Translation: AAQ89457.1.
CD367473 Genomic DNA. No translation available.
AC233723 Genomic DNA. No translation available.
BC038467 mRNA. Translation: AAH38467.1.
BC104195 mRNA. Translation: AAI04196.1.
CCDSiCCDS11055.1. [Q7Z5L0-1]
CCDS45585.1. [Q7Z5L0-2]
CCDS45586.1. [Q7Z5L0-3]
CCDS45587.1. [Q7Z5L0-4]
RefSeqiNP_001138411.1. NM_001144939.1. [Q7Z5L0-4]
NP_001138412.1. NM_001144940.1. [Q7Z5L0-3]
NP_001138413.1. NM_001144941.1. [Q7Z5L0-2]
NP_872372.1. NM_182566.2. [Q7Z5L0-1]
UniGeneiHs.122561.

3D structure databases

ProteinModelPortaliQ7Z5L0.
SMRiQ7Z5L0. Positions 32-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328397.

Polymorphism and mutation databases

BioMutaiVMO1.
DMDMi60390935.

Proteomic databases

PaxDbiQ7Z5L0.
PRIDEiQ7Z5L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328739; ENSP00000328397; ENSG00000182853. [Q7Z5L0-1]
ENST00000354194; ENSP00000346133; ENSG00000182853. [Q7Z5L0-2]
ENST00000416307; ENSP00000390450; ENSG00000182853. [Q7Z5L0-3]
ENST00000441199; ENSP00000408166; ENSG00000182853. [Q7Z5L0-4]
GeneIDi284013.
KEGGihsa:284013.
UCSCiuc002fyx.4. human. [Q7Z5L0-1]

Organism-specific databases

CTDi284013.
GeneCardsiVMO1.
HGNCiHGNC:30387. VMO1.
HPAiHPA023038.
neXtProtiNX_Q7Z5L0.
PharmGKBiPA142670619.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ9K. Eukaryota.
ENOG4111VSS. LUCA.
GeneTreeiENSGT00390000009313.
HOGENOMiHOG000234360.
HOVERGENiHBG017336.
InParanoidiQ7Z5L0.
OMAiRFRCSDG.
OrthoDBiEOG73FQP2.
PhylomeDBiQ7Z5L0.
TreeFamiTF315374.

Miscellaneous databases

GenomeRNAii284013.
PROiQ7Z5L0.

Gene expression databases

BgeeiQ7Z5L0.
CleanExiHS_VMO1.
GenevisibleiQ7Z5L0. HS.

Family and domain databases

Gene3Di2.100.10.20. 1 hit.
InterProiIPR005515. VOMI.
[Graphical view]
PANTHERiPTHR18841. PTHR18841. 1 hit.
PfamiPF03762. VOMI. 1 hit.
[Graphical view]
SUPFAMiSSF51092. SSF51092. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ding P., Han W., Ying W., Liu Y., Wang L., Qiu X., Ma D.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-26.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Alveolar macrophage.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-26.
    Tissue: Pancreas.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.

Entry informationi

Entry nameiVMO1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5L0
Secondary accession number(s): C9JQ15
, E9PAU9, E9PGP4, Q3SXP1, Q8IUY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.