Q7Z5L0 (VMO1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vitelline membrane outer layer protein 1 homolog

Gene names

Name:	VMO1
ORF Names:	UNQ6350/PRO21055

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the VMO1 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	vitelline membrane formation Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.4
	Chain	25 – 202	178	Vitelline membrane outer layer protein 1 homolog		PRO_0000036407
Amino acid modifications
	Disulfide bond	53 ↔ 86		By similarity
	Disulfide bond	114 ↔ 146		By similarity
	Disulfide bond	169 ↔ 199		By similarity
	Disulfide bond	174 ↔ 200		By similarity
Natural variations
	Natural variant	26	1	T → A. Corresponds to variant rs4790706 [ dbSNP | Ensembl ].		VAR_053736
	Natural variant	77	1	T → S. Corresponds to variant rs2279961 [ dbSNP | Ensembl ].		VAR_034584

Sequences

	Sequence		Length	Mass (Da)
	Q7Z5L0 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 5C62A561693EE086	FASTA	202	21,534
	10 20 30 40 50 60 MERGAGAKLL PLLLLLRATG FTCAQTDGRN GYTAVIEVTS GGPWGDWAWP EMCPDGFFAS 70 80 90 100 110 120 GFSLKVEPPQ GIPGDDTALN GIRLHCARGN VLGNTHVVES QSGSWGEWSE PLWCRGGAYL 130 140 150 160 170 180 VAFSLRVEAP TTLGDNTAAN NVRFRCSDGE ELQGPGLSWG DFGDWSDHCP KGACGLQTKI 190 200 QGPRGLGDDT ALNDARLFCC RS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ding P., Han W., Ying W., Liu Y., Wang L., Qiu X., Ma D. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF521892 mRNA. Translation: AAP80865.1. AY359099 mRNA. Translation: AAQ89457.1. BC104195 mRNA. Translation: AAI04196.1.
IPI	IPI00216914.
RefSeq	NP_001138412.1. NM_001144940.1. NP_872372.1. NM_182566.2.
UniGene	Hs.122561.
3D structure databases
ProteinModelPortal	Q7Z5L0.
SMR	Q7Z5L0. Positions 30-201.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7Z5L0.
Polymorphism databases
DMDM	60390935.
Proteomic databases
PRIDE	Q7Z5L0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328739; ENSP00000328397; ENSG00000182853.
GeneID	284013.
KEGG	hsa:284013.
UCSC	uc002fyx.1. human.
Organism-specific databases
CTD	284013.
GeneCards	GC17M004688.
H-InvDB	HIX0027329.
HGNC	HGNC:30387. VMO1.
HPA	HPA023038.
neXtProt	NX_Q7Z5L0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19073.
GeneTree	ENSGT00390000009313.
HOGENOM	HBG716604.
HOVERGEN	HBG017336.
InParanoid	Q7Z5L0.
OMA	WSEPLWC.
OrthoDB	EOG4T1HNP.
PhylomeDB	Q7Z5L0.
Gene expression databases
ArrayExpress	Q7Z5L0.
Bgee	Q7Z5L0.
CleanEx	HS_VMO1.
Genevestigator	Q7Z5L0.
GermOnline	ENSG00000182853. Homo sapiens.
Family and domain databases
InterPro	IPR005515. VOMI. [Graphical view]
Gene3D	G3DSA:2.100.10.20. VOMI. 1 hit.
PANTHER	PTHR18841. VOMI. 1 hit.
Pfam	PF03762. VOMI. 1 hit. [Graphical view]
SUPFAM	SSF51092. VOMI. 1 hit.
ProtoNet	Search...
Other
NextBio	94447.

Entry information

Entry name

VMO1_HUMAN

Accession

Primary (citable) accession number: Q7Z5L0
Secondary accession number(s): Q3SXP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.