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Q7Z5J4

- RAI1_HUMAN

UniProt

Q7Z5J4 - RAI1_HUMAN

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Protein

Retinoic acid-induced protein 1

Gene

RAI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1856 – 190348PHD-typeAdd
BLAST

GO - Molecular functioni

  1. enhancer binding Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. circadian regulation of gene expression Source: UniProtKB
  2. negative regulation of multicellular organism growth Source: Ensembl
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid-induced protein 1
Gene namesi
Name:RAI1
Synonyms:KIAA1820
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:9834. RAI1.

Subcellular locationi

Cytoplasm. Nucleus
Note: In neurons, localized to neurites.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Smith-Magenis syndrome (SMS) [MIM:182290]: Characterized by congenital mental retardation associated with development and growth delays. Affected persons have characteristic behavioral abnormalities, including self-injurious behaviors and sleep disturbance, and distinct craniofacial and skeletal anomalies.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi182290. phenotype.
Orphaneti1713. 17p11.2 microduplication syndrome.
819. Smith-Magenis syndrome.
PharmGKBiPA34188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19061906Retinoic acid-induced protein 1PRO_0000097159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei568 – 5681Phosphoserine1 Publication
Modified residuei683 – 6831Phosphoserine3 Publications
Modified residuei696 – 6961Phosphothreonine1 Publication
Modified residuei880 – 8801Phosphoserine1 Publication
Modified residuei892 – 8921Phosphoserine1 Publication
Modified residuei1064 – 10641Phosphoserine1 Publication
Modified residuei1068 – 10681Phosphothreonine1 Publication
Modified residuei1122 – 11221Phosphoserine1 Publication
Modified residuei1352 – 13521Phosphoserine2 Publications
Modified residuei1358 – 13581Phosphoserine2 Publications
Modified residuei1374 – 13741Phosphoserine3 Publications
Modified residuei1431 – 14311Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z5J4.
PaxDbiQ7Z5J4.
PRIDEiQ7Z5J4.

PTM databases

PhosphoSiteiQ7Z5J4.

Expressioni

Tissue specificityi

Expressed in all tissues examined with higher expression in the heart and brain. No expression was seen in the corpus callosum of the brain.1 Publication

Gene expression databases

BgeeiQ7Z5J4.
CleanExiHS_RAI1.
ExpressionAtlasiQ7Z5J4. baseline and differential.
GenevestigatoriQ7Z5J4.

Organism-specific databases

HPAiHPA023898.
HPA054906.

Interactioni

Protein-protein interaction databases

BioGridi115966. 21 interactions.
IntActiQ7Z5J4. 10 interactions.
MINTiMINT-1477867.
STRINGi9606.ENSP00000323074.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1160 – 117718Nuclear localization signalSequence AnalysisAdd
BLAST
Motifi1223 – 124018Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi124 – 13512Poly-ProAdd
BLAST
Compositional biasi156 – 336181Gln-richAdd
BLAST
Compositional biasi278 – 29114Poly-GlnAdd
BLAST
Compositional biasi1243 – 12497Poly-Ser
Compositional biasi1493 – 14964Poly-Gly
Compositional biasi1628 – 164114Ser-richAdd
BLAST
Compositional biasi1746 – 17516Poly-Ala

Sequence similaritiesi

Contains 1 PHD-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1856 – 190348PHD-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG146768.
GeneTreeiENSGT00530000063684.
HOVERGENiHBG056862.
InParanoidiQ7Z5J4.
OMAiPRMCTRS.
OrthoDBiEOG7G4QDB.
PhylomeDBiQ7Z5J4.
TreeFamiTF331317.

Family and domain databases

InterProiIPR001965. Znf_PHD.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z5J4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQSFRERCGF HGKQQNYQQT SQETSRLENY RQPSQAGLSC DRQRLLAKDY
60 70 80 90 100
YNPQPYPSYE GGAGTPSGTA AAVAADKYHR GSKALPTQQG LQGRPAFPGY
110 120 130 140 150
GVQDSSPYPG RYAGEESLQA WGAPQPPPPQ PQPLPAGVAK YDENLMKKTA
160 170 180 190 200
VPPSRQYAEQ GAQVPFRTHS LHVQQPPPPQ QPLAYPKLQR QKLQNDIASP
210 220 230 240 250
LPFPQGTHFP QHSQSFPTSS TYSSSVQGGG QGAHSYKSCT APTAQPHDRP
260 270 280 290 300
LTASSSLAPG QRVQNLHAYQ SGRLSYDQQQ QQQQQQQQQQ QALQSRHHAQ
310 320 330 340 350
ETLHYQNLAK YQHYGQQGQG YCQPDAAVRT PEQYYQTFSP SSSHSPARSV
360 370 380 390 400
GRSPSYSSTP SPLMPNLENF PYSQQPLSTG AFPAGITDHS HFMPLLNPSP
410 420 430 440 450
TDATSSVDTQ AGNCKPLQKD KLPENLLSDL SLQSLTALTS QVENISNTVQ
460 470 480 490 500
QLLLSKAAVP QKKGVKNLVS RTPEQHKSQH CSPEGSGYSA EPAGTPLSEP
510 520 530 540 550
PSSTPQSTHA EPQEADYLSG SEDPLERSFL YCNQARGSPA RVNSNSKAKP
560 570 580 590 600
ESVSTCSVTS PDDMSTKSDD SFQSLHGSLP LDSFSKFVAG ERDCPRLLLS
610 620 630 640 650
ALAQEDLASE ILGLQEAIGE KADKAWAEAP SLVKDSSKPP FSLENHSACL
660 670 680 690 700
DSVAKSAWPR PGEPEALPDS LQLDKGGNAK DFSPGLFEDP SVAFATPDPK
710 720 730 740 750
KTTGPLSFGT KPTLGVPAPD PTTAAFDCFP DTTAASSADS ANPFAWPEEN
760 770 780 790 800
LGDACPRWGL HPGELTKGLE QGGKASDGIS KGDTHEASAC LGFQEEDPPG
810 820 830 840 850
EKVASLPGDF KQEEVGGVKE EAGGLLQCPE VAKADRWLED SRHCCSTADF
860 870 880 890 900
GDLPLLPPTS RKEDLEAEEE YSSLCELLGS PEQRPGMQDP LSPKAPLICT
910 920 930 940 950
KEEVEEVLDS KAGWGSPCHL SGESVILLGP TVGTESKVQS WFESSLSHMK
960 970 980 990 1000
PGEEGPDGER APGDSTTSDA SLAQKPNKPA VPEAPIAKKE PVPRGKSLRS
1010 1020 1030 1040 1050
RRVHRGLPEA EDSPCRAPVL PKDLLLPESC TGPPQGQMEG AGAPGRGASE
1060 1070 1080 1090 1100
GLPRMCTRSL TALSEPRTPG PPGLTTTPAP PDKLGGKQRA AFKSGKRVGK
1110 1120 1130 1140 1150
PSPKAASSPS NPAALPVASD SSPMGSKTKE TDSPSTPGKD QRSMILRSRT
1160 1170 1180 1190 1200
KTQEIFHSKR RRPSEGRLPN CRATKKLLDN SHLPATFKVS SSPQKEGRVS
1210 1220 1230 1240 1250
QRARVPKPGA GSKLSDRPLH ALKRKSAFMA PVPTKKRNLV LRSRSSSSSN
1260 1270 1280 1290 1300
ASGNGGDGKE ERPEGSPTLF KRMSSPKKAK PTKGNGEPAT KLPPPETPDA
1310 1320 1330 1340 1350
CLKLASRAAF QGAMKTKVLP PRKGRGLKLE AIVQKITSPS LKKFACKAPG
1360 1370 1380 1390 1400
ASPGNPLSPS LSDKDRGLKG AGGSPVGVEE GLVNVGTGQK LPTSGADPLC
1410 1420 1430 1440 1450
RNPTNRSLKG KLMNSKKLSS TDCFKTEAFT SPEALQPGGT ALAPKKRSRK
1460 1470 1480 1490 1500
GRAGAHGLSK GPLEKRPYLG PALLLTPRDR ASGTQGASED NSGGGGKKPK
1510 1520 1530 1540 1550
MEELGLASQP PEGRPCQPQT RAQKQPGHTN YSSYSKRKRL TRGRAKNTTS
1560 1570 1580 1590 1600
SPCKGRAKRR RQQQVLPLDP AEPEIRLKYI SSCKRLRSDS RTPAFSPFVR
1610 1620 1630 1640 1650
VEKRDAFTTI CTVVNSPGDA PKPHRKPSSS ASSSSSSSSF SLDAAGASLA
1660 1670 1680 1690 1700
TLPGGSILQP RPSLPLSSTM HLGPVVSKAL STSCLVCCLC QNPANFKDLG
1710 1720 1730 1740 1750
DLCGPYYPEH CLPKKKPKLK EKVRPEGTCE EASLPLERTL KGPECAAAAT
1760 1770 1780 1790 1800
AGKPPRPDGP ADPAKQGPLR TSARGLSRRL QSCYCCDGRE DGGEEAAPAD
1810 1820 1830 1840 1850
KGRKHECSKE APAEPGGEAQ EHWVHEACAV WTGGVYLVAG KLFGLQEAMK
1860 1870 1880 1890 1900
VAVDMMCSSC QEAGATIGCC HKGCLHTYHY PCASDAGCIF IEENFSLKCP

KHKRLP
Length:1,906
Mass (Da):203,352
Last modified:July 19, 2004 - v2
Checksum:i8D33A56C33BFE888
GO
Isoform 2 (identifier: Q7Z5J4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-233: THFPQHSQSFPTSSTYSSSVQGGGQGA → WWAGG
     407-434: VDTQAGNCKPLQKDKLPENLLSDLSLQS → PAD
     1415-1479: Missing.
     1803-1821: Missing.
     1856-1906: MCSSCQEAGA...LKCPKHKRLP → HGGTVALAPG...LCWAMPGTWK

Show »
Length:1,862
Mass (Da):198,392
Checksum:i9C4D9E4EF917A911
GO
Isoform 3 (identifier: Q7Z5J4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1598-1640: FVRVEKRDAF...ASSSSSSSSF → LEPSLGAQNP...AYSAREQGQR
     1641-1906: Missing.

Note: No experimental confirmation available.

Show »
Length:1,640
Mass (Da):175,343
Checksum:iA178ECCDECEDA431
GO
Isoform 4 (identifier: Q7Z5J4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     947-966: SHMKPGEEGPDGERAPGDST → YSVYICIHIHIYNIYEDCKC
     967-1906: Missing.

Note: No experimental confirmation available.

Show »
Length:966
Mass (Da):104,319
Checksum:iEBD2A4453EADBA58
GO

Sequence cautioni

The sequence BAB47449.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti440 – 4401S → L in AAO31738. (PubMed:12837267)Curated
Sequence conflicti1302 – 13021L → F in AAO31738. (PubMed:12837267)Curated
Sequence conflicti1513 – 15131G → A in AAO31738. (PubMed:12837267)Curated
Sequence conflicti1682 – 16821T → A in CAD39144. (PubMed:17974005)Curated

Polymorphismi

The poly-Gln tract is polymorphic and the number of Gln varies from 12 to 14. The size of the poly-Gln region may influence the age at onset of spinocerebellar ataxia type 2 (SCA2).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901G → A.
Corresponds to variant rs3803763 [ dbSNP | Ensembl ].
VAR_051300
Natural varianti165 – 1651P → T.
Corresponds to variant rs11649804 [ dbSNP | Ensembl ].
VAR_024344
Natural varianti939 – 9391Q → P.
Corresponds to variant rs1759075 [ dbSNP | Ensembl ].
VAR_051301

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei207 – 23327THFPQ…GGQGA → WWAGG in isoform 2. 1 PublicationVSP_010995Add
BLAST
Alternative sequencei407 – 43428VDTQA…LSLQS → PAD in isoform 2. 1 PublicationVSP_010996Add
BLAST
Alternative sequencei947 – 96620SHMKP…PGDST → YSVYICIHIHIYNIYEDCKC in isoform 4. 1 PublicationVSP_010997Add
BLAST
Alternative sequencei967 – 1906940Missing in isoform 4. 1 PublicationVSP_010998Add
BLAST
Alternative sequencei1415 – 147965Missing in isoform 2. 1 PublicationVSP_010999Add
BLAST
Alternative sequencei1598 – 164043FVRVE…SSSSF → LEPSLGAQNPRSGQNAPPAP ADARPLCTTRDRRAYSAREQ GQR in isoform 3. 1 PublicationVSP_011000Add
BLAST
Alternative sequencei1641 – 1906266Missing in isoform 3. 1 PublicationVSP_011001Add
BLAST
Alternative sequencei1803 – 182119Missing in isoform 2. 1 PublicationVSP_011002Add
BLAST
Alternative sequencei1856 – 190651MCSSC…HKRLP → HGGTVALAPGDFSLPGLRFA SLFQGPSWCDCPVLATSTPS SWSRCVPAAKKPGPPLGAAT KDASTPTTTRVPAMQVRARP GTGGHWSPSKQSRGTLPGHS SPNPGPISLFSFPPLLPQQF FYPSVCLDLCWAMPGTWK in isoform 2. 1 PublicationVSP_011003Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271790 mRNA. Translation: CAC20423.1.
AJ271791 Genomic DNA. Translation: CAC20424.1.
AY172136 mRNA. Translation: AAO31738.1.
AB058723 mRNA. Translation: BAB47449.1. Different initiation.
BC021209 mRNA. Translation: AAH21209.1.
AL133649 mRNA. Translation: CAB63768.1.
AL834468 mRNA. Translation: CAD39127.1.
AL834486 mRNA. Translation: CAD39144.1.
CCDSiCCDS11188.1. [Q7Z5J4-1]
PIRiT43490.
RefSeqiNP_109590.3. NM_030665.3. [Q7Z5J4-1]
UniGeneiHs.655395.
Hs.727059.

Genome annotation databases

EnsembliENST00000353383; ENSP00000323074; ENSG00000108557. [Q7Z5J4-1]
GeneIDi10743.
KEGGihsa:10743.
UCSCiuc002grm.3. human. [Q7Z5J4-1]

Polymorphism databases

DMDMi50400978.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, Triplet repeat expansion

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271790 mRNA. Translation: CAC20423.1 .
AJ271791 Genomic DNA. Translation: CAC20424.1 .
AY172136 mRNA. Translation: AAO31738.1 .
AB058723 mRNA. Translation: BAB47449.1 . Different initiation.
BC021209 mRNA. Translation: AAH21209.1 .
AL133649 mRNA. Translation: CAB63768.1 .
AL834468 mRNA. Translation: CAD39127.1 .
AL834486 mRNA. Translation: CAD39144.1 .
CCDSi CCDS11188.1. [Q7Z5J4-1 ]
PIRi T43490.
RefSeqi NP_109590.3. NM_030665.3. [Q7Z5J4-1 ]
UniGenei Hs.655395.
Hs.727059.

3D structure databases

ProteinModelPortali Q7Z5J4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115966. 21 interactions.
IntActi Q7Z5J4. 10 interactions.
MINTi MINT-1477867.
STRINGi 9606.ENSP00000323074.

PTM databases

PhosphoSitei Q7Z5J4.

Polymorphism databases

DMDMi 50400978.

Proteomic databases

MaxQBi Q7Z5J4.
PaxDbi Q7Z5J4.
PRIDEi Q7Z5J4.

Protocols and materials databases

DNASUi 10743.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000353383 ; ENSP00000323074 ; ENSG00000108557 . [Q7Z5J4-1 ]
GeneIDi 10743.
KEGGi hsa:10743.
UCSCi uc002grm.3. human. [Q7Z5J4-1 ]

Organism-specific databases

CTDi 10743.
GeneCardsi GC17P017525.
GeneReviewsi RAI1.
H-InvDB HIX0013588.
HGNCi HGNC:9834. RAI1.
HPAi HPA023898.
HPA054906.
MIMi 182290. phenotype.
607642. gene.
neXtProti NX_Q7Z5J4.
Orphaneti 1713. 17p11.2 microduplication syndrome.
819. Smith-Magenis syndrome.
PharmGKBi PA34188.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146768.
GeneTreei ENSGT00530000063684.
HOVERGENi HBG056862.
InParanoidi Q7Z5J4.
OMAi PRMCTRS.
OrthoDBi EOG7G4QDB.
PhylomeDBi Q7Z5J4.
TreeFami TF331317.

Miscellaneous databases

ChiTaRSi RAI1. human.
GenomeRNAii 10743.
NextBioi 40793.
PROi Q7Z5J4.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z5J4.
CleanExi HS_RAI1.
ExpressionAtlasi Q7Z5J4. baseline and differential.
Genevestigatori Q7Z5J4.

Family and domain databases

InterProi IPR001965. Znf_PHD.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RAI1 is a novel polyglutamine encoding gene that is deleted in Smith-Magenis syndrome patients."
    Seranski P., Hoff C., Radelof U., Henning S., Reinhard R., Schwartz C.E., Heiss N., Poustka A.
    Gene 270:69-76(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), POLYMORPHISM OF POLY-GLN REGION, INVOLVEMENT IN SMITH-MAGENIS SYNDROME.
  2. "Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia."
    Toulouse A., Rochefort D., Roussel J., Joober R., Rouleau G.A.
    Genomics 82:162-171(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Muscle.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 622-1906.
    Tissue: Melanoma and Testis.
  6. "Mutations in RAI1 associated with Smith-Magenis syndrome."
    Slager R.E., Newton T.L., Vlangos C.N., Finucane B., Elsea S.H.
    Nat. Genet. 33:466-468(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SMITH-MAGENIS SYNDROME.
  7. "CAG repeat length in RAI1 is associated with age at onset variability in spinocerebellar ataxia type 2 (SCA2)."
    Hayes S., Turecki G., Brisebois K., Lopes-Cendes I., Gaspar C., Riess O., Ranum L.P., Pulst S.M., Rouleau G.A.
    Hum. Mol. Genet. 9:1753-1758(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE OF THE POLY-GLN REGION IN SPINOCEREBELLAR ATAXIA TYPE 2.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683; THR-696; SER-880; SER-892; SER-1122; SER-1352; SER-1358; SER-1374 AND SER-1431, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683; SER-1064; THR-1068 AND SER-1374, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568; SER-683; SER-1352; SER-1358 AND SER-1374, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity."
    Williams S.R., Zies D., Mullegama S.V., Grotewiel M.S., Elsea S.H.
    Am. J. Hum. Genet. 90:941-949(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRAI1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5J4
Secondary accession number(s): Q8N3B4
, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3