ID   DHI1L_HUMAN             Reviewed;         315 AA.
AC   Q7Z5J1; Q05D45; Q52LF4; Q7Z5I9; Q7Z5J0; Q7Z5P5; Q7Z5P6; Q7Z5P7; Q7Z5P8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 143.
DE   RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein;
DE            EC=1.1.1.-;
DE   AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3;
DE            Short=11-DH3;
DE            Short=11-beta-HSD3;
DE   AltName: Full=Short chain dehydrogenase/reductase family 26C member 2;
DE   AltName: Full=Short-chain dehydrogenase/reductase 10;
DE   Flags: Precursor;
GN   Name=HSD11B1L; Synonyms=HSD3, SCDR10, SDR26C2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7).
RA   Huang C.Q., Wu S.L., Chen Z., Xiao P.J.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 106-315 (ISOFORM 5).
RC   TISSUE=Brain, and Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=8;
CC       Name=1;
CC         IsoId=Q7Z5J1-1; Sequence=Displayed;
CC       Name=2; Synonyms=B;
CC         IsoId=Q7Z5J1-2; Sequence=VSP_030796, VSP_030797;
CC       Name=3; Synonyms=G;
CC         IsoId=Q7Z5J1-3; Sequence=VSP_030793;
CC       Name=4; Synonyms=F;
CC         IsoId=Q7Z5J1-4; Sequence=VSP_030791;
CC       Name=5; Synonyms=C;
CC         IsoId=Q7Z5J1-5; Sequence=VSP_030792, VSP_030796, VSP_030797;
CC       Name=6; Synonyms=A;
CC         IsoId=Q7Z5J1-6; Sequence=VSP_030793, VSP_030796, VSP_030797;
CC       Name=7; Synonyms=D;
CC         IsoId=Q7Z5J1-7; Sequence=VSP_030791, VSP_030796, VSP_030797;
CC       Name=8;
CC         IsoId=Q7Z5J1-8; Sequence=VSP_030794, VSP_030795;
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AY268351; AAP42285.1; -; mRNA.
DR   EMBL; AY268352; AAP42286.1; -; mRNA.
DR   EMBL; AY268353; AAP42287.1; -; mRNA.
DR   EMBL; AY268354; AAP42288.1; -; mRNA.
DR   EMBL; AY313894; AAP83166.1; -; mRNA.
DR   EMBL; AY313895; AAP83167.1; -; mRNA.
DR   EMBL; AY313896; AAP83168.1; -; mRNA.
DR   EMBL; AC011499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471139; EAW69156.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW69157.1; -; Genomic_DNA.
DR   EMBL; BC053546; AAH53546.1; -; mRNA.
DR   EMBL; BC072434; AAH72434.1; -; mRNA.
DR   EMBL; BC093950; AAH93950.1; -; mRNA.
DR   EMBL; BC112187; AAI12188.1; -; mRNA.
DR   EMBL; BC018336; AAH18336.1; -; mRNA.
DR   CCDS; CCDS12144.1; -. [Q7Z5J1-6]
DR   CCDS; CCDS12145.1; -. [Q7Z5J1-2]
DR   CCDS; CCDS12146.1; -. [Q7Z5J1-5]
DR   CCDS; CCDS45931.1; -. [Q7Z5J1-1]
DR   CCDS; CCDS45932.1; -. [Q7Z5J1-4]
DR   CCDS; CCDS58641.1; -. [Q7Z5J1-3]
DR   CCDS; CCDS58642.1; -. [Q7Z5J1-7]
DR   RefSeq; NP_001254798.1; NM_001267869.1. [Q7Z5J1-7]
DR   RefSeq; NP_001254799.1; NM_001267870.1.
DR   RefSeq; NP_001254800.1; NM_001267871.1. [Q7Z5J1-3]
DR   RefSeq; NP_940935.1; NM_198533.2. [Q7Z5J1-1]
DR   RefSeq; NP_941993.1; NM_198704.2. [Q7Z5J1-4]
DR   RefSeq; NP_941994.1; NM_198705.2. [Q7Z5J1-6]
DR   RefSeq; NP_941995.1; NM_198706.2. [Q7Z5J1-2]
DR   RefSeq; NP_941996.1; NM_198707.2. [Q7Z5J1-5]
DR   RefSeq; NP_941997.1; NM_198708.2. [Q7Z5J1-7]
DR   AlphaFoldDB; Q7Z5J1; -.
DR   SMR; Q7Z5J1; -.
DR   BioGRID; 131927; 6.
DR   IntAct; Q7Z5J1; 2.
DR   MINT; Q7Z5J1; -.
DR   STRING; 9606.ENSP00000480443; -.
DR   iPTMnet; Q7Z5J1; -.
DR   PhosphoSitePlus; Q7Z5J1; -.
DR   BioMuta; HSD11B1L; -.
DR   DMDM; 74750135; -.
DR   MassIVE; Q7Z5J1; -.
DR   PaxDb; 9606-ENSP00000480443; -.
DR   PeptideAtlas; Q7Z5J1; -.
DR   Antibodypedia; 64961; 138 antibodies from 19 providers.
DR   DNASU; 374875; -.
DR   Ensembl; ENST00000301382.8; ENSP00000301382.4; ENSG00000167733.14. [Q7Z5J1-6]
DR   Ensembl; ENST00000339423.7; ENSP00000340436.2; ENSG00000167733.14. [Q7Z5J1-2]
DR   Ensembl; ENST00000342970.6; ENSP00000343451.2; ENSG00000167733.14. [Q7Z5J1-5]
DR   Ensembl; ENST00000411793.6; ENSP00000398955.2; ENSG00000167733.14. [Q7Z5J1-4]
DR   Ensembl; ENST00000422535.6; ENSP00000409592.2; ENSG00000167733.14. [Q7Z5J1-8]
DR   Ensembl; ENST00000423665.6; ENSP00000407154.2; ENSG00000167733.14. [Q7Z5J1-1]
DR   Ensembl; ENST00000577917.5; ENSP00000463073.1; ENSG00000167733.14. [Q7Z5J1-3]
DR   Ensembl; ENST00000581521.5; ENSP00000463794.1; ENSG00000167733.14. [Q7Z5J1-2]
DR   Ensembl; ENST00000581773.5; ENSP00000462975.1; ENSG00000167733.14. [Q7Z5J1-2]
DR   Ensembl; ENST00000581893.5; ENSP00000464454.1; ENSG00000167733.14. [Q7Z5J1-7]
DR   Ensembl; ENST00000583928.5; ENSP00000462586.1; ENSG00000167733.14. [Q7Z5J1-7]
DR   GeneID; 374875; -.
DR   KEGG; hsa:374875; -.
DR   MANE-Select; ENST00000339423.7; ENSP00000340436.2; NM_198706.3; NP_941995.1. [Q7Z5J1-2]
DR   UCSC; uc002mcj.6; human. [Q7Z5J1-1]
DR   AGR; HGNC:30419; -.
DR   CTD; 374875; -.
DR   DisGeNET; 374875; -.
DR   GeneCards; HSD11B1L; -.
DR   HGNC; HGNC:30419; HSD11B1L.
DR   HPA; ENSG00000167733; Tissue enriched (brain).
DR   neXtProt; NX_Q7Z5J1; -.
DR   OpenTargets; ENSG00000167733; -.
DR   PharmGKB; PA144596423; -.
DR   VEuPathDB; HostDB:ENSG00000167733; -.
DR   eggNOG; KOG1205; Eukaryota.
DR   GeneTree; ENSGT00940000162487; -.
DR   HOGENOM; CLU_1488559_0_0_1; -.
DR   InParanoid; Q7Z5J1; -.
DR   OMA; EYTRWLM; -.
DR   OrthoDB; 2904540at2759; -.
DR   PhylomeDB; Q7Z5J1; -.
DR   TreeFam; TF329114; -.
DR   PathwayCommons; Q7Z5J1; -.
DR   SignaLink; Q7Z5J1; -.
DR   BioGRID-ORCS; 374875; 72 hits in 1155 CRISPR screens.
DR   ChiTaRS; HSD11B1L; human.
DR   GenomeRNAi; 374875; -.
DR   Pharos; Q7Z5J1; Tbio.
DR   PRO; PR:Q7Z5J1; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q7Z5J1; Protein.
DR   Bgee; ENSG00000167733; Expressed in cingulate cortex and 132 other cell types or tissues.
DR   ExpressionAtlas; Q7Z5J1; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR44279; HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED; 1.
DR   PANTHER; PTHR44279:SF3; HYDROXYSTEROID 11-BETA-DEHYDROGENASE 1-LIKE PROTEIN; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
DR   Genevisible; Q7Z5J1; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; NADP; Oxidoreductase; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..315
FT                   /note="Hydroxysteroid 11-beta-dehydrogenase 1-like protein"
FT                   /id="PRO_0000316816"
FT   REGION          221..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        178
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         36..62
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         87..88
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         114..116
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         165
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         178..182
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         211..217
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..134
FT                   /note="Missing (in isoform 4 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_030791"
FT   VAR_SEQ         1..87
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_030792"
FT   VAR_SEQ         25..105
FT                   /note="Missing (in isoform 3 and isoform 6)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_030793"
FT   VAR_SEQ         69..87
FT                   /note="VVGNCRKLGAPKVFYIAAD -> ARWLTLVVSTLGGRGKWIT (in
FT                   isoform 8)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_030794"
FT   VAR_SEQ         88..315
FT                   /note="Missing (in isoform 8)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_030795"
FT   VAR_SEQ         223..234
FT                   /note="Missing (in isoform 2, isoform 5, isoform 6 and
FT                   isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_030796"
FT   VAR_SEQ         238..315
FT                   /note="PLQSQTAMFLPPTVPGARTLTETPLRGWPQPKMKSSRQKSKTEKNDGHLEPV
FT                   TAWEVQVPRVRRLCRGLARPHLFGHD -> TRVKAAPGPKAALAVIRGGATRAAGVFYP
FT                   WRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA (in isoform 2, isoform 5,
FT                   isoform 6 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_030797"
SQ   SEQUENCE   315 AA;  34288 MW;  F7C3A61476A1E48F CRC64;
     MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA RLGSHLVLTA
     HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF ALDKLGGLDY LVLNHIGGAP
     AGTRARSPQA TRWLMQVNFV SYVQLTSRAL PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA
     AKFALDGFFG SLRRELDVQD VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ
     SQTAMFLPPT VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR
     RLCRGLARPH LFGHD
//