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Q7Z5J1

- DHI1L_HUMAN

UniProt

Q7Z5J1 - DHI1L_HUMAN

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Protein

Hydroxysteroid 11-beta-dehydrogenase 1-like protein

Gene
HSD11B1L, HSD3, SCDR10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei165 – 1651Substrate By similarity
Active sitei178 – 1781Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 6227NADP By similarityAdd
BLAST
Nucleotide bindingi87 – 882NADP By similarity
Nucleotide bindingi114 – 1163NADP By similarity
Nucleotide bindingi178 – 1825NADP By similarity
Nucleotide bindingi211 – 2177NADP By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 3
Short name:
11-DH3
Short name:
11-beta-HSD3
Short-chain dehydrogenase/reductase 10
Gene namesi
Synonyms:HSD3, SCDR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30419. HSD11B1L.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed predictionAdd
BLAST
Chaini16 – 315300Hydroxysteroid 11-beta-dehydrogenase 1-like proteinPRO_0000316816Add
BLAST

Proteomic databases

PaxDbiQ7Z5J1.
PRIDEiQ7Z5J1.

PTM databases

PhosphoSiteiQ7Z5J1.

Expressioni

Gene expression databases

ArrayExpressiQ7Z5J1.
BgeeiQ7Z5J1.
CleanExiHS_HSD11B1L.
GenevestigatoriQ7Z5J1.

Interactioni

Protein-protein interaction databases

BioGridi131927. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5J1.
SMRiQ7Z5J1. Positions 20-257.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG005481.
OMAiWRFRLLC.
PhylomeDBiQ7Z5J1.
TreeFamiTF329114.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z5J1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA    50
RLGSHLVLTA HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF 100
ALDKLGGLDY LVLNHIGGAP AGTRARSPQA TRWLMQVNFV SYVQLTSRAL 150
PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA AKFALDGFFG SLRRELDVQD 200
VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ SQTAMFLPPT 250
VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR 300
RLCRGLARPH LFGHD 315
Length:315
Mass (Da):34,288
Last modified:October 1, 2003 - v1
Checksum:iF7C3A61476A1E48F
GO
Isoform 2 (identifier: Q7Z5J1-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:286
Mass (Da):30,848
Checksum:i7311D355E25C630B
GO
Isoform 3 (identifier: Q7Z5J1-3) [UniParc]FASTAAdd to Basket

Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.

Show »
Length:234
Mass (Da):25,788
Checksum:i7CBF1C61D948593E
GO
Isoform 4 (identifier: Q7Z5J1-4) [UniParc]FASTAAdd to Basket

Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:181
Mass (Da):19,965
Checksum:iCA0DD79B7AF1D205
GO
Isoform 5 (identifier: Q7Z5J1-5) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:199
Mass (Da):21,469
Checksum:iAD34645BA242F217
GO
Isoform 6 (identifier: Q7Z5J1-6) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:205
Mass (Da):22,347
Checksum:i211008CB138A957A
GO
Isoform 7 (identifier: Q7Z5J1-7) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:152
Mass (Da):16,524
Checksum:i78DB1E38E7C9E87D
GO
Isoform 8 (identifier: Q7Z5J1-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-87: VVGNCRKLGAPKVFYIAAD → ARWLTLVVSTLGGRGKWIT
     88-315: Missing.

Show »
Length:87
Mass (Da):9,490
Checksum:iD5974BC809897C2A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 134134Missing in isoform 4 and isoform 7. VSP_030791Add
BLAST
Alternative sequencei1 – 8787Missing in isoform 5. VSP_030792Add
BLAST
Alternative sequencei25 – 10581Missing in isoform 3 and isoform 6. VSP_030793Add
BLAST
Alternative sequencei69 – 8719VVGNC…YIAAD → ARWLTLVVSTLGGRGKWIT in isoform 8. VSP_030794Add
BLAST
Alternative sequencei88 – 315228Missing in isoform 8. VSP_030795Add
BLAST
Alternative sequencei223 – 23412Missing in isoform 2, isoform 5, isoform 6 and isoform 7. VSP_030796Add
BLAST
Alternative sequencei238 – 31578PLQSQ…LFGHD → TRVKAAPGPKAALAVIRGGA TRAAGVFYPWRFRLLCLLRR WLPRPRAWFIRQELNVTAAA A in isoform 2, isoform 5, isoform 6 and isoform 7. VSP_030797Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY268351 mRNA. Translation: AAP42285.1.
AY268352 mRNA. Translation: AAP42286.1.
AY268353 mRNA. Translation: AAP42287.1.
AY268354 mRNA. Translation: AAP42288.1.
AY313894 mRNA. Translation: AAP83166.1.
AY313895 mRNA. Translation: AAP83167.1.
AY313896 mRNA. Translation: AAP83168.1.
AC011499 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69156.1.
CH471139 Genomic DNA. Translation: EAW69157.1.
BC053546 mRNA. Translation: AAH53546.1.
BC072434 mRNA. Translation: AAH72434.1.
BC093950 mRNA. Translation: AAH93950.1.
BC112187 mRNA. Translation: AAI12188.1.
BC018336 mRNA. Translation: AAH18336.1.
CCDSiCCDS12144.1. [Q7Z5J1-6]
CCDS12145.1. [Q7Z5J1-2]
CCDS12146.1. [Q7Z5J1-5]
CCDS45931.1. [Q7Z5J1-1]
CCDS45932.1. [Q7Z5J1-4]
CCDS58641.1. [Q7Z5J1-3]
CCDS58642.1. [Q7Z5J1-7]
RefSeqiNP_001254798.1. NM_001267869.1. [Q7Z5J1-7]
NP_001254799.1. NM_001267870.1.
NP_001254800.1. NM_001267871.1. [Q7Z5J1-3]
NP_940935.1. NM_198533.2. [Q7Z5J1-1]
NP_941993.1. NM_198704.2. [Q7Z5J1-4]
NP_941994.1. NM_198705.2. [Q7Z5J1-6]
NP_941995.1. NM_198706.2. [Q7Z5J1-2]
NP_941996.1. NM_198707.2. [Q7Z5J1-5]
NP_941997.1. NM_198708.2. [Q7Z5J1-7]
UniGeneiHs.631840.
Hs.739286.

Genome annotation databases

EnsembliENST00000301382; ENSP00000301382; ENSG00000167733. [Q7Z5J1-6]
ENST00000339423; ENSP00000340436; ENSG00000167733. [Q7Z5J1-2]
ENST00000342970; ENSP00000343451; ENSG00000167733. [Q7Z5J1-5]
ENST00000411793; ENSP00000398955; ENSG00000167733. [Q7Z5J1-4]
ENST00000422535; ENSP00000409592; ENSG00000167733. [Q7Z5J1-8]
ENST00000423665; ENSP00000407154; ENSG00000167733. [Q7Z5J1-1]
ENST00000577917; ENSP00000463073; ENSG00000167733. [Q7Z5J1-3]
ENST00000581521; ENSP00000463794; ENSG00000167733. [Q7Z5J1-2]
ENST00000581773; ENSP00000462975; ENSG00000167733. [Q7Z5J1-2]
ENST00000581893; ENSP00000464454; ENSG00000167733. [Q7Z5J1-7]
ENST00000583928; ENSP00000462586; ENSG00000167733. [Q7Z5J1-7]
GeneIDi374875.
KEGGihsa:374875.
UCSCiuc002mck.4. human. [Q7Z5J1-1]
uc002mcl.4. human. [Q7Z5J1-3]
uc002mcn.4. human. [Q7Z5J1-2]
uc002mco.4. human. [Q7Z5J1-5]
uc002mcp.4. human. [Q7Z5J1-7]
uc002mcr.4. human. [Q7Z5J1-6]

Polymorphism databases

DMDMi74750135.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY268351 mRNA. Translation: AAP42285.1 .
AY268352 mRNA. Translation: AAP42286.1 .
AY268353 mRNA. Translation: AAP42287.1 .
AY268354 mRNA. Translation: AAP42288.1 .
AY313894 mRNA. Translation: AAP83166.1 .
AY313895 mRNA. Translation: AAP83167.1 .
AY313896 mRNA. Translation: AAP83168.1 .
AC011499 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69156.1 .
CH471139 Genomic DNA. Translation: EAW69157.1 .
BC053546 mRNA. Translation: AAH53546.1 .
BC072434 mRNA. Translation: AAH72434.1 .
BC093950 mRNA. Translation: AAH93950.1 .
BC112187 mRNA. Translation: AAI12188.1 .
BC018336 mRNA. Translation: AAH18336.1 .
CCDSi CCDS12144.1. [Q7Z5J1-6 ]
CCDS12145.1. [Q7Z5J1-2 ]
CCDS12146.1. [Q7Z5J1-5 ]
CCDS45931.1. [Q7Z5J1-1 ]
CCDS45932.1. [Q7Z5J1-4 ]
CCDS58641.1. [Q7Z5J1-3 ]
CCDS58642.1. [Q7Z5J1-7 ]
RefSeqi NP_001254798.1. NM_001267869.1. [Q7Z5J1-7 ]
NP_001254799.1. NM_001267870.1.
NP_001254800.1. NM_001267871.1. [Q7Z5J1-3 ]
NP_940935.1. NM_198533.2. [Q7Z5J1-1 ]
NP_941993.1. NM_198704.2. [Q7Z5J1-4 ]
NP_941994.1. NM_198705.2. [Q7Z5J1-6 ]
NP_941995.1. NM_198706.2. [Q7Z5J1-2 ]
NP_941996.1. NM_198707.2. [Q7Z5J1-5 ]
NP_941997.1. NM_198708.2. [Q7Z5J1-7 ]
UniGenei Hs.631840.
Hs.739286.

3D structure databases

ProteinModelPortali Q7Z5J1.
SMRi Q7Z5J1. Positions 20-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131927. 1 interaction.

PTM databases

PhosphoSitei Q7Z5J1.

Polymorphism databases

DMDMi 74750135.

Proteomic databases

PaxDbi Q7Z5J1.
PRIDEi Q7Z5J1.

Protocols and materials databases

DNASUi 374875.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301382 ; ENSP00000301382 ; ENSG00000167733 . [Q7Z5J1-6 ]
ENST00000339423 ; ENSP00000340436 ; ENSG00000167733 . [Q7Z5J1-2 ]
ENST00000342970 ; ENSP00000343451 ; ENSG00000167733 . [Q7Z5J1-5 ]
ENST00000411793 ; ENSP00000398955 ; ENSG00000167733 . [Q7Z5J1-4 ]
ENST00000422535 ; ENSP00000409592 ; ENSG00000167733 . [Q7Z5J1-8 ]
ENST00000423665 ; ENSP00000407154 ; ENSG00000167733 . [Q7Z5J1-1 ]
ENST00000577917 ; ENSP00000463073 ; ENSG00000167733 . [Q7Z5J1-3 ]
ENST00000581521 ; ENSP00000463794 ; ENSG00000167733 . [Q7Z5J1-2 ]
ENST00000581773 ; ENSP00000462975 ; ENSG00000167733 . [Q7Z5J1-2 ]
ENST00000581893 ; ENSP00000464454 ; ENSG00000167733 . [Q7Z5J1-7 ]
ENST00000583928 ; ENSP00000462586 ; ENSG00000167733 . [Q7Z5J1-7 ]
GeneIDi 374875.
KEGGi hsa:374875.
UCSCi uc002mck.4. human. [Q7Z5J1-1 ]
uc002mcl.4. human. [Q7Z5J1-3 ]
uc002mcn.4. human. [Q7Z5J1-2 ]
uc002mco.4. human. [Q7Z5J1-5 ]
uc002mcp.4. human. [Q7Z5J1-7 ]
uc002mcr.4. human. [Q7Z5J1-6 ]

Organism-specific databases

CTDi 374875.
GeneCardsi GC19P005680.
HGNCi HGNC:30419. HSD11B1L.
neXtProti NX_Q7Z5J1.
PharmGKBi PA144596423.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG005481.
OMAi WRFRLLC.
PhylomeDBi Q7Z5J1.
TreeFami TF329114.

Miscellaneous databases

GenomeRNAii 374875.
NextBioi 100285.
PROi Q7Z5J1.

Gene expression databases

ArrayExpressi Q7Z5J1.
Bgeei Q7Z5J1.
CleanExi HS_HSD11B1L.
Genevestigatori Q7Z5J1.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Wu S.L., Chen Z., Xiao P.J.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-315 (ISOFORM 5).
    Tissue: Brain and Ovary.

Entry informationi

Entry nameiDHI1L_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5J1
Secondary accession number(s): Q05D45
, Q52LF4, Q7Z5I9, Q7Z5J0, Q7Z5P5, Q7Z5P6, Q7Z5P7, Q7Z5P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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