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Q7Z5J1 (DHI1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein

EC=1.1.1.-
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 3
Short name=11-DH3
Short name=11-beta-HSD3
Short-chain dehydrogenase/reductase 10
Gene names
Name:HSD11B1L
Synonyms:HSD3, SCDR10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z5J1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z5J1-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA
Isoform 3 (identifier: Q7Z5J1-3)

Also known as: G;

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.
Isoform 4 (identifier: Q7Z5J1-4)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
Isoform 5 (identifier: Q7Z5J1-5)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA
Isoform 6 (identifier: Q7Z5J1-6)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA
Isoform 7 (identifier: Q7Z5J1-7)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA
Isoform 8 (identifier: Q7Z5J1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     69-87: VVGNCRKLGAPKVFYIAAD → ARWLTLVVSTLGGRGKWIT
     88-315: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 315300Hydroxysteroid 11-beta-dehydrogenase 1-like protein
PRO_0000316816

Regions

Nucleotide binding36 – 6227NADP By similarity
Nucleotide binding87 – 882NADP By similarity
Nucleotide binding114 – 1163NADP By similarity
Nucleotide binding178 – 1825NADP By similarity
Nucleotide binding211 – 2177NADP By similarity

Sites

Active site1781Proton acceptor By similarity
Binding site1651Substrate By similarity

Natural variations

Alternative sequence1 – 134134Missing in isoform 4 and isoform 7.
VSP_030791
Alternative sequence1 – 8787Missing in isoform 5.
VSP_030792
Alternative sequence25 – 10581Missing in isoform 3 and isoform 6.
VSP_030793
Alternative sequence69 – 8719VVGNC…YIAAD → ARWLTLVVSTLGGRGKWIT in isoform 8.
VSP_030794
Alternative sequence88 – 315228Missing in isoform 8.
VSP_030795
Alternative sequence223 – 23412Missing in isoform 2, isoform 5, isoform 6 and isoform 7.
VSP_030796
Alternative sequence238 – 31578PLQSQ…LFGHD → TRVKAAPGPKAALAVIRGGA TRAAGVFYPWRFRLLCLLRR WLPRPRAWFIRQELNVTAAA A in isoform 2, isoform 5, isoform 6 and isoform 7.
VSP_030797

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F7C3A61476A1E48F

FASTA31534,288
        10         20         30         40         50         60 
MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA RLGSHLVLTA 

        70         80         90        100        110        120 
HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF ALDKLGGLDY LVLNHIGGAP 

       130        140        150        160        170        180 
AGTRARSPQA TRWLMQVNFV SYVQLTSRAL PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA 

       190        200        210        220        230        240 
AKFALDGFFG SLRRELDVQD VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ 

       250        260        270        280        290        300 
SQTAMFLPPT VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR 

       310 
RLCRGLARPH LFGHD 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 7311D355E25C630B
Show »

FASTA28630,848
Isoform 3 (G) [UniParc].

Checksum: 7CBF1C61D948593E
Show »

FASTA23425,788
Isoform 4 (F) [UniParc].

Checksum: CA0DD79B7AF1D205
Show »

FASTA18119,965
Isoform 5 (C) [UniParc].

Checksum: AD34645BA242F217
Show »

FASTA19921,469
Isoform 6 (A) [UniParc].

Checksum: 211008CB138A957A
Show »

FASTA20522,347
Isoform 7 (D) [UniParc].

Checksum: 78DB1E38E7C9E87D
Show »

FASTA15216,524
Isoform 8 [UniParc].

Checksum: D5974BC809897C2A
Show »

FASTA879,490

References

« Hide 'large scale' references
[1]Huang C.Q., Wu S.L., Chen Z., Xiao P.J.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7).
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-315 (ISOFORM 5).
Tissue: Brain and Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY268351 mRNA. Translation: AAP42285.1.
AY268352 mRNA. Translation: AAP42286.1.
AY268353 mRNA. Translation: AAP42287.1.
AY268354 mRNA. Translation: AAP42288.1.
AY313894 mRNA. Translation: AAP83166.1.
AY313895 mRNA. Translation: AAP83167.1.
AY313896 mRNA. Translation: AAP83168.1.
AC011499 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69156.1.
CH471139 Genomic DNA. Translation: EAW69157.1.
BC053546 mRNA. Translation: AAH53546.1.
BC072434 mRNA. Translation: AAH72434.1.
BC093950 mRNA. Translation: AAH93950.1.
BC112187 mRNA. Translation: AAI12188.1.
BC018336 mRNA. Translation: AAH18336.1.
CCDSCCDS12144.1. [Q7Z5J1-6]
CCDS12145.1. [Q7Z5J1-2]
CCDS12146.1. [Q7Z5J1-5]
CCDS45931.1. [Q7Z5J1-1]
CCDS45932.1. [Q7Z5J1-4]
CCDS58641.1. [Q7Z5J1-3]
CCDS58642.1. [Q7Z5J1-7]
RefSeqNP_001254798.1. NM_001267869.1. [Q7Z5J1-7]
NP_001254799.1. NM_001267870.1.
NP_001254800.1. NM_001267871.1. [Q7Z5J1-3]
NP_940935.1. NM_198533.2. [Q7Z5J1-1]
NP_941993.1. NM_198704.2. [Q7Z5J1-4]
NP_941994.1. NM_198705.2. [Q7Z5J1-6]
NP_941995.1. NM_198706.2. [Q7Z5J1-2]
NP_941996.1. NM_198707.2. [Q7Z5J1-5]
NP_941997.1. NM_198708.2. [Q7Z5J1-7]
UniGeneHs.631840.
Hs.739286.

3D structure databases

ProteinModelPortalQ7Z5J1.
SMRQ7Z5J1. Positions 20-257.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131927. 1 interaction.

PTM databases

PhosphoSiteQ7Z5J1.

Polymorphism databases

DMDM74750135.

Proteomic databases

PaxDbQ7Z5J1.
PRIDEQ7Z5J1.

Protocols and materials databases

DNASU374875.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301382; ENSP00000301382; ENSG00000167733. [Q7Z5J1-6]
ENST00000339423; ENSP00000340436; ENSG00000167733. [Q7Z5J1-2]
ENST00000342970; ENSP00000343451; ENSG00000167733. [Q7Z5J1-5]
ENST00000411793; ENSP00000398955; ENSG00000167733. [Q7Z5J1-4]
ENST00000422535; ENSP00000409592; ENSG00000167733. [Q7Z5J1-8]
ENST00000423665; ENSP00000407154; ENSG00000167733. [Q7Z5J1-1]
ENST00000577917; ENSP00000463073; ENSG00000167733. [Q7Z5J1-3]
ENST00000581521; ENSP00000463794; ENSG00000167733. [Q7Z5J1-2]
ENST00000581773; ENSP00000462975; ENSG00000167733. [Q7Z5J1-2]
ENST00000581893; ENSP00000464454; ENSG00000167733. [Q7Z5J1-7]
ENST00000583928; ENSP00000462586; ENSG00000167733. [Q7Z5J1-7]
GeneID374875.
KEGGhsa:374875.
UCSCuc002mck.4. human. [Q7Z5J1-1]
uc002mcl.4. human. [Q7Z5J1-3]
uc002mcn.4. human. [Q7Z5J1-2]
uc002mco.4. human. [Q7Z5J1-5]
uc002mcp.4. human. [Q7Z5J1-7]
uc002mcr.4. human. [Q7Z5J1-6]

Organism-specific databases

CTD374875.
GeneCardsGC19P005680.
HGNCHGNC:30419. HSD11B1L.
neXtProtNX_Q7Z5J1.
PharmGKBPA144596423.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1028.
HOVERGENHBG005481.
OMAWRFRLLC.
PhylomeDBQ7Z5J1.
TreeFamTF329114.

Gene expression databases

ArrayExpressQ7Z5J1.
BgeeQ7Z5J1.
CleanExHS_HSD11B1L.
GenevestigatorQ7Z5J1.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi374875.
NextBio100285.
PROQ7Z5J1.

Entry information

Entry nameDHI1L_HUMAN
AccessionPrimary (citable) accession number: Q7Z5J1
Secondary accession number(s): Q05D45 expand/collapse secondary AC list , Q52LF4, Q7Z5I9, Q7Z5J0, Q7Z5P5, Q7Z5P6, Q7Z5P7, Q7Z5P8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM