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Q7Z5J1

- DHI1L_HUMAN

UniProt

Q7Z5J1 - DHI1L_HUMAN

Protein

Hydroxysteroid 11-beta-dehydrogenase 1-like protein

Gene

HSD11B1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • Format
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei165 – 1651SubstrateBy similarity
    Active sitei178 – 1781Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 6227NADPBy similarityAdd
    BLAST
    Nucleotide bindingi87 – 882NADPBy similarity
    Nucleotide bindingi114 – 1163NADPBy similarity
    Nucleotide bindingi178 – 1825NADPBy similarity
    Nucleotide bindingi211 – 2177NADPBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC:1.1.1.-)
    Alternative name(s):
    11-beta-hydroxysteroid dehydrogenase type 3
    Short name:
    11-DH3
    Short name:
    11-beta-HSD3
    Short-chain dehydrogenase/reductase 10
    Gene namesi
    Name:HSD11B1L
    Synonyms:HSD3, SCDR10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30419. HSD11B1L.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596423.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 315300Hydroxysteroid 11-beta-dehydrogenase 1-like proteinPRO_0000316816Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z5J1.
    PRIDEiQ7Z5J1.

    PTM databases

    PhosphoSiteiQ7Z5J1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z5J1.
    BgeeiQ7Z5J1.
    CleanExiHS_HSD11B1L.
    GenevestigatoriQ7Z5J1.

    Interactioni

    Protein-protein interaction databases

    BioGridi131927. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z5J1.
    SMRiQ7Z5J1. Positions 20-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG005481.
    OMAiWRFRLLC.
    PhylomeDBiQ7Z5J1.
    TreeFamiTF329114.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z5J1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA    50
    RLGSHLVLTA HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF 100
    ALDKLGGLDY LVLNHIGGAP AGTRARSPQA TRWLMQVNFV SYVQLTSRAL 150
    PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA AKFALDGFFG SLRRELDVQD 200
    VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ SQTAMFLPPT 250
    VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR 300
    RLCRGLARPH LFGHD 315
    Length:315
    Mass (Da):34,288
    Last modified:October 1, 2003 - v1
    Checksum:iF7C3A61476A1E48F
    GO
    Isoform 2 (identifier: Q7Z5J1-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         223-234: Missing.
         238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

    Show »
    Length:286
    Mass (Da):30,848
    Checksum:i7311D355E25C630B
    GO
    Isoform 3 (identifier: Q7Z5J1-3) [UniParc]FASTAAdd to Basket

    Also known as: G

    The sequence of this isoform differs from the canonical sequence as follows:
         25-105: Missing.

    Show »
    Length:234
    Mass (Da):25,788
    Checksum:i7CBF1C61D948593E
    GO
    Isoform 4 (identifier: Q7Z5J1-4) [UniParc]FASTAAdd to Basket

    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         1-134: Missing.

    Show »
    Length:181
    Mass (Da):19,965
    Checksum:iCA0DD79B7AF1D205
    GO
    Isoform 5 (identifier: Q7Z5J1-5) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         223-234: Missing.
         238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

    Show »
    Length:199
    Mass (Da):21,469
    Checksum:iAD34645BA242F217
    GO
    Isoform 6 (identifier: Q7Z5J1-6) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         25-105: Missing.
         223-234: Missing.
         238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

    Show »
    Length:205
    Mass (Da):22,347
    Checksum:i211008CB138A957A
    GO
    Isoform 7 (identifier: Q7Z5J1-7) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         1-134: Missing.
         223-234: Missing.
         238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

    Show »
    Length:152
    Mass (Da):16,524
    Checksum:i78DB1E38E7C9E87D
    GO
    Isoform 8 (identifier: Q7Z5J1-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         69-87: VVGNCRKLGAPKVFYIAAD → ARWLTLVVSTLGGRGKWIT
         88-315: Missing.

    Show »
    Length:87
    Mass (Da):9,490
    Checksum:iD5974BC809897C2A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 134134Missing in isoform 4 and isoform 7. 2 PublicationsVSP_030791Add
    BLAST
    Alternative sequencei1 – 8787Missing in isoform 5. 2 PublicationsVSP_030792Add
    BLAST
    Alternative sequencei25 – 10581Missing in isoform 3 and isoform 6. 1 PublicationVSP_030793Add
    BLAST
    Alternative sequencei69 – 8719VVGNC…YIAAD → ARWLTLVVSTLGGRGKWIT in isoform 8. 1 PublicationVSP_030794Add
    BLAST
    Alternative sequencei88 – 315228Missing in isoform 8. 1 PublicationVSP_030795Add
    BLAST
    Alternative sequencei223 – 23412Missing in isoform 2, isoform 5, isoform 6 and isoform 7. 2 PublicationsVSP_030796Add
    BLAST
    Alternative sequencei238 – 31578PLQSQ…LFGHD → TRVKAAPGPKAALAVIRGGA TRAAGVFYPWRFRLLCLLRR WLPRPRAWFIRQELNVTAAA A in isoform 2, isoform 5, isoform 6 and isoform 7. 2 PublicationsVSP_030797Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY268351 mRNA. Translation: AAP42285.1.
    AY268352 mRNA. Translation: AAP42286.1.
    AY268353 mRNA. Translation: AAP42287.1.
    AY268354 mRNA. Translation: AAP42288.1.
    AY313894 mRNA. Translation: AAP83166.1.
    AY313895 mRNA. Translation: AAP83167.1.
    AY313896 mRNA. Translation: AAP83168.1.
    AC011499 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69156.1.
    CH471139 Genomic DNA. Translation: EAW69157.1.
    BC053546 mRNA. Translation: AAH53546.1.
    BC072434 mRNA. Translation: AAH72434.1.
    BC093950 mRNA. Translation: AAH93950.1.
    BC112187 mRNA. Translation: AAI12188.1.
    BC018336 mRNA. Translation: AAH18336.1.
    CCDSiCCDS12144.1. [Q7Z5J1-6]
    CCDS12145.1. [Q7Z5J1-2]
    CCDS12146.1. [Q7Z5J1-5]
    CCDS45931.1. [Q7Z5J1-1]
    CCDS45932.1. [Q7Z5J1-4]
    CCDS58641.1. [Q7Z5J1-3]
    CCDS58642.1. [Q7Z5J1-7]
    RefSeqiNP_001254798.1. NM_001267869.1. [Q7Z5J1-7]
    NP_001254799.1. NM_001267870.1.
    NP_001254800.1. NM_001267871.1. [Q7Z5J1-3]
    NP_940935.1. NM_198533.2. [Q7Z5J1-1]
    NP_941993.1. NM_198704.2. [Q7Z5J1-4]
    NP_941994.1. NM_198705.2. [Q7Z5J1-6]
    NP_941995.1. NM_198706.2. [Q7Z5J1-2]
    NP_941996.1. NM_198707.2. [Q7Z5J1-5]
    NP_941997.1. NM_198708.2. [Q7Z5J1-7]
    UniGeneiHs.631840.
    Hs.739286.

    Genome annotation databases

    EnsembliENST00000301382; ENSP00000301382; ENSG00000167733. [Q7Z5J1-6]
    ENST00000339423; ENSP00000340436; ENSG00000167733. [Q7Z5J1-2]
    ENST00000342970; ENSP00000343451; ENSG00000167733. [Q7Z5J1-5]
    ENST00000411793; ENSP00000398955; ENSG00000167733. [Q7Z5J1-4]
    ENST00000422535; ENSP00000409592; ENSG00000167733. [Q7Z5J1-8]
    ENST00000423665; ENSP00000407154; ENSG00000167733. [Q7Z5J1-1]
    ENST00000577917; ENSP00000463073; ENSG00000167733. [Q7Z5J1-3]
    ENST00000581521; ENSP00000463794; ENSG00000167733. [Q7Z5J1-2]
    ENST00000581773; ENSP00000462975; ENSG00000167733. [Q7Z5J1-2]
    ENST00000581893; ENSP00000464454; ENSG00000167733. [Q7Z5J1-7]
    ENST00000583928; ENSP00000462586; ENSG00000167733. [Q7Z5J1-7]
    GeneIDi374875.
    KEGGihsa:374875.
    UCSCiuc002mck.4. human. [Q7Z5J1-1]
    uc002mcl.4. human. [Q7Z5J1-3]
    uc002mcn.4. human. [Q7Z5J1-2]
    uc002mco.4. human. [Q7Z5J1-5]
    uc002mcp.4. human. [Q7Z5J1-7]
    uc002mcr.4. human. [Q7Z5J1-6]

    Polymorphism databases

    DMDMi74750135.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY268351 mRNA. Translation: AAP42285.1 .
    AY268352 mRNA. Translation: AAP42286.1 .
    AY268353 mRNA. Translation: AAP42287.1 .
    AY268354 mRNA. Translation: AAP42288.1 .
    AY313894 mRNA. Translation: AAP83166.1 .
    AY313895 mRNA. Translation: AAP83167.1 .
    AY313896 mRNA. Translation: AAP83168.1 .
    AC011499 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69156.1 .
    CH471139 Genomic DNA. Translation: EAW69157.1 .
    BC053546 mRNA. Translation: AAH53546.1 .
    BC072434 mRNA. Translation: AAH72434.1 .
    BC093950 mRNA. Translation: AAH93950.1 .
    BC112187 mRNA. Translation: AAI12188.1 .
    BC018336 mRNA. Translation: AAH18336.1 .
    CCDSi CCDS12144.1. [Q7Z5J1-6 ]
    CCDS12145.1. [Q7Z5J1-2 ]
    CCDS12146.1. [Q7Z5J1-5 ]
    CCDS45931.1. [Q7Z5J1-1 ]
    CCDS45932.1. [Q7Z5J1-4 ]
    CCDS58641.1. [Q7Z5J1-3 ]
    CCDS58642.1. [Q7Z5J1-7 ]
    RefSeqi NP_001254798.1. NM_001267869.1. [Q7Z5J1-7 ]
    NP_001254799.1. NM_001267870.1.
    NP_001254800.1. NM_001267871.1. [Q7Z5J1-3 ]
    NP_940935.1. NM_198533.2. [Q7Z5J1-1 ]
    NP_941993.1. NM_198704.2. [Q7Z5J1-4 ]
    NP_941994.1. NM_198705.2. [Q7Z5J1-6 ]
    NP_941995.1. NM_198706.2. [Q7Z5J1-2 ]
    NP_941996.1. NM_198707.2. [Q7Z5J1-5 ]
    NP_941997.1. NM_198708.2. [Q7Z5J1-7 ]
    UniGenei Hs.631840.
    Hs.739286.

    3D structure databases

    ProteinModelPortali Q7Z5J1.
    SMRi Q7Z5J1. Positions 20-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131927. 1 interaction.

    PTM databases

    PhosphoSitei Q7Z5J1.

    Polymorphism databases

    DMDMi 74750135.

    Proteomic databases

    PaxDbi Q7Z5J1.
    PRIDEi Q7Z5J1.

    Protocols and materials databases

    DNASUi 374875.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301382 ; ENSP00000301382 ; ENSG00000167733 . [Q7Z5J1-6 ]
    ENST00000339423 ; ENSP00000340436 ; ENSG00000167733 . [Q7Z5J1-2 ]
    ENST00000342970 ; ENSP00000343451 ; ENSG00000167733 . [Q7Z5J1-5 ]
    ENST00000411793 ; ENSP00000398955 ; ENSG00000167733 . [Q7Z5J1-4 ]
    ENST00000422535 ; ENSP00000409592 ; ENSG00000167733 . [Q7Z5J1-8 ]
    ENST00000423665 ; ENSP00000407154 ; ENSG00000167733 . [Q7Z5J1-1 ]
    ENST00000577917 ; ENSP00000463073 ; ENSG00000167733 . [Q7Z5J1-3 ]
    ENST00000581521 ; ENSP00000463794 ; ENSG00000167733 . [Q7Z5J1-2 ]
    ENST00000581773 ; ENSP00000462975 ; ENSG00000167733 . [Q7Z5J1-2 ]
    ENST00000581893 ; ENSP00000464454 ; ENSG00000167733 . [Q7Z5J1-7 ]
    ENST00000583928 ; ENSP00000462586 ; ENSG00000167733 . [Q7Z5J1-7 ]
    GeneIDi 374875.
    KEGGi hsa:374875.
    UCSCi uc002mck.4. human. [Q7Z5J1-1 ]
    uc002mcl.4. human. [Q7Z5J1-3 ]
    uc002mcn.4. human. [Q7Z5J1-2 ]
    uc002mco.4. human. [Q7Z5J1-5 ]
    uc002mcp.4. human. [Q7Z5J1-7 ]
    uc002mcr.4. human. [Q7Z5J1-6 ]

    Organism-specific databases

    CTDi 374875.
    GeneCardsi GC19P005680.
    HGNCi HGNC:30419. HSD11B1L.
    neXtProti NX_Q7Z5J1.
    PharmGKBi PA144596423.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG005481.
    OMAi WRFRLLC.
    PhylomeDBi Q7Z5J1.
    TreeFami TF329114.

    Miscellaneous databases

    GenomeRNAii 374875.
    NextBioi 100285.
    PROi Q7Z5J1.

    Gene expression databases

    ArrayExpressi Q7Z5J1.
    Bgeei Q7Z5J1.
    CleanExi HS_HSD11B1L.
    Genevestigatori Q7Z5J1.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Huang C.Q., Wu S.L., Chen Z., Xiao P.J.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7).
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-315 (ISOFORM 5).
      Tissue: Brain and Ovary.

    Entry informationi

    Entry nameiDHI1L_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z5J1
    Secondary accession number(s): Q05D45
    , Q52LF4, Q7Z5I9, Q7Z5J0, Q7Z5P5, Q7Z5P6, Q7Z5P7, Q7Z5P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3