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Protein

Hydroxysteroid 11-beta-dehydrogenase 1-like protein

Gene

HSD11B1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165SubstrateBy similarity1
Active sitei178Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 62NADPBy similarityAdd BLAST27
Nucleotide bindingi87 – 88NADPBy similarity2
Nucleotide bindingi114 – 116NADPBy similarity3
Nucleotide bindingi178 – 182NADPBy similarity5
Nucleotide bindingi211 – 217NADPBy similarity7

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 3
Short name:
11-DH3
Short name:
11-beta-HSD3
Short chain dehydrogenase/reductase family 26C member 2
Short-chain dehydrogenase/reductase 10
Gene namesi
Name:HSD11B1L
Synonyms:HSD3, SCDR10, SDR26C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30419. HSD11B1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi374875.
OpenTargetsiENSG00000167733.
PharmGKBiPA144596423.

Polymorphism and mutation databases

BioMutaiHSD11B1L.
DMDMi74750135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000031681616 – 315Hydroxysteroid 11-beta-dehydrogenase 1-like proteinAdd BLAST300

Proteomic databases

PaxDbiQ7Z5J1.
PeptideAtlasiQ7Z5J1.
PRIDEiQ7Z5J1.

PTM databases

iPTMnetiQ7Z5J1.
PhosphoSitePlusiQ7Z5J1.

Expressioni

Gene expression databases

BgeeiENSG00000167733.
CleanExiHS_HSD11B1L.
ExpressionAtlasiQ7Z5J1. baseline and differential.
GenevisibleiQ7Z5J1. HS.

Interactioni

Protein-protein interaction databases

BioGridi131927. 1 interactor.
STRINGi9606.ENSP00000407154.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5J1.
SMRiQ7Z5J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00860000133821.
HOVERGENiHBG005481.
InParanoidiQ7Z5J1.
PhylomeDBiQ7Z5J1.
TreeFamiTF329114.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5J1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA
60 70 80 90 100
RLGSHLVLTA HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF
110 120 130 140 150
ALDKLGGLDY LVLNHIGGAP AGTRARSPQA TRWLMQVNFV SYVQLTSRAL
160 170 180 190 200
PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA AKFALDGFFG SLRRELDVQD
210 220 230 240 250
VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ SQTAMFLPPT
260 270 280 290 300
VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR
310
RLCRGLARPH LFGHD
Length:315
Mass (Da):34,288
Last modified:October 1, 2003 - v1
Checksum:iF7C3A61476A1E48F
GO
Isoform 2 (identifier: Q7Z5J1-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:286
Mass (Da):30,848
Checksum:i7311D355E25C630B
GO
Isoform 3 (identifier: Q7Z5J1-3) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.

Show »
Length:234
Mass (Da):25,788
Checksum:i7CBF1C61D948593E
GO
Isoform 4 (identifier: Q7Z5J1-4) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:181
Mass (Da):19,965
Checksum:iCA0DD79B7AF1D205
GO
Isoform 5 (identifier: Q7Z5J1-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:199
Mass (Da):21,469
Checksum:iAD34645BA242F217
GO
Isoform 6 (identifier: Q7Z5J1-6) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:205
Mass (Da):22,347
Checksum:i211008CB138A957A
GO
Isoform 7 (identifier: Q7Z5J1-7) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:152
Mass (Da):16,524
Checksum:i78DB1E38E7C9E87D
GO
Isoform 8 (identifier: Q7Z5J1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-87: VVGNCRKLGAPKVFYIAAD → ARWLTLVVSTLGGRGKWIT
     88-315: Missing.

Show »
Length:87
Mass (Da):9,490
Checksum:iD5974BC809897C2A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0307911 – 134Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST134
Alternative sequenceiVSP_0307921 – 87Missing in isoform 5. 2 PublicationsAdd BLAST87
Alternative sequenceiVSP_03079325 – 105Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_03079469 – 87VVGNC…YIAAD → ARWLTLVVSTLGGRGKWIT in isoform 8. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_03079588 – 315Missing in isoform 8. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_030796223 – 234Missing in isoform 2, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_030797238 – 315PLQSQ…LFGHD → TRVKAAPGPKAALAVIRGGA TRAAGVFYPWRFRLLCLLRR WLPRPRAWFIRQELNVTAAA A in isoform 2, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST78

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY268351 mRNA. Translation: AAP42285.1.
AY268352 mRNA. Translation: AAP42286.1.
AY268353 mRNA. Translation: AAP42287.1.
AY268354 mRNA. Translation: AAP42288.1.
AY313894 mRNA. Translation: AAP83166.1.
AY313895 mRNA. Translation: AAP83167.1.
AY313896 mRNA. Translation: AAP83168.1.
AC011499 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69156.1.
CH471139 Genomic DNA. Translation: EAW69157.1.
BC053546 mRNA. Translation: AAH53546.1.
BC072434 mRNA. Translation: AAH72434.1.
BC093950 mRNA. Translation: AAH93950.1.
BC112187 mRNA. Translation: AAI12188.1.
BC018336 mRNA. Translation: AAH18336.1.
CCDSiCCDS12144.1. [Q7Z5J1-6]
CCDS12145.1. [Q7Z5J1-2]
CCDS12146.1. [Q7Z5J1-5]
CCDS45931.1. [Q7Z5J1-1]
CCDS45932.1. [Q7Z5J1-4]
CCDS58641.1. [Q7Z5J1-3]
CCDS58642.1. [Q7Z5J1-7]
RefSeqiNP_001254798.1. NM_001267869.1. [Q7Z5J1-7]
NP_001254799.1. NM_001267870.1.
NP_001254800.1. NM_001267871.1. [Q7Z5J1-3]
NP_940935.1. NM_198533.2. [Q7Z5J1-1]
NP_941993.1. NM_198704.2. [Q7Z5J1-4]
NP_941994.1. NM_198705.2. [Q7Z5J1-6]
NP_941995.1. NM_198706.2. [Q7Z5J1-2]
NP_941996.1. NM_198707.2. [Q7Z5J1-5]
NP_941997.1. NM_198708.2. [Q7Z5J1-7]
UniGeneiHs.631840.
Hs.739286.

Genome annotation databases

EnsembliENST00000301382; ENSP00000301382; ENSG00000167733. [Q7Z5J1-6]
ENST00000339423; ENSP00000340436; ENSG00000167733. [Q7Z5J1-2]
ENST00000342970; ENSP00000343451; ENSG00000167733. [Q7Z5J1-5]
ENST00000411793; ENSP00000398955; ENSG00000167733. [Q7Z5J1-4]
ENST00000422535; ENSP00000409592; ENSG00000167733. [Q7Z5J1-8]
ENST00000423665; ENSP00000407154; ENSG00000167733. [Q7Z5J1-1]
ENST00000577917; ENSP00000463073; ENSG00000167733. [Q7Z5J1-3]
ENST00000581521; ENSP00000463794; ENSG00000167733. [Q7Z5J1-2]
ENST00000581773; ENSP00000462975; ENSG00000167733. [Q7Z5J1-2]
ENST00000581893; ENSP00000464454; ENSG00000167733. [Q7Z5J1-7]
ENST00000583928; ENSP00000462586; ENSG00000167733. [Q7Z5J1-7]
GeneIDi374875.
KEGGihsa:374875.
UCSCiuc002mcj.6. human. [Q7Z5J1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY268351 mRNA. Translation: AAP42285.1.
AY268352 mRNA. Translation: AAP42286.1.
AY268353 mRNA. Translation: AAP42287.1.
AY268354 mRNA. Translation: AAP42288.1.
AY313894 mRNA. Translation: AAP83166.1.
AY313895 mRNA. Translation: AAP83167.1.
AY313896 mRNA. Translation: AAP83168.1.
AC011499 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69156.1.
CH471139 Genomic DNA. Translation: EAW69157.1.
BC053546 mRNA. Translation: AAH53546.1.
BC072434 mRNA. Translation: AAH72434.1.
BC093950 mRNA. Translation: AAH93950.1.
BC112187 mRNA. Translation: AAI12188.1.
BC018336 mRNA. Translation: AAH18336.1.
CCDSiCCDS12144.1. [Q7Z5J1-6]
CCDS12145.1. [Q7Z5J1-2]
CCDS12146.1. [Q7Z5J1-5]
CCDS45931.1. [Q7Z5J1-1]
CCDS45932.1. [Q7Z5J1-4]
CCDS58641.1. [Q7Z5J1-3]
CCDS58642.1. [Q7Z5J1-7]
RefSeqiNP_001254798.1. NM_001267869.1. [Q7Z5J1-7]
NP_001254799.1. NM_001267870.1.
NP_001254800.1. NM_001267871.1. [Q7Z5J1-3]
NP_940935.1. NM_198533.2. [Q7Z5J1-1]
NP_941993.1. NM_198704.2. [Q7Z5J1-4]
NP_941994.1. NM_198705.2. [Q7Z5J1-6]
NP_941995.1. NM_198706.2. [Q7Z5J1-2]
NP_941996.1. NM_198707.2. [Q7Z5J1-5]
NP_941997.1. NM_198708.2. [Q7Z5J1-7]
UniGeneiHs.631840.
Hs.739286.

3D structure databases

ProteinModelPortaliQ7Z5J1.
SMRiQ7Z5J1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131927. 1 interactor.
STRINGi9606.ENSP00000407154.

PTM databases

iPTMnetiQ7Z5J1.
PhosphoSitePlusiQ7Z5J1.

Polymorphism and mutation databases

BioMutaiHSD11B1L.
DMDMi74750135.

Proteomic databases

PaxDbiQ7Z5J1.
PeptideAtlasiQ7Z5J1.
PRIDEiQ7Z5J1.

Protocols and materials databases

DNASUi374875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301382; ENSP00000301382; ENSG00000167733. [Q7Z5J1-6]
ENST00000339423; ENSP00000340436; ENSG00000167733. [Q7Z5J1-2]
ENST00000342970; ENSP00000343451; ENSG00000167733. [Q7Z5J1-5]
ENST00000411793; ENSP00000398955; ENSG00000167733. [Q7Z5J1-4]
ENST00000422535; ENSP00000409592; ENSG00000167733. [Q7Z5J1-8]
ENST00000423665; ENSP00000407154; ENSG00000167733. [Q7Z5J1-1]
ENST00000577917; ENSP00000463073; ENSG00000167733. [Q7Z5J1-3]
ENST00000581521; ENSP00000463794; ENSG00000167733. [Q7Z5J1-2]
ENST00000581773; ENSP00000462975; ENSG00000167733. [Q7Z5J1-2]
ENST00000581893; ENSP00000464454; ENSG00000167733. [Q7Z5J1-7]
ENST00000583928; ENSP00000462586; ENSG00000167733. [Q7Z5J1-7]
GeneIDi374875.
KEGGihsa:374875.
UCSCiuc002mcj.6. human. [Q7Z5J1-1]

Organism-specific databases

CTDi374875.
DisGeNETi374875.
GeneCardsiHSD11B1L.
HGNCiHGNC:30419. HSD11B1L.
neXtProtiNX_Q7Z5J1.
OpenTargetsiENSG00000167733.
PharmGKBiPA144596423.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00860000133821.
HOVERGENiHBG005481.
InParanoidiQ7Z5J1.
PhylomeDBiQ7Z5J1.
TreeFamiTF329114.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167733-MONOMER.

Miscellaneous databases

GenomeRNAii374875.
PROiQ7Z5J1.

Gene expression databases

BgeeiENSG00000167733.
CleanExiHS_HSD11B1L.
ExpressionAtlasiQ7Z5J1. baseline and differential.
GenevisibleiQ7Z5J1. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHI1L_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5J1
Secondary accession number(s): Q05D45
, Q52LF4, Q7Z5I9, Q7Z5J0, Q7Z5P5, Q7Z5P6, Q7Z5P7, Q7Z5P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.