ID VN1R4_HUMAN Reviewed; 301 AA. AC Q7Z5H5; Q2M3E2; Q7Z5H6; Q7Z5H7; Q8TDU2; DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 24-JAN-2024, sequence version 3. DT 27-MAR-2024, entry version 149. DE RecName: Full=Vomeronasal type-1 receptor 4; DE AltName: Full=G-protein coupled receptor GPCR27; DE Short=hGPCR27; DE AltName: Full=V1r-like receptor 4; GN Name=VN1R4; Synonyms=V1RL4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASP-220. RX PubMed=12123587; DOI=10.1016/s0960-9822(02)00909-0; RA Rodriguez I., Mombaerts P.; RT "Novel human vomeronasal receptor-like genes reveal species-specific RT families."; RL Curr. Biol. 12:R409-R411(2002). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-52; LEU-58 AND ASP-220. RX PubMed=12826614; DOI=10.1073/pnas.1331721100; RA Zhang J., Webb D.M.; RT "Evolutionary deterioration of the vomeronasal pheromone transduction RT pathway in catarrhine primates."; RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASP-220. RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human genome RT sequence."; RL FEBS Lett. 520:97-101(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-220. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Putative pheromone receptor. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- POLYMORPHISM: Various VN1R4 alleles are known. The sequence shown is CC that of allele VN1R4*2. {ECO:0000269|PubMed:12826614}. CC -!- MISCELLANEOUS: The chimpanzee and gorilla orthologous proteins do not CC exist, their genes are pseudogenes. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of CC August 2005; CC URL="https://web.expasy.org/spotlight/back_issues/061"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY114733; AAM66754.1; -; Genomic_DNA. DR EMBL; AY312485; AAP85618.1; -; Genomic_DNA. DR EMBL; AY312486; AAP85619.1; -; Genomic_DNA. DR EMBL; AY312487; AAP85620.1; -; Genomic_DNA. DR EMBL; AY312488; AAP85621.1; -; Genomic_DNA. DR EMBL; AB083609; BAB89322.1; -; Genomic_DNA. DR EMBL; BC104935; AAI04936.1; -; mRNA. DR EMBL; BC104939; AAI04940.1; -; mRNA. DR CCDS; CCDS33099.1; -. DR RefSeq; NP_776256.2; NM_173857.2. DR RefSeq; XP_011525187.1; XM_011526885.1. DR AlphaFoldDB; Q7Z5H5; -. DR SMR; Q7Z5H5; -. DR BioGRID; 130445; 3. DR STRING; 9606.ENSP00000310856; -. DR GlyCosmos; Q7Z5H5; 2 sites, No reported glycans. DR GlyGen; Q7Z5H5; 2 sites. DR PhosphoSitePlus; Q7Z5H5; -. DR BioMuta; VN1R4; -. DR DMDM; 68566197; -. DR PaxDb; 9606-ENSP00000310856; -. DR PeptideAtlas; Q7Z5H5; -. DR Antibodypedia; 49778; 132 antibodies from 24 providers. DR DNASU; 317703; -. DR Ensembl; ENST00000311170.5; ENSP00000310856.4; ENSG00000228567.3. DR GeneID; 317703; -. DR KEGG; hsa:317703; -. DR MANE-Select; ENST00000311170.5; ENSP00000310856.4; NM_173857.3; NP_776256.2. DR UCSC; uc010ydu.3; human. DR AGR; HGNC:19871; -. DR CTD; 317703; -. DR DisGeNET; 317703; -. DR GeneCards; VN1R4; -. DR HGNC; HGNC:19871; VN1R4. DR HPA; ENSG00000228567; Not detected. DR neXtProt; NX_Q7Z5H5; -. DR OpenTargets; ENSG00000228567; -. DR PharmGKB; PA134985458; -. DR VEuPathDB; HostDB:ENSG00000228567; -. DR eggNOG; ENOG502RD1P; Eukaryota. DR GeneTree; ENSGT00960000186612; -. DR HOGENOM; CLU_058641_1_0_1; -. DR InParanoid; Q7Z5H5; -. DR OrthoDB; 4113734at2759; -. DR PhylomeDB; Q7Z5H5; -. DR PathwayCommons; Q7Z5H5; -. DR BioGRID-ORCS; 317703; 8 hits in 1095 CRISPR screens. DR GeneWiki; VN1R4; -. DR GenomeRNAi; 317703; -. DR Pharos; Q7Z5H5; Tbio. DR PRO; PR:Q7Z5H5; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q7Z5H5; Protein. DR Bgee; ENSG00000228567; Expressed in male germ line stem cell (sensu Vertebrata) in testis. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro. DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt. DR CDD; cd13949; 7tm_V1R_pheromone; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004072; Vmron_rcpt_1. DR PANTHER; PTHR24062; VOMERONASAL TYPE-1 RECEPTOR; 1. DR PANTHER; PTHR24062:SF192; VOMERONASAL TYPE-1 RECEPTOR 4; 1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; Q7Z5H5; HS. PE 2: Evidence at transcript level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; KW Pheromone response; Receptor; Reference proteome; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1..301 FT /note="Vomeronasal type-1 receptor 4" FT /id="PRO_0000070217" FT TOPO_DOM 1..5 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 6..26 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 27..48 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 49..69 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 70..88 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 89..109 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 110..126 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 127..147 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 148..185 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 186..206 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 207..234 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 235..255 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 256..264 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 265..285 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 286..301 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 154 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 157 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VARIANT 52 FT /note="A -> V (in allele VN1R4*3; dbSNP:rs74429916)" FT /evidence="ECO:0000269|PubMed:12826614" FT /id="VAR_022799" FT VARIANT 58 FT /note="R -> L (in allele VN1R4*4; dbSNP:rs140031028)" FT /evidence="ECO:0000269|PubMed:12826614" FT /id="VAR_022800" FT VARIANT 220 FT /note="N -> D (in allele VN1R4*1 and allele VN1R4*4; FT dbSNP:rs12977715)" FT /evidence="ECO:0000269|PubMed:12044878, FT ECO:0000269|PubMed:12123587, ECO:0000269|PubMed:12826614, FT ECO:0000269|PubMed:15489334" FT /id="VAR_022801" SQ SEQUENCE 301 AA; 33556 MW; AB72F79FF81BF1C6 CRC64; MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI VANFLALRCK GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL LSVFQVITVS SRKSRWAKLK EKAPKHVGFS VLLCWIVCML VNIIFPMYVT GKWNYTNITV NEDLGYCSGG GNNKIAQTLR AMLLSFPDVL CLGLMLWVSS SMVCILHRHK QRVQHIDRSN LSPRASPENR ATQSILILVS TFVSSYTLSC LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK R //