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Protein

Vomeronasal type-1 receptor 4

Gene

VN1R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 4
Alternative name(s):
G-protein coupled receptor GPCR27
Short name:
hGPCR27
V1r-like receptor 4
Gene namesi
Name:VN1R4
Synonyms:V1RL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19871. VN1R4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5ExtracellularSequence analysis5
Transmembranei6 – 26Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini27 – 48CytoplasmicSequence analysisAdd BLAST22
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini70 – 88ExtracellularSequence analysisAdd BLAST19
Transmembranei89 – 109Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini110 – 126CytoplasmicSequence analysisAdd BLAST17
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 185ExtracellularSequence analysisAdd BLAST38
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 234CytoplasmicSequence analysisAdd BLAST28
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 264ExtracellularSequence analysis9
Transmembranei265 – 285Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini286 – 301CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi317703.
PharmGKBiPA134985458.

Polymorphism and mutation databases

BioMutaiVN1R4.
DMDMi68566197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702171 – 301Vomeronasal type-1 receptor 4Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z5H5.
PRIDEiQ7Z5H5.

PTM databases

PhosphoSitePlusiQ7Z5H5.

Expressioni

Gene expression databases

CleanExiHS_VN1R4.
GenevisibleiQ7Z5H5. HS.

Organism-specific databases

HPAiHPA027018.

Interactioni

Protein-protein interaction databases

IntActiQ7Z5H5. 1 interactor.
STRINGi9606.ENSP00000310856.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIB. Eukaryota.
ENOG4111F74. LUCA.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ7Z5H5.
KOiK04614.
OrthoDBiEOG091G0H9A.
PhylomeDBiQ7Z5H5.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z5H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI
60 70 80 90 100
VANFLALRCK GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL
110 120 130 140 150
LSVFQVITVS SRKSRWAKLK EKAPKHVGFS VLLCWIVCML VNIIFPMYVT
160 170 180 190 200
GKWNYTNITV NEDLGYCSGG GNNKIAQTLR AMLLSFPDVL CLGLMLWVSS
210 220 230 240 250
SMVCILHRHK QRVQHIDRSD LSPRASPENR ATQSILILVS TFVSSYTLSC
260 270 280 290 300
LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK

R
Length:301
Mass (Da):33,557
Last modified:July 5, 2005 - v2
Checksum:iAB7F9792957BFCA6
GO

Polymorphismi

Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02279952A → V in allele VN1R4*3. 1 PublicationCorresponds to variant rs112711591dbSNPEnsembl.1
Natural variantiVAR_02280058R → L in allele VN1R4*4. 1 Publication1
Natural variantiVAR_022801220D → N in allele VN1R4*2 and allele VN1R4*3. 1 PublicationCorresponds to variant rs12977715dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114733 Genomic DNA. Translation: AAM66754.1.
AY312485 Genomic DNA. Translation: AAP85618.1.
AY312486 Genomic DNA. Translation: AAP85619.1.
AY312487 Genomic DNA. Translation: AAP85620.1.
AY312488 Genomic DNA. Translation: AAP85621.1.
AB083609 Genomic DNA. Translation: BAB89322.1.
BC104935 mRNA. Translation: AAI04936.1.
BC104939 mRNA. Translation: AAI04940.1.
CCDSiCCDS33099.1.
RefSeqiNP_776256.2. NM_173857.2.
XP_011525187.1. XM_011526885.1.
UniGeneiHs.553685.

Genome annotation databases

EnsembliENST00000311170; ENSP00000310856; ENSG00000228567.
GeneIDi317703.
KEGGihsa:317703.
UCSCiuc010ydu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114733 Genomic DNA. Translation: AAM66754.1.
AY312485 Genomic DNA. Translation: AAP85618.1.
AY312486 Genomic DNA. Translation: AAP85619.1.
AY312487 Genomic DNA. Translation: AAP85620.1.
AY312488 Genomic DNA. Translation: AAP85621.1.
AB083609 Genomic DNA. Translation: BAB89322.1.
BC104935 mRNA. Translation: AAI04936.1.
BC104939 mRNA. Translation: AAI04940.1.
CCDSiCCDS33099.1.
RefSeqiNP_776256.2. NM_173857.2.
XP_011525187.1. XM_011526885.1.
UniGeneiHs.553685.

3D structure databases

ProteinModelPortaliQ7Z5H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z5H5. 1 interactor.
STRINGi9606.ENSP00000310856.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ7Z5H5.

Polymorphism and mutation databases

BioMutaiVN1R4.
DMDMi68566197.

Proteomic databases

PaxDbiQ7Z5H5.
PRIDEiQ7Z5H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311170; ENSP00000310856; ENSG00000228567.
GeneIDi317703.
KEGGihsa:317703.
UCSCiuc010ydu.3. human.

Organism-specific databases

CTDi317703.
DisGeNETi317703.
GeneCardsiVN1R4.
H-InvDBHIX0021898.
HIX0202926.
HGNCiHGNC:19871. VN1R4.
HPAiHPA027018.
neXtProtiNX_Q7Z5H5.
PharmGKBiPA134985458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKIB. Eukaryota.
ENOG4111F74. LUCA.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ7Z5H5.
KOiK04614.
OrthoDBiEOG091G0H9A.
PhylomeDBiQ7Z5H5.

Miscellaneous databases

GeneWikiiVN1R4.
GenomeRNAii317703.
PROiQ7Z5H5.

Gene expression databases

CleanExiHS_VN1R4.
GenevisibleiQ7Z5H5. HS.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVN1R4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5H5
Secondary accession number(s): Q2M3E2
, Q7Z5H6, Q7Z5H7, Q8TDU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.