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Protein

Vomeronasal type-1 receptor 4

Gene

VN1R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 4
Alternative name(s):
G-protein coupled receptor GPCR27
Short name:
hGPCR27
V1r-like receptor 4
Gene namesi
Name:VN1R4
Synonyms:V1RL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19871. VN1R4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55ExtracellularSequence Analysis
Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini27 – 4822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini70 – 8819ExtracellularSequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini110 – 12617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini148 – 18538ExtracellularSequence AnalysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini207 – 23428CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini256 – 2649ExtracellularSequence Analysis
Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini286 – 30116CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Vomeronasal type-1 receptor 4PRO_0000070217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z5H5.
PRIDEiQ7Z5H5.

PTM databases

PhosphoSiteiQ7Z5H5.

Expressioni

Gene expression databases

BgeeiQ7Z5H5.
CleanExiHS_VN1R4.
GenevestigatoriQ7Z5H5.

Organism-specific databases

HPAiHPA027018.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310856.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG78462.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ7Z5H5.
KOiK04614.
OrthoDBiEOG7CG70G.
PhylomeDBiQ7Z5H5.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z5H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI
60 70 80 90 100
VANFLALRCK GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL
110 120 130 140 150
LSVFQVITVS SRKSRWAKLK EKAPKHVGFS VLLCWIVCML VNIIFPMYVT
160 170 180 190 200
GKWNYTNITV NEDLGYCSGG GNNKIAQTLR AMLLSFPDVL CLGLMLWVSS
210 220 230 240 250
SMVCILHRHK QRVQHIDRSD LSPRASPENR ATQSILILVS TFVSSYTLSC
260 270 280 290 300
LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK

R
Length:301
Mass (Da):33,557
Last modified:July 5, 2005 - v2
Checksum:iAB7F9792957BFCA6
GO

Polymorphismi

Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521A → V in allele VN1R4*3. 1 Publication
Corresponds to variant rs112711591 [ dbSNP | Ensembl ].
VAR_022799
Natural varianti58 – 581R → L in allele VN1R4*4. 1 Publication
VAR_022800
Natural varianti220 – 2201D → N in allele VN1R4*2 and allele VN1R4*3. 1 Publication
Corresponds to variant rs12977715 [ dbSNP | Ensembl ].
VAR_022801

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114733 Genomic DNA. Translation: AAM66754.1.
AY312485 Genomic DNA. Translation: AAP85618.1.
AY312486 Genomic DNA. Translation: AAP85619.1.
AY312487 Genomic DNA. Translation: AAP85620.1.
AY312488 Genomic DNA. Translation: AAP85621.1.
AB083609 Genomic DNA. Translation: BAB89322.1.
BC104935 mRNA. Translation: AAI04936.1.
BC104939 mRNA. Translation: AAI04940.1.
CCDSiCCDS33099.1.
RefSeqiNP_776256.2. NM_173857.2.
UniGeneiHs.553685.

Genome annotation databases

EnsembliENST00000311170; ENSP00000310856; ENSG00000228567.
GeneIDi317703.
KEGGihsa:317703.
UCSCiuc010ydu.2. human.

Polymorphism databases

DMDMi68566197.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114733 Genomic DNA. Translation: AAM66754.1.
AY312485 Genomic DNA. Translation: AAP85618.1.
AY312486 Genomic DNA. Translation: AAP85619.1.
AY312487 Genomic DNA. Translation: AAP85620.1.
AY312488 Genomic DNA. Translation: AAP85621.1.
AB083609 Genomic DNA. Translation: BAB89322.1.
BC104935 mRNA. Translation: AAI04936.1.
BC104939 mRNA. Translation: AAI04940.1.
CCDSiCCDS33099.1.
RefSeqiNP_776256.2. NM_173857.2.
UniGeneiHs.553685.

3D structure databases

ProteinModelPortaliQ7Z5H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310856.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7Z5H5.

Polymorphism databases

DMDMi68566197.

Proteomic databases

PaxDbiQ7Z5H5.
PRIDEiQ7Z5H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311170; ENSP00000310856; ENSG00000228567.
GeneIDi317703.
KEGGihsa:317703.
UCSCiuc010ydu.2. human.

Organism-specific databases

CTDi317703.
GeneCardsiGC19M053770.
H-InvDBHIX0021898.
HIX0202926.
HGNCiHGNC:19871. VN1R4.
HPAiHPA027018.
neXtProtiNX_Q7Z5H5.
PharmGKBiPA134985458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78462.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ7Z5H5.
KOiK04614.
OrthoDBiEOG7CG70G.
PhylomeDBiQ7Z5H5.

Miscellaneous databases

GeneWikiiVN1R4.
GenomeRNAii317703.
NextBioi96368.
PROiQ7Z5H5.

Gene expression databases

BgeeiQ7Z5H5.
CleanExiHS_VN1R4.
GenevestigatoriQ7Z5H5.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
    Rodriguez I., Mombaerts P.
    Curr. Biol. 12:R409-R411(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-52; LEU-58 AND ASN-220.
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiVN1R4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5H5
Secondary accession number(s): Q2M3E2
, Q7Z5H6, Q7Z5H7, Q8TDU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 4, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.