Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7Z5H5

- VN1R4_HUMAN

UniProt

Q7Z5H5 - VN1R4_HUMAN

Protein

Vomeronasal type-1 receptor 4

Gene

VN1R4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Putative pheromone receptor.

    GO - Molecular functioni

    1. pheromone receptor activity Source: InterPro

    GO - Biological processi

    1. response to pheromone Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Pheromone response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vomeronasal type-1 receptor 4
    Alternative name(s):
    G-protein coupled receptor GPCR27
    Short name:
    hGPCR27
    V1r-like receptor 4
    Gene namesi
    Name:VN1R4
    Synonyms:V1RL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:19871. VN1R4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134985458.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Vomeronasal type-1 receptor 4PRO_0000070217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7Z5H5.
    PRIDEiQ7Z5H5.

    PTM databases

    PhosphoSiteiQ7Z5H5.

    Expressioni

    Gene expression databases

    BgeeiQ7Z5H5.
    CleanExiHS_VN1R4.
    GenevestigatoriQ7Z5H5.

    Organism-specific databases

    HPAiHPA027018.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000310856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z5H5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini27 – 4822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8819ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 18538ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini207 – 23428CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 2649ExtracellularSequence Analysis
    Topological domaini286 – 30116CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG78462.
    HOGENOMiHOG000231675.
    HOVERGENiHBG073430.
    InParanoidiQ7Z5H5.
    KOiK04614.
    OrthoDBiEOG7CG70G.
    PhylomeDBiQ7Z5H5.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view]
    PfamiPF03402. V1R. 1 hit.
    [Graphical view]
    PRINTSiPR01534. VOMERONASL1R.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z5H5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI    50
    VANFLALRCK GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL 100
    LSVFQVITVS SRKSRWAKLK EKAPKHVGFS VLLCWIVCML VNIIFPMYVT 150
    GKWNYTNITV NEDLGYCSGG GNNKIAQTLR AMLLSFPDVL CLGLMLWVSS 200
    SMVCILHRHK QRVQHIDRSD LSPRASPENR ATQSILILVS TFVSSYTLSC 250
    LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK 300
    R 301
    Length:301
    Mass (Da):33,557
    Last modified:July 5, 2005 - v2
    Checksum:iAB7F9792957BFCA6
    GO

    Polymorphismi

    Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti52 – 521A → V in allele VN1R4*3. 1 Publication
    Corresponds to variant rs112711591 [ dbSNP | Ensembl ].
    VAR_022799
    Natural varianti58 – 581R → L in allele VN1R4*4. 1 Publication
    VAR_022800
    Natural varianti220 – 2201D → N in allele VN1R4*2 and allele VN1R4*3. 1 Publication
    Corresponds to variant rs12977715 [ dbSNP | Ensembl ].
    VAR_022801

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114733 Genomic DNA. Translation: AAM66754.1.
    AY312485 Genomic DNA. Translation: AAP85618.1.
    AY312486 Genomic DNA. Translation: AAP85619.1.
    AY312487 Genomic DNA. Translation: AAP85620.1.
    AY312488 Genomic DNA. Translation: AAP85621.1.
    AB083609 Genomic DNA. Translation: BAB89322.1.
    BC104935 mRNA. Translation: AAI04936.1.
    BC104939 mRNA. Translation: AAI04940.1.
    CCDSiCCDS33099.1.
    RefSeqiNP_776256.2. NM_173857.2.
    UniGeneiHs.553685.

    Genome annotation databases

    EnsembliENST00000311170; ENSP00000310856; ENSG00000228567.
    GeneIDi317703.
    KEGGihsa:317703.
    UCSCiuc010ydu.2. human.

    Polymorphism databases

    DMDMi68566197.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No one nose - Issue 61 of August 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114733 Genomic DNA. Translation: AAM66754.1 .
    AY312485 Genomic DNA. Translation: AAP85618.1 .
    AY312486 Genomic DNA. Translation: AAP85619.1 .
    AY312487 Genomic DNA. Translation: AAP85620.1 .
    AY312488 Genomic DNA. Translation: AAP85621.1 .
    AB083609 Genomic DNA. Translation: BAB89322.1 .
    BC104935 mRNA. Translation: AAI04936.1 .
    BC104939 mRNA. Translation: AAI04940.1 .
    CCDSi CCDS33099.1.
    RefSeqi NP_776256.2. NM_173857.2.
    UniGenei Hs.553685.

    3D structure databases

    ProteinModelPortali Q7Z5H5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000310856.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7Z5H5.

    Polymorphism databases

    DMDMi 68566197.

    Proteomic databases

    PaxDbi Q7Z5H5.
    PRIDEi Q7Z5H5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311170 ; ENSP00000310856 ; ENSG00000228567 .
    GeneIDi 317703.
    KEGGi hsa:317703.
    UCSCi uc010ydu.2. human.

    Organism-specific databases

    CTDi 317703.
    GeneCardsi GC19M053770.
    H-InvDB HIX0021898.
    HIX0202926.
    HGNCi HGNC:19871. VN1R4.
    HPAi HPA027018.
    neXtProti NX_Q7Z5H5.
    PharmGKBi PA134985458.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78462.
    HOGENOMi HOG000231675.
    HOVERGENi HBG073430.
    InParanoidi Q7Z5H5.
    KOi K04614.
    OrthoDBi EOG7CG70G.
    PhylomeDBi Q7Z5H5.

    Miscellaneous databases

    GeneWikii VN1R4.
    GenomeRNAii 317703.
    NextBioi 96368.
    PROi Q7Z5H5.

    Gene expression databases

    Bgeei Q7Z5H5.
    CleanExi HS_VN1R4.
    Genevestigatori Q7Z5H5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view ]
    Pfami PF03402. V1R. 1 hit.
    [Graphical view ]
    PRINTSi PR01534. VOMERONASL1R.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
      Rodriguez I., Mombaerts P.
      Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
      Zhang J., Webb D.M.
      Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-52; LEU-58 AND ASN-220.
    3. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiVN1R4_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z5H5
    Secondary accession number(s): Q2M3E2
    , Q7Z5H6, Q7Z5H7, Q8TDU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3