Q7Z5H5 (VN1R4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vomeronasal type-1 receptor 4

Alternative name(s):
G-protein coupled receptor GPCR27
Short name=hGPCR27
V1r-like receptor 4

Gene names

Name:	VN1R4
Synonyms:	V1RL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative pheromone receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.
Miscellaneous	The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	actin cytoskeleton Inferred from direct assay. Source: HPA cytoplasm Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Vomeronasal type-1 receptor 4		PRO_0000070217
Regions
	Topological domain	1 – 5	5	Extracellular Potential
	Transmembrane	6 – 26	21	Helical; Name=1; Potential
	Topological domain	27 – 48	22	Cytoplasmic Potential
	Transmembrane	49 – 69	21	Helical; Name=2; Potential
	Topological domain	70 – 88	19	Extracellular Potential
	Transmembrane	89 – 109	21	Helical; Name=3; Potential
	Topological domain	110 – 126	17	Cytoplasmic Potential
	Transmembrane	127 – 147	21	Helical; Name=4; Potential
	Topological domain	148 – 185	38	Extracellular Potential
	Transmembrane	186 – 206	21	Helical; Name=5; Potential
	Topological domain	207 – 234	28	Cytoplasmic Potential
	Transmembrane	235 – 255	21	Helical; Name=6; Potential
	Topological domain	256 – 264	9	Extracellular Potential
	Transmembrane	265 – 285	21	Helical; Name=7; Potential
	Topological domain	286 – 301	16	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	154	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	52	1	A → V in allele VN1R4*3. Ref.2		VAR_022799
	Natural variant	58	1	R → L in allele VN1R4*4. Ref.2		VAR_022800
	Natural variant	220	1	D → N in allele VN1R4*2 and allele VN1R4*3. Ref.2 Corresponds to variant rs12977715 [ dbSNP | Ensembl ].		VAR_022801

Sequences

	Sequence		Length	Mass (Da)
	Q7Z5H5 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: AB7F9792957BFCA6	FASTA	301	33,557
	10 20 30 40 50 60 MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI VANFLALRCK 70 80 90 100 110 120 GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL LSVFQVITVS SRKSRWAKLK 130 140 150 160 170 180 EKAPKHVGFS VLLCWIVCML VNIIFPMYVT GKWNYTNITV NEDLGYCSGG GNNKIAQTLR 190 200 210 220 230 240 AMLLSFPDVL CLGLMLWVSS SMVCILHRHK QRVQHIDRSD LSPRASPENR ATQSILILVS 250 260 270 280 290 300 TFVSSYTLSC LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human vomeronasal receptor-like genes reveal species-specific families." Rodriguez I., Mombaerts P. Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates." Zhang J., Webb D.M. Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-52; LEU-58 AND ASN-220.
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY114733 Genomic DNA. Translation: AAM66754.1. AY312485 Genomic DNA. Translation: AAP85618.1. AY312486 Genomic DNA. Translation: AAP85619.1. AY312487 Genomic DNA. Translation: AAP85620.1. AY312488 Genomic DNA. Translation: AAP85621.1. AB083609 Genomic DNA. Translation: BAB89322.1. BC104935 mRNA. Translation: AAI04936.1. BC104939 mRNA. Translation: AAI04940.1.
IPI	IPI00152613.
RefSeq	NP_776256.2. NM_173857.2.
UniGene	Hs.553685.
3D structure databases
ProteinModelPortal	Q7Z5H5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000310856.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q7Z5H5.
Polymorphism databases
DMDM	68566197.
Proteomic databases
PaxDb	Q7Z5H5.
PRIDE	Q7Z5H5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311170; ENSP00000310856; ENSG00000228567.
GeneID	317703.
KEGG	hsa:317703.
UCSC	uc010ydu.2. human.
Organism-specific databases
CTD	317703.
GeneCards	GC19M053770.
H-InvDB	HIX0021898. HIX0202926.
HGNC	HGNC:19871. VN1R4.
HPA	HPA027018.
neXtProt	NX_Q7Z5H5.
PharmGKB	PA134985458.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78462.
HOGENOM	HOG000231675.
HOVERGEN	HBG073430.
InParanoid	Q7Z5H5.
KO	K04614.
OrthoDB	EOG45DWQ9.
Gene expression databases
Bgee	Q7Z5H5.
CleanEx	HS_VN1R4.
Genevestigator	Q7Z5H5.
GermOnline	ENSG00000174677. Homo sapiens.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR004072. Vmron_rcpt_1. [Graphical view]
Pfam	PF03402. V1R. 1 hit. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	317703.
NextBio	96368.

Entry information

Entry name

VN1R4_HUMAN

Accession

Primary (citable) accession number: Q7Z5H5
Secondary accession number(s): Q2M3E2 , Q7Z5H6, Q7Z5H7, Q8TDU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	April 3, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.