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Q7Z5H5 (VN1R4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vomeronasal type-1 receptor 4
Alternative name(s):
G-protein coupled receptor GPCR27
Short name=hGPCR27
V1r-like receptor 4
Gene names
Name:VN1R4
Synonyms:V1RL4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative pheromone receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.

Miscellaneous

The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processPheromone response
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to pheromone

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpheromone receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Vomeronasal type-1 receptor 4
PRO_0000070217

Regions

Topological domain1 – 55Extracellular Potential
Transmembrane6 – 2621Helical; Name=1; Potential
Topological domain27 – 4822Cytoplasmic Potential
Transmembrane49 – 6921Helical; Name=2; Potential
Topological domain70 – 8819Extracellular Potential
Transmembrane89 – 10921Helical; Name=3; Potential
Topological domain110 – 12617Cytoplasmic Potential
Transmembrane127 – 14721Helical; Name=4; Potential
Topological domain148 – 18538Extracellular Potential
Transmembrane186 – 20621Helical; Name=5; Potential
Topological domain207 – 23428Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=6; Potential
Topological domain256 – 2649Extracellular Potential
Transmembrane265 – 28521Helical; Name=7; Potential
Topological domain286 – 30116Cytoplasmic Potential

Amino acid modifications

Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1571N-linked (GlcNAc...) Potential

Natural variations

Natural variant521A → V in allele VN1R4*3. Ref.2
Corresponds to variant rs112711591 [ dbSNP | Ensembl ].
VAR_022799
Natural variant581R → L in allele VN1R4*4. Ref.2
VAR_022800
Natural variant2201D → N in allele VN1R4*2 and allele VN1R4*3. Ref.2
Corresponds to variant rs12977715 [ dbSNP | Ensembl ].
VAR_022801

Sequences

Sequence LengthMass (Da)Tools
Q7Z5H5 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: AB7F9792957BFCA6

FASTA30133,557
        10         20         30         40         50         60 
MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI VANFLALRCK 

        70         80         90        100        110        120 
GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL LSVFQVITVS SRKSRWAKLK 

       130        140        150        160        170        180 
EKAPKHVGFS VLLCWIVCML VNIIFPMYVT GKWNYTNITV NEDLGYCSGG GNNKIAQTLR 

       190        200        210        220        230        240 
AMLLSFPDVL CLGLMLWVSS SMVCILHRHK QRVQHIDRSD LSPRASPENR ATQSILILVS 

       250        260        270        280        290        300 
TFVSSYTLSC LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK 


R 

« Hide

References

« Hide 'large scale' references
[1]"Novel human vomeronasal receptor-like genes reveal species-specific families."
Rodriguez I., Mombaerts P.
Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
Zhang J., Webb D.M.
Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-52; LEU-58 AND ASN-220.
[3]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY114733 Genomic DNA. Translation: AAM66754.1.
AY312485 Genomic DNA. Translation: AAP85618.1.
AY312486 Genomic DNA. Translation: AAP85619.1.
AY312487 Genomic DNA. Translation: AAP85620.1.
AY312488 Genomic DNA. Translation: AAP85621.1.
AB083609 Genomic DNA. Translation: BAB89322.1.
BC104935 mRNA. Translation: AAI04936.1.
BC104939 mRNA. Translation: AAI04940.1.
CCDSCCDS33099.1.
RefSeqNP_776256.2. NM_173857.2.
UniGeneHs.553685.

3D structure databases

ProteinModelPortalQ7Z5H5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000310856.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ7Z5H5.

Polymorphism databases

DMDM68566197.

Proteomic databases

PaxDbQ7Z5H5.
PRIDEQ7Z5H5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311170; ENSP00000310856; ENSG00000228567.
GeneID317703.
KEGGhsa:317703.
UCSCuc010ydu.2. human.

Organism-specific databases

CTD317703.
GeneCardsGC19M053770.
H-InvDBHIX0021898.
HIX0202926.
HGNCHGNC:19871. VN1R4.
HPAHPA027018.
neXtProtNX_Q7Z5H5.
PharmGKBPA134985458.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78462.
HOGENOMHOG000231675.
HOVERGENHBG073430.
InParanoidQ7Z5H5.
KOK04614.
OrthoDBEOG7CG70G.
PhylomeDBQ7Z5H5.

Gene expression databases

BgeeQ7Z5H5.
CleanExHS_VN1R4.
GenevestigatorQ7Z5H5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamPF03402. V1R. 1 hit.
[Graphical view]
PRINTSPR01534. VOMERONASL1R.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiVN1R4.
GenomeRNAi317703.
NextBio96368.
PROQ7Z5H5.

Entry information

Entry nameVN1R4_HUMAN
AccessionPrimary (citable) accession number: Q7Z5H5
Secondary accession number(s): Q2M3E2 expand/collapse secondary AC list , Q7Z5H6, Q7Z5H7, Q8TDU2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

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