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Protein

Vomeronasal type-1 receptor 5

Gene

VN1R5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 5
Alternative name(s):
G-protein coupled receptor GPCR26
Short name:
hGPCR26
V1r-like receptor 5
Gene namesi
Name:VN1R5
Synonyms:V1RL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19870. VN1R5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33ExtracellularSequence Analysis
Transmembranei4 – 2421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini25 – 5228CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 818ExtracellularSequence Analysis
Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini103 – 13028CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini152 – 16312ExtracellularSequence AnalysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini185 – 26985CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini291 – 30010ExtracellularSequence Analysis
Transmembranei301 – 32121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini322 – 35736CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Vomeronasal type-1 receptor 5PRO_0000070220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7Z5H4.

PTM databases

PhosphoSiteiQ7Z5H4.

Expressioni

Gene expression databases

CleanExiHS_VN1R5.
GenevestigatoriQ7Z5H4.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG098604.
InParanoidiQ7Z5H4.
KOiK04614.
PhylomeDBiQ7Z5H4.

Family and domain databases

InterProiIPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 2 hits.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.

Sequencei

Sequence statusi: Complete.

Q7Z5H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY
60 70 80 90 100
PQASFGISAN TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI
110 120 130 140 150
LVSLDFFGSQ NTQDDLRYKV IVFLNKVMRG LSICTPCLLS VLQAIISPSI
160 170 180 190 200
FSLAKLKHPS ASHILGFFLF SWVLNMFIGV IFCCTLRLPP VKRGQSSVCH
210 220 230 240 250
TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD YFIQTIRGYL
260 270 280 290 300
SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL
310 320 330 340 350
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR

QCGSTKK
Length:357
Mass (Da):40,779
Last modified:July 5, 2005 - v2
Checksum:i0E01BA2B43D5F2FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661F → Y in BAB89321. (PubMed:12044878)Curated

Polymorphismi

There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti350 – 3501R → C in allele VN1R5*3. 1 Publication
Corresponds to variant rs41308154 [ dbSNP | Ensembl ].
VAR_022802

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114735 Genomic DNA. Translation: AAM66756.1.
AY312489 Genomic DNA. Translation: AAP85622.1.
AY312490 Genomic DNA. No translation available.
AY312491 Genomic DNA. Translation: AAP85623.1.
AB083608 Genomic DNA. Translation: BAB89321.1.
BC126341 mRNA. Translation: AAI26342.1.
BC126367 mRNA. Translation: AAI26368.1.
RefSeqiNP_776257.1. NM_173858.1.
UniGeneiHs.553686.

Genome annotation databases

GeneIDi317705.
KEGGihsa:317705.
UCSCiuc010pyu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114735 Genomic DNA. Translation: AAM66756.1.
AY312489 Genomic DNA. Translation: AAP85622.1.
AY312490 Genomic DNA. No translation available.
AY312491 Genomic DNA. Translation: AAP85623.1.
AB083608 Genomic DNA. Translation: BAB89321.1.
BC126341 mRNA. Translation: AAI26342.1.
BC126367 mRNA. Translation: AAI26368.1.
RefSeqiNP_776257.1. NM_173858.1.
UniGeneiHs.553686.

3D structure databases

ProteinModelPortaliQ7Z5H4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7Z5H4.

Proteomic databases

PRIDEiQ7Z5H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi317705.
KEGGihsa:317705.
UCSCiuc010pyu.2. human.

Organism-specific databases

CTDi317705.
GeneCardsiGC01P247419.
H-InvDBHIX0093782.
HGNCiHGNC:19870. VN1R5.
neXtProtiNX_Q7Z5H4.
PharmGKBiPA134993066.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG098604.
InParanoidiQ7Z5H4.
KOiK04614.
PhylomeDBiQ7Z5H4.

Miscellaneous databases

GeneWikiiVN1R5.
GenomeRNAii317705.
NextBioi96372.
PROiQ7Z5H4.

Gene expression databases

CleanExiHS_VN1R5.
GenevestigatoriQ7Z5H4.

Family and domain databases

InterProiIPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 2 hits.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
    Rodriguez I., Mombaerts P.
    Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT CYS-350.
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiVN1R5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5H4
Secondary accession number(s): A0AVG1, Q8NEU5, Q8TDU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.