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Q7Z5H4

- VN1R5_HUMAN

UniProt

Q7Z5H4 - VN1R5_HUMAN

Protein

Vomeronasal type-1 receptor 5

Gene

VN1R5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Putative pheromone receptor.

    GO - Molecular functioni

    1. pheromone receptor activity Source: InterPro

    GO - Biological processi

    1. response to pheromone Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Pheromone response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vomeronasal type-1 receptor 5
    Alternative name(s):
    G-protein coupled receptor GPCR26
    Short name:
    hGPCR26
    V1r-like receptor 5
    Gene namesi
    Name:VN1R5
    Synonyms:V1RL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:19870. VN1R5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134993066.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Vomeronasal type-1 receptor 5PRO_0000070220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ7Z5H4.

    PTM databases

    PhosphoSiteiQ7Z5H4.

    Expressioni

    Gene expression databases

    CleanExiHS_VN1R5.
    GenevestigatoriQ7Z5H4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z5H4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33ExtracellularSequence Analysis
    Topological domaini25 – 5228CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini74 – 818ExtracellularSequence Analysis
    Topological domaini103 – 13028CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 16312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 26985CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini291 – 30010ExtracellularSequence Analysis
    Topological domaini322 – 35736CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG098604.
    InParanoidiQ7Z5H4.
    KOiK04614.
    PhylomeDBiQ7Z5H4.

    Family and domain databases

    InterProiIPR004072. Vmron_rcpt_1.
    [Graphical view]
    PfamiPF03402. V1R. 2 hits.
    [Graphical view]
    PRINTSiPR01534. VOMERONASL1R.

    Sequencei

    Sequence statusi: Complete.

    Q7Z5H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY    50
    PQASFGISAN TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI 100
    LVSLDFFGSQ NTQDDLRYKV IVFLNKVMRG LSICTPCLLS VLQAIISPSI 150
    FSLAKLKHPS ASHILGFFLF SWVLNMFIGV IFCCTLRLPP VKRGQSSVCH 200
    TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD YFIQTIRGYL 250
    SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL 300
    LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR 350
    QCGSTKK 357
    Length:357
    Mass (Da):40,779
    Last modified:July 5, 2005 - v2
    Checksum:i0E01BA2B43D5F2FE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661F → Y in BAB89321. (PubMed:12044878)Curated

    Polymorphismi

    There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti350 – 3501R → C in allele VN1R5*3. 1 Publication
    Corresponds to variant rs41308154 [ dbSNP | Ensembl ].
    VAR_022802

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114735 Genomic DNA. Translation: AAM66756.1.
    AY312489 Genomic DNA. Translation: AAP85622.1.
    AY312490 Genomic DNA. No translation available.
    AY312491 Genomic DNA. Translation: AAP85623.1.
    AB083608 Genomic DNA. Translation: BAB89321.1.
    BC126341 mRNA. Translation: AAI26342.1.
    BC126367 mRNA. Translation: AAI26368.1.
    RefSeqiNP_776257.1. NM_173858.1.
    UniGeneiHs.553686.

    Genome annotation databases

    GeneIDi317705.
    KEGGihsa:317705.
    UCSCiuc010pyu.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No one nose - Issue 61 of August 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114735 Genomic DNA. Translation: AAM66756.1 .
    AY312489 Genomic DNA. Translation: AAP85622.1 .
    AY312490 Genomic DNA. No translation available.
    AY312491 Genomic DNA. Translation: AAP85623.1 .
    AB083608 Genomic DNA. Translation: BAB89321.1 .
    BC126341 mRNA. Translation: AAI26342.1 .
    BC126367 mRNA. Translation: AAI26368.1 .
    RefSeqi NP_776257.1. NM_173858.1.
    UniGenei Hs.553686.

    3D structure databases

    ProteinModelPortali Q7Z5H4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7Z5H4.

    Proteomic databases

    PRIDEi Q7Z5H4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 317705.
    KEGGi hsa:317705.
    UCSCi uc010pyu.2. human.

    Organism-specific databases

    CTDi 317705.
    GeneCardsi GC01P247419.
    H-InvDB HIX0093782.
    HGNCi HGNC:19870. VN1R5.
    neXtProti NX_Q7Z5H4.
    PharmGKBi PA134993066.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG098604.
    InParanoidi Q7Z5H4.
    KOi K04614.
    PhylomeDBi Q7Z5H4.

    Miscellaneous databases

    GeneWikii VN1R5.
    GenomeRNAii 317705.
    NextBioi 96372.
    PROi Q7Z5H4.

    Gene expression databases

    CleanExi HS_VN1R5.
    Genevestigatori Q7Z5H4.

    Family and domain databases

    InterProi IPR004072. Vmron_rcpt_1.
    [Graphical view ]
    Pfami PF03402. V1R. 2 hits.
    [Graphical view ]
    PRINTSi PR01534. VOMERONASL1R.
    ProtoNeti Search...

    Publicationsi

    1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
      Rodriguez I., Mombaerts P.
      Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
      Zhang J., Webb D.M.
      Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT CYS-350.
    3. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiVN1R5_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z5H4
    Secondary accession number(s): A0AVG1, Q8NEU5, Q8TDU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3