Vomeronasal type-1 receptor 5 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q7Z5H4 (VN1R5_HUMAN)

Last modified February 9, 2010. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Vomeronasal type-1 receptor 5
Alternative name(s):
    V1r-like receptor 5
    G-protein coupled receptor GPCR26
      Short name=hGPCR26

Gene names

Name:	VN1R5
Synonyms:	V1RL5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Putative pheromone receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.
Miscellaneous	The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 357

357

Vomeronasal type-1 receptor 5

PRO_0000070220

Regions

Topological domain

1 – 3

Extracellular Potential

Transmembrane

4 – 24

1 Potential

Topological domain

25 – 52

Cytoplasmic Potential

Transmembrane

53 – 73

2 Potential

Topological domain

74 – 81

Extracellular Potential

Transmembrane

82 – 102

3 Potential

Topological domain

103 – 130

Cytoplasmic Potential

Transmembrane

131 – 151

4 Potential

Topological domain

152 – 163

Extracellular Potential

Transmembrane

164 – 184

5 Potential

Topological domain

185 – 269

Cytoplasmic Potential

Transmembrane

270 – 290

6 Potential

Topological domain

291 – 300

Extracellular Potential

Transmembrane

301 – 321

7 Potential

Topological domain

322 – 357

Cytoplasmic Potential

Amino acid modifications

Glycosylation

297

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

350

R → C in allele VN1R5*3. dbSNP rs41308154. Ref.2

VAR_022802

Experimental info

Sequence conflict

F → Y in BAB89321. Ref.3

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Sequences

Sequence

Length

Mass (Da)

Tools

Q7Z5H4-1 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 0E01BA2B43D5F2FE
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FASTA

357

40,779

        10         20         30         40         50         60 
MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY PQASFGISAN 

        70         80         90        100        110        120 
TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI LVSLDFFGSQ NTQDDLRYKV 

       130        140        150        160        170        180 
IVFLNKVMRG LSICTPCLLS VLQAIISPSI FSLAKLKHPS ASHILGFFLF SWVLNMFIGV 

       190        200        210        220        230        240 
IFCCTLRLPP VKRGQSSVCH TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD 

       250        260        270        280        290        300 
YFIQTIRGYL SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL 

       310        320        330        340        350 
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR QCGSTKK

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human vomeronasal receptor-like genes reveal species-specific families." Rodriguez I., Mombaerts P. Curr. Biol. 12:R409-R411(2002) [PubMed: 12123587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates." Zhang J., Webb D.M. Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed: 12826614] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT CYS-350.
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed: 12044878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

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Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AY114735 Genomic DNA. Translation: AAM66756.1. AY312489 Genomic DNA. Translation: AAP85622.1. AY312490 Genomic DNA. No translation available. AY312491 Genomic DNA. Translation: AAP85623.1. AB083608 Genomic DNA. Translation: BAB89321.1. BC126341 mRNA. Translation: AAI26342.1. BC126367 mRNA. Translation: AAI26368.1.
IPI	IPI00168753.
RefSeq	NP_776257.1.
UniGene	Hs.553686
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q7Z5H4.
Genome annotation databases
GeneID	317705.
KEGG	hsa:317705.
Organism-specific databases
CTD	317705.
GeneCards	GC01P245485.
H-InvDB	HIX0029586. HIX0029720.
HGNC	HGNC:19870. VN1R5.
PharmGKB	PA134993066.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q7Z5H4.
InParanoid	Q7Z5H4.
Gene expression databases
CleanEx	HS_VN1R5.
Genevestigator	Q7Z5H4.
Family and domain databases
InterPro	IPR004072. Vmron_rcpt_1. [Graphical view]
PANTHER	PTHR11391. Vmron_rcpt_1. 1 hit.
Pfam	PF03402. V1R. 2 hits. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	96372.

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Entry information

Entry name

VN1R5_HUMAN

Accession

Primary (citable) accession number: Q7Z5H4
Secondary accession number(s): A0AVG1, Q8NEU5, Q8TDU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	February 9, 2010
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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