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Q7Z5H4 (VN1R5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vomeronasal type-1 receptor 5
Alternative name(s):
G-protein coupled receptor GPCR26
Short name=hGPCR26
V1r-like receptor 5
Gene names
Name:VN1R5
Synonyms:V1RL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative pheromone receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.

Miscellaneous

The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processPheromone response
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to pheromone

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpheromone receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Vomeronasal type-1 receptor 5
PRO_0000070220

Regions

Topological domain1 – 33Extracellular Potential
Transmembrane4 – 2421Helical; Name=1; Potential
Topological domain25 – 5228Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 818Extracellular Potential
Transmembrane82 – 10221Helical; Name=3; Potential
Topological domain103 – 13028Cytoplasmic Potential
Transmembrane131 – 15121Helical; Name=4; Potential
Topological domain152 – 16312Extracellular Potential
Transmembrane164 – 18421Helical; Name=5; Potential
Topological domain185 – 26985Cytoplasmic Potential
Transmembrane270 – 29021Helical; Name=6; Potential
Topological domain291 – 30010Extracellular Potential
Transmembrane301 – 32121Helical; Name=7; Potential
Topological domain322 – 35736Cytoplasmic Potential

Amino acid modifications

Glycosylation2971N-linked (GlcNAc...) Potential

Natural variations

Natural variant3501R → C in allele VN1R5*3. Ref.2
Corresponds to variant rs41308154 [ dbSNP | Ensembl ].
VAR_022802

Experimental info

Sequence conflict661F → Y in BAB89321. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q7Z5H4 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 0E01BA2B43D5F2FE

FASTA35740,779
        10         20         30         40         50         60 
MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY PQASFGISAN 

        70         80         90        100        110        120 
TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI LVSLDFFGSQ NTQDDLRYKV 

       130        140        150        160        170        180 
IVFLNKVMRG LSICTPCLLS VLQAIISPSI FSLAKLKHPS ASHILGFFLF SWVLNMFIGV 

       190        200        210        220        230        240 
IFCCTLRLPP VKRGQSSVCH TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD 

       250        260        270        280        290        300 
YFIQTIRGYL SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL 

       310        320        330        340        350 
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR QCGSTKK 

« Hide

References

« Hide 'large scale' references
[1]"Novel human vomeronasal receptor-like genes reveal species-specific families."
Rodriguez I., Mombaerts P.
Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
Zhang J., Webb D.M.
Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT CYS-350.
[3]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY114735 Genomic DNA. Translation: AAM66756.1.
AY312489 Genomic DNA. Translation: AAP85622.1.
AY312490 Genomic DNA. No translation available.
AY312491 Genomic DNA. Translation: AAP85623.1.
AB083608 Genomic DNA. Translation: BAB89321.1.
BC126341 mRNA. Translation: AAI26342.1.
BC126367 mRNA. Translation: AAI26368.1.
RefSeqNP_776257.1. NM_173858.1.
UniGeneHs.553686.

3D structure databases

ProteinModelPortalQ7Z5H4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ7Z5H4.

Proteomic databases

PRIDEQ7Z5H4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID317705.
KEGGhsa:317705.
UCSCuc010pyu.2. human.

Organism-specific databases

CTD317705.
GeneCardsGC01P247419.
H-InvDBHIX0093782.
HGNCHGNC:19870. VN1R5.
neXtProtNX_Q7Z5H4.
PharmGKBPA134993066.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG098604.
InParanoidQ7Z5H4.
KOK04614.
PhylomeDBQ7Z5H4.

Gene expression databases

CleanExHS_VN1R5.
GenevestigatorQ7Z5H4.

Family and domain databases

InterProIPR004072. Vmron_rcpt_1.
[Graphical view]
PfamPF03402. V1R. 2 hits.
[Graphical view]
PRINTSPR01534. VOMERONASL1R.
ProtoNetSearch...

Other

GeneWikiVN1R5.
GenomeRNAi317705.
NextBio96372.
PROQ7Z5H4.

Entry information

Entry nameVN1R5_HUMAN
AccessionPrimary (citable) accession number: Q7Z5H4
Secondary accession number(s): A0AVG1, Q8NEU5, Q8TDU3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries