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Q7Z5H4

- VN1R5_HUMAN

UniProt

Q7Z5H4 - VN1R5_HUMAN

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Protein
Vomeronasal type-1 receptor 5
Gene
VN1R5, V1RL5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 5
Alternative name(s):
G-protein coupled receptor GPCR26
Short name:
hGPCR26
V1r-like receptor 5
Gene namesi
Name:VN1R5
Synonyms:V1RL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19870. VN1R5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33Extracellular Reviewed prediction
Transmembranei4 – 2421Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini25 – 5228Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei53 – 7321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini74 – 818Extracellular Reviewed prediction
Transmembranei82 – 10221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini103 – 13028Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei131 – 15121Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini152 – 16312Extracellular Reviewed prediction
Add
BLAST
Transmembranei164 – 18421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini185 – 26985Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini291 – 30010Extracellular Reviewed prediction
Transmembranei301 – 32121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini322 – 35736Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Vomeronasal type-1 receptor 5
PRO_0000070220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7Z5H4.

PTM databases

PhosphoSiteiQ7Z5H4.

Expressioni

Gene expression databases

CleanExiHS_VN1R5.
GenevestigatoriQ7Z5H4.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5H4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG098604.
InParanoidiQ7Z5H4.
KOiK04614.
PhylomeDBiQ7Z5H4.

Family and domain databases

InterProiIPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 2 hits.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.

Sequencei

Sequence statusi: Complete.

Q7Z5H4-1 [UniParc]FASTAAdd to Basket

« Hide

MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY    50
PQASFGISAN TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI 100
LVSLDFFGSQ NTQDDLRYKV IVFLNKVMRG LSICTPCLLS VLQAIISPSI 150
FSLAKLKHPS ASHILGFFLF SWVLNMFIGV IFCCTLRLPP VKRGQSSVCH 200
TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD YFIQTIRGYL 250
SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL 300
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR 350
QCGSTKK 357
Length:357
Mass (Da):40,779
Last modified:July 5, 2005 - v2
Checksum:i0E01BA2B43D5F2FE
GO

Polymorphismi

There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti350 – 3501R → C in allele VN1R5*3. 1 Publication
Corresponds to variant rs41308154 [ dbSNP | Ensembl ].
VAR_022802

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661F → Y in BAB89321. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114735 Genomic DNA. Translation: AAM66756.1.
AY312489 Genomic DNA. Translation: AAP85622.1.
AY312490 Genomic DNA. No translation available.
AY312491 Genomic DNA. Translation: AAP85623.1.
AB083608 Genomic DNA. Translation: BAB89321.1.
BC126341 mRNA. Translation: AAI26342.1.
BC126367 mRNA. Translation: AAI26368.1.
RefSeqiNP_776257.1. NM_173858.1.
UniGeneiHs.553686.

Genome annotation databases

GeneIDi317705.
KEGGihsa:317705.
UCSCiuc010pyu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114735 Genomic DNA. Translation: AAM66756.1 .
AY312489 Genomic DNA. Translation: AAP85622.1 .
AY312490 Genomic DNA. No translation available.
AY312491 Genomic DNA. Translation: AAP85623.1 .
AB083608 Genomic DNA. Translation: BAB89321.1 .
BC126341 mRNA. Translation: AAI26342.1 .
BC126367 mRNA. Translation: AAI26368.1 .
RefSeqi NP_776257.1. NM_173858.1.
UniGenei Hs.553686.

3D structure databases

ProteinModelPortali Q7Z5H4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q7Z5H4.

Proteomic databases

PRIDEi Q7Z5H4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 317705.
KEGGi hsa:317705.
UCSCi uc010pyu.2. human.

Organism-specific databases

CTDi 317705.
GeneCardsi GC01P247419.
H-InvDB HIX0093782.
HGNCi HGNC:19870. VN1R5.
neXtProti NX_Q7Z5H4.
PharmGKBi PA134993066.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG098604.
InParanoidi Q7Z5H4.
KOi K04614.
PhylomeDBi Q7Z5H4.

Miscellaneous databases

GeneWikii VN1R5.
GenomeRNAii 317705.
NextBioi 96372.
PROi Q7Z5H4.

Gene expression databases

CleanExi HS_VN1R5.
Genevestigatori Q7Z5H4.

Family and domain databases

InterProi IPR004072. Vmron_rcpt_1.
[Graphical view ]
Pfami PF03402. V1R. 2 hits.
[Graphical view ]
PRINTSi PR01534. VOMERONASL1R.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
    Rodriguez I., Mombaerts P.
    Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT CYS-350.
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiVN1R5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5H4
Secondary accession number(s): A0AVG1, Q8NEU5, Q8TDU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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