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Protein

Rho GTPase-activating protein 22

Gene

ARHGAP22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. regulation of small GTPase mediated signal transduction Source: Reactome
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. small GTPase mediated signal transduction Source: Reactome
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, GTPase activation

Keywords - Biological processi

Angiogenesis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 22
Alternative name(s):
Rho-type GTPase-activating protein 22
Gene namesi
Name:ARHGAP22
Synonyms:RHOGAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30320. ARHGAP22.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Mainly cytoplasmic. Some fraction is nuclear (By similarity).By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. focal adhesion Source: UniProtKB
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Rho GTPase-activating protein 22PRO_0000280469Add
BLAST

Proteomic databases

MaxQBiQ7Z5H3.
PaxDbiQ7Z5H3.
PRIDEiQ7Z5H3.

PTM databases

PhosphoSiteiQ7Z5H3.

Expressioni

Gene expression databases

BgeeiQ7Z5H3.
CleanExiHS_ARHGAP22.
ExpressionAtlasiQ7Z5H3. baseline and differential.
GenevestigatoriQ7Z5H3.

Organism-specific databases

HPAiCAB020696.
HPA040391.
HPA046797.
HPA064439.

Interactioni

Subunit structurei

Interacts with VEZF1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3866859,EBI-766279

Protein-protein interaction databases

BioGridi121832. 2 interactions.
IntActiQ7Z5H3. 1 interaction.
STRINGi9606.ENSP00000249601.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5H3.
SMRiQ7Z5H3. Positions 36-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 145109PHPROSITE-ProRule annotationAdd
BLAST
Domaini155 – 349195Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili590 – 68798Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi427 – 587161Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG246008.
GeneTreeiENSGT00760000118863.
HOGENOMiHOG000232151.
HOVERGENiHBG058875.
InParanoidiQ7Z5H3.
OMAiGEREKVP.
OrthoDBiEOG79W94M.
PhylomeDBiQ7Z5H3.
TreeFamiTF323577.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5H3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI
60 70 80 90 100
MKNWQQRWFV LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK
110 120 130 140 150
HLFEISPGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG
160 170 180 190 200
GIFGQRLEET VHHERKYGPR LAPLLVEQCV DFIRERGLTE EGLFRMPGQA
210 220 230 240 250
NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE PVVPFARYED
260 270 280 290 300
FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV
310 320 330 340 350
NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT
360 370 380 390 400
APVPEGPTSP RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA
410 420 430 440 450
VAVLSRTAPT GPGSRCSPGK KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE
460 470 480 490 500
VPIISSGGNW LMNGLSSLRG HRRASSGDRL KDSGSVQRLS TYDNVPAPGL
510 520 530 540 550
VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR SSLHTDWALE
560 570 580 590 600
PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ
610 620 630 640 650
GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI
660 670 680 690
MLEIKLRNSE RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK
Length:698
Mass (Da):76,779
Last modified:October 1, 2003 - v1
Checksum:i3CE8CEB0A9E5D0F8
GO
Isoform 2 (identifier: Q7Z5H3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: G → GGTARRSHAHPLEPLPP

Note: No experimental confirmation available.

Show »
Length:714
Mass (Da):78,497
Checksum:i74AB4A00D66DE416
GO
Isoform 3 (identifier: Q7Z5H3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MLSPKIRQAR...PGKHLFEISP → MPFWPIRCLKRSRRMPR

Note: No experimental confirmation available.

Show »
Length:608
Mass (Da):66,611
Checksum:i2D7543609C576A5D
GO
Isoform 4 (identifier: Q7Z5H3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: MLSPKIRQAR...QVEDPVTIME → MGQPREFWHL...QGPSPPLFPA

Note: No experimental confirmation available.

Show »
Length:494
Mass (Da):52,697
Checksum:i2E77D20B3241012D
GO
Isoform 5 (identifier: Q7Z5H3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLSPKIRQARRA → MLPTASSKRRTFAARYFT

Note: No experimental confirmation available.

Show »
Length:704
Mass (Da):77,457
Checksum:iBC4DB2D59C466994
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti410 – 4101T → K.
Corresponds to variant rs1867586 [ dbSNP | Ensembl ].
VAR_031153
Natural varianti612 – 6121R → C.
Corresponds to variant rs3747853 [ dbSNP | Ensembl ].
VAR_031154

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 329329MLSPK…VTIME → MGQPREFWHLRSQVPVPTCH LLTVQPWCLLPHPTPAGGRE RRHSASSLLAALCLRKAVLR PHPAVLPGVGGCVVLSSGRM KAPLRGGLALGTGPAPTKLQ LLHDWQSEPGPSGWQQGPSP PLFPA in isoform 4. 1 PublicationVSP_023703Add
BLAST
Alternative sequencei1 – 107107MLSPK…FEISP → MPFWPIRCLKRSRRMPR in isoform 3. 1 PublicationVSP_023704Add
BLAST
Alternative sequencei1 – 1212MLSPK…QARRA → MLPTASSKRRTFAARYFT in isoform 5. 1 PublicationVSP_053502Add
BLAST
Alternative sequencei150 – 1501G → GGTARRSHAHPLEPLPP in isoform 2. 1 PublicationVSP_023705

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324801 mRNA. Translation: AAP85632.1.
AK127586 mRNA. Translation: BAC87044.1.
AK293579 mRNA. Translation: BAG57049.1.
U90908 mRNA. Translation: AAB51057.1.
EF560749 mRNA. Translation: ABQ59059.1.
AC016397 Genomic DNA. No translation available.
AC016399 Genomic DNA. No translation available.
AC068898 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93127.1.
BC126444 mRNA. Translation: AAI26445.1.
BC136319 mRNA. Translation: AAI36320.1.
CCDSiCCDS58079.1. [Q7Z5H3-3]
CCDS58080.1. [Q7Z5H3-2]
CCDS58081.1. [Q7Z5H3-5]
CCDS7227.1. [Q7Z5H3-1]
RefSeqiNP_001242953.1. NM_001256024.1. [Q7Z5H3-2]
NP_001242954.1. NM_001256025.2. [Q7Z5H3-5]
NP_001242955.1. NM_001256026.1. [Q7Z5H3-3]
NP_067049.2. NM_021226.3. [Q7Z5H3-1]
UniGeneiHs.655672.

Genome annotation databases

EnsembliENST00000249601; ENSP00000249601; ENSG00000128805. [Q7Z5H3-1]
ENST00000417247; ENSP00000410054; ENSG00000128805. [Q7Z5H3-3]
ENST00000417912; ENSP00000412461; ENSG00000128805. [Q7Z5H3-2]
ENST00000435790; ENSP00000416701; ENSG00000128805. [Q7Z5H3-5]
GeneIDi58504.
KEGGihsa:58504.
UCSCiuc001jgr.4. human. [Q7Z5H3-4]
uc001jgs.4. human. [Q7Z5H3-3]
uc001jgt.4. human. [Q7Z5H3-1]
uc001jgu.4. human. [Q7Z5H3-2]
uc010qgm.3. human.

Polymorphism databases

DMDMi74750129.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324801 mRNA. Translation: AAP85632.1.
AK127586 mRNA. Translation: BAC87044.1.
AK293579 mRNA. Translation: BAG57049.1.
U90908 mRNA. Translation: AAB51057.1.
EF560749 mRNA. Translation: ABQ59059.1.
AC016397 Genomic DNA. No translation available.
AC016399 Genomic DNA. No translation available.
AC068898 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93127.1.
BC126444 mRNA. Translation: AAI26445.1.
BC136319 mRNA. Translation: AAI36320.1.
CCDSiCCDS58079.1. [Q7Z5H3-3]
CCDS58080.1. [Q7Z5H3-2]
CCDS58081.1. [Q7Z5H3-5]
CCDS7227.1. [Q7Z5H3-1]
RefSeqiNP_001242953.1. NM_001256024.1. [Q7Z5H3-2]
NP_001242954.1. NM_001256025.2. [Q7Z5H3-5]
NP_001242955.1. NM_001256026.1. [Q7Z5H3-3]
NP_067049.2. NM_021226.3. [Q7Z5H3-1]
UniGeneiHs.655672.

3D structure databases

ProteinModelPortaliQ7Z5H3.
SMRiQ7Z5H3. Positions 36-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121832. 2 interactions.
IntActiQ7Z5H3. 1 interaction.
STRINGi9606.ENSP00000249601.

PTM databases

PhosphoSiteiQ7Z5H3.

Polymorphism databases

DMDMi74750129.

Proteomic databases

MaxQBiQ7Z5H3.
PaxDbiQ7Z5H3.
PRIDEiQ7Z5H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249601; ENSP00000249601; ENSG00000128805. [Q7Z5H3-1]
ENST00000417247; ENSP00000410054; ENSG00000128805. [Q7Z5H3-3]
ENST00000417912; ENSP00000412461; ENSG00000128805. [Q7Z5H3-2]
ENST00000435790; ENSP00000416701; ENSG00000128805. [Q7Z5H3-5]
GeneIDi58504.
KEGGihsa:58504.
UCSCiuc001jgr.4. human. [Q7Z5H3-4]
uc001jgs.4. human. [Q7Z5H3-3]
uc001jgt.4. human. [Q7Z5H3-1]
uc001jgu.4. human. [Q7Z5H3-2]
uc010qgm.3. human.

Organism-specific databases

CTDi58504.
GeneCardsiGC10M049654.
HGNCiHGNC:30320. ARHGAP22.
HPAiCAB020696.
HPA040391.
HPA046797.
HPA064439.
MIMi610585. gene.
neXtProtiNX_Q7Z5H3.
PharmGKBiPA134979724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG246008.
GeneTreeiENSGT00760000118863.
HOGENOMiHOG000232151.
HOVERGENiHBG058875.
InParanoidiQ7Z5H3.
OMAiGEREKVP.
OrthoDBiEOG79W94M.
PhylomeDBiQ7Z5H3.
TreeFamiTF323577.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARHGAP22. human.
GenomeRNAii58504.
NextBioi65012.
PROiQ7Z5H3.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z5H3.
CleanExiHS_ARHGAP22.
ExpressionAtlasiQ7Z5H3. baseline and differential.
GenevestigatoriQ7Z5H3.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Shan Y.X., Liu S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
    Tissue: Cerebellum and Erythroleukemia.
  3. Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung and Testis.
  8. "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 14:333-338(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiRHG22_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5H3
Secondary accession number(s): A0AVP7
, A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: March 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.