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Q7Z5H3

- RHG22_HUMAN

UniProt

Q7Z5H3 - RHG22_HUMAN

Protein

Rho GTPase-activating protein 22

Gene

ARHGAP22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. regulation of small GTPase mediated signal transduction Source: Reactome
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. small GTPase mediated signal transduction Source: Reactome
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, GTPase activation

    Keywords - Biological processi

    Angiogenesis, Differentiation, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein 22
    Alternative name(s):
    Rho-type GTPase-activating protein 22
    Gene namesi
    Name:ARHGAP22
    Synonyms:RHOGAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:30320. ARHGAP22.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Mainly cytoplasmic. Some fraction is nuclear By similarity.By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134979724.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 698698Rho GTPase-activating protein 22PRO_0000280469Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z5H3.
    PaxDbiQ7Z5H3.
    PRIDEiQ7Z5H3.

    PTM databases

    PhosphoSiteiQ7Z5H3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z5H3.
    BgeeiQ7Z5H3.
    CleanExiHS_ARHGAP22.
    GenevestigatoriQ7Z5H3.

    Organism-specific databases

    HPAiCAB020696.
    HPA040391.
    HPA046797.

    Interactioni

    Subunit structurei

    Interacts with VEZF1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CACNA1AO005552EBI-3866859,EBI-766279

    Protein-protein interaction databases

    BioGridi121832. 1 interaction.
    IntActiQ7Z5H3. 1 interaction.
    STRINGi9606.ENSP00000249601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z5H3.
    SMRiQ7Z5H3. Positions 36-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 145109PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini155 – 349195Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili590 – 68798Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi427 – 587161Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG246008.
    HOGENOMiHOG000232151.
    HOVERGENiHBG058875.
    InParanoidiQ7Z5H3.
    OMAiGEREKVP.
    OrthoDBiEOG79W94M.
    PhylomeDBiQ7Z5H3.
    TreeFamiTF323577.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z5H3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI    50
    MKNWQQRWFV LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK 100
    HLFEISPGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG 150
    GIFGQRLEET VHHERKYGPR LAPLLVEQCV DFIRERGLTE EGLFRMPGQA 200
    NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE PVVPFARYED 250
    FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV 300
    NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT 350
    APVPEGPTSP RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA 400
    VAVLSRTAPT GPGSRCSPGK KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE 450
    VPIISSGGNW LMNGLSSLRG HRRASSGDRL KDSGSVQRLS TYDNVPAPGL 500
    VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR SSLHTDWALE 550
    PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ 600
    GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI 650
    MLEIKLRNSE RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK 698
    Length:698
    Mass (Da):76,779
    Last modified:October 1, 2003 - v1
    Checksum:i3CE8CEB0A9E5D0F8
    GO
    Isoform 2 (identifier: Q7Z5H3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-150: G → GGTARRSHAHPLEPLPP

    Note: No experimental confirmation available.

    Show »
    Length:714
    Mass (Da):78,497
    Checksum:i74AB4A00D66DE416
    GO
    Isoform 3 (identifier: Q7Z5H3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: MLSPKIRQAR...PGKHLFEISP → MPFWPIRCLKRSRRMPR

    Note: No experimental confirmation available.

    Show »
    Length:608
    Mass (Da):66,611
    Checksum:i2D7543609C576A5D
    GO
    Isoform 4 (identifier: Q7Z5H3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-329: MLSPKIRQAR...QVEDPVTIME → MGQPREFWHL...QGPSPPLFPA

    Note: No experimental confirmation available.

    Show »
    Length:494
    Mass (Da):52,697
    Checksum:i2E77D20B3241012D
    GO
    Isoform 5 (identifier: Q7Z5H3-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MLSPKIRQARRA → MLPTASSKRRTFAARYFT

    Note: No experimental confirmation available.

    Show »
    Length:704
    Mass (Da):77,457
    Checksum:iBC4DB2D59C466994
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti410 – 4101T → K.
    Corresponds to variant rs1867586 [ dbSNP | Ensembl ].
    VAR_031153
    Natural varianti612 – 6121R → C.
    Corresponds to variant rs3747853 [ dbSNP | Ensembl ].
    VAR_031154

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 329329MLSPK…VTIME → MGQPREFWHLRSQVPVPTCH LLTVQPWCLLPHPTPAGGRE RRHSASSLLAALCLRKAVLR PHPAVLPGVGGCVVLSSGRM KAPLRGGLALGTGPAPTKLQ LLHDWQSEPGPSGWQQGPSP PLFPA in isoform 4. 1 PublicationVSP_023703Add
    BLAST
    Alternative sequencei1 – 107107MLSPK…FEISP → MPFWPIRCLKRSRRMPR in isoform 3. 1 PublicationVSP_023704Add
    BLAST
    Alternative sequencei1 – 1212MLSPK…QARRA → MLPTASSKRRTFAARYFT in isoform 5. 1 PublicationVSP_053502Add
    BLAST
    Alternative sequencei150 – 1501G → GGTARRSHAHPLEPLPP in isoform 2. 1 PublicationVSP_023705

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY324801 mRNA. Translation: AAP85632.1.
    AK127586 mRNA. Translation: BAC87044.1.
    AK293579 mRNA. Translation: BAG57049.1.
    U90908 mRNA. Translation: AAB51057.1.
    EF560749 mRNA. Translation: ABQ59059.1.
    AC016397 Genomic DNA. No translation available.
    AC016399 Genomic DNA. No translation available.
    AC068898 Genomic DNA. No translation available.
    CH471187 Genomic DNA. Translation: EAW93127.1.
    BC126444 mRNA. Translation: AAI26445.1.
    BC136319 mRNA. Translation: AAI36320.1.
    CCDSiCCDS58079.1. [Q7Z5H3-3]
    CCDS58080.1. [Q7Z5H3-2]
    CCDS58081.1. [Q7Z5H3-5]
    CCDS7227.1. [Q7Z5H3-1]
    RefSeqiNP_001242953.1. NM_001256024.1. [Q7Z5H3-2]
    NP_001242954.1. NM_001256025.2. [Q7Z5H3-5]
    NP_001242955.1. NM_001256026.1. [Q7Z5H3-3]
    NP_067049.2. NM_021226.3. [Q7Z5H3-1]
    UniGeneiHs.655672.

    Genome annotation databases

    EnsembliENST00000249601; ENSP00000249601; ENSG00000128805. [Q7Z5H3-1]
    ENST00000417247; ENSP00000410054; ENSG00000128805. [Q7Z5H3-3]
    ENST00000417912; ENSP00000412461; ENSG00000128805. [Q7Z5H3-2]
    ENST00000435790; ENSP00000416701; ENSG00000128805. [Q7Z5H3-5]
    GeneIDi58504.
    KEGGihsa:58504.
    UCSCiuc001jgr.4. human. [Q7Z5H3-4]
    uc001jgs.4. human. [Q7Z5H3-3]
    uc001jgt.4. human. [Q7Z5H3-1]
    uc001jgu.4. human. [Q7Z5H3-2]

    Polymorphism databases

    DMDMi74750129.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY324801 mRNA. Translation: AAP85632.1 .
    AK127586 mRNA. Translation: BAC87044.1 .
    AK293579 mRNA. Translation: BAG57049.1 .
    U90908 mRNA. Translation: AAB51057.1 .
    EF560749 mRNA. Translation: ABQ59059.1 .
    AC016397 Genomic DNA. No translation available.
    AC016399 Genomic DNA. No translation available.
    AC068898 Genomic DNA. No translation available.
    CH471187 Genomic DNA. Translation: EAW93127.1 .
    BC126444 mRNA. Translation: AAI26445.1 .
    BC136319 mRNA. Translation: AAI36320.1 .
    CCDSi CCDS58079.1. [Q7Z5H3-3 ]
    CCDS58080.1. [Q7Z5H3-2 ]
    CCDS58081.1. [Q7Z5H3-5 ]
    CCDS7227.1. [Q7Z5H3-1 ]
    RefSeqi NP_001242953.1. NM_001256024.1. [Q7Z5H3-2 ]
    NP_001242954.1. NM_001256025.2. [Q7Z5H3-5 ]
    NP_001242955.1. NM_001256026.1. [Q7Z5H3-3 ]
    NP_067049.2. NM_021226.3. [Q7Z5H3-1 ]
    UniGenei Hs.655672.

    3D structure databases

    ProteinModelPortali Q7Z5H3.
    SMRi Q7Z5H3. Positions 36-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121832. 1 interaction.
    IntActi Q7Z5H3. 1 interaction.
    STRINGi 9606.ENSP00000249601.

    PTM databases

    PhosphoSitei Q7Z5H3.

    Polymorphism databases

    DMDMi 74750129.

    Proteomic databases

    MaxQBi Q7Z5H3.
    PaxDbi Q7Z5H3.
    PRIDEi Q7Z5H3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249601 ; ENSP00000249601 ; ENSG00000128805 . [Q7Z5H3-1 ]
    ENST00000417247 ; ENSP00000410054 ; ENSG00000128805 . [Q7Z5H3-3 ]
    ENST00000417912 ; ENSP00000412461 ; ENSG00000128805 . [Q7Z5H3-2 ]
    ENST00000435790 ; ENSP00000416701 ; ENSG00000128805 . [Q7Z5H3-5 ]
    GeneIDi 58504.
    KEGGi hsa:58504.
    UCSCi uc001jgr.4. human. [Q7Z5H3-4 ]
    uc001jgs.4. human. [Q7Z5H3-3 ]
    uc001jgt.4. human. [Q7Z5H3-1 ]
    uc001jgu.4. human. [Q7Z5H3-2 ]

    Organism-specific databases

    CTDi 58504.
    GeneCardsi GC10M049654.
    HGNCi HGNC:30320. ARHGAP22.
    HPAi CAB020696.
    HPA040391.
    HPA046797.
    MIMi 610585. gene.
    neXtProti NX_Q7Z5H3.
    PharmGKBi PA134979724.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246008.
    HOGENOMi HOG000232151.
    HOVERGENi HBG058875.
    InParanoidi Q7Z5H3.
    OMAi GEREKVP.
    OrthoDBi EOG79W94M.
    PhylomeDBi Q7Z5H3.
    TreeFami TF323577.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    GenomeRNAii 58504.
    NextBioi 65012.
    PROi Q7Z5H3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z5H3.
    Bgeei Q7Z5H3.
    CleanExi HS_ARHGAP22.
    Genevestigatori Q7Z5H3.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Huang C.Q., Shan Y.X., Liu S.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
      Tissue: Cerebellum and Erythroleukemia.
    3. Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung and Testis.
    8. "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico."
      Katoh M., Katoh M.
      Int. J. Mol. Med. 14:333-338(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiRHG22_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z5H3
    Secondary accession number(s): A0AVP7
    , A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3