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Q7Z5H3 (RHG22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho GTPase-activating protein 22
Alternative name(s):
Rho-type GTPase-activating protein 22
Gene names
Name:ARHGAP22
Synonyms:RHOGAP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length698 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter By similarity.

Subunit structure

Interacts with VEZF1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Mainly cytoplasmic. Some fraction is nuclear By similarity.

Sequence similarities

Contains 1 PH domain.

Contains 1 Rho-GAP domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CACNA1AO005552EBI-3866859,EBI-766279

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z5H3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z5H3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: G → GGTARRSHAHPLEPLPP
Note: No experimental confirmation available.
Isoform 3 (identifier: Q7Z5H3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MLSPKIRQAR...PGKHLFEISP → MPFWPIRCLKRSRRMPR
Note: No experimental confirmation available.
Isoform 4 (identifier: Q7Z5H3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: MLSPKIRQAR...QVEDPVTIME → MGQPREFWHL...QGPSPPLFPA
Note: No experimental confirmation available.
Isoform 5 (identifier: Q7Z5H3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLSPKIRQARRA → MLPTASSKRRTFAARYFT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 698698Rho GTPase-activating protein 22
PRO_0000280469

Regions

Domain37 – 145109PH
Domain155 – 349195Rho-GAP
Coiled coil590 – 68798 Potential
Compositional bias427 – 587161Ser-rich

Natural variations

Alternative sequence1 – 329329MLSPK…VTIME → MGQPREFWHLRSQVPVPTCH LLTVQPWCLLPHPTPAGGRE RRHSASSLLAALCLRKAVLR PHPAVLPGVGGCVVLSSGRM KAPLRGGLALGTGPAPTKLQ LLHDWQSEPGPSGWQQGPSP PLFPA in isoform 4.
VSP_023703
Alternative sequence1 – 107107MLSPK…FEISP → MPFWPIRCLKRSRRMPR in isoform 3.
VSP_023704
Alternative sequence1 – 1212MLSPK…QARRA → MLPTASSKRRTFAARYFT in isoform 5.
VSP_053502
Alternative sequence1501G → GGTARRSHAHPLEPLPP in isoform 2.
VSP_023705
Natural variant4101T → K.
Corresponds to variant rs1867586 [ dbSNP | Ensembl ].
VAR_031153
Natural variant6121R → C.
Corresponds to variant rs3747853 [ dbSNP | Ensembl ].
VAR_031154

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3CE8CEB0A9E5D0F8

FASTA69876,779
        10         20         30         40         50         60 
MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI MKNWQQRWFV 

        70         80         90        100        110        120 
LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK HLFEISPGGA GEREKVPANP 

       130        140        150        160        170        180 
EALLLMASSQ RDMEDWVQAI RRVIWAPLGG GIFGQRLEET VHHERKYGPR LAPLLVEQCV 

       190        200        210        220        230        240 
DFIRERGLTE EGLFRMPGQA NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE 

       250        260        270        280        290        300 
PVVPFARYED FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV 

       310        320        330        340        350        360 
NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT APVPEGPTSP 

       370        380        390        400        410        420 
RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA VAVLSRTAPT GPGSRCSPGK 

       430        440        450        460        470        480 
KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE VPIISSGGNW LMNGLSSLRG HRRASSGDRL 

       490        500        510        520        530        540 
KDSGSVQRLS TYDNVPAPGL VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR 

       550        560        570        580        590        600 
SSLHTDWALE PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ 

       610        620        630        640        650        660 
GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI MLEIKLRNSE 

       670        680        690 
RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK 

« Hide

Isoform 2 [UniParc].

Checksum: 74AB4A00D66DE416
Show »

FASTA71478,497
Isoform 3 [UniParc].

Checksum: 2D7543609C576A5D
Show »

FASTA60866,611
Isoform 4 [UniParc].

Checksum: 2E77D20B3241012D
Show »

FASTA49452,697
Isoform 5 [UniParc].

Checksum: BC4DB2D59C466994
Show »

FASTA70477,457

References

« Hide 'large scale' references
[1]Huang C.Q., Shan Y.X., Liu S.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
Tissue: Cerebellum and Erythroleukemia.
[3]Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung and Testis.
[8]"Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico."
Katoh M., Katoh M.
Int. J. Mol. Med. 14:333-338(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY324801 mRNA. Translation: AAP85632.1.
AK127586 mRNA. Translation: BAC87044.1.
AK293579 mRNA. Translation: BAG57049.1.
U90908 mRNA. Translation: AAB51057.1.
EF560749 mRNA. Translation: ABQ59059.1.
AC016397 Genomic DNA. No translation available.
AC016399 Genomic DNA. No translation available.
AC068898 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93127.1.
BC126444 mRNA. Translation: AAI26445.1.
BC136319 mRNA. Translation: AAI36320.1.
CCDSCCDS58079.1. [Q7Z5H3-3]
CCDS58080.1. [Q7Z5H3-2]
CCDS58081.1. [Q7Z5H3-5]
CCDS7227.1. [Q7Z5H3-1]
RefSeqNP_001242953.1. NM_001256024.1. [Q7Z5H3-2]
NP_001242954.1. NM_001256025.2. [Q7Z5H3-5]
NP_001242955.1. NM_001256026.1. [Q7Z5H3-3]
NP_067049.2. NM_021226.3. [Q7Z5H3-1]
UniGeneHs.655672.

3D structure databases

ProteinModelPortalQ7Z5H3.
SMRQ7Z5H3. Positions 36-348.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121832. 1 interaction.
IntActQ7Z5H3. 1 interaction.
STRING9606.ENSP00000249601.

PTM databases

PhosphoSiteQ7Z5H3.

Polymorphism databases

DMDM74750129.

Proteomic databases

MaxQBQ7Z5H3.
PaxDbQ7Z5H3.
PRIDEQ7Z5H3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249601; ENSP00000249601; ENSG00000128805. [Q7Z5H3-1]
ENST00000417247; ENSP00000410054; ENSG00000128805. [Q7Z5H3-3]
ENST00000417912; ENSP00000412461; ENSG00000128805. [Q7Z5H3-2]
ENST00000435790; ENSP00000416701; ENSG00000128805. [Q7Z5H3-5]
GeneID58504.
KEGGhsa:58504.
UCSCuc001jgr.4. human. [Q7Z5H3-4]
uc001jgs.4. human. [Q7Z5H3-3]
uc001jgt.4. human. [Q7Z5H3-1]
uc001jgu.4. human. [Q7Z5H3-2]

Organism-specific databases

CTD58504.
GeneCardsGC10M049654.
HGNCHGNC:30320. ARHGAP22.
HPACAB020696.
HPA040391.
HPA046797.
MIM610585. gene.
neXtProtNX_Q7Z5H3.
PharmGKBPA134979724.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG246008.
HOGENOMHOG000232151.
HOVERGENHBG058875.
InParanoidQ7Z5H3.
OMAGEREKVP.
OrthoDBEOG79W94M.
PhylomeDBQ7Z5H3.
TreeFamTF323577.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ7Z5H3.
BgeeQ7Z5H3.
CleanExHS_ARHGAP22.
GenevestigatorQ7Z5H3.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi58504.
NextBio65012.
PROQ7Z5H3.
SOURCESearch...

Entry information

Entry nameRHG22_HUMAN
AccessionPrimary (citable) accession number: Q7Z5H3
Secondary accession number(s): A0AVP7 expand/collapse secondary AC list , A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM