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Protein

Golgin subfamily A member 7

Gene

GOLGA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.2 Publications

GO - Biological processi

  • Golgi to plasma membrane protein transport Source: UniProtKB
  • peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  • protein stabilization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 7
Alternative name(s):
Golgi complex-associated protein of 16 kDa
Gene namesi
Name:GOLGA7
Synonyms:GCP16
ORF Names:HDCKB03P, HSPC041
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24876. GOLGA7.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi stack Source: UniProtKB
  • intrinsic component of Golgi membrane Source: UniProtKB
  • palmitoyltransferase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi24 – 241C → A: Slightly reduces palmitoylation. 1 Publication
Mutagenesisi69 – 691C → A: Strongly reduces palmitoylation. Abolishes palmitoylation and Golgi localization; when associated with A-72. 1 Publication
Mutagenesisi72 – 721C → A: Strongly reduces palmitoylation. Abolishes palmitoylation and Golgi localization; when associated with A-69. 1 Publication
Mutagenesisi81 – 811C → A: Slightly reduces palmitoylation. 1 Publication

Organism-specific databases

PharmGKBiPA37002.

Polymorphism and mutation databases

BioMutaiGOLGA7.
DMDMi82592879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Golgin subfamily A member 7PRO_0000213977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi69 – 691S-palmitoyl cysteine1 Publication
Lipidationi72 – 721S-palmitoyl cysteine1 Publication

Post-translational modificationi

Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ7Z5G4.
MaxQBiQ7Z5G4.
PaxDbiQ7Z5G4.
PeptideAtlasiQ7Z5G4.
PRIDEiQ7Z5G4.

PTM databases

iPTMnetiQ7Z5G4.
PhosphoSiteiQ7Z5G4.
SwissPalmiQ7Z5G4.

Expressioni

Tissue specificityi

Expressed in all tissues except colon and thymus.2 Publications

Gene expression databases

BgeeiQ7Z5G4.
CleanExiHS_GOLGA7.
GenevisibleiQ7Z5G4. HS.

Organism-specific databases

HPAiHPA046878.

Interactioni

Subunit structurei

Interacts with GOLGA3. Interacts with ZDHHC9.2 Publications

Protein-protein interaction databases

BioGridi119312. 9 interactions.
IntActiQ7Z5G4. 1 interaction.
STRINGi9606.ENSP00000350378.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERF4 family.Curated

Phylogenomic databases

eggNOGiKOG4069. Eukaryota.
ENOG4111NS1. LUCA.
GeneTreeiENSGT00390000000134.
HOGENOMiHOG000010289.
HOVERGENiHBG054534.
InParanoidiQ7Z5G4.
OMAiNERVYNP.
OrthoDBiEOG7KQ23H.
PhylomeDBiQ7Z5G4.
TreeFamiTF313115.

Family and domain databases

InterProiIPR019383. Golgin_A_7/ERF4.
[Graphical view]
PfamiPF10256. Erf4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQQAPVSG KVFIQRDYSS GTRCQFQTKF PAELENRIDR QQFEETVRTL
60 70 80 90 100
NNLYAEAEKL GGQSYLEGCL ACLTAYTIFL CMETHYEKVL KKVSKYIQEQ
110 120 130
NEKIYAPQGL LLTDPIERGL RVIEITIYED RGMSSGR
Length:137
Mass (Da):15,824
Last modified:November 22, 2005 - v2
Checksum:i00280547DE3702A3
GO
Isoform 2 (identifier: Q7Z5G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-137: IEITIYEDRGMSSGR → FRLKLPFMKTEA

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,578
Checksum:iF614ED426C60ADB9
GO

Sequence cautioni

The sequence AAD39919.1 differs from that shown. Reason: Frameshift at position 36. Curated
The sequence AAF65180.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241C → Y in AAF65180 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei123 – 13715IEITI…MSSGR → FRLKLPFMKTEA in isoform 2. CuratedVSP_046793Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB104615 mRNA. Translation: BAC82368.1.
AF068291 mRNA. Translation: AAF65180.1. Different initiation.
AF125102 mRNA. Translation: AAD39919.1. Sequence problems.
AC009630 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63258.1.
CH471080 Genomic DNA. Translation: EAW63259.1.
BC012032 mRNA. Translation: AAH12032.1.
CCDSiCCDS34887.1. [Q7Z5G4-1]
CCDS55226.1. [Q7Z5G4-3]
RefSeqiNP_001002296.1. NM_001002296.1. [Q7Z5G4-1]
NP_001167595.1. NM_001174124.1. [Q7Z5G4-3]
NP_057183.2. NM_016099.2. [Q7Z5G4-1]
UniGeneiHs.654773.

Genome annotation databases

EnsembliENST00000357743; ENSP00000350378; ENSG00000147533. [Q7Z5G4-1]
ENST00000405786; ENSP00000386030; ENSG00000147533. [Q7Z5G4-3]
ENST00000518270; ENSP00000429329; ENSG00000147533. [Q7Z5G4-1]
ENST00000520817; ENSP00000429480; ENSG00000147533. [Q7Z5G4-1]
GeneIDi51125.
KEGGihsa:51125.
UCSCiuc003xnu.4. human. [Q7Z5G4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB104615 mRNA. Translation: BAC82368.1.
AF068291 mRNA. Translation: AAF65180.1. Different initiation.
AF125102 mRNA. Translation: AAD39919.1. Sequence problems.
AC009630 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63258.1.
CH471080 Genomic DNA. Translation: EAW63259.1.
BC012032 mRNA. Translation: AAH12032.1.
CCDSiCCDS34887.1. [Q7Z5G4-1]
CCDS55226.1. [Q7Z5G4-3]
RefSeqiNP_001002296.1. NM_001002296.1. [Q7Z5G4-1]
NP_001167595.1. NM_001174124.1. [Q7Z5G4-3]
NP_057183.2. NM_016099.2. [Q7Z5G4-1]
UniGeneiHs.654773.

3D structure databases

ProteinModelPortaliQ7Z5G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119312. 9 interactions.
IntActiQ7Z5G4. 1 interaction.
STRINGi9606.ENSP00000350378.

PTM databases

iPTMnetiQ7Z5G4.
PhosphoSiteiQ7Z5G4.
SwissPalmiQ7Z5G4.

Polymorphism and mutation databases

BioMutaiGOLGA7.
DMDMi82592879.

Proteomic databases

EPDiQ7Z5G4.
MaxQBiQ7Z5G4.
PaxDbiQ7Z5G4.
PeptideAtlasiQ7Z5G4.
PRIDEiQ7Z5G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357743; ENSP00000350378; ENSG00000147533. [Q7Z5G4-1]
ENST00000405786; ENSP00000386030; ENSG00000147533. [Q7Z5G4-3]
ENST00000518270; ENSP00000429329; ENSG00000147533. [Q7Z5G4-1]
ENST00000520817; ENSP00000429480; ENSG00000147533. [Q7Z5G4-1]
GeneIDi51125.
KEGGihsa:51125.
UCSCiuc003xnu.4. human. [Q7Z5G4-1]

Organism-specific databases

CTDi51125.
GeneCardsiGOLGA7.
HGNCiHGNC:24876. GOLGA7.
HPAiHPA046878.
MIMi609453. gene.
neXtProtiNX_Q7Z5G4.
PharmGKBiPA37002.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4069. Eukaryota.
ENOG4111NS1. LUCA.
GeneTreeiENSGT00390000000134.
HOGENOMiHOG000010289.
HOVERGENiHBG054534.
InParanoidiQ7Z5G4.
OMAiNERVYNP.
OrthoDBiEOG7KQ23H.
PhylomeDBiQ7Z5G4.
TreeFamiTF313115.

Miscellaneous databases

ChiTaRSiGOLGA7. human.
GenomeRNAii51125.
PROiQ7Z5G4.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z5G4.
CleanExiHS_GOLGA7.
GenevisibleiQ7Z5G4. HS.

Family and domain databases

InterProiIPR019383. Golgin_A_7/ERF4.
[Graphical view]
PfamiPF10256. Erf4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170."
    Ohta E., Misumi Y., Sohda M., Fujiwara T., Yano A., Ikehara Y.
    J. Biol. Chem. 278:51957-51967(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH GOLGA3, TISSUE SPECIFICITY, PALMITOYLATION AT CYS-69 AND CYS-72, MUTAGENESIS OF CYS-24; CYS-69; CYS-72 AND CYS-81, SUBCELLULAR LOCATION, FUNCTION.
  2. "A novel gene from human dendritic cell."
    Zhao Z., Huang X., Li N., Zhu X., Cao X.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  7. "DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras."
    Swarthout J.T., Lobo S., Farh L., Croke M.R., Greentree W.K., Deschenes R.J., Linder M.E.
    J. Biol. Chem. 280:31141-31148(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ZDHHC9, FUNCTION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGOGA7_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5G4
Secondary accession number(s): D3DSX9
, J3KQ24, Q96EQ4, Q9P1S0, Q9Y5U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.