Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein RIC-3

Gene

RIC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.7 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi8.A.71.1.1. the ric3 protein (ric3) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RIC-3
Alternative name(s):
Resistant to inhibitor of cholinesterase 3
Gene namesi
Name:RIC3
ORF Names:UNQ720/PRO1385
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30338. RIC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 95LumenalSequence analysisAdd BLAST67
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 369CytoplasmicSequence analysisAdd BLAST253

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79608.
OpenTargetsiENSG00000166405.
PharmGKBiPA142671066.

Polymorphism and mutation databases

BioMutaiRIC3.
DMDMi74713638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000030273129 – 369Protein RIC-3Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202N6-acetyllysine; alternateCombined sources1
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ7Z5B4.
PRIDEiQ7Z5B4.

PTM databases

iPTMnetiQ7Z5B4.
PhosphoSitePlusiQ7Z5B4.

Expressioni

Tissue specificityi

Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain.3 Publications

Gene expression databases

BgeeiENSG00000166405.
CleanExiHS_RIC3.
ExpressionAtlasiQ7Z5B4. baseline and differential.
GenevisibleiQ7Z5B4. HS.

Organism-specific databases

HPAiHPA065016.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 and HTR3A.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122743. 34 interactors.
IntActiQ7Z5B4. 2 interactors.
MINTiMINT-8343009.
STRINGi9606.ENSP00000308820.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5B4.
SMRiQ7Z5B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili140 – 169By similarityAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 94Poly-GlyAdd BLAST14
Compositional biasi269 – 272Poly-Glu4

Domaini

The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3 molecules, promoting stepwise ACHR homomeric assembly at the membrane.By similarity

Sequence similaritiesi

Belongs to the ric-3 family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK2V. Eukaryota.
ENOG410XS3H. LUCA.
GeneTreeiENSGT00440000034107.
HOGENOMiHOG000034648.
HOVERGENiHBG106009.
InParanoidiQ7Z5B4.
OMAiTPGNTHR.
OrthoDBiEOG091G0E1P.
PhylomeDBiQ7Z5B4.
TreeFamiTF333291.

Family and domain databases

InterProiIPR026160. Ric3.
IPR032763. RIC3_N.
[Graphical view]
PANTHERiPTHR21723. PTHR21723. 1 hit.
PfamiPF15361. RIC3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5B4-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYSTVQRVA LASGLVLALS LLLPKAFLSR GKRQEPPPTP EGKLGRFPPM
60 70 80 90 100
MHHHQAPSDG QTPGARFQRS HLAEAFAKAK GSGGGAGGGG SGRGLMGQII
110 120 130 140 150
PIYGFGIFLY ILYILFKLSK GKTTAEDGKC YTAMPGNTHR KITSFELAQL
160 170 180 190 200
QEKLKETEAA MEKLINRVGP NGESRAQTVT SDQEKRLLHQ LREITRVMKE
210 220 230 240 250
GKFIDRFSPE KEAEEAPYME DWEGYPEETY PIYDLSDCIK RRQETILVDY
260 270 280 290 300
PDPKELSAEE IAERMGMIEE EESDHLGWES LPTDPRAQED NSVTSCDPKP
310 320 330 340 350
ETCSCCFHED EDPAVLAENA GFSADSYPEQ EETTKEEWSQ DFKDEGLGIS
360
TDKAYTGSML RKRNPQGLE
Length:369
Mass (Da):41,092
Last modified:October 1, 2003 - v1
Checksum:i15FD70384070345D
GO
Isoform 2 (identifier: Q7Z5B4-2) [UniParc]FASTAAdd to basket
Also known as: d

The sequence of this isoform differs from the canonical sequence as follows:
     118-128: LSKGKTTAEDG → VSRIILIILHQ
     129-369: Missing.

Show »
Length:128
Mass (Da):13,663
Checksum:i01D76A36CC9F0C2F
GO
Isoform 3 (identifier: Q7Z5B4-3) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     41-222: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):20,954
Checksum:iC51C0B8B8F21B4B2
GO
Isoform 4 (identifier: Q7Z5B4-5) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Missing.

Show »
Length:368
Mass (Da):41,005
Checksum:iC66CFFD8641778DA
GO
Isoform 5 (identifier: Q7Z5B4-6) [UniParc]FASTAAdd to basket
Also known as: e

The sequence of this isoform differs from the canonical sequence as follows:
     143-224: TSFELAQLQE...EAPYMEDWEG → S

Show »
Length:288
Mass (Da):31,643
Checksum:i2D0010517F3E6E20
GO

Sequence cautioni

The sequence BAB13871 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Missing in AAP92163 (PubMed:12821669).Curated1
Sequence conflicti165I → F in AAH22455 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q7Z5B4-2)
Sequence conflicti124I → T in AAP92163 (PubMed:12821669).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03494357P → H.1 PublicationCorresponds to variant rs17855498dbSNPEnsembl.1
Natural variantiVAR_062208130C → Y.Corresponds to variant rs55990541dbSNPEnsembl.1
Natural variantiVAR_036391346G → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02793941 – 222Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_027940118 – 128LSKGKTTAEDG → VSRIILIILHQ in isoform 2. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_027941129 – 369Missing in isoform 2. 2 PublicationsAdd BLAST241
Alternative sequenceiVSP_043786143 – 224TSFEL…EDWEG → S in isoform 5. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_027943174Missing in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326435 mRNA. Translation: AAP92162.1.
AY326436 mRNA. Translation: AAP92163.1.
AM422214 mRNA. Translation: CAM12309.1.
AY358475 mRNA. Translation: AAQ88839.1.
AK021670 mRNA. Translation: BAB13871.1. Sequence problems.
AK315379 mRNA. Translation: BAG37772.1.
AL832601 mRNA. Translation: CAD89943.1.
AC091013 Genomic DNA. No translation available.
AC116456 Genomic DNA. No translation available.
AC129895 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68628.1.
CH471064 Genomic DNA. Translation: EAW68630.1.
BC022455 mRNA. Translation: AAH22455.1.
CCDSiCCDS44533.1. [Q7Z5B4-3]
CCDS55741.1. [Q7Z5B4-6]
CCDS55742.1. [Q7Z5B4-1]
CCDS7788.1. [Q7Z5B4-5]
RefSeqiNP_001128581.1. NM_001135109.2. [Q7Z5B4-3]
NP_001193600.1. NM_001206671.2. [Q7Z5B4-1]
NP_001193601.1. NM_001206672.2. [Q7Z5B4-6]
NP_078833.3. NM_024557.4. [Q7Z5B4-5]
XP_006718381.1. XM_006718318.3. [Q7Z5B4-5]
UniGeneiHs.231850.
Hs.568986.
Hs.733193.

Genome annotation databases

EnsembliENST00000309737; ENSP00000308820; ENSG00000166405. [Q7Z5B4-1]
ENST00000335425; ENSP00000333988; ENSG00000166405. [Q7Z5B4-3]
ENST00000343202; ENSP00000344904; ENSG00000166405. [Q7Z5B4-5]
ENST00000419822; ENSP00000404415; ENSG00000166405. [Q7Z5B4-2]
ENST00000425599; ENSP00000395320; ENSG00000166405. [Q7Z5B4-6]
GeneIDi79608.
KEGGihsa:79608.
UCSCiuc001mgc.3. human. [Q7Z5B4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326435 mRNA. Translation: AAP92162.1.
AY326436 mRNA. Translation: AAP92163.1.
AM422214 mRNA. Translation: CAM12309.1.
AY358475 mRNA. Translation: AAQ88839.1.
AK021670 mRNA. Translation: BAB13871.1. Sequence problems.
AK315379 mRNA. Translation: BAG37772.1.
AL832601 mRNA. Translation: CAD89943.1.
AC091013 Genomic DNA. No translation available.
AC116456 Genomic DNA. No translation available.
AC129895 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68628.1.
CH471064 Genomic DNA. Translation: EAW68630.1.
BC022455 mRNA. Translation: AAH22455.1.
CCDSiCCDS44533.1. [Q7Z5B4-3]
CCDS55741.1. [Q7Z5B4-6]
CCDS55742.1. [Q7Z5B4-1]
CCDS7788.1. [Q7Z5B4-5]
RefSeqiNP_001128581.1. NM_001135109.2. [Q7Z5B4-3]
NP_001193600.1. NM_001206671.2. [Q7Z5B4-1]
NP_001193601.1. NM_001206672.2. [Q7Z5B4-6]
NP_078833.3. NM_024557.4. [Q7Z5B4-5]
XP_006718381.1. XM_006718318.3. [Q7Z5B4-5]
UniGeneiHs.231850.
Hs.568986.
Hs.733193.

3D structure databases

ProteinModelPortaliQ7Z5B4.
SMRiQ7Z5B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122743. 34 interactors.
IntActiQ7Z5B4. 2 interactors.
MINTiMINT-8343009.
STRINGi9606.ENSP00000308820.

Protein family/group databases

TCDBi8.A.71.1.1. the ric3 protein (ric3) family.

PTM databases

iPTMnetiQ7Z5B4.
PhosphoSitePlusiQ7Z5B4.

Polymorphism and mutation databases

BioMutaiRIC3.
DMDMi74713638.

Proteomic databases

PaxDbiQ7Z5B4.
PRIDEiQ7Z5B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309737; ENSP00000308820; ENSG00000166405. [Q7Z5B4-1]
ENST00000335425; ENSP00000333988; ENSG00000166405. [Q7Z5B4-3]
ENST00000343202; ENSP00000344904; ENSG00000166405. [Q7Z5B4-5]
ENST00000419822; ENSP00000404415; ENSG00000166405. [Q7Z5B4-2]
ENST00000425599; ENSP00000395320; ENSG00000166405. [Q7Z5B4-6]
GeneIDi79608.
KEGGihsa:79608.
UCSCiuc001mgc.3. human. [Q7Z5B4-1]

Organism-specific databases

CTDi79608.
DisGeNETi79608.
GeneCardsiRIC3.
H-InvDBHIX0009421.
HGNCiHGNC:30338. RIC3.
HPAiHPA065016.
MIMi610509. gene.
neXtProtiNX_Q7Z5B4.
OpenTargetsiENSG00000166405.
PharmGKBiPA142671066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK2V. Eukaryota.
ENOG410XS3H. LUCA.
GeneTreeiENSGT00440000034107.
HOGENOMiHOG000034648.
HOVERGENiHBG106009.
InParanoidiQ7Z5B4.
OMAiTPGNTHR.
OrthoDBiEOG091G0E1P.
PhylomeDBiQ7Z5B4.
TreeFamiTF333291.

Miscellaneous databases

GeneWikiiRIC3.
GenomeRNAii79608.
PROiQ7Z5B4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166405.
CleanExiHS_RIC3.
ExpressionAtlasiQ7Z5B4. baseline and differential.
GenevisibleiQ7Z5B4. HS.

Family and domain databases

InterProiIPR026160. Ric3.
IPR032763. RIC3_N.
[Graphical view]
PANTHERiPTHR21723. PTHR21723. 1 hit.
PfamiPF15361. RIC3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIC3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5B4
Secondary accession number(s): B0B1U0
, B2RD25, D3DQU5, Q6UX78, Q7Z5B3, Q86T94, Q8TBJ9, Q9HAH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.