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Protein

Protein FAM19A1

Gene

FAM19A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM19A1
Alternative name(s):
Chemokine-like protein TAFA-1
Gene namesi
Name:FAM19A1
Synonyms:TAFA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:21587. FAM19A1.

Subcellular locationi

  1. Secreted 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: LIFEdb
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907870.

Polymorphism and mutation databases

BioMutaiFAM19A1.
DMDMi74738719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 133114Protein FAM19A1PRO_0000042721Add
BLAST

Proteomic databases

PaxDbiQ7Z5A9.
PRIDEiQ7Z5A9.

PTM databases

PhosphoSiteiQ7Z5A9.

Expressioni

Tissue specificityi

Brain-specific.1 Publication

Gene expression databases

BgeeiQ7Z5A9.
CleanExiHS_FAM19A1.
GenevestigatoriQ7Z5A9.

Organism-specific databases

HPAiHPA013407.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RABGGTBP536113EBI-10257895,EBI-536715

Protein-protein interaction databases

BioGridi135906. 5 interactions.
IntActiQ7Z5A9. 1 interaction.
MINTiMINT-4722638.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM19/TAFA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42910.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7Z5A9.
OMAiWILYLWI.
OrthoDBiEOG7JDR0R.
PhylomeDBiQ7Z5A9.
TreeFamiTF331749.

Family and domain databases

InterProiIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamiPF12020. TAFA. 1 hit.
[Graphical view]
ProDomiPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z5A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVSAMSWV LYLWISACAM LLCHGSLQHT FQQHHLHRPE GGTCEVIAAH
60 70 80 90 100
RCCNKNRIEE RSQTVKCSCL PGKVAGTTRN RPSCVDASIV IGKWWCEMEP
110 120 130
CLEGEECKTL PDNSGWMCAT GNKIKTTRIH PRT
Length:133
Mass (Da):14,901
Last modified:October 1, 2003 - v1
Checksum:iC5DD1C7E5F997386
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921G → W in CAD28501 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325114 mRNA. Translation: AAP92406.1.
AK289668 mRNA. Translation: BAF82357.1.
AK290446 mRNA. Translation: BAF83135.1.
AL713702 mRNA. Translation: CAD28501.1.
BC025746 mRNA. Translation: AAH25746.1.
CCDSiCCDS54606.1.
RefSeqiNP_001239145.1. NM_001252216.1.
NP_998774.2. NM_213609.3.
UniGeneiHs.655061.
Hs.731727.

Genome annotation databases

EnsembliENST00000478136; ENSP00000418575; ENSG00000183662.
ENST00000496687; ENSP00000417496; ENSG00000183662.
GeneIDi407738.
KEGGihsa:407738.
UCSCiuc003dnd.3. human.

Polymorphism and mutation databases

BioMutaiFAM19A1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325114 mRNA. Translation: AAP92406.1.
AK289668 mRNA. Translation: BAF82357.1.
AK290446 mRNA. Translation: BAF83135.1.
AL713702 mRNA. Translation: CAD28501.1.
BC025746 mRNA. Translation: AAH25746.1.
CCDSiCCDS54606.1.
RefSeqiNP_001239145.1. NM_001252216.1.
NP_998774.2. NM_213609.3.
UniGeneiHs.655061.
Hs.731727.

3D structure databases

ProteinModelPortaliQ7Z5A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135906. 5 interactions.
IntActiQ7Z5A9. 1 interaction.
MINTiMINT-4722638.

PTM databases

PhosphoSiteiQ7Z5A9.

Polymorphism and mutation databases

BioMutaiFAM19A1.
DMDMi74738719.

Proteomic databases

PaxDbiQ7Z5A9.
PRIDEiQ7Z5A9.

Protocols and materials databases

DNASUi407738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000478136; ENSP00000418575; ENSG00000183662.
ENST00000496687; ENSP00000417496; ENSG00000183662.
GeneIDi407738.
KEGGihsa:407738.
UCSCiuc003dnd.3. human.

Organism-specific databases

CTDi407738.
GeneCardsiGC03P068139.
HGNCiHGNC:21587. FAM19A1.
HPAiHPA013407.
neXtProtiNX_Q7Z5A9.
PharmGKBiPA134907870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42910.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7Z5A9.
OMAiWILYLWI.
OrthoDBiEOG7JDR0R.
PhylomeDBiQ7Z5A9.
TreeFamiTF331749.

Miscellaneous databases

ChiTaRSiFAM19A1. human.
GenomeRNAii407738.
NextBioi108332.
PROiQ7Z5A9.

Gene expression databases

BgeeiQ7Z5A9.
CleanExiHS_FAM19A1.
GenevestigatoriQ7Z5A9.

Family and domain databases

InterProiIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamiPF12020. TAFA. 1 hit.
[Graphical view]
ProDomiPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain."
    Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.
    Genomics 83:727-734(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiF19A1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5A9
Secondary accession number(s): A8K0V3, Q8TCL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2003
Last modified: April 29, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.