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Q7Z5A9

- F19A1_HUMAN

UniProt

Q7Z5A9 - F19A1_HUMAN

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Protein

Protein FAM19A1

Gene
FAM19A1, TAFA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM19A1
Alternative name(s):
Chemokine-like protein TAFA-1
Gene namesi
Name:FAM19A1
Synonyms:TAFA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:21587. FAM19A1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: LIFEdb
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 133114Protein FAM19A1PRO_0000042721Add
BLAST

Proteomic databases

PaxDbiQ7Z5A9.
PRIDEiQ7Z5A9.

PTM databases

PhosphoSiteiQ7Z5A9.

Expressioni

Tissue specificityi

Brain-specific.1 Publication

Gene expression databases

BgeeiQ7Z5A9.
CleanExiHS_FAM19A1.
GenevestigatoriQ7Z5A9.

Organism-specific databases

HPAiHPA013407.

Interactioni

Protein-protein interaction databases

MINTiMINT-4722638.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5A9.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM19/TAFA family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42910.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7Z5A9.
OMAiGWMCYAG.
OrthoDBiEOG7JDR0R.
PhylomeDBiQ7Z5A9.
TreeFamiTF331749.

Family and domain databases

InterProiIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamiPF12020. TAFA. 1 hit.
[Graphical view]
ProDomiPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z5A9-1 [UniParc]FASTAAdd to Basket

« Hide

MAMVSAMSWV LYLWISACAM LLCHGSLQHT FQQHHLHRPE GGTCEVIAAH    50
RCCNKNRIEE RSQTVKCSCL PGKVAGTTRN RPSCVDASIV IGKWWCEMEP 100
CLEGEECKTL PDNSGWMCAT GNKIKTTRIH PRT 133
Length:133
Mass (Da):14,901
Last modified:October 1, 2003 - v1
Checksum:iC5DD1C7E5F997386
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921G → W in CAD28501. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY325114 mRNA. Translation: AAP92406.1.
AK289668 mRNA. Translation: BAF82357.1.
AK290446 mRNA. Translation: BAF83135.1.
AL713702 mRNA. Translation: CAD28501.1.
BC025746 mRNA. Translation: AAH25746.1.
CCDSiCCDS54606.1.
RefSeqiNP_001239145.1. NM_001252216.1.
NP_998774.2. NM_213609.3.
UniGeneiHs.655061.
Hs.731727.

Genome annotation databases

EnsembliENST00000478136; ENSP00000418575; ENSG00000183662.
ENST00000496687; ENSP00000417496; ENSG00000183662.
GeneIDi407738.
KEGGihsa:407738.
UCSCiuc003dnd.3. human.

Polymorphism databases

DMDMi74738719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY325114 mRNA. Translation: AAP92406.1 .
AK289668 mRNA. Translation: BAF82357.1 .
AK290446 mRNA. Translation: BAF83135.1 .
AL713702 mRNA. Translation: CAD28501.1 .
BC025746 mRNA. Translation: AAH25746.1 .
CCDSi CCDS54606.1.
RefSeqi NP_001239145.1. NM_001252216.1.
NP_998774.2. NM_213609.3.
UniGenei Hs.655061.
Hs.731727.

3D structure databases

ProteinModelPortali Q7Z5A9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4722638.

PTM databases

PhosphoSitei Q7Z5A9.

Polymorphism databases

DMDMi 74738719.

Proteomic databases

PaxDbi Q7Z5A9.
PRIDEi Q7Z5A9.

Protocols and materials databases

DNASUi 407738.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000478136 ; ENSP00000418575 ; ENSG00000183662 .
ENST00000496687 ; ENSP00000417496 ; ENSG00000183662 .
GeneIDi 407738.
KEGGi hsa:407738.
UCSCi uc003dnd.3. human.

Organism-specific databases

CTDi 407738.
GeneCardsi GC03P068139.
HGNCi HGNC:21587. FAM19A1.
HPAi HPA013407.
neXtProti NX_Q7Z5A9.
PharmGKBi PA134907870.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42910.
HOGENOMi HOG000236302.
HOVERGENi HBG081496.
InParanoidi Q7Z5A9.
OMAi GWMCYAG.
OrthoDBi EOG7JDR0R.
PhylomeDBi Q7Z5A9.
TreeFami TF331749.

Miscellaneous databases

ChiTaRSi FAM19A1. human.
GenomeRNAii 407738.
NextBioi 108332.
PROi Q7Z5A9.

Gene expression databases

Bgeei Q7Z5A9.
CleanExi HS_FAM19A1.
Genevestigatori Q7Z5A9.

Family and domain databases

InterProi IPR020350. Chemokine-like_FAM19A2.
[Graphical view ]
Pfami PF12020. TAFA. 1 hit.
[Graphical view ]
ProDomi PD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain."
    Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.
    Genomics 83:727-734(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiF19A1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5A9
Secondary accession number(s): A8K0V3, Q8TCL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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