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Q7Z5A9 (F19A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM19A1
Alternative name(s):
Chemokine-like protein TAFA-1
Gene names
Name:FAM19A1
Synonyms:TAFA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Ref.1.

Tissue specificity

Brain-specific. Ref.1

Sequence similarities

Belongs to the FAM19/TAFA family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum

Inferred from direct assay. Source: LIFEdb

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 133114Protein FAM19A1
PRO_0000042721

Experimental info

Sequence conflict921G → W in CAD28501. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q7Z5A9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: C5DD1C7E5F997386

FASTA13314,901
        10         20         30         40         50         60 
MAMVSAMSWV LYLWISACAM LLCHGSLQHT FQQHHLHRPE GGTCEVIAAH RCCNKNRIEE 

        70         80         90        100        110        120 
RSQTVKCSCL PGKVAGTTRN RPSCVDASIV IGKWWCEMEP CLEGEECKTL PDNSGWMCAT 

       130 
GNKIKTTRIH PRT 

« Hide

References

« Hide 'large scale' references
[1]"TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain."
Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.
Genomics 83:727-734(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala and Brain.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY325114 mRNA. Translation: AAP92406.1.
AK289668 mRNA. Translation: BAF82357.1.
AK290446 mRNA. Translation: BAF83135.1.
AL713702 mRNA. Translation: CAD28501.1.
BC025746 mRNA. Translation: AAH25746.1.
CCDSCCDS54606.1.
RefSeqNP_001239145.1. NM_001252216.1.
NP_998774.2. NM_213609.3.
UniGeneHs.655061.
Hs.731727.

3D structure databases

ProteinModelPortalQ7Z5A9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4722638.

PTM databases

PhosphoSiteQ7Z5A9.

Polymorphism databases

DMDM74738719.

Proteomic databases

PaxDbQ7Z5A9.
PRIDEQ7Z5A9.

Protocols and materials databases

DNASU407738.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000478136; ENSP00000418575; ENSG00000183662.
ENST00000496687; ENSP00000417496; ENSG00000183662.
GeneID407738.
KEGGhsa:407738.
UCSCuc003dnd.3. human.

Organism-specific databases

CTD407738.
GeneCardsGC03P068139.
HGNCHGNC:21587. FAM19A1.
HPAHPA013407.
neXtProtNX_Q7Z5A9.
PharmGKBPA134907870.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42910.
HOGENOMHOG000236302.
HOVERGENHBG081496.
InParanoidQ7Z5A9.
OMAGWMCYAG.
OrthoDBEOG7JDR0R.
PhylomeDBQ7Z5A9.
TreeFamTF331749.

Gene expression databases

BgeeQ7Z5A9.
CleanExHS_FAM19A1.
GenevestigatorQ7Z5A9.

Family and domain databases

InterProIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamPF12020. TAFA. 1 hit.
[Graphical view]
ProDomPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

ChiTaRSFAM19A1. human.
GenomeRNAi407738.
NextBio108332.
PROQ7Z5A9.

Entry information

Entry nameF19A1_HUMAN
AccessionPrimary (citable) accession number: Q7Z5A9
Secondary accession number(s): A8K0V3, Q8TCL8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM