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Protein

Protein FAM19A3

Gene

FAM19A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of microglia polarization.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM19A3
Alternative name(s):
Chemokine-like protein TAFA-3
Gene namesi
Name:FAM19A3
Synonyms:TAFA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21590. FAM19A3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi284467.
OpenTargetsiENSG00000184599.
PharmGKBiPA134899352.

Polymorphism and mutation databases

BioMutaiFAM19A3.
DMDMi74750123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004272631 – 133Protein FAM19A3Add BLAST103

Proteomic databases

PaxDbiQ7Z5A8.
PRIDEiQ7Z5A8.

PTM databases

PhosphoSitePlusiQ7Z5A8.

Expressioni

Tissue specificityi

Brain-specific.2 Publications

Gene expression databases

BgeeiENSG00000184599.
CleanExiHS_FAM19A3.

Organism-specific databases

HPAiHPA055927.

Interactioni

Protein-protein interaction databases

BioGridi129885. 74 interactors.
STRINGi9606.ENSP00000358644.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5A8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM19/TAFA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1AW. Eukaryota.
ENOG410YX51. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7Z5A8.
OMAiRSHDSSW.
OrthoDBiEOG091G0TKK.
PhylomeDBiQ7Z5A8.
TreeFamiTF331749.

Family and domain databases

InterProiView protein in InterPro
IPR020350. Chemokine-like_FAM19A2.
PfamiView protein in Pfam
PF12020. TAFA. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD298472. Chemokine-like_2FAM19A2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5A8-1) [UniParc]FASTAAdd to basket
Also known as: TAFA3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSERVERNWS TGGWLLALCL AWLWTHLTLA ALQPPTATVL VQQGTCEVIA
60 70 80 90 100
AHRCCNRNRI EERSQTVKCS CFSGQVAGTT RAKPSCVDAS IVLQRWWCQM
110 120 130
EPCLPGEECK VLPDLSGWSC SSGHKVKTTK VTR
Length:133
Mass (Da):14,776
Last modified:October 1, 2003 - v1
Checksum:iC074C703817D008D
GO
Isoform 2 (identifier: Q7Z5A8-2) [UniParc]FASTAAdd to basket
Also known as: TAFA3.2

The sequence of this isoform differs from the canonical sequence as follows:
     89-133: ASIVLQRWWC...HKVKTTKVTR → DLLLAAHCAR...GSRPGQERLD

Show »
Length:169
Mass (Da):18,549
Checksum:iA7726BC3E9D48496
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01606789 – 133ASIVL…TKVTR → DLLLAAHCARRDPRAALRLL LPQPPSSCRDGGVRWSPACR GRSVRCSRTCRDGAAAVDTK SKPPRSHDSSWGSRPGQERL D in isoform 2. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325116 mRNA. Translation: AAP92408.1.
AY325119 mRNA. Translation: AAP92411.1.
AL603832 Genomic DNA. Translation: CAI14063.1.
AL603832 Genomic DNA. Translation: CAI14064.1.
CH471122 Genomic DNA. Translation: EAW56548.1.
CH471122 Genomic DNA. Translation: EAW56549.1.
BC112268 mRNA. Translation: AAI12269.1.
BC117479 mRNA. Translation: AAI17480.1.
BC144043 mRNA. Translation: AAI44044.1.
CCDSiCCDS30806.1. [Q7Z5A8-2]
CCDS856.1. [Q7Z5A8-1]
RefSeqiNP_001004440.1. NM_001004440.1. [Q7Z5A8-2]
NP_877436.1. NM_182759.2. [Q7Z5A8-1]
XP_005270823.1. XM_005270766.3. [Q7Z5A8-1]
XP_006710645.1. XM_006710582.3. [Q7Z5A8-2]
UniGeneiHs.439116.

Genome annotation databases

EnsembliENST00000361886; ENSP00000355042; ENSG00000184599. [Q7Z5A8-1]
ENST00000369630; ENSP00000358644; ENSG00000184599. [Q7Z5A8-2]
GeneIDi284467.
KEGGihsa:284467.
UCSCiuc001ecu.4. human. [Q7Z5A8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF19A3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5A8
Secondary accession number(s): B7ZLU0, Q2M1P9, Q7Z5A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2003
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families