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Protein

Protein FAM19A3

Gene

FAM19A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33104-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM19A3
Alternative name(s):
Chemokine-like protein TAFA-3
Gene namesi
Name:FAM19A3
Synonyms:TAFA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21590. FAM19A3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi284467.
OpenTargetsiENSG00000184599.
PharmGKBiPA134899352.

Polymorphism and mutation databases

BioMutaiFAM19A3.
DMDMi74750123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004272631 – 133Protein FAM19A3Add BLAST103

Proteomic databases

PaxDbiQ7Z5A8.
PRIDEiQ7Z5A8.

PTM databases

PhosphoSitePlusiQ7Z5A8.

Expressioni

Tissue specificityi

Brain-specific.1 Publication

Gene expression databases

BgeeiENSG00000184599.
CleanExiHS_FAM19A3.

Organism-specific databases

HPAiHPA055927.

Interactioni

Protein-protein interaction databases

BioGridi129885. 74 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ7Z5A8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM19/TAFA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1AW. Eukaryota.
ENOG410YX51. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7Z5A8.
OMAiRSHDSSW.
OrthoDBiEOG091G0TKK.
PhylomeDBiQ7Z5A8.
TreeFamiTF331749.

Family and domain databases

InterProiIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamiPF12020. TAFA. 1 hit.
[Graphical view]
ProDomiPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5A8-1) [UniParc]FASTAAdd to basket
Also known as: TAFA3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSERVERNWS TGGWLLALCL AWLWTHLTLA ALQPPTATVL VQQGTCEVIA
60 70 80 90 100
AHRCCNRNRI EERSQTVKCS CFSGQVAGTT RAKPSCVDAS IVLQRWWCQM
110 120 130
EPCLPGEECK VLPDLSGWSC SSGHKVKTTK VTR
Length:133
Mass (Da):14,776
Last modified:October 1, 2003 - v1
Checksum:iC074C703817D008D
GO
Isoform 2 (identifier: Q7Z5A8-2) [UniParc]FASTAAdd to basket
Also known as: TAFA3.2

The sequence of this isoform differs from the canonical sequence as follows:
     89-133: ASIVLQRWWC...HKVKTTKVTR → DLLLAAHCAR...GSRPGQERLD

Show »
Length:169
Mass (Da):18,549
Checksum:iA7726BC3E9D48496
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01606789 – 133ASIVL…TKVTR → DLLLAAHCARRDPRAALRLL LPQPPSSCRDGGVRWSPACR GRSVRCSRTCRDGAAAVDTK SKPPRSHDSSWGSRPGQERL D in isoform 2. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325116 mRNA. Translation: AAP92408.1.
AY325119 mRNA. Translation: AAP92411.1.
AL603832 Genomic DNA. Translation: CAI14063.1.
AL603832 Genomic DNA. Translation: CAI14064.1.
CH471122 Genomic DNA. Translation: EAW56548.1.
CH471122 Genomic DNA. Translation: EAW56549.1.
BC112268 mRNA. Translation: AAI12269.1.
BC117479 mRNA. Translation: AAI17480.1.
BC144043 mRNA. Translation: AAI44044.1.
CCDSiCCDS30806.1. [Q7Z5A8-2]
CCDS856.1. [Q7Z5A8-1]
RefSeqiNP_001004440.1. NM_001004440.1. [Q7Z5A8-2]
NP_877436.1. NM_182759.2. [Q7Z5A8-1]
XP_005270823.1. XM_005270766.3. [Q7Z5A8-1]
XP_006710645.1. XM_006710582.3. [Q7Z5A8-2]
UniGeneiHs.439116.

Genome annotation databases

EnsembliENST00000361886; ENSP00000355042; ENSG00000184599. [Q7Z5A8-1]
ENST00000369630; ENSP00000358644; ENSG00000184599. [Q7Z5A8-2]
GeneIDi284467.
KEGGihsa:284467.
UCSCiuc001ecu.4. human. [Q7Z5A8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325116 mRNA. Translation: AAP92408.1.
AY325119 mRNA. Translation: AAP92411.1.
AL603832 Genomic DNA. Translation: CAI14063.1.
AL603832 Genomic DNA. Translation: CAI14064.1.
CH471122 Genomic DNA. Translation: EAW56548.1.
CH471122 Genomic DNA. Translation: EAW56549.1.
BC112268 mRNA. Translation: AAI12269.1.
BC117479 mRNA. Translation: AAI17480.1.
BC144043 mRNA. Translation: AAI44044.1.
CCDSiCCDS30806.1. [Q7Z5A8-2]
CCDS856.1. [Q7Z5A8-1]
RefSeqiNP_001004440.1. NM_001004440.1. [Q7Z5A8-2]
NP_877436.1. NM_182759.2. [Q7Z5A8-1]
XP_005270823.1. XM_005270766.3. [Q7Z5A8-1]
XP_006710645.1. XM_006710582.3. [Q7Z5A8-2]
UniGeneiHs.439116.

3D structure databases

ProteinModelPortaliQ7Z5A8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129885. 74 interactors.

PTM databases

PhosphoSitePlusiQ7Z5A8.

Polymorphism and mutation databases

BioMutaiFAM19A3.
DMDMi74750123.

Proteomic databases

PaxDbiQ7Z5A8.
PRIDEiQ7Z5A8.

Protocols and materials databases

DNASUi284467.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361886; ENSP00000355042; ENSG00000184599. [Q7Z5A8-1]
ENST00000369630; ENSP00000358644; ENSG00000184599. [Q7Z5A8-2]
GeneIDi284467.
KEGGihsa:284467.
UCSCiuc001ecu.4. human. [Q7Z5A8-1]

Organism-specific databases

CTDi284467.
DisGeNETi284467.
GeneCardsiFAM19A3.
HGNCiHGNC:21590. FAM19A3.
HPAiHPA055927.
neXtProtiNX_Q7Z5A8.
OpenTargetsiENSG00000184599.
PharmGKBiPA134899352.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1AW. Eukaryota.
ENOG410YX51. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7Z5A8.
OMAiRSHDSSW.
OrthoDBiEOG091G0TKK.
PhylomeDBiQ7Z5A8.
TreeFamiTF331749.

Enzyme and pathway databases

BioCyciZFISH:G66-33104-MONOMER.

Miscellaneous databases

GenomeRNAii284467.
PROiQ7Z5A8.

Gene expression databases

BgeeiENSG00000184599.
CleanExiHS_FAM19A3.

Family and domain databases

InterProiIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamiPF12020. TAFA. 1 hit.
[Graphical view]
ProDomiPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiF19A3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5A8
Secondary accession number(s): B7ZLU0, Q2M1P9, Q7Z5A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.