SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7Z597

- Q7Z597_HUMAN

UniProt

Q7Z597 - Q7Z597_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: NOD2
Gene
NOD2, CARD15
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. muramyl dipeptide binding Source: Ensembl

GO - Biological processi

  1. activation of immune response Source: Ensembl
  2. cellular response to peptidoglycan Source: Ensembl
  3. defense response to Gram-positive bacterium Source: Ensembl
  4. immunoglobulin production involved in immunoglobulin mediated immune response Source: Ensembl
  5. innate immune response in mucosa Source: Ensembl
  6. macrophage inflammatory protein-1 alpha production Source: Ensembl
  7. microglial cell activation involved in immune response Source: Ensembl
  8. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
  9. negative regulation of T cell mediated immunity Source: Ensembl
  10. negative regulation of growth of symbiont in host Source: Ensembl
  11. negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
  12. negative regulation of interferon-gamma production Source: Ensembl
  13. negative regulation of interleukin-12 production Source: Ensembl
  14. negative regulation of interleukin-18 production Source: Ensembl
  15. negative regulation of interleukin-2 production Source: Ensembl
  16. negative regulation of toll-like receptor 2 signaling pathway Source: Ensembl
  17. negative regulation of tumor necrosis factor production Source: Ensembl
  18. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  19. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  20. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  21. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  22. positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Source: Ensembl
  23. positive regulation of cell proliferation Source: Ensembl
  24. positive regulation of dendritic cell cytokine production Source: Ensembl
  25. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  26. positive regulation of interleukin-1 beta secretion Source: Ensembl
  27. positive regulation of interleukin-12 production Source: Ensembl
  28. positive regulation of interleukin-6 production Source: Ensembl
  29. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  30. positive regulation of phagocytosis Source: Ensembl
  31. positive regulation of tumor necrosis factor production Source: Ensembl
  32. regulation of neutrophil chemotaxis Source: Ensembl
  33. response to exogenous dsRNA Source: Ensembl
  34. response to lipopolysaccharide Source: Ensembl
  35. response to muramyl dipeptide Source: Ensembl
  36. response to nutrient Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NOD2Imported
Submitted name:
Nucleotide-binding oligomerization domain containing 2Imported
Gene namesi
Name:NOD2Imported
Synonyms:CARD15Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ7Z597.
BgeeiQ7Z597.

Sequencei

Sequence statusi: Fragment.

Q7Z597-1 [UniParc]FASTAAdd to Basket

« Hide

LSNNCITYLG AEALLQALER NDTILEV                            27
Length:27
Mass (Da):2,977
Last modified:October 1, 2003 - v1
Checksum:i3D5C3B988107E039
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei27 – 271Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF385085 Genomic DNA. Translation: AAK70863.1.
DQ869189 Genomic DNA. Translation: ABI96990.1.
AB542701 Genomic DNA. Translation: BAJ13470.1.
UniGeneiHs.592072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF385085 Genomic DNA. Translation: AAK70863.1 .
DQ869189 Genomic DNA. Translation: ABI96990.1 .
AB542701 Genomic DNA. Translation: BAJ13470.1 .
UniGenei Hs.592072.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q7Z597.
Bgeei Q7Z597.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis."
    Rodriguez-Perez N., Aguinaga-Barrilero A., Gorrono-Echebarria M.B., Perez-Blas M., Martin-Villa J.M.
    Dis. Markers 24:111-117(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Population specific susceptibility to Crohn's disease and ulcerative colitis and their dominant/recessive relative risks in the Japanese population."
    Nakagome S., Takeyama Y., Mano S., Sakisaka S., Matsui T., Kawamura S., Oota H.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7Z597_HUMAN
AccessioniPrimary (citable) accession number: Q7Z597
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi