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Q7Z597

- Q7Z597_HUMAN

UniProt

Q7Z597 - Q7Z597_HUMAN

Protein
Submitted name:

NOD2

Gene

NOD2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. muramyl dipeptide binding Source: Ensembl

    GO - Biological processi

    1. activation of immune response Source: Ensembl
    2. cellular response to peptidoglycan Source: Ensembl
    3. defense response to Gram-positive bacterium Source: Ensembl
    4. immunoglobulin production involved in immunoglobulin mediated immune response Source: Ensembl
    5. innate immune response in mucosa Source: Ensembl
    6. macrophage inflammatory protein-1 alpha production Source: Ensembl
    7. microglial cell activation involved in immune response Source: Ensembl
    8. negative regulation of growth of symbiont in host Source: Ensembl
    9. negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
    10. negative regulation of interferon-gamma production Source: Ensembl
    11. negative regulation of interleukin-12 production Source: Ensembl
    12. negative regulation of interleukin-18 production Source: Ensembl
    13. negative regulation of interleukin-2 production Source: Ensembl
    14. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
    15. negative regulation of T cell mediated immunity Source: Ensembl
    16. negative regulation of toll-like receptor 2 signaling pathway Source: Ensembl
    17. negative regulation of tumor necrosis factor production Source: Ensembl
    18. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
    19. positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Source: Ensembl
    20. positive regulation of cell proliferation Source: Ensembl
    21. positive regulation of dendritic cell cytokine production Source: Ensembl
    22. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    23. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
    24. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    25. positive regulation of interleukin-12 production Source: Ensembl
    26. positive regulation of interleukin-1 beta secretion Source: Ensembl
    27. positive regulation of interleukin-6 production Source: Ensembl
    28. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    29. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    30. positive regulation of phagocytosis Source: Ensembl
    31. positive regulation of tumor necrosis factor production Source: Ensembl
    32. regulation of neutrophil chemotaxis Source: Ensembl
    33. response to exogenous dsRNA Source: Ensembl
    34. response to lipopolysaccharide Source: Ensembl
    35. response to muramyl dipeptide Source: Ensembl
    36. response to nutrient Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NOD2Imported
    Submitted name:
    Nucleotide-binding oligomerization domain containing 2Imported
    Gene namesi
    Name:NOD2Imported
    Synonyms:CARD15Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z597.
    BgeeiQ7Z597.

    Sequencei

    Sequence statusi: Fragment.

    Q7Z597-1 [UniParc]FASTAAdd to Basket

    « Hide

    LSNNCITYLG AEALLQALER NDTILEV                            27
    Length:27
    Mass (Da):2,977
    Last modified:October 1, 2003 - v1
    Checksum:i3D5C3B988107E039
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei27 – 271Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385085 Genomic DNA. Translation: AAK70863.1.
    DQ869189 Genomic DNA. Translation: ABI96990.1.
    AB542701 Genomic DNA. Translation: BAJ13470.1.
    UniGeneiHs.592072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385085 Genomic DNA. Translation: AAK70863.1 .
    DQ869189 Genomic DNA. Translation: ABI96990.1 .
    AB542701 Genomic DNA. Translation: BAJ13470.1 .
    UniGenei Hs.592072.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q7Z597.
    Bgeei Q7Z597.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis."
      Rodriguez-Perez N., Aguinaga-Barrilero A., Gorrono-Echebarria M.B., Perez-Blas M., Martin-Villa J.M.
      Dis. Markers 24:111-117(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Population specific susceptibility to Crohn's disease and ulcerative colitis and their dominant/recessive relative risks in the Japanese population."
      Nakagome S., Takeyama Y., Mano S., Sakisaka S., Matsui T., Kawamura S., Oota H.
      Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ7Z597_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z597
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.