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Q7Z597 (Q7Z597_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Nucleotide-binding oligomerization domain containing 2 EMBL BAJ13470.1
Gene names
Name:NOD2 EMBL AAK70863.1
Synonyms:CARD15 EMBL ABI96990.1
OrganismHomo sapiens (Human) EMBL AAK70863.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length27 AA.
Sequence statusFragment.
Protein existencePredicted

Ontologies

Gene Ontology (GO)
   Biological_processactivation of immune response

Inferred from electronic annotation. Source: Ensembl

cellular response to peptidoglycan

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-positive bacterium

Inferred from electronic annotation. Source: Ensembl

immunoglobulin production involved in immunoglobulin mediated immune response

Inferred from electronic annotation. Source: Ensembl

innate immune response in mucosa

Inferred from electronic annotation. Source: Ensembl

macrophage inflammatory protein-1 alpha production

Inferred from electronic annotation. Source: Ensembl

microglial cell activation involved in immune response

Inferred from electronic annotation. Source: Ensembl

negative regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of T cell mediated immunity

Inferred from electronic annotation. Source: Ensembl

negative regulation of growth of symbiont in host

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response to antigenic stimulus

Inferred from electronic annotation. Source: Ensembl

negative regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-18 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-2 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of toll-like receptor 2 signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of dendritic cell cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of humoral immune response mediated by circulating immunoglobulin

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of phagocytosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

regulation of neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

response to exogenous dsRNA

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to muramyl dipeptide

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionmuramyl dipeptide binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAK70863.1
Non-terminal residue271 EMBL AAK70863.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z597 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3D5C3B988107E039

FASTA272,977
        10         20 
LSNNCITYLG AEALLQALER NDTILEV 

« Hide

References

[1]"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease."
Ogura Y., Bonen D.K., Inohara N., Nicolae D.L., Chen F.F., Ramos R., Britton H., Moran T., Karaliuskas R., Duerr R.H., Achkar J.P., Brant S.R., Bayless T.M., Kirschner B.S., Hanauer S.B., Nunez G., Cho J.H.
Nature 411:603-606(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis."
Rodriguez-Perez N., Aguinaga-Barrilero A., Gorrono-Echebarria M.B., Perez-Blas M., Martin-Villa J.M.
Dis. Markers 24:111-117(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Population specific susceptibility to Crohn's disease and ulcerative colitis and their dominant/recessive relative risks in the Japanese population."
Nakagome S., Takeyama Y., Mano S., Sakisaka S., Matsui T., Kawamura S., Oota H.
Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF385085 Genomic DNA. Translation: AAK70863.1.
DQ869189 Genomic DNA. Translation: ABI96990.1.
AB542701 Genomic DNA. Translation: BAJ13470.1.
UniGeneHs.592072.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Gene expression databases

ArrayExpressQ7Z597.
BgeeQ7Z597.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameQ7Z597_HUMAN
AccessionPrimary (citable) accession number: Q7Z597
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.