Q7Z597 (Q7Z597_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
NOD2 EMBL AAK70863.1

Submitted name:
Nucleotide-binding oligomerization domain containing 2 EMBL BAJ13470.1

Gene names

Name:	NOD2 EMBL AAK70863.1
Synonyms:	CARD15 EMBL ABI96990.1

Organism

Homo sapiens (Human) EMBL AAK70863.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	27 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	activation of immune response Inferred from electronic annotation. Source: Compara cellular response to peptidoglycan Inferred from electronic annotation. Source: Compara defense response to Gram-positive bacterium Inferred from electronic annotation. Source: Compara immunoglobulin production involved in immunoglobulin mediated immune response Inferred from electronic annotation. Source: Compara innate immune response in mucosa Inferred from electronic annotation. Source: Compara macrophage inflammatory protein-1 alpha production Inferred from electronic annotation. Source: Compara microglial cell activation involved in immune response Inferred from electronic annotation. Source: Compara negative regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara negative regulation of T cell mediated immunity Inferred from electronic annotation. Source: Compara negative regulation of growth of symbiont in host Inferred from electronic annotation. Source: Compara negative regulation of inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-12 production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-18 production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-2 production Inferred from electronic annotation. Source: Compara negative regulation of toll-like receptor 2 signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of dendritic cell cytokine production Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from electronic annotation. Source: Compara positive regulation of interleukin-1 beta secretion Inferred from electronic annotation. Source: Compara positive regulation of interleukin-12 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of phagocytosis Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara regulation of neutrophil chemotaxis Inferred from electronic annotation. Source: Compara response to exogenous dsRNA Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to muramyl dipeptide Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAK70863.1
	Non-terminal residue	27	1	EMBL AAK70863.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z597 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 3D5C3B988107E039	FASTA	27	2,977
	10 20 LSNNCITYLG AEALLQALER NDTILEV

References

[1]	"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease." Ogura Y., Bonen D.K., Inohara N., Nicolae D.L., Chen F.F., Ramos R., Britton H., Moran T., Karaliuskas R., Duerr R.H., Achkar J.P., Brant S.R., Bayless T.M., Kirschner B.S., Hanauer S.B., Nunez G., Cho J.H. Nature 411:603-606(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis." Rodriguez-Perez N., Aguinaga-Barrilero A., Gorrono-Echebarria M.B., Perez-Blas M., Martin-Villa J.M. Dis. Markers 24:111-117(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Population specific susceptibility to Crohn's disease and ulcerative colitis and their dominant/recessive relative risks in the Japanese population." Nakagome S., Takeyama Y., Mano S., Sakisaka S., Matsui T., Kawamura S., Oota H. Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF385085 Genomic DNA. Translation: AAK70863.1. DQ869189 Genomic DNA. Translation: ABI96990.1. AB542701 Genomic DNA. Translation: BAJ13470.1.
IPI	IPI00910731.
UniGene	Hs.592072.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7Z597.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	Q7Z597.
Bgee	Q7Z597.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

Q7Z597_HUMAN

Accession

Primary (citable) accession number: Q7Z597

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.