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Q7Z597

- Q7Z597_HUMAN

UniProt

Q7Z597 - Q7Z597_HUMAN

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Protein
Submitted name:

NOD2

Gene

NOD2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. muramyl dipeptide binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity involved in innate immune response Source: Ensembl
  2. cellular response to peptidoglycan Source: Ensembl
  3. defense response to Gram-positive bacterium Source: Ensembl
  4. immunoglobulin production involved in immunoglobulin mediated immune response Source: Ensembl
  5. innate immune response in mucosa Source: Ensembl
  6. macrophage inflammatory protein-1 alpha production Source: Ensembl
  7. microglial cell activation involved in immune response Source: Ensembl
  8. negative regulation of growth of symbiont in host Source: Ensembl
  9. negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
  10. negative regulation of interferon-gamma production Source: Ensembl
  11. negative regulation of interleukin-12 production Source: Ensembl
  12. negative regulation of interleukin-18 production Source: Ensembl
  13. negative regulation of interleukin-2 production Source: Ensembl
  14. negative regulation of macrophage apoptotic process Source: Ensembl
  15. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
  16. negative regulation of T cell mediated immunity Source: Ensembl
  17. negative regulation of toll-like receptor 2 signaling pathway Source: Ensembl
  18. negative regulation of tumor necrosis factor production Source: Ensembl
  19. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  20. positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Source: Ensembl
  21. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
  22. positive regulation of dendritic cell cytokine production Source: Ensembl
  23. positive regulation of epithelial cell proliferation Source: Ensembl
  24. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  25. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  26. positive regulation of interleukin-10 production Source: Ensembl
  27. positive regulation of interleukin-12 production Source: Ensembl
  28. positive regulation of interleukin-6 production Source: Ensembl
  29. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  30. positive regulation of Notch signaling pathway Source: Ensembl
  31. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  32. positive regulation of phagocytosis Source: Ensembl
  33. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
  34. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  35. positive regulation of prostaglandin-E synthase activity Source: Ensembl
  36. positive regulation of protein ubiquitination Source: Ensembl
  37. positive regulation of tumor necrosis factor production Source: Ensembl
  38. regulation of neutrophil chemotaxis Source: Ensembl
  39. response to exogenous dsRNA Source: Ensembl
  40. response to lipopolysaccharide Source: Ensembl
  41. response to muramyl dipeptide Source: Ensembl
  42. response to nutrient Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NOD2Imported
Submitted name:
Nucleotide-binding oligomerization domain containing 2Imported
Gene namesi
Name:NOD2Imported
Synonyms:CARD15Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ7Z597.
ExpressionAtlasiQ7Z597. baseline and differential.

Sequencei

Sequence statusi: Fragment.

Q7Z597-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
LSNNCITYLG AEALLQALER NDTILEV
Length:27
Mass (Da):2,977
Last modified:October 1, 2003 - v1
Checksum:i3D5C3B988107E039
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei27 – 271Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF385085 Genomic DNA. Translation: AAK70863.1.
DQ869189 Genomic DNA. Translation: ABI96990.1.
AB542701 Genomic DNA. Translation: BAJ13470.1.
UniGeneiHs.592072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF385085 Genomic DNA. Translation: AAK70863.1 .
DQ869189 Genomic DNA. Translation: ABI96990.1 .
AB542701 Genomic DNA. Translation: BAJ13470.1 .
UniGenei Hs.592072.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q7Z597.
ExpressionAtlasi Q7Z597. baseline and differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis."
    Rodriguez-Perez N., Aguinaga-Barrilero A., Gorrono-Echebarria M.B., Perez-Blas M., Martin-Villa J.M.
    Dis. Markers 24:111-117(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Population specific susceptibility to Crohn's disease and ulcerative colitis and their dominant/recessive relative risks in the Japanese population."
    Nakagome S., Takeyama Y., Mano S., Sakisaka S., Matsui T., Kawamura S., Oota H.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7Z597_HUMAN
AccessioniPrimary (citable) accession number: Q7Z597
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.