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Protein
Submitted name:

NOD2

Gene

NOD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. muramyl dipeptide binding Source: Ensembl

GO - Biological processi

  1. cellular response to organic cyclic compound Source: Ensembl
  2. cellular response to peptidoglycan Source: Ensembl
  3. defense response to Gram-positive bacterium Source: Ensembl
  4. immunoglobulin production involved in immunoglobulin mediated immune response Source: Ensembl
  5. innate immune response in mucosa Source: Ensembl
  6. macrophage inflammatory protein-1 alpha production Source: Ensembl
  7. negative regulation of growth of symbiont in host Source: Ensembl
  8. negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
  9. negative regulation of interferon-gamma production Source: Ensembl
  10. negative regulation of interleukin-12 production Source: Ensembl
  11. negative regulation of interleukin-18 production Source: Ensembl
  12. negative regulation of interleukin-2 production Source: Ensembl
  13. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
  14. negative regulation of T cell mediated immunity Source: Ensembl
  15. negative regulation of toll-like receptor 2 signaling pathway Source: Ensembl
  16. negative regulation of tumor necrosis factor production Source: Ensembl
  17. nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
  18. positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Source: Ensembl
  19. positive regulation of cell proliferation Source: Ensembl
  20. positive regulation of dendritic cell cytokine production Source: Ensembl
  21. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  22. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  23. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  24. positive regulation of interleukin-12 production Source: Ensembl
  25. positive regulation of interleukin-1 beta secretion Source: Ensembl
  26. positive regulation of interleukin-6 production Source: Ensembl
  27. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  28. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  29. positive regulation of phagocytosis Source: Ensembl
  30. positive regulation of tumor necrosis factor production Source: Ensembl
  31. regulation of neutrophil chemotaxis Source: Ensembl
  32. response to exogenous dsRNA Source: Ensembl
  33. response to lipopolysaccharide Source: Ensembl
  34. response to muramyl dipeptide Source: Ensembl
  35. response to nutrient Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NOD2Imported
Submitted name:
Nucleotide-binding oligomerization domain containing 2Imported
Gene namesi
Name:NOD2Imported
Synonyms:CARD15Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ7Z597.
ExpressionAtlasiQ7Z597. baseline and differential.

Sequencei

Sequence statusi: Fragment.

Q7Z597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
LSNNCITYLG AEALLQALER NDTILEV
Length:27
Mass (Da):2,977
Last modified:October 1, 2003 - v1
Checksum:i3D5C3B988107E039
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei27 – 271Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385085 Genomic DNA. Translation: AAK70863.1.
DQ869189 Genomic DNA. Translation: ABI96990.1.
AB542701 Genomic DNA. Translation: BAJ13470.1.
UniGeneiHs.592072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385085 Genomic DNA. Translation: AAK70863.1.
DQ869189 Genomic DNA. Translation: ABI96990.1.
AB542701 Genomic DNA. Translation: BAJ13470.1.
UniGeneiHs.592072.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ7Z597.
ExpressionAtlasiQ7Z597. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis."
    Rodriguez-Perez N., Aguinaga-Barrilero A., Gorrono-Echebarria M.B., Perez-Blas M., Martin-Villa J.M.
    Dis. Markers 24:111-117(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Population specific susceptibility to Crohn's disease and ulcerative colitis and their dominant/recessive relative risks in the Japanese population."
    Nakagome S., Takeyama Y., Mano S., Sakisaka S., Matsui T., Kawamura S., Oota H.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7Z597_HUMAN
AccessioniPrimary (citable) accession number: Q7Z597
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: March 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.