Reviewed, UniProtKB/Swiss-Prot Q7Z591 (AKNA_HUMAN)

Names and origin

Protein names

Recommended name:
    AT-hook-containing transcription factor

Gene names

Name:	AKNA
Synonyms:	KIAA1968

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters. Ref.6
Subcellular location	Nucleus. Ref.6
Tissue specificity	Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a+CD14- but not CD1a-CD14+ dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow. Ref.6
Sequence similarities	Contains 1 A.T hook DNA-binding domain.
Sequence caution	The sequence AAK83024.1 differs from that shown. Reason: Frameshift at position 1228. The sequence AAU34192.1 differs from that shown. Reason: Frameshift at position 1227. The sequence BAC85132.1 differs from that shown. Reason: Frameshift at position 1340. The sequence BAD18725.1 differs from that shown. Reason: Frameshift at positions 820, 1017, 1340, 1387 and 1434.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z591-1)

Also known as: B2; D;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z591-2)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MASSETEIRW...DSESGETSGE → MLRSEWPVFP

Isoform 3 (identifier: Q7Z591-3)

The sequence of this isoform differs from the canonical sequence as follows:
     832-1439: Missing.

Isoform 4 (identifier: Q7Z591-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1055: Missing.
     1056-1074: PCGPTETIPSFLLTRAGRD → MSAGGGTRGYSPRSPGATS

Note: No experimental confirmation available.

Isoform 5 (identifier: Q7Z591-5)

Also known as: F1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-753: Missing.

Isoform 6 (identifier: Q7Z591-6)

The sequence of this isoform differs from the canonical sequence as follows:
     448-572: EDYHRLLTKY...TQALASQASQ → VSGTHGCGCV...GGWLGQEALG
     573-1439: Missing.

Isoform 7 (identifier: Q7Z591-7)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Isoform 8 (identifier: Q7Z591-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1439	1439	AT-hook-containing transcription factor		PRO_0000289159
Regions
	DNA binding	1115 – 1123	9	A.T hook Ref.6
	Region	771 – 804	34	PEST
	Region	911 – 932	22	PEST
Amino acid modifications
	Modified residue	839	1	Phosphoserine Ref.7
	Modified residue	848	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 1055	1055	Missing in isoform 4.		VSP_025932
	Alternative sequence	1 – 753	753	Missing in isoform 5.		VSP_025933
	Alternative sequence	1 – 540	540	Missing in isoform 8.		VSP_025934
	Alternative sequence	1 – 119	119	Missing in isoform 7.		VSP_025935
	Alternative sequence	1 – 91	91	MASSE…ETSGE → MLRSEWPVFP in isoform 2.		VSP_025936
	Alternative sequence	448 – 572	125	EDYHR…SQASQ → VSGTHGCGCVTKAPVGLGWR LIGVGRPGVEAGWGGEAWDR AWLGWEALGRRLVGWGGLGW RLARVGSPGMEASGVGRPGV GSPGVEPGGVGRPGVEAGWG RKPWDRGWWGGEAWGGGWLG QEALG in isoform 6.		VSP_025937
	Alternative sequence	573 – 1439	867	Missing in isoform 6.		VSP_025938
	Alternative sequence	832 – 1439	608	Missing in isoform 3.		VSP_025939
	Alternative sequence	1056 – 1074	19	PCGPT…RAGRD → MSAGGGTRGYSPRSPGATS in isoform 4.		VSP_025940
	Natural variant	624	1	P → L: dbSNP rs3748176. Ref.2 Ref.3		VAR_032586
	Natural variant	1097	1	Q → R: dbSNP rs1265891.		VAR_032587
	Natural variant	1119	1	R → Q: dbSNP rs3748178. Ref.3		VAR_032588
	Natural variant	1303	1	S → P: dbSNP rs2250242. Ref.3 Ref.5		VAR_032589
	Natural variant	1327	1	Y → C: dbSNP rs2787344.		VAR_032590
Experimental info
	Sequence conflict	799	1	D → V in BAD18725. Ref.3
	Sequence conflict	799	1	D → V in BAC85132. Ref.3
	Sequence conflict	816	1	R → S in BAD18725. Ref.3
	Sequence conflict	1037	1	L → F in AAK83024. Ref.6
	Sequence conflict	1103	1	P → Q in BAD18725. Ref.3
	Sequence conflict	1114	1	A → P in BAD18725. Ref.3
	Sequence conflict	1429	1	Q → P in BAD18725. Ref.3
	Sequence conflict	1435 – 1436	2	GS → AP in BAD18725. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (B2) (D) [UniParc]. Last modified May 29, 2007. Version 2. Checksum: 51688A0C5C55A7BE	FASTA	1,439	155,139
	10 20 30 40 50 60 MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA TSPELLEDFR 70 80 90 100 110 120 LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS PASSHEPLAW LPQQGRQLDM 130 140 150 160 170 180 TEEEPDGTLG SLEVEEAGES SSRLGYEAGL SLEGHGNTSP MALGHGQARG WVASGEQASG 190 200 210 220 230 240 DKLSEHSEVN PSVELSPARS WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS 250 260 270 280 290 300 HHLLSPDGRT GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT 310 320 330 340 350 360 KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG RGQLNYPLPD 370 380 390 400 410 420 FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP AEIVQEVLLS SGEAALAKDT 430 440 450 460 470 480 PPAHPITRVP QEFQTPEQAT ELVHQLQEDY HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP 490 500 510 520 530 540 QPNHSIHTGM VPQGTKVLSF TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS 550 560 570 580 590 600 MPTLGWLPEN RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR 610 620 630 640 650 660 LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS CLEELKEHID 670 680 690 700 710 720 QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP AIKTSCPEPA TTTAAASTGP 730 740 750 760 770 780 CPLHVNVEVS SGNSEVEDRP QDPLARLRHK ELQMEQVYHG LMERYLSVKS LPEAMRMEEE 790 800 810 820 830 840 EEGEEEEEEE GGGDSLEVDG VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM 850 860 870 880 890 900 KPPGFQASLA RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP 910 920 930 940 950 960 QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST AGTLAQPFAA 970 980 990 1000 1010 1020 SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG PLRQRAPNFS LERTLAAEMA 1030 1040 1050 1060 1070 1080 VPGSEFEGHK RISEQPLPNK TISPPPAPAP AAAPLPCGPT ETIPSFLLTR AGRDQAICEL 1090 1100 1110 1120 1130 1140 QEEVSRLRLR LEDSLHQPLQ GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP 1150 1160 1170 1180 1190 1200 GEPRGEEQIV PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG 1210 1220 1230 1240 1250 1260 KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ DAGGAVTGDP 1270 1280 1290 1300 1310 1320 LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR KASSTPSPKQ RSKQAGSSPR 1330 1340 1350 1360 1370 1380 PPPGLWYLAT APPAPAPPAF AYISSVPIMP YPPAAVYYAP AGPTSAQPAA KWPPTASPPP 1390 1400 1410 1420 1430 ARRHRHSIQL DLGDLEELNK ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF
	Isoform 2 (E). Checksum: A96C7EBC4EF10401	FASTA	1,358	145,921
	10 20 30 40 50 60 MLRSEWPVFP EAEAEDVDSP ASSHEPLAWL PQQGRQLDMT EEEPDGTLGS LEVEEAGESS 70 80 90 100 110 120 SRLGYEAGLS LEGHGNTSPM ALGHGQARGW VASGEQASGD KLSEHSEVNP SVELSPARSW 130 140 150 160 170 180 SSGTVSLDHP SDSLDSTWEG ETDGPQPTAL AETLPEGPSH HLLSPDGRTG GSVARATPME 190 200 210 220 230 240 FQDSSAPPAQ SPQHATDRWR RETTRFFCPQ PKEHIWKQTK TSPKPLPSRF IGSISPLNPQ 250 260 270 280 290 300 PRPTRQGRPL PRQGATLAGR SSSNAPKYGR GQLNYPLPDF SKVGPRVRFP KDESYRPPKS 310 320 330 340 350 360 RSHNRKPQAP ARPLIFKSPA EIVQEVLLSS GEAALAKDTP PAHPITRVPQ EFQTPEQATE 370 380 390 400 410 420 LVHQLQEDYH RLLTKYAEAE NTIDQLRLGA KVNLFSDPPQ PNHSIHTGMV PQGTKVLSFT 430 440 450 460 470 480 IPQPRSAEWW PGPAEDPQAS AASGWPSARG DLSPSSLTSM PTLGWLPENR DISEDQSSAE 490 500 510 520 530 540 QTQALASQAS QFLAKVESFE RLIQAGRLMP QDQVKGFQRL KAAHAALEEE YLKACREQHP 550 560 570 580 590 600 AQPLAGSKGT PGRFDPRREL EAEIYRLGSC LEELKEHIDQ TQQEPEPPGS DSALDSTPAL 610 620 630 640 650 660 PCLHQPTHLP APSGQAPMPA IKTSCPEPAT TTAAASTGPC PLHVNVEVSS GNSEVEDRPQ 670 680 690 700 710 720 DPLARLRHKE LQMEQVYHGL MERYLSVKSL PEAMRMEEEE EGEEEEEEEG GGDSLEVDGV 730 740 750 760 770 780 AATPGKAEAT RVLPRQCPVQ AEKSHGAPLE EATEKMVSMK PPGFQASLAR DGHMSGLGKA 790 800 810 820 830 840 EAAPPGPGVP PHPPGTKSAA SHQSSMTSLE GSGISERLPQ KPLHRGGGPH LEETWMASPE 850 860 870 880 890 900 TDSGFVGSET SRVSPLTQTP EHRLSHISTA GTLAQPFAAS VPRDGASYPK ARGSLIPRRA 910 920 930 940 950 960 TEPSTPRSQA QRYLSSPSGP LRQRAPNFSL ERTLAAEMAV PGSEFEGHKR ISEQPLPNKT 970 980 990 1000 1010 1020 ISPPPAPAPA AAPLPCGPTE TIPSFLLTRA GRDQAICELQ EEVSRLRLRL EDSLHQPLQG 1030 1040 1050 1060 1070 1080 SPTRPASAFD RPARTRGRPA DSPATWGSHY GSKSTERLPG EPRGEEQIVP PGRQRARSSS 1090 1100 1110 1120 1130 1140 VPREVLRLSL SSESELPSLP LFSEKSKTTK DSPQAARDGK RGVGSAGWPD RVTFRGQYTG 1150 1160 1170 1180 1190 1200 HEYHVLSPKA VPKGNGTVSC PHCRPIRTQD AGGAVTGDPL GPPPADTLQC PLCGQVGSPP 1210 1220 1230 1240 1250 1260 EADGPGSATS GAEKATTRRK ASSTPSPKQR SKQAGSSPRP PPGLWYLATA PPAPAPPAFA 1270 1280 1290 1300 1310 1320 YISSVPIMPY PPAAVYYAPA GPTSAQPAAK WPPTASPPPA RRHRHSIQLD LGDLEELNKA 1330 1340 1350 LSRAVQAAES VRSTTRQMRS SLSADLRQAH SLRGSCLF
	Isoform 3. Checksum: 60F24D16072CF37D	FASTA	831	90,917
	10 20 30 40 50 60 MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA TSPELLEDFR 70 80 90 100 110 120 LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS PASSHEPLAW LPQQGRQLDM 130 140 150 160 170 180 TEEEPDGTLG SLEVEEAGES SSRLGYEAGL SLEGHGNTSP MALGHGQARG WVASGEQASG 190 200 210 220 230 240 DKLSEHSEVN PSVELSPARS WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS 250 260 270 280 290 300 HHLLSPDGRT GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT 310 320 330 340 350 360 KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG RGQLNYPLPD 370 380 390 400 410 420 FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP AEIVQEVLLS SGEAALAKDT 430 440 450 460 470 480 PPAHPITRVP QEFQTPEQAT ELVHQLQEDY HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP 490 500 510 520 530 540 QPNHSIHTGM VPQGTKVLSF TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS 550 560 570 580 590 600 MPTLGWLPEN RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR 610 620 630 640 650 660 LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS CLEELKEHID 670 680 690 700 710 720 QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP AIKTSCPEPA TTTAAASTGP 730 740 750 760 770 780 CPLHVNVEVS SGNSEVEDRP QDPLARLRHK ELQMEQVYHG LMERYLSVKS LPEAMRMEEE 790 800 810 820 830 EEGEEEEEEE GGGDSLEVDG VAATPGKAEA TRVLPRQCPV QAEKSHGAPL E
	Isoform 4. Checksum: D195D6878CCF4F5C	FASTA	384	40,606
	10 20 30 40 50 60 MSAGGGTRGY SPRSPGATSQ AICELQEEVS RLRLRLEDSL HQPLQGSPTR PASAFDRPAR 70 80 90 100 110 120 TRGRPADSPA TWGSHYGSKS TERLPGEPRG EEQIVPPGRQ RARSSSVPRE VLRLSLSSES 130 140 150 160 170 180 ELPSLPLFSE KSKTTKDSPQ AARDGKRGVG SAGWPDRVTF RGQYTGHEYH VLSPKAVPKG 190 200 210 220 230 240 NGTVSCPHCR PIRTQDAGGA VTGDPLGPPP ADTLQCPLCG QVGSPPEADG PGSATSGAEK 250 260 270 280 290 300 ATTRRKASST PSPKQRSKQA GSSPRPPPGL WYLATAPPAP APPAFAYISS VPIMPYPPAA 310 320 330 340 350 360 VYYAPAGPTS AQPAAKWPPT ASPPPARRHR HSIQLDLGDL EELNKALSRA VQAAESVRST 370 380 TRQMRSSLSA DLRQAHSLRG SCLF
	Isoform 5 (F1). Checksum: 77843A242C71E4E2	FASTA	686	72,810
	10 20 30 40 50 60 MEQVYHGLME RYLSVKSLPE AMRMEEEEEG EEEEEEEGGG DSLEVDGVAA TPGKAEATRV 70 80 90 100 110 120 LPRQCPVQAE KSHGAPLEEA TEKMVSMKPP GFQASLARDG HMSGLGKAEA APPGPGVPPH 130 140 150 160 170 180 PPGTKSAASH QSSMTSLEGS GISERLPQKP LHRGGGPHLE ETWMASPETD SGFVGSETSR 190 200 210 220 230 240 VSPLTQTPEH RLSHISTAGT LAQPFAASVP RDGASYPKAR GSLIPRRATE PSTPRSQAQR 250 260 270 280 290 300 YLSSPSGPLR QRAPNFSLER TLAAEMAVPG SEFEGHKRIS EQPLPNKTIS PPPAPAPAAA 310 320 330 340 350 360 PLPCGPTETI PSFLLTRAGR DQAICELQEE VSRLRLRLED SLHQPLQGSP TRPASAFDRP 370 380 390 400 410 420 ARTRGRPADS PATWGSHYGS KSTERLPGEP RGEEQIVPPG RQRARSSSVP REVLRLSLSS 430 440 450 460 470 480 ESELPSLPLF SEKSKTTKDS PQAARDGKRG VGSAGWPDRV TFRGQYTGHE YHVLSPKAVP 490 500 510 520 530 540 KGNGTVSCPH CRPIRTQDAG GAVTGDPLGP PPADTLQCPL CGQVGSPPEA DGPGSATSGA 550 560 570 580 590 600 EKATTRRKAS STPSPKQRSK QAGSSPRPPP GLWYLATAPP APAPPAFAYI SSVPIMPYPP 610 620 630 640 650 660 AAVYYAPAGP TSAQPAAKWP PTASPPPARR HRHSIQLDLG DLEELNKALS RAVQAAESVR 670 680 STTRQMRSSL SADLRQAHSL RGSCLF
	Isoform 6. Checksum: C5AA7024B767C695	FASTA	572	61,839
	10 20 30 40 50 60 MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA TSPELLEDFR 70 80 90 100 110 120 LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS PASSHEPLAW LPQQGRQLDM 130 140 150 160 170 180 TEEEPDGTLG SLEVEEAGES SSRLGYEAGL SLEGHGNTSP MALGHGQARG WVASGEQASG 190 200 210 220 230 240 DKLSEHSEVN PSVELSPARS WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS 250 260 270 280 290 300 HHLLSPDGRT GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT 310 320 330 340 350 360 KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG RGQLNYPLPD 370 380 390 400 410 420 FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP AEIVQEVLLS SGEAALAKDT 430 440 450 460 470 480 PPAHPITRVP QEFQTPEQAT ELVHQLQVSG THGCGCVTKA PVGLGWRLIG VGRPGVEAGW 490 500 510 520 530 540 GGEAWDRAWL GWEALGRRLV GWGGLGWRLA RVGSPGMEAS GVGRPGVGSP GVEPGGVGRP 550 560 570 GVEAGWGRKP WDRGWWGGEA WGGGWLGQEA LG
	Isoform 7 (A). Checksum: BB6B6B38C6C0AFB0	FASTA	1,320	141,619
	10 20 30 40 50 60 MTEEEPDGTL GSLEVEEAGE SSSRLGYEAG LSLEGHGNTS PMALGHGQAR GWVASGEQAS 70 80 90 100 110 120 GDKLSEHSEV NPSVELSPAR SWSSGTVSLD HPSDSLDSTW EGETDGPQPT ALAETLPEGP 130 140 150 160 170 180 SHHLLSPDGR TGGSVARATP MEFQDSSAPP AQSPQHATDR WRRETTRFFC PQPKEHIWKQ 190 200 210 220 230 240 TKTSPKPLPS RFIGSISPLN PQPRPTRQGR PLPRQGATLA GRSSSNAPKY GRGQLNYPLP 250 260 270 280 290 300 DFSKVGPRVR FPKDESYRPP KSRSHNRKPQ APARPLIFKS PAEIVQEVLL SSGEAALAKD 310 320 330 340 350 360 TPPAHPITRV PQEFQTPEQA TELVHQLQED YHRLLTKYAE AENTIDQLRL GAKVNLFSDP 370 380 390 400 410 420 PQPNHSIHTG MVPQGTKVLS FTIPQPRSAE WWPGPAEDPQ ASAASGWPSA RGDLSPSSLT 430 440 450 460 470 480 SMPTLGWLPE NRDISEDQSS AEQTQALASQ ASQFLAKVES FERLIQAGRL MPQDQVKGFQ 490 500 510 520 530 540 RLKAAHAALE EEYLKACREQ HPAQPLAGSK GTPGRFDPRR ELEAEIYRLG SCLEELKEHI 550 560 570 580 590 600 DQTQQEPEPP GSDSALDSTP ALPCLHQPTH LPAPSGQAPM PAIKTSCPEP ATTTAAASTG 610 620 630 640 650 660 PCPLHVNVEV SSGNSEVEDR PQDPLARLRH KELQMEQVYH GLMERYLSVK SLPEAMRMEE 670 680 690 700 710 720 EEEGEEEEEE EGGGDSLEVD GVAATPGKAE ATRVLPRQCP VQAEKSHGAP LEEATEKMVS 730 740 750 760 770 780 MKPPGFQASL ARDGHMSGLG KAEAAPPGPG VPPHPPGTKS AASHQSSMTS LEGSGISERL 790 800 810 820 830 840 PQKPLHRGGG PHLEETWMAS PETDSGFVGS ETSRVSPLTQ TPEHRLSHIS TAGTLAQPFA 850 860 870 880 890 900 ASVPRDGASY PKARGSLIPR RATEPSTPRS QAQRYLSSPS GPLRQRAPNF SLERTLAAEM 910 920 930 940 950 960 AVPGSEFEGH KRISEQPLPN KTISPPPAPA PAAAPLPCGP TETIPSFLLT RAGRDQAICE 970 980 990 1000 1010 1020 LQEEVSRLRL RLEDSLHQPL QGSPTRPASA FDRPARTRGR PADSPATWGS HYGSKSTERL 1030 1040 1050 1060 1070 1080 PGEPRGEEQI VPPGRQRARS SSVPREVLRL SLSSESELPS LPLFSEKSKT TKDSPQAARD 1090 1100 1110 1120 1130 1140 GKRGVGSAGW PDRVTFRGQY TGHEYHVLSP KAVPKGNGTV SCPHCRPIRT QDAGGAVTGD 1150 1160 1170 1180 1190 1200 PLGPPPADTL QCPLCGQVGS PPEADGPGSA TSGAEKATTR RKASSTPSPK QRSKQAGSSP 1210 1220 1230 1240 1250 1260 RPPPGLWYLA TAPPAPAPPA FAYISSVPIM PYPPAAVYYA PAGPTSAQPA AKWPPTASPP 1270 1280 1290 1300 1310 1320 PARRHRHSIQ LDLGDLEELN KALSRAVQAA ESVRSTTRQM RSSLSADLRQ AHSLRGSCLF
	Isoform 8. Checksum: CB0341DD1715B61F	FASTA	899	96,014
	10 20 30 40 50 60 MPTLGWLPEN RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR 70 80 90 100 110 120 LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS CLEELKEHID 130 140 150 160 170 180 QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP AIKTSCPEPA TTTAAASTGP 190 200 210 220 230 240 CPLHVNVEVS SGNSEVEDRP QDPLARLRHK ELQMEQVYHG LMERYLSVKS LPEAMRMEEE 250 260 270 280 290 300 EEGEEEEEEE GGGDSLEVDG VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM 310 320 330 340 350 360 KPPGFQASLA RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP 370 380 390 400 410 420 QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST AGTLAQPFAA 430 440 450 460 470 480 SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG PLRQRAPNFS LERTLAAEMA 490 500 510 520 530 540 VPGSEFEGHK RISEQPLPNK TISPPPAPAP AAAPLPCGPT ETIPSFLLTR AGRDQAICEL 550 560 570 580 590 600 QEEVSRLRLR LEDSLHQPLQ GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP 610 620 630 640 650 660 GEPRGEEQIV PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG 670 680 690 700 710 720 KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ DAGGAVTGDP 730 740 750 760 770 780 LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR KASSTPSPKQ RSKQAGSSPR 790 800 810 820 830 840 PPPGLWYLAT APPAPAPPAF AYISSVPIMP YPPAAVYYAP AGPTSAQPAA KWPPTASPPP 850 860 870 880 890 ARRHRHSIQL DLGDLEELNK ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF

References

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[1]	"The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation." Sims-Mourtada J.C., Bruce S., McKeller M.R., Rangel R., Guzman-Rojas L., Cain K., Lopez C., Zimonjic D.B., Popescu N.C., Gordon J., Wilkinson M.F., Martinez-Valdez H. DNA Cell Biol. 24:325-338(2005) [PubMed: 15869410] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5; 6 AND 7).
[2]	"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed: 11853319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-624. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8), VARIANTS LEU-624; GLN-1119 AND PRO-1303. Tissue: Spleen.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT PRO-1303. Tissue: Eye.
[6]	"Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA." Siddiqa A., Sims-Mourtada J.C., Guzman-Rojas L., Rangel R., Guret C., Madrid-Marina V., Sun Y., Martinez-Valdez H. Nature 410:383-387(2001) [PubMed: 11268217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 762-1395, FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-839 AND SER-848, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY703039 mRNA. Translation: AAU34186.1. AY703043 mRNA. Translation: AAU34190.1. AY703044 mRNA. Translation: AAU34191.1. AY703045 mRNA. Translation: AAU34192.1. Frameshift. AB075848 mRNA. Translation: BAB85554.1. Different initiation. AK024431 mRNA. Translation: BAB15721.1. AK074040 mRNA. Translation: BAB84866.1. Different initiation. AK131082 mRNA. Translation: BAC85132.1. Sequence problems. AK160382 mRNA. Translation: BAD18725.1. Sequence problems. AL356796 Genomic DNA. Translation: CAM23638.1. AL356796 Genomic DNA. Translation: CAI16861.1. AL356796 Genomic DNA. Translation: CAI16862.2. AL356796 Genomic DNA. Translation: CAI16863.1. BC042202 mRNA. Translation: AAH42202.1. BC055285 mRNA. Translation: AAH55285.1. AF286341 mRNA. Translation: AAK83024.1. Frameshift.
IPI	IPI00291825. IPI00377187. IPI00445384. IPI00477282. IPI00657833. IPI00847273. IPI00847363. IPI00847998.
RefSeq	NP_110394.3.
UniGene	Hs.494895
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q7Z591.
Proteomic databases
PRIDE	Q7Z591.
Genome annotation databases
Ensembl	ENST00000223791; ENSP00000223791; ENSG00000106948; Homo sapiens. [Genome view] ENST00000307564; ENSP00000303769; ENSG00000106948; Homo sapiens. [Genome view] ENST00000312033; ENSP00000309222; ENSG00000106948; Homo sapiens. [Genome view] ENST00000320310; ENSP00000314538; ENSG00000106948; Homo sapiens. [Genome view] ENST00000374075; ENSP00000363188; ENSG00000106948; Homo sapiens. [Genome view] ENST00000374079; ENSP00000363192; ENSG00000106948; Homo sapiens. [Genome view] ENST00000374088; ENSP00000363201; ENSG00000106948; Homo sapiens. [Genome view] ENST00000394574; ENSP00000378075; ENSG00000106948; Homo sapiens. [Genome view] ENST00000394582; ENSP00000378083; ENSG00000106948; Homo sapiens. [Genome view]
GeneID	80709.
KEGG	hsa:80709.
NMPDR	fig|9606.3.peg.31792.
UCSC	uc004bin.2. human. uc004bio.2. human. uc004biq.2. human. uc004biv.1. human. uc004biw.1. human.
Organism-specific databases
CTD	80709.
GeneCards	GC09M116138.
HGNC	HGNC:24108. AKNA.
MIM	605729. gene.
PharmGKB	PA134908332.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q7Z591.
OMA	GVEAGWG.
Gene expression databases
ArrayExpress	Q7Z591.
Bgee	Q7Z591.
Genevestigator	Q7Z591.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	71009.
PMAP-CutDB	Q7Z591.
SOURCE	Search...

Entry information

Entry name

AKNA_HUMAN

Accession

Primary (citable) accession number: Q7Z591
Secondary accession number(s): Q05BK5 , Q5T535, Q5T536, Q5T537, Q64FX6, Q64FX7, Q64FX8, Q64FY2, Q6ZMK0, Q6ZNL2, Q6ZTX0, Q8TET1, Q8TF33, Q96RR9, Q9H7P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	November 3, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.