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Q7Z591

- AKNA_HUMAN

UniProt

Q7Z591 - AKNA_HUMAN

Protein

AT-hook-containing transcription factor

Gene

AKNA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi1115 – 11239A.T hook

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AT-hook-containing transcription factor
    Gene namesi
    Name:AKNA
    Synonyms:KIAA1968
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:24108. AKNA.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134908332.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14391439AT-hook-containing transcription factorPRO_0000289159Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei534 – 5341Phosphoserine1 Publication
    Modified residuei1387 – 13871Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z591.
    PaxDbiQ7Z591.
    PRIDEiQ7Z591.

    PTM databases

    PhosphoSiteiQ7Z591.

    Miscellaneous databases

    PMAP-CutDBQ7Z591.

    Expressioni

    Tissue specificityi

    Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a+CD14- but not CD1a-CD14+ dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.1 Publication

    Gene expression databases

    BgeeiQ7Z591.
    GenevestigatoriQ7Z591.

    Interactioni

    Protein-protein interaction databases

    BioGridi123268. 2 interactions.
    IntActiQ7Z591. 2 interactions.
    MINTiMINT-1366492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni771 – 80434PESTAdd
    BLAST
    Regioni911 – 93222PESTAdd
    BLAST

    Sequence similaritiesi

    Contains 1 A.T hook DNA-binding domain.Curated

    Phylogenomic databases

    eggNOGiNOG73466.
    HOVERGENiHBG097463.
    OMAiPEAMRME.
    OrthoDBiEOG754HQ8.
    PhylomeDBiQ7Z591.
    TreeFamiTF336885.

    Family and domain databases

    InterProiIPR022150. TF_AT-hook.
    [Graphical view]
    PfamiPF12443. AKNA. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z591-1) [UniParc]FASTAAdd to Basket

    Also known as: B2, D

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA     50
    TSPELLEDFR LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS 100
    PASSHEPLAW LPQQGRQLDM TEEEPDGTLG SLEVEEAGES SSRLGYEAGL 150
    SLEGHGNTSP MALGHGQARG WVASGEQASG DKLSEHSEVN PSVELSPARS 200
    WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS HHLLSPDGRT 250
    GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT 300
    KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG 350
    RGQLNYPLPD FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP 400
    AEIVQEVLLS SGEAALAKDT PPAHPITRVP QEFQTPEQAT ELVHQLQEDY 450
    HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP QPNHSIHTGM VPQGTKVLSF 500
    TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS MPTLGWLPEN 550
    RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR 600
    LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS 650
    CLEELKEHID QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP 700
    AIKTSCPEPA TTTAAASTGP CPLHVNVEVS SGNSEVEDRP QDPLARLRHK 750
    ELQMEQVYHG LMERYLSVKS LPEAMRMEEE EEGEEEEEEE GGGDSLEVDG 800
    VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM KPPGFQASLA 850
    RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP 900
    QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST 950
    AGTLAQPFAA SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG 1000
    PLRQRAPNFS LERTLAAEMA VPGSEFEGHK RISEQPLPNK TISPPPAPAP 1050
    AAAPLPCGPT ETIPSFLLTR AGRDQAICEL QEEVSRLRLR LEDSLHQPLQ 1100
    GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP GEPRGEEQIV 1150
    PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG 1200
    KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ 1250
    DAGGAVTGDP LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR 1300
    KASSTPSPKQ RSKQAGSSPR PPPGLWYLAT APPAPAPPAF AYISSVPIMP 1350
    YPPAAVYYAP AGPTSAQPAA KWPPTASPPP ARRHRHSIQL DLGDLEELNK 1400
    ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF 1439
    Length:1,439
    Mass (Da):155,139
    Last modified:May 29, 2007 - v2
    Checksum:i51688A0C5C55A7BE
    GO
    Isoform 2 (identifier: Q7Z591-2) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         1-91: MASSETEIRW...DSESGETSGE → MLRSEWPVFP

    Show »
    Length:1,358
    Mass (Da):145,921
    Checksum:iA96C7EBC4EF10401
    GO
    Isoform 3 (identifier: Q7Z591-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         832-1439: Missing.

    Show »
    Length:831
    Mass (Da):90,917
    Checksum:i60F24D16072CF37D
    GO
    Isoform 4 (identifier: Q7Z591-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1055: Missing.
         1056-1074: PCGPTETIPSFLLTRAGRD → MSAGGGTRGYSPRSPGATS

    Note: No experimental confirmation available.

    Show »
    Length:384
    Mass (Da):40,606
    Checksum:iD195D6878CCF4F5C
    GO
    Isoform 5 (identifier: Q7Z591-5) [UniParc]FASTAAdd to Basket

    Also known as: F1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-753: Missing.

    Show »
    Length:686
    Mass (Da):72,810
    Checksum:i77843A242C71E4E2
    GO
    Isoform 6 (identifier: Q7Z591-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         448-572: EDYHRLLTKY...TQALASQASQ → VSGTHGCGCV...GGWLGQEALG
         573-1439: Missing.

    Show »
    Length:572
    Mass (Da):61,839
    Checksum:iC5AA7024B767C695
    GO
    Isoform 7 (identifier: Q7Z591-7) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-119: Missing.

    Show »
    Length:1,320
    Mass (Da):141,619
    Checksum:iBB6B6B38C6C0AFB0
    GO
    Isoform 8 (identifier: Q7Z591-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-540: Missing.

    Show »
    Length:899
    Mass (Da):96,014
    Checksum:iCB0341DD1715B61F
    GO

    Sequence cautioni

    The sequence AAK83024.1 differs from that shown. Reason: Frameshift at position 1228.
    The sequence AAU34192.1 differs from that shown. Reason: Frameshift at position 1227.
    The sequence BAC85132.1 differs from that shown. Reason: Frameshift at position 1340.
    The sequence BAD18725.1 differs from that shown. Reason: Frameshift at positions 820, 1017, 1340, 1387 and 1434.
    The sequence BAB84866.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB85554.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti799 – 7991D → V in BAD18725. (PubMed:14702039)Curated
    Sequence conflicti799 – 7991D → V in BAC85132. (PubMed:14702039)Curated
    Sequence conflicti816 – 8161R → S in BAD18725. (PubMed:14702039)Curated
    Sequence conflicti1037 – 10371L → F in AAK83024. (PubMed:11268217)Curated
    Sequence conflicti1103 – 11031P → Q in BAD18725. (PubMed:14702039)Curated
    Sequence conflicti1114 – 11141A → P in BAD18725. (PubMed:14702039)Curated
    Sequence conflicti1429 – 14291Q → P in BAD18725. (PubMed:14702039)Curated
    Sequence conflicti1435 – 14362GS → AP in BAD18725. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti624 – 6241P → L.2 Publications
    Corresponds to variant rs3748176 [ dbSNP | Ensembl ].
    VAR_032586
    Natural varianti1097 – 10971Q → R.
    Corresponds to variant rs1265891 [ dbSNP | Ensembl ].
    VAR_032587
    Natural varianti1119 – 11191R → Q.1 Publication
    Corresponds to variant rs3748178 [ dbSNP | Ensembl ].
    VAR_032588
    Natural varianti1303 – 13031S → P.2 Publications
    Corresponds to variant rs2250242 [ dbSNP | Ensembl ].
    VAR_032589
    Natural varianti1327 – 13271Y → C.
    Corresponds to variant rs2787344 [ dbSNP | Ensembl ].
    VAR_032590

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 10551055Missing in isoform 4. 1 PublicationVSP_025932Add
    BLAST
    Alternative sequencei1 – 753753Missing in isoform 5. 1 PublicationVSP_025933Add
    BLAST
    Alternative sequencei1 – 540540Missing in isoform 8. 1 PublicationVSP_025934Add
    BLAST
    Alternative sequencei1 – 119119Missing in isoform 7. 1 PublicationVSP_025935Add
    BLAST
    Alternative sequencei1 – 9191MASSE…ETSGE → MLRSEWPVFP in isoform 2. 1 PublicationVSP_025936Add
    BLAST
    Alternative sequencei448 – 572125EDYHR…SQASQ → VSGTHGCGCVTKAPVGLGWR LIGVGRPGVEAGWGGEAWDR AWLGWEALGRRLVGWGGLGW RLARVGSPGMEASGVGRPGV GSPGVEPGGVGRPGVEAGWG RKPWDRGWWGGEAWGGGWLG QEALG in isoform 6. 1 PublicationVSP_025937Add
    BLAST
    Alternative sequencei573 – 1439867Missing in isoform 6. 1 PublicationVSP_025938Add
    BLAST
    Alternative sequencei832 – 1439608Missing in isoform 3. 1 PublicationVSP_025939Add
    BLAST
    Alternative sequencei1056 – 107419PCGPT…RAGRD → MSAGGGTRGYSPRSPGATS in isoform 4. 1 PublicationVSP_025940Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY703039 mRNA. Translation: AAU34186.1.
    AY703043 mRNA. Translation: AAU34190.1.
    AY703044 mRNA. Translation: AAU34191.1.
    AY703045 mRNA. Translation: AAU34192.1. Frameshift.
    AB075848 mRNA. Translation: BAB85554.1. Different initiation.
    AK024431 mRNA. Translation: BAB15721.1.
    AK074040 mRNA. Translation: BAB84866.1. Different initiation.
    AK131082 mRNA. Translation: BAC85132.1. Sequence problems.
    AK160382 mRNA. Translation: BAD18725.1. Sequence problems.
    AL356796 Genomic DNA. Translation: CAM23638.1.
    AL356796 Genomic DNA. Translation: CAI16861.1.
    AL356796 Genomic DNA. Translation: CAI16862.2.
    AL356796 Genomic DNA. Translation: CAI16863.1.
    BC042202 mRNA. Translation: AAH42202.1.
    BC055285 mRNA. Translation: AAH55285.1.
    AF286341 mRNA. Translation: AAK83024.1. Frameshift.
    CCDSiCCDS6805.1. [Q7Z591-1]
    RefSeqiNP_110394.3. NM_030767.4. [Q7Z591-1]
    XP_005252300.1. XM_005252243.1. [Q7Z591-1]
    XP_005252301.1. XM_005252244.1. [Q7Z591-1]
    XP_005252302.1. XM_005252245.1. [Q7Z591-1]
    XP_005252303.1. XM_005252246.2. [Q7Z591-1]
    XP_005252304.1. XM_005252247.2. [Q7Z591-1]
    XP_006717357.1. XM_006717294.1. [Q7Z591-1]
    XP_006717358.1. XM_006717295.1. [Q7Z591-3]
    UniGeneiHs.494895.

    Genome annotation databases

    EnsembliENST00000223791; ENSP00000223791; ENSG00000106948. [Q7Z591-8]
    ENST00000307564; ENSP00000303769; ENSG00000106948. [Q7Z591-1]
    ENST00000312033; ENSP00000309222; ENSG00000106948. [Q7Z591-3]
    ENST00000374075; ENSP00000363188; ENSG00000106948. [Q7Z591-2]
    ENST00000374079; ENSP00000363192; ENSG00000106948. [Q7Z591-4]
    ENST00000374088; ENSP00000363201; ENSG00000106948. [Q7Z591-1]
    GeneIDi80709.
    KEGGihsa:80709.
    UCSCiuc004bin.3. human. [Q7Z591-5]
    uc004bio.3. human. [Q7Z591-1]
    uc004bip.3. human. [Q7Z591-2]
    uc004biw.1. human. [Q7Z591-6]

    Polymorphism databases

    DMDMi150416853.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY703039 mRNA. Translation: AAU34186.1 .
    AY703043 mRNA. Translation: AAU34190.1 .
    AY703044 mRNA. Translation: AAU34191.1 .
    AY703045 mRNA. Translation: AAU34192.1 . Frameshift.
    AB075848 mRNA. Translation: BAB85554.1 . Different initiation.
    AK024431 mRNA. Translation: BAB15721.1 .
    AK074040 mRNA. Translation: BAB84866.1 . Different initiation.
    AK131082 mRNA. Translation: BAC85132.1 . Sequence problems.
    AK160382 mRNA. Translation: BAD18725.1 . Sequence problems.
    AL356796 Genomic DNA. Translation: CAM23638.1 .
    AL356796 Genomic DNA. Translation: CAI16861.1 .
    AL356796 Genomic DNA. Translation: CAI16862.2 .
    AL356796 Genomic DNA. Translation: CAI16863.1 .
    BC042202 mRNA. Translation: AAH42202.1 .
    BC055285 mRNA. Translation: AAH55285.1 .
    AF286341 mRNA. Translation: AAK83024.1 . Frameshift.
    CCDSi CCDS6805.1. [Q7Z591-1 ]
    RefSeqi NP_110394.3. NM_030767.4. [Q7Z591-1 ]
    XP_005252300.1. XM_005252243.1. [Q7Z591-1 ]
    XP_005252301.1. XM_005252244.1. [Q7Z591-1 ]
    XP_005252302.1. XM_005252245.1. [Q7Z591-1 ]
    XP_005252303.1. XM_005252246.2. [Q7Z591-1 ]
    XP_005252304.1. XM_005252247.2. [Q7Z591-1 ]
    XP_006717357.1. XM_006717294.1. [Q7Z591-1 ]
    XP_006717358.1. XM_006717295.1. [Q7Z591-3 ]
    UniGenei Hs.494895.

    3D structure databases

    ProteinModelPortali Q7Z591.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123268. 2 interactions.
    IntActi Q7Z591. 2 interactions.
    MINTi MINT-1366492.

    PTM databases

    PhosphoSitei Q7Z591.

    Polymorphism databases

    DMDMi 150416853.

    Proteomic databases

    MaxQBi Q7Z591.
    PaxDbi Q7Z591.
    PRIDEi Q7Z591.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000223791 ; ENSP00000223791 ; ENSG00000106948 . [Q7Z591-8 ]
    ENST00000307564 ; ENSP00000303769 ; ENSG00000106948 . [Q7Z591-1 ]
    ENST00000312033 ; ENSP00000309222 ; ENSG00000106948 . [Q7Z591-3 ]
    ENST00000374075 ; ENSP00000363188 ; ENSG00000106948 . [Q7Z591-2 ]
    ENST00000374079 ; ENSP00000363192 ; ENSG00000106948 . [Q7Z591-4 ]
    ENST00000374088 ; ENSP00000363201 ; ENSG00000106948 . [Q7Z591-1 ]
    GeneIDi 80709.
    KEGGi hsa:80709.
    UCSCi uc004bin.3. human. [Q7Z591-5 ]
    uc004bio.3. human. [Q7Z591-1 ]
    uc004bip.3. human. [Q7Z591-2 ]
    uc004biw.1. human. [Q7Z591-6 ]

    Organism-specific databases

    CTDi 80709.
    GeneCardsi GC09M117096.
    HGNCi HGNC:24108. AKNA.
    MIMi 605729. gene.
    neXtProti NX_Q7Z591.
    PharmGKBi PA134908332.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73466.
    HOVERGENi HBG097463.
    OMAi PEAMRME.
    OrthoDBi EOG754HQ8.
    PhylomeDBi Q7Z591.
    TreeFami TF336885.

    Miscellaneous databases

    ChiTaRSi AKNA. human.
    GenomeRNAii 80709.
    NextBioi 71009.
    PMAP-CutDB Q7Z591.
    PROi Q7Z591.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7Z591.
    Genevestigatori Q7Z591.

    Family and domain databases

    InterProi IPR022150. TF_AT-hook.
    [Graphical view ]
    Pfami PF12443. AKNA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation."
      Sims-Mourtada J.C., Bruce S., McKeller M.R., Rangel R., Guzman-Rojas L., Cain K., Lopez C., Zimonjic D.B., Popescu N.C., Gordon J., Wilkinson M.F., Martinez-Valdez H.
      DNA Cell Biol. 24:325-338(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5; 6 AND 7).
    2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-624.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8), VARIANTS LEU-624; GLN-1119 AND PRO-1303.
      Tissue: Spleen.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT PRO-1303.
      Tissue: Eye.
    6. "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA."
      Siddiqa A., Sims-Mourtada J.C., Guzman-Rojas L., Rangel R., Guret C., Madrid-Marina V., Sun Y., Martinez-Valdez H.
      Nature 410:383-387(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 762-1395, FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534 AND SER-1387, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiAKNA_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z591
    Secondary accession number(s): Q05BK5
    , Q5T535, Q5T536, Q5T537, Q64FX6, Q64FX7, Q64FX8, Q64FY2, Q6ZMK0, Q6ZNL2, Q6ZTX0, Q8TET1, Q8TF33, Q96RR9, Q9H7P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3