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Protein

AT-hook-containing transcription factor

Gene

AKNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1115 – 11239A.T hook

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-hook-containing transcription factor
Gene namesi
Name:AKNA
Synonyms:KIAA1968
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:24108. AKNA.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14391439AT-hook-containing transcription factorPRO_0000289159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei534 – 5341Phosphoserine1 Publication
Modified residuei1387 – 13871Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z591.
PaxDbiQ7Z591.
PRIDEiQ7Z591.

PTM databases

PhosphoSiteiQ7Z591.

Miscellaneous databases

PMAP-CutDBQ7Z591.

Expressioni

Tissue specificityi

Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a+CD14- but not CD1a-CD14+ dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.1 Publication

Gene expression databases

BgeeiQ7Z591.
GenevestigatoriQ7Z591.

Interactioni

Protein-protein interaction databases

BioGridi123268. 2 interactions.
IntActiQ7Z591. 2 interactions.
MINTiMINT-1366492.

Structurei

3D structure databases

ProteinModelPortaliQ7Z591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni771 – 80434PESTAdd
BLAST
Regioni911 – 93222PESTAdd
BLAST

Sequence similaritiesi

Contains 1 A.T hook DNA-binding domain.Curated

Phylogenomic databases

eggNOGiNOG73466.
GeneTreeiENSGT00390000003745.
HOVERGENiHBG097463.
InParanoidiQ7Z591.
OMAiPEAMRME.
OrthoDBiEOG754HQ8.
PhylomeDBiQ7Z591.
TreeFamiTF336885.

Family and domain databases

InterProiIPR022150. TF_AT-hook.
[Graphical view]
PfamiPF12443. AKNA. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z591-1) [UniParc]FASTAAdd to basket

Also known as: B2, D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA
60 70 80 90 100
TSPELLEDFR LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS
110 120 130 140 150
PASSHEPLAW LPQQGRQLDM TEEEPDGTLG SLEVEEAGES SSRLGYEAGL
160 170 180 190 200
SLEGHGNTSP MALGHGQARG WVASGEQASG DKLSEHSEVN PSVELSPARS
210 220 230 240 250
WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS HHLLSPDGRT
260 270 280 290 300
GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT
310 320 330 340 350
KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG
360 370 380 390 400
RGQLNYPLPD FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP
410 420 430 440 450
AEIVQEVLLS SGEAALAKDT PPAHPITRVP QEFQTPEQAT ELVHQLQEDY
460 470 480 490 500
HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP QPNHSIHTGM VPQGTKVLSF
510 520 530 540 550
TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS MPTLGWLPEN
560 570 580 590 600
RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR
610 620 630 640 650
LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS
660 670 680 690 700
CLEELKEHID QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP
710 720 730 740 750
AIKTSCPEPA TTTAAASTGP CPLHVNVEVS SGNSEVEDRP QDPLARLRHK
760 770 780 790 800
ELQMEQVYHG LMERYLSVKS LPEAMRMEEE EEGEEEEEEE GGGDSLEVDG
810 820 830 840 850
VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM KPPGFQASLA
860 870 880 890 900
RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP
910 920 930 940 950
QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST
960 970 980 990 1000
AGTLAQPFAA SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG
1010 1020 1030 1040 1050
PLRQRAPNFS LERTLAAEMA VPGSEFEGHK RISEQPLPNK TISPPPAPAP
1060 1070 1080 1090 1100
AAAPLPCGPT ETIPSFLLTR AGRDQAICEL QEEVSRLRLR LEDSLHQPLQ
1110 1120 1130 1140 1150
GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP GEPRGEEQIV
1160 1170 1180 1190 1200
PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG
1210 1220 1230 1240 1250
KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ
1260 1270 1280 1290 1300
DAGGAVTGDP LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR
1310 1320 1330 1340 1350
KASSTPSPKQ RSKQAGSSPR PPPGLWYLAT APPAPAPPAF AYISSVPIMP
1360 1370 1380 1390 1400
YPPAAVYYAP AGPTSAQPAA KWPPTASPPP ARRHRHSIQL DLGDLEELNK
1410 1420 1430
ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF
Length:1,439
Mass (Da):155,139
Last modified:May 28, 2007 - v2
Checksum:i51688A0C5C55A7BE
GO
Isoform 2 (identifier: Q7Z591-2) [UniParc]FASTAAdd to basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MASSETEIRW...DSESGETSGE → MLRSEWPVFP

Show »
Length:1,358
Mass (Da):145,921
Checksum:iA96C7EBC4EF10401
GO
Isoform 3 (identifier: Q7Z591-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-1439: Missing.

Show »
Length:831
Mass (Da):90,917
Checksum:i60F24D16072CF37D
GO
Isoform 4 (identifier: Q7Z591-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1055: Missing.
     1056-1074: PCGPTETIPSFLLTRAGRD → MSAGGGTRGYSPRSPGATS

Note: No experimental confirmation available.

Show »
Length:384
Mass (Da):40,606
Checksum:iD195D6878CCF4F5C
GO
Isoform 5 (identifier: Q7Z591-5) [UniParc]FASTAAdd to basket

Also known as: F1

The sequence of this isoform differs from the canonical sequence as follows:
     1-753: Missing.

Show »
Length:686
Mass (Da):72,810
Checksum:i77843A242C71E4E2
GO
Isoform 6 (identifier: Q7Z591-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-572: EDYHRLLTKY...TQALASQASQ → VSGTHGCGCV...GGWLGQEALG
     573-1439: Missing.

Show »
Length:572
Mass (Da):61,839
Checksum:iC5AA7024B767C695
GO
Isoform 7 (identifier: Q7Z591-7) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Show »
Length:1,320
Mass (Da):141,619
Checksum:iBB6B6B38C6C0AFB0
GO
Isoform 8 (identifier: Q7Z591-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Show »
Length:899
Mass (Da):96,014
Checksum:iCB0341DD1715B61F
GO

Sequence cautioni

The sequence AAK83024.1 differs from that shown. Reason: Frameshift at position 1228. Curated
The sequence AAU34192.1 differs from that shown. Reason: Frameshift at position 1227. Curated
The sequence BAB84866.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB85554.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC85132.1 differs from that shown. Reason: Frameshift at position 1340. Curated
The sequence BAD18725.1 differs from that shown. Reason: Frameshift at positions 820, 1017, 1340, 1387 and 1434. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti799 – 7991D → V in BAD18725 (PubMed:14702039).Curated
Sequence conflicti799 – 7991D → V in BAC85132 (PubMed:14702039).Curated
Sequence conflicti816 – 8161R → S in BAD18725 (PubMed:14702039).Curated
Sequence conflicti1037 – 10371L → F in AAK83024 (PubMed:11268217).Curated
Sequence conflicti1103 – 11031P → Q in BAD18725 (PubMed:14702039).Curated
Sequence conflicti1114 – 11141A → P in BAD18725 (PubMed:14702039).Curated
Sequence conflicti1429 – 14291Q → P in BAD18725 (PubMed:14702039).Curated
Sequence conflicti1435 – 14362GS → AP in BAD18725 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti624 – 6241P → L.2 Publications
Corresponds to variant rs3748176 [ dbSNP | Ensembl ].
VAR_032586
Natural varianti1097 – 10971Q → R.
Corresponds to variant rs1265891 [ dbSNP | Ensembl ].
VAR_032587
Natural varianti1119 – 11191R → Q.1 Publication
Corresponds to variant rs3748178 [ dbSNP | Ensembl ].
VAR_032588
Natural varianti1303 – 13031S → P.2 Publications
Corresponds to variant rs2250242 [ dbSNP | Ensembl ].
VAR_032589
Natural varianti1327 – 13271Y → C.
Corresponds to variant rs2787344 [ dbSNP | Ensembl ].
VAR_032590

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10551055Missing in isoform 4. 1 PublicationVSP_025932Add
BLAST
Alternative sequencei1 – 753753Missing in isoform 5. 1 PublicationVSP_025933Add
BLAST
Alternative sequencei1 – 540540Missing in isoform 8. 1 PublicationVSP_025934Add
BLAST
Alternative sequencei1 – 119119Missing in isoform 7. 1 PublicationVSP_025935Add
BLAST
Alternative sequencei1 – 9191MASSE…ETSGE → MLRSEWPVFP in isoform 2. 1 PublicationVSP_025936Add
BLAST
Alternative sequencei448 – 572125EDYHR…SQASQ → VSGTHGCGCVTKAPVGLGWR LIGVGRPGVEAGWGGEAWDR AWLGWEALGRRLVGWGGLGW RLARVGSPGMEASGVGRPGV GSPGVEPGGVGRPGVEAGWG RKPWDRGWWGGEAWGGGWLG QEALG in isoform 6. 1 PublicationVSP_025937Add
BLAST
Alternative sequencei573 – 1439867Missing in isoform 6. 1 PublicationVSP_025938Add
BLAST
Alternative sequencei832 – 1439608Missing in isoform 3. 1 PublicationVSP_025939Add
BLAST
Alternative sequencei1056 – 107419PCGPT…RAGRD → MSAGGGTRGYSPRSPGATS in isoform 4. 1 PublicationVSP_025940Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY703039 mRNA. Translation: AAU34186.1.
AY703043 mRNA. Translation: AAU34190.1.
AY703044 mRNA. Translation: AAU34191.1.
AY703045 mRNA. Translation: AAU34192.1. Frameshift.
AB075848 mRNA. Translation: BAB85554.1. Different initiation.
AK024431 mRNA. Translation: BAB15721.1.
AK074040 mRNA. Translation: BAB84866.1. Different initiation.
AK131082 mRNA. Translation: BAC85132.1. Sequence problems.
AK160382 mRNA. Translation: BAD18725.1. Sequence problems.
AL356796 Genomic DNA. Translation: CAM23638.1.
AL356796 Genomic DNA. Translation: CAI16861.1.
AL356796 Genomic DNA. Translation: CAI16862.2.
AL356796 Genomic DNA. Translation: CAI16863.1.
BC042202 mRNA. Translation: AAH42202.1.
BC055285 mRNA. Translation: AAH55285.1.
AF286341 mRNA. Translation: AAK83024.1. Frameshift.
CCDSiCCDS6805.1. [Q7Z591-1]
RefSeqiNP_110394.3. NM_030767.4. [Q7Z591-1]
XP_005252300.1. XM_005252243.1. [Q7Z591-1]
XP_005252301.1. XM_005252244.1. [Q7Z591-1]
XP_005252302.1. XM_005252245.1. [Q7Z591-1]
XP_005252303.1. XM_005252246.2. [Q7Z591-1]
XP_005252304.1. XM_005252247.2. [Q7Z591-1]
XP_006717357.1. XM_006717294.1. [Q7Z591-1]
XP_006717358.1. XM_006717295.1. [Q7Z591-3]
UniGeneiHs.494895.

Genome annotation databases

EnsembliENST00000223791; ENSP00000223791; ENSG00000106948. [Q7Z591-8]
ENST00000307564; ENSP00000303769; ENSG00000106948. [Q7Z591-1]
ENST00000312033; ENSP00000309222; ENSG00000106948. [Q7Z591-3]
ENST00000374075; ENSP00000363188; ENSG00000106948. [Q7Z591-2]
ENST00000374079; ENSP00000363192; ENSG00000106948. [Q7Z591-4]
ENST00000374088; ENSP00000363201; ENSG00000106948. [Q7Z591-1]
GeneIDi80709.
KEGGihsa:80709.
UCSCiuc004bin.3. human. [Q7Z591-5]
uc004bio.3. human. [Q7Z591-1]
uc004bip.3. human. [Q7Z591-2]
uc004biw.1. human. [Q7Z591-6]

Polymorphism databases

DMDMi150416853.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY703039 mRNA. Translation: AAU34186.1.
AY703043 mRNA. Translation: AAU34190.1.
AY703044 mRNA. Translation: AAU34191.1.
AY703045 mRNA. Translation: AAU34192.1. Frameshift.
AB075848 mRNA. Translation: BAB85554.1. Different initiation.
AK024431 mRNA. Translation: BAB15721.1.
AK074040 mRNA. Translation: BAB84866.1. Different initiation.
AK131082 mRNA. Translation: BAC85132.1. Sequence problems.
AK160382 mRNA. Translation: BAD18725.1. Sequence problems.
AL356796 Genomic DNA. Translation: CAM23638.1.
AL356796 Genomic DNA. Translation: CAI16861.1.
AL356796 Genomic DNA. Translation: CAI16862.2.
AL356796 Genomic DNA. Translation: CAI16863.1.
BC042202 mRNA. Translation: AAH42202.1.
BC055285 mRNA. Translation: AAH55285.1.
AF286341 mRNA. Translation: AAK83024.1. Frameshift.
CCDSiCCDS6805.1. [Q7Z591-1]
RefSeqiNP_110394.3. NM_030767.4. [Q7Z591-1]
XP_005252300.1. XM_005252243.1. [Q7Z591-1]
XP_005252301.1. XM_005252244.1. [Q7Z591-1]
XP_005252302.1. XM_005252245.1. [Q7Z591-1]
XP_005252303.1. XM_005252246.2. [Q7Z591-1]
XP_005252304.1. XM_005252247.2. [Q7Z591-1]
XP_006717357.1. XM_006717294.1. [Q7Z591-1]
XP_006717358.1. XM_006717295.1. [Q7Z591-3]
UniGeneiHs.494895.

3D structure databases

ProteinModelPortaliQ7Z591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123268. 2 interactions.
IntActiQ7Z591. 2 interactions.
MINTiMINT-1366492.

PTM databases

PhosphoSiteiQ7Z591.

Polymorphism databases

DMDMi150416853.

Proteomic databases

MaxQBiQ7Z591.
PaxDbiQ7Z591.
PRIDEiQ7Z591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223791; ENSP00000223791; ENSG00000106948. [Q7Z591-8]
ENST00000307564; ENSP00000303769; ENSG00000106948. [Q7Z591-1]
ENST00000312033; ENSP00000309222; ENSG00000106948. [Q7Z591-3]
ENST00000374075; ENSP00000363188; ENSG00000106948. [Q7Z591-2]
ENST00000374079; ENSP00000363192; ENSG00000106948. [Q7Z591-4]
ENST00000374088; ENSP00000363201; ENSG00000106948. [Q7Z591-1]
GeneIDi80709.
KEGGihsa:80709.
UCSCiuc004bin.3. human. [Q7Z591-5]
uc004bio.3. human. [Q7Z591-1]
uc004bip.3. human. [Q7Z591-2]
uc004biw.1. human. [Q7Z591-6]

Organism-specific databases

CTDi80709.
GeneCardsiGC09M117096.
HGNCiHGNC:24108. AKNA.
MIMi605729. gene.
neXtProtiNX_Q7Z591.
PharmGKBiPA134908332.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG73466.
GeneTreeiENSGT00390000003745.
HOVERGENiHBG097463.
InParanoidiQ7Z591.
OMAiPEAMRME.
OrthoDBiEOG754HQ8.
PhylomeDBiQ7Z591.
TreeFamiTF336885.

Miscellaneous databases

ChiTaRSiAKNA. human.
GenomeRNAii80709.
NextBioi71009.
PMAP-CutDBQ7Z591.
PROiQ7Z591.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z591.
GenevestigatoriQ7Z591.

Family and domain databases

InterProiIPR022150. TF_AT-hook.
[Graphical view]
PfamiPF12443. AKNA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation."
    Sims-Mourtada J.C., Bruce S., McKeller M.R., Rangel R., Guzman-Rojas L., Cain K., Lopez C., Zimonjic D.B., Popescu N.C., Gordon J., Wilkinson M.F., Martinez-Valdez H.
    DNA Cell Biol. 24:325-338(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5; 6 AND 7).
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-624.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8), VARIANTS LEU-624; GLN-1119 AND PRO-1303.
    Tissue: Spleen.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT PRO-1303.
    Tissue: Eye.
  6. "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA."
    Siddiqa A., Sims-Mourtada J.C., Guzman-Rojas L., Rangel R., Guret C., Madrid-Marina V., Sun Y., Martinez-Valdez H.
    Nature 410:383-387(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 762-1395, FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534 AND SER-1387, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiAKNA_HUMAN
AccessioniPrimary (citable) accession number: Q7Z591
Secondary accession number(s): Q05BK5
, Q5T535, Q5T536, Q5T537, Q64FX6, Q64FX7, Q64FX8, Q64FY2, Q6ZMK0, Q6ZNL2, Q6ZTX0, Q8TET1, Q8TF33, Q96RR9, Q9H7P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 28, 2007
Last sequence update: May 28, 2007
Last modified: January 6, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.