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Protein

AT-hook-containing transcription factor

Gene

AKNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1115 – 1123A.T hook9

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-hook-containing transcription factor
Gene namesi
Name:AKNA
Synonyms:KIAA1968
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:24108. AKNA.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80709.
OpenTargetsiENSG00000106948.
PharmGKBiPA134908332.

Polymorphism and mutation databases

BioMutaiAKNA.
DMDMi150416853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891591 – 1439AT-hook-containing transcription factorAdd BLAST1439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei848PhosphoserineCombined sources1
Modified residuei886PhosphoserineCombined sources1
Modified residuei997PhosphoserineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1172PhosphoserineBy similarity1
Modified residuei1173PhosphoserineBy similarity1
Modified residuei1228PhosphoserineCombined sources1
Modified residuei1377PhosphoserineCombined sources1
Modified residuei1387PhosphoserineCombined sources1
Modified residuei1424PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z591.
MaxQBiQ7Z591.
PaxDbiQ7Z591.
PeptideAtlasiQ7Z591.
PRIDEiQ7Z591.

PTM databases

iPTMnetiQ7Z591.
PhosphoSitePlusiQ7Z591.

Miscellaneous databases

PMAP-CutDBQ7Z591.

Expressioni

Tissue specificityi

Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a+CD14- but not CD1a-CD14+ dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000106948.
GenevisibleiQ7Z591. HS.

Organism-specific databases

HPAiHPA052367.
HPA063993.

Interactioni

Protein-protein interaction databases

BioGridi123268. 1 interactor.
IntActiQ7Z591. 3 interactors.
MINTiMINT-1366492.
STRINGi9606.ENSP00000303769.

Structurei

3D structure databases

ProteinModelPortaliQ7Z591.
SMRiQ7Z591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni771 – 804PESTAdd BLAST34
Regioni911 – 932PESTAdd BLAST22

Sequence similaritiesi

Contains 1 A.T hook DNA-binding domain.Curated

Phylogenomic databases

eggNOGiENOG410IDZE. Eukaryota.
ENOG4111ICK. LUCA.
GeneTreeiENSGT00390000003745.
HOVERGENiHBG097463.
InParanoidiQ7Z591.
OMAiLEEPWMA.
OrthoDBiEOG091G0EXN.
PhylomeDBiQ7Z591.
TreeFamiTF336885.

Family and domain databases

InterProiIPR022150. TF_AT-hook.
[Graphical view]
PfamiPF12443. AKNA. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z591-1) [UniParc]FASTAAdd to basket
Also known as: B2, D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA
60 70 80 90 100
TSPELLEDFR LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS
110 120 130 140 150
PASSHEPLAW LPQQGRQLDM TEEEPDGTLG SLEVEEAGES SSRLGYEAGL
160 170 180 190 200
SLEGHGNTSP MALGHGQARG WVASGEQASG DKLSEHSEVN PSVELSPARS
210 220 230 240 250
WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS HHLLSPDGRT
260 270 280 290 300
GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT
310 320 330 340 350
KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG
360 370 380 390 400
RGQLNYPLPD FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP
410 420 430 440 450
AEIVQEVLLS SGEAALAKDT PPAHPITRVP QEFQTPEQAT ELVHQLQEDY
460 470 480 490 500
HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP QPNHSIHTGM VPQGTKVLSF
510 520 530 540 550
TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS MPTLGWLPEN
560 570 580 590 600
RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR
610 620 630 640 650
LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS
660 670 680 690 700
CLEELKEHID QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP
710 720 730 740 750
AIKTSCPEPA TTTAAASTGP CPLHVNVEVS SGNSEVEDRP QDPLARLRHK
760 770 780 790 800
ELQMEQVYHG LMERYLSVKS LPEAMRMEEE EEGEEEEEEE GGGDSLEVDG
810 820 830 840 850
VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM KPPGFQASLA
860 870 880 890 900
RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP
910 920 930 940 950
QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST
960 970 980 990 1000
AGTLAQPFAA SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG
1010 1020 1030 1040 1050
PLRQRAPNFS LERTLAAEMA VPGSEFEGHK RISEQPLPNK TISPPPAPAP
1060 1070 1080 1090 1100
AAAPLPCGPT ETIPSFLLTR AGRDQAICEL QEEVSRLRLR LEDSLHQPLQ
1110 1120 1130 1140 1150
GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP GEPRGEEQIV
1160 1170 1180 1190 1200
PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG
1210 1220 1230 1240 1250
KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ
1260 1270 1280 1290 1300
DAGGAVTGDP LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR
1310 1320 1330 1340 1350
KASSTPSPKQ RSKQAGSSPR PPPGLWYLAT APPAPAPPAF AYISSVPIMP
1360 1370 1380 1390 1400
YPPAAVYYAP AGPTSAQPAA KWPPTASPPP ARRHRHSIQL DLGDLEELNK
1410 1420 1430
ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF
Length:1,439
Mass (Da):155,139
Last modified:May 29, 2007 - v2
Checksum:i51688A0C5C55A7BE
GO
Isoform 2 (identifier: Q7Z591-2) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MASSETEIRW...DSESGETSGE → MLRSEWPVFP

Show »
Length:1,358
Mass (Da):145,921
Checksum:iA96C7EBC4EF10401
GO
Isoform 3 (identifier: Q7Z591-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-1439: Missing.

Show »
Length:831
Mass (Da):90,917
Checksum:i60F24D16072CF37D
GO
Isoform 4 (identifier: Q7Z591-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1055: Missing.
     1056-1074: PCGPTETIPSFLLTRAGRD → MSAGGGTRGYSPRSPGATS

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):40,606
Checksum:iD195D6878CCF4F5C
GO
Isoform 5 (identifier: Q7Z591-5) [UniParc]FASTAAdd to basket
Also known as: F1

The sequence of this isoform differs from the canonical sequence as follows:
     1-753: Missing.

Show »
Length:686
Mass (Da):72,810
Checksum:i77843A242C71E4E2
GO
Isoform 6 (identifier: Q7Z591-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-572: EDYHRLLTKY...TQALASQASQ → VSGTHGCGCV...GGWLGQEALG
     573-1439: Missing.

Show »
Length:572
Mass (Da):61,839
Checksum:iC5AA7024B767C695
GO
Isoform 7 (identifier: Q7Z591-7) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Show »
Length:1,320
Mass (Da):141,619
Checksum:iBB6B6B38C6C0AFB0
GO
Isoform 8 (identifier: Q7Z591-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Show »
Length:899
Mass (Da):96,014
Checksum:iCB0341DD1715B61F
GO

Sequence cautioni

The sequence AAK83024 differs from that shown. Reason: Frameshift at position 1228.Curated
The sequence AAU34192 differs from that shown. Reason: Frameshift at position 1227.Curated
The sequence BAB84866 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB85554 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85132 differs from that shown. Reason: Frameshift at position 1340.Curated
The sequence BAD18725 differs from that shown. Reason: Frameshift at positions 820, 1017, 1340, 1387 and 1434.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti799D → V in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti799D → V in BAC85132 (PubMed:14702039).Curated1
Sequence conflicti816R → S in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1037L → F in AAK83024 (PubMed:11268217).Curated1
Sequence conflicti1103P → Q in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1114A → P in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1429Q → P in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1435 – 1436GS → AP in BAD18725 (PubMed:14702039).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032586624P → L.2 PublicationsCorresponds to variant rs3748176dbSNPEnsembl.1
Natural variantiVAR_0325871097Q → R.Corresponds to variant rs1265891dbSNPEnsembl.1
Natural variantiVAR_0325881119R → Q.1 PublicationCorresponds to variant rs3748178dbSNPEnsembl.1
Natural variantiVAR_0325891303S → P.2 PublicationsCorresponds to variant rs2250242dbSNPEnsembl.1
Natural variantiVAR_0325901327Y → C.Corresponds to variant rs2787344dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0259321 – 1055Missing in isoform 4. 1 PublicationAdd BLAST1055
Alternative sequenceiVSP_0259331 – 753Missing in isoform 5. 1 PublicationAdd BLAST753
Alternative sequenceiVSP_0259341 – 540Missing in isoform 8. 1 PublicationAdd BLAST540
Alternative sequenceiVSP_0259351 – 119Missing in isoform 7. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_0259361 – 91MASSE…ETSGE → MLRSEWPVFP in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_025937448 – 572EDYHR…SQASQ → VSGTHGCGCVTKAPVGLGWR LIGVGRPGVEAGWGGEAWDR AWLGWEALGRRLVGWGGLGW RLARVGSPGMEASGVGRPGV GSPGVEPGGVGRPGVEAGWG RKPWDRGWWGGEAWGGGWLG QEALG in isoform 6. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_025938573 – 1439Missing in isoform 6. 1 PublicationAdd BLAST867
Alternative sequenceiVSP_025939832 – 1439Missing in isoform 3. 1 PublicationAdd BLAST608
Alternative sequenceiVSP_0259401056 – 1074PCGPT…RAGRD → MSAGGGTRGYSPRSPGATS in isoform 4. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY703039 mRNA. Translation: AAU34186.1.
AY703043 mRNA. Translation: AAU34190.1.
AY703044 mRNA. Translation: AAU34191.1.
AY703045 mRNA. Translation: AAU34192.1. Frameshift.
AB075848 mRNA. Translation: BAB85554.1. Different initiation.
AK024431 mRNA. Translation: BAB15721.1.
AK074040 mRNA. Translation: BAB84866.1. Different initiation.
AK131082 mRNA. Translation: BAC85132.1. Sequence problems.
AK160382 mRNA. Translation: BAD18725.1. Sequence problems.
AL356796 Genomic DNA. Translation: CAM23638.1.
AL356796 Genomic DNA. Translation: CAI16861.1.
AL356796 Genomic DNA. Translation: CAI16862.2.
AL356796 Genomic DNA. Translation: CAI16863.1.
BC042202 mRNA. Translation: AAH42202.1.
BC055285 mRNA. Translation: AAH55285.1.
AF286341 mRNA. Translation: AAK83024.1. Frameshift.
CCDSiCCDS6805.1. [Q7Z591-1]
RefSeqiNP_001304879.1. NM_001317950.1. [Q7Z591-1]
NP_001304881.1. NM_001317952.1. [Q7Z591-7]
NP_110394.3. NM_030767.5. [Q7Z591-1]
XP_005252301.1. XM_005252244.2. [Q7Z591-1]
XP_005252302.1. XM_005252245.1. [Q7Z591-1]
XP_005252304.1. XM_005252247.4. [Q7Z591-1]
XP_006717357.1. XM_006717294.1. [Q7Z591-1]
XP_006717358.1. XM_006717295.2. [Q7Z591-3]
XP_011517365.1. XM_011519063.2. [Q7Z591-7]
XP_011517367.2. XM_011519065.2. [Q7Z591-7]
XP_016870661.1. XM_017015172.1. [Q7Z591-7]
UniGeneiHs.494895.

Genome annotation databases

EnsembliENST00000223791; ENSP00000223791; ENSG00000106948. [Q7Z591-8]
ENST00000307564; ENSP00000303769; ENSG00000106948. [Q7Z591-1]
ENST00000312033; ENSP00000309222; ENSG00000106948. [Q7Z591-3]
ENST00000374075; ENSP00000363188; ENSG00000106948. [Q7Z591-2]
ENST00000374079; ENSP00000363192; ENSG00000106948. [Q7Z591-4]
ENST00000374088; ENSP00000363201; ENSG00000106948. [Q7Z591-1]
GeneIDi80709.
KEGGihsa:80709.
UCSCiuc004bio.5. human. [Q7Z591-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY703039 mRNA. Translation: AAU34186.1.
AY703043 mRNA. Translation: AAU34190.1.
AY703044 mRNA. Translation: AAU34191.1.
AY703045 mRNA. Translation: AAU34192.1. Frameshift.
AB075848 mRNA. Translation: BAB85554.1. Different initiation.
AK024431 mRNA. Translation: BAB15721.1.
AK074040 mRNA. Translation: BAB84866.1. Different initiation.
AK131082 mRNA. Translation: BAC85132.1. Sequence problems.
AK160382 mRNA. Translation: BAD18725.1. Sequence problems.
AL356796 Genomic DNA. Translation: CAM23638.1.
AL356796 Genomic DNA. Translation: CAI16861.1.
AL356796 Genomic DNA. Translation: CAI16862.2.
AL356796 Genomic DNA. Translation: CAI16863.1.
BC042202 mRNA. Translation: AAH42202.1.
BC055285 mRNA. Translation: AAH55285.1.
AF286341 mRNA. Translation: AAK83024.1. Frameshift.
CCDSiCCDS6805.1. [Q7Z591-1]
RefSeqiNP_001304879.1. NM_001317950.1. [Q7Z591-1]
NP_001304881.1. NM_001317952.1. [Q7Z591-7]
NP_110394.3. NM_030767.5. [Q7Z591-1]
XP_005252301.1. XM_005252244.2. [Q7Z591-1]
XP_005252302.1. XM_005252245.1. [Q7Z591-1]
XP_005252304.1. XM_005252247.4. [Q7Z591-1]
XP_006717357.1. XM_006717294.1. [Q7Z591-1]
XP_006717358.1. XM_006717295.2. [Q7Z591-3]
XP_011517365.1. XM_011519063.2. [Q7Z591-7]
XP_011517367.2. XM_011519065.2. [Q7Z591-7]
XP_016870661.1. XM_017015172.1. [Q7Z591-7]
UniGeneiHs.494895.

3D structure databases

ProteinModelPortaliQ7Z591.
SMRiQ7Z591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123268. 1 interactor.
IntActiQ7Z591. 3 interactors.
MINTiMINT-1366492.
STRINGi9606.ENSP00000303769.

PTM databases

iPTMnetiQ7Z591.
PhosphoSitePlusiQ7Z591.

Polymorphism and mutation databases

BioMutaiAKNA.
DMDMi150416853.

Proteomic databases

EPDiQ7Z591.
MaxQBiQ7Z591.
PaxDbiQ7Z591.
PeptideAtlasiQ7Z591.
PRIDEiQ7Z591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223791; ENSP00000223791; ENSG00000106948. [Q7Z591-8]
ENST00000307564; ENSP00000303769; ENSG00000106948. [Q7Z591-1]
ENST00000312033; ENSP00000309222; ENSG00000106948. [Q7Z591-3]
ENST00000374075; ENSP00000363188; ENSG00000106948. [Q7Z591-2]
ENST00000374079; ENSP00000363192; ENSG00000106948. [Q7Z591-4]
ENST00000374088; ENSP00000363201; ENSG00000106948. [Q7Z591-1]
GeneIDi80709.
KEGGihsa:80709.
UCSCiuc004bio.5. human. [Q7Z591-1]

Organism-specific databases

CTDi80709.
DisGeNETi80709.
GeneCardsiAKNA.
HGNCiHGNC:24108. AKNA.
HPAiHPA052367.
HPA063993.
MIMi605729. gene.
neXtProtiNX_Q7Z591.
OpenTargetsiENSG00000106948.
PharmGKBiPA134908332.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDZE. Eukaryota.
ENOG4111ICK. LUCA.
GeneTreeiENSGT00390000003745.
HOVERGENiHBG097463.
InParanoidiQ7Z591.
OMAiLEEPWMA.
OrthoDBiEOG091G0EXN.
PhylomeDBiQ7Z591.
TreeFamiTF336885.

Miscellaneous databases

ChiTaRSiAKNA. human.
GenomeRNAii80709.
PMAP-CutDBQ7Z591.
PROiQ7Z591.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106948.
GenevisibleiQ7Z591. HS.

Family and domain databases

InterProiIPR022150. TF_AT-hook.
[Graphical view]
PfamiPF12443. AKNA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKNA_HUMAN
AccessioniPrimary (citable) accession number: Q7Z591
Secondary accession number(s): Q05BK5
, Q5T535, Q5T536, Q5T537, Q64FX6, Q64FX7, Q64FX8, Q64FY2, Q6ZMK0, Q6ZNL2, Q6ZTX0, Q8TET1, Q8TF33, Q96RR9, Q9H7P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.