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Q7Z591

- AKNA_HUMAN

UniProt

Q7Z591 - AKNA_HUMAN

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Protein
AT-hook-containing transcription factor
Gene
AKNA, KIAA1968
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1115 – 11239A.T hook1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-hook-containing transcription factor
Gene namesi
Name:AKNA
Synonyms:KIAA1968
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:24108. AKNA.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14391439AT-hook-containing transcription factor
PRO_0000289159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei534 – 5341Phosphoserine1 Publication
Modified residuei1387 – 13871Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z591.
PaxDbiQ7Z591.
PRIDEiQ7Z591.

PTM databases

PhosphoSiteiQ7Z591.

Miscellaneous databases

PMAP-CutDBQ7Z591.

Expressioni

Tissue specificityi

Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a+CD14- but not CD1a-CD14+ dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.1 Publication

Gene expression databases

BgeeiQ7Z591.
GenevestigatoriQ7Z591.

Interactioni

Protein-protein interaction databases

BioGridi123268. 2 interactions.
IntActiQ7Z591. 2 interactions.
MINTiMINT-1366492.

Structurei

3D structure databases

ProteinModelPortaliQ7Z591.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni771 – 80434PEST
Add
BLAST
Regioni911 – 93222PEST
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG73466.
HOVERGENiHBG097463.
OMAiPEAMRME.
OrthoDBiEOG754HQ8.
PhylomeDBiQ7Z591.
TreeFamiTF336885.

Family and domain databases

InterProiIPR022150. TF_AT-hook.
[Graphical view]
PfamiPF12443. AKNA. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z591-1) [UniParc]FASTAAdd to Basket

Also known as: B2, D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA     50
TSPELLEDFR LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS 100
PASSHEPLAW LPQQGRQLDM TEEEPDGTLG SLEVEEAGES SSRLGYEAGL 150
SLEGHGNTSP MALGHGQARG WVASGEQASG DKLSEHSEVN PSVELSPARS 200
WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS HHLLSPDGRT 250
GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT 300
KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG 350
RGQLNYPLPD FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP 400
AEIVQEVLLS SGEAALAKDT PPAHPITRVP QEFQTPEQAT ELVHQLQEDY 450
HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP QPNHSIHTGM VPQGTKVLSF 500
TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS MPTLGWLPEN 550
RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR 600
LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS 650
CLEELKEHID QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP 700
AIKTSCPEPA TTTAAASTGP CPLHVNVEVS SGNSEVEDRP QDPLARLRHK 750
ELQMEQVYHG LMERYLSVKS LPEAMRMEEE EEGEEEEEEE GGGDSLEVDG 800
VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM KPPGFQASLA 850
RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP 900
QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST 950
AGTLAQPFAA SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG 1000
PLRQRAPNFS LERTLAAEMA VPGSEFEGHK RISEQPLPNK TISPPPAPAP 1050
AAAPLPCGPT ETIPSFLLTR AGRDQAICEL QEEVSRLRLR LEDSLHQPLQ 1100
GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP GEPRGEEQIV 1150
PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG 1200
KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ 1250
DAGGAVTGDP LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR 1300
KASSTPSPKQ RSKQAGSSPR PPPGLWYLAT APPAPAPPAF AYISSVPIMP 1350
YPPAAVYYAP AGPTSAQPAA KWPPTASPPP ARRHRHSIQL DLGDLEELNK 1400
ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF 1439
Length:1,439
Mass (Da):155,139
Last modified:May 29, 2007 - v2
Checksum:i51688A0C5C55A7BE
GO
Isoform 2 (identifier: Q7Z591-2) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MASSETEIRW...DSESGETSGE → MLRSEWPVFP

Show »
Length:1,358
Mass (Da):145,921
Checksum:iA96C7EBC4EF10401
GO
Isoform 3 (identifier: Q7Z591-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-1439: Missing.

Show »
Length:831
Mass (Da):90,917
Checksum:i60F24D16072CF37D
GO
Isoform 4 (identifier: Q7Z591-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1055: Missing.
     1056-1074: PCGPTETIPSFLLTRAGRD → MSAGGGTRGYSPRSPGATS

Note: No experimental confirmation available.

Show »
Length:384
Mass (Da):40,606
Checksum:iD195D6878CCF4F5C
GO
Isoform 5 (identifier: Q7Z591-5) [UniParc]FASTAAdd to Basket

Also known as: F1

The sequence of this isoform differs from the canonical sequence as follows:
     1-753: Missing.

Show »
Length:686
Mass (Da):72,810
Checksum:i77843A242C71E4E2
GO
Isoform 6 (identifier: Q7Z591-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-572: EDYHRLLTKY...TQALASQASQ → VSGTHGCGCV...GGWLGQEALG
     573-1439: Missing.

Show »
Length:572
Mass (Da):61,839
Checksum:iC5AA7024B767C695
GO
Isoform 7 (identifier: Q7Z591-7) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Show »
Length:1,320
Mass (Da):141,619
Checksum:iBB6B6B38C6C0AFB0
GO
Isoform 8 (identifier: Q7Z591-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Show »
Length:899
Mass (Da):96,014
Checksum:iCB0341DD1715B61F
GO

Sequence cautioni

The sequence AAK83024.1 differs from that shown. Reason: Frameshift at position 1228.
The sequence AAU34192.1 differs from that shown. Reason: Frameshift at position 1227.
The sequence BAC85132.1 differs from that shown. Reason: Frameshift at position 1340.
The sequence BAD18725.1 differs from that shown. Reason: Frameshift at positions 820, 1017, 1340, 1387 and 1434.
The sequence BAB84866.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB85554.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti624 – 6241P → L.2 Publications
Corresponds to variant rs3748176 [ dbSNP | Ensembl ].
VAR_032586
Natural varianti1097 – 10971Q → R.
Corresponds to variant rs1265891 [ dbSNP | Ensembl ].
VAR_032587
Natural varianti1119 – 11191R → Q.1 Publication
Corresponds to variant rs3748178 [ dbSNP | Ensembl ].
VAR_032588
Natural varianti1303 – 13031S → P.2 Publications
Corresponds to variant rs2250242 [ dbSNP | Ensembl ].
VAR_032589
Natural varianti1327 – 13271Y → C.
Corresponds to variant rs2787344 [ dbSNP | Ensembl ].
VAR_032590

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10551055Missing in isoform 4.
VSP_025932Add
BLAST
Alternative sequencei1 – 753753Missing in isoform 5.
VSP_025933Add
BLAST
Alternative sequencei1 – 540540Missing in isoform 8.
VSP_025934Add
BLAST
Alternative sequencei1 – 119119Missing in isoform 7.
VSP_025935Add
BLAST
Alternative sequencei1 – 9191MASSE…ETSGE → MLRSEWPVFP in isoform 2.
VSP_025936Add
BLAST
Alternative sequencei448 – 572125EDYHR…SQASQ → VSGTHGCGCVTKAPVGLGWR LIGVGRPGVEAGWGGEAWDR AWLGWEALGRRLVGWGGLGW RLARVGSPGMEASGVGRPGV GSPGVEPGGVGRPGVEAGWG RKPWDRGWWGGEAWGGGWLG QEALG in isoform 6.
VSP_025937Add
BLAST
Alternative sequencei573 – 1439867Missing in isoform 6.
VSP_025938Add
BLAST
Alternative sequencei832 – 1439608Missing in isoform 3.
VSP_025939Add
BLAST
Alternative sequencei1056 – 107419PCGPT…RAGRD → MSAGGGTRGYSPRSPGATS in isoform 4.
VSP_025940Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti799 – 7991D → V in BAD18725. 1 Publication
Sequence conflicti799 – 7991D → V in BAC85132. 1 Publication
Sequence conflicti816 – 8161R → S in BAD18725. 1 Publication
Sequence conflicti1037 – 10371L → F in AAK83024. 1 Publication
Sequence conflicti1103 – 11031P → Q in BAD18725. 1 Publication
Sequence conflicti1114 – 11141A → P in BAD18725. 1 Publication
Sequence conflicti1429 – 14291Q → P in BAD18725. 1 Publication
Sequence conflicti1435 – 14362GS → AP in BAD18725. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY703039 mRNA. Translation: AAU34186.1.
AY703043 mRNA. Translation: AAU34190.1.
AY703044 mRNA. Translation: AAU34191.1.
AY703045 mRNA. Translation: AAU34192.1. Frameshift.
AB075848 mRNA. Translation: BAB85554.1. Different initiation.
AK024431 mRNA. Translation: BAB15721.1.
AK074040 mRNA. Translation: BAB84866.1. Different initiation.
AK131082 mRNA. Translation: BAC85132.1. Sequence problems.
AK160382 mRNA. Translation: BAD18725.1. Sequence problems.
AL356796 Genomic DNA. Translation: CAM23638.1.
AL356796 Genomic DNA. Translation: CAI16861.1.
AL356796 Genomic DNA. Translation: CAI16862.2.
AL356796 Genomic DNA. Translation: CAI16863.1.
BC042202 mRNA. Translation: AAH42202.1.
BC055285 mRNA. Translation: AAH55285.1.
AF286341 mRNA. Translation: AAK83024.1. Frameshift.
CCDSiCCDS6805.1. [Q7Z591-1]
RefSeqiNP_110394.3. NM_030767.4. [Q7Z591-1]
XP_005252300.1. XM_005252243.1. [Q7Z591-1]
XP_005252301.1. XM_005252244.1. [Q7Z591-1]
XP_005252302.1. XM_005252245.1. [Q7Z591-1]
XP_005252303.1. XM_005252246.2. [Q7Z591-1]
XP_005252304.1. XM_005252247.2. [Q7Z591-1]
XP_006717357.1. XM_006717294.1. [Q7Z591-1]
XP_006717358.1. XM_006717295.1. [Q7Z591-3]
UniGeneiHs.494895.

Genome annotation databases

EnsembliENST00000223791; ENSP00000223791; ENSG00000106948. [Q7Z591-8]
ENST00000307564; ENSP00000303769; ENSG00000106948. [Q7Z591-1]
ENST00000312033; ENSP00000309222; ENSG00000106948. [Q7Z591-3]
ENST00000374075; ENSP00000363188; ENSG00000106948. [Q7Z591-2]
ENST00000374079; ENSP00000363192; ENSG00000106948. [Q7Z591-4]
ENST00000374088; ENSP00000363201; ENSG00000106948. [Q7Z591-1]
GeneIDi80709.
KEGGihsa:80709.
UCSCiuc004bin.3. human. [Q7Z591-5]
uc004bio.3. human. [Q7Z591-1]
uc004bip.3. human. [Q7Z591-2]
uc004biw.1. human. [Q7Z591-6]

Polymorphism databases

DMDMi150416853.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY703039 mRNA. Translation: AAU34186.1 .
AY703043 mRNA. Translation: AAU34190.1 .
AY703044 mRNA. Translation: AAU34191.1 .
AY703045 mRNA. Translation: AAU34192.1 . Frameshift.
AB075848 mRNA. Translation: BAB85554.1 . Different initiation.
AK024431 mRNA. Translation: BAB15721.1 .
AK074040 mRNA. Translation: BAB84866.1 . Different initiation.
AK131082 mRNA. Translation: BAC85132.1 . Sequence problems.
AK160382 mRNA. Translation: BAD18725.1 . Sequence problems.
AL356796 Genomic DNA. Translation: CAM23638.1 .
AL356796 Genomic DNA. Translation: CAI16861.1 .
AL356796 Genomic DNA. Translation: CAI16862.2 .
AL356796 Genomic DNA. Translation: CAI16863.1 .
BC042202 mRNA. Translation: AAH42202.1 .
BC055285 mRNA. Translation: AAH55285.1 .
AF286341 mRNA. Translation: AAK83024.1 . Frameshift.
CCDSi CCDS6805.1. [Q7Z591-1 ]
RefSeqi NP_110394.3. NM_030767.4. [Q7Z591-1 ]
XP_005252300.1. XM_005252243.1. [Q7Z591-1 ]
XP_005252301.1. XM_005252244.1. [Q7Z591-1 ]
XP_005252302.1. XM_005252245.1. [Q7Z591-1 ]
XP_005252303.1. XM_005252246.2. [Q7Z591-1 ]
XP_005252304.1. XM_005252247.2. [Q7Z591-1 ]
XP_006717357.1. XM_006717294.1. [Q7Z591-1 ]
XP_006717358.1. XM_006717295.1. [Q7Z591-3 ]
UniGenei Hs.494895.

3D structure databases

ProteinModelPortali Q7Z591.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123268. 2 interactions.
IntActi Q7Z591. 2 interactions.
MINTi MINT-1366492.

PTM databases

PhosphoSitei Q7Z591.

Polymorphism databases

DMDMi 150416853.

Proteomic databases

MaxQBi Q7Z591.
PaxDbi Q7Z591.
PRIDEi Q7Z591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000223791 ; ENSP00000223791 ; ENSG00000106948 . [Q7Z591-8 ]
ENST00000307564 ; ENSP00000303769 ; ENSG00000106948 . [Q7Z591-1 ]
ENST00000312033 ; ENSP00000309222 ; ENSG00000106948 . [Q7Z591-3 ]
ENST00000374075 ; ENSP00000363188 ; ENSG00000106948 . [Q7Z591-2 ]
ENST00000374079 ; ENSP00000363192 ; ENSG00000106948 . [Q7Z591-4 ]
ENST00000374088 ; ENSP00000363201 ; ENSG00000106948 . [Q7Z591-1 ]
GeneIDi 80709.
KEGGi hsa:80709.
UCSCi uc004bin.3. human. [Q7Z591-5 ]
uc004bio.3. human. [Q7Z591-1 ]
uc004bip.3. human. [Q7Z591-2 ]
uc004biw.1. human. [Q7Z591-6 ]

Organism-specific databases

CTDi 80709.
GeneCardsi GC09M117096.
HGNCi HGNC:24108. AKNA.
MIMi 605729. gene.
neXtProti NX_Q7Z591.
PharmGKBi PA134908332.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73466.
HOVERGENi HBG097463.
OMAi PEAMRME.
OrthoDBi EOG754HQ8.
PhylomeDBi Q7Z591.
TreeFami TF336885.

Miscellaneous databases

ChiTaRSi AKNA. human.
GenomeRNAii 80709.
NextBioi 71009.
PMAP-CutDB Q7Z591.
PROi Q7Z591.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z591.
Genevestigatori Q7Z591.

Family and domain databases

InterProi IPR022150. TF_AT-hook.
[Graphical view ]
Pfami PF12443. AKNA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation."
    Sims-Mourtada J.C., Bruce S., McKeller M.R., Rangel R., Guzman-Rojas L., Cain K., Lopez C., Zimonjic D.B., Popescu N.C., Gordon J., Wilkinson M.F., Martinez-Valdez H.
    DNA Cell Biol. 24:325-338(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5; 6 AND 7).
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-624.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8), VARIANTS LEU-624; GLN-1119 AND PRO-1303.
    Tissue: Spleen.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT PRO-1303.
    Tissue: Eye.
  6. "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA."
    Siddiqa A., Sims-Mourtada J.C., Guzman-Rojas L., Rangel R., Guret C., Madrid-Marina V., Sun Y., Martinez-Valdez H.
    Nature 410:383-387(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 762-1395, FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534 AND SER-1387, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiAKNA_HUMAN
AccessioniPrimary (citable) accession number: Q7Z591
Secondary accession number(s): Q05BK5
, Q5T535, Q5T536, Q5T537, Q64FX6, Q64FX7, Q64FX8, Q64FY2, Q6ZMK0, Q6ZNL2, Q6ZTX0, Q8TET1, Q8TF33, Q96RR9, Q9H7P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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