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Protein

BRCA2-interacting transcriptional repressor EMSY

Gene

EMSY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA2-interacting transcriptional repressor EMSYImported
Gene namesi
Name:EMSYImported
Synonyms:C11orf30
ORF Names:GL002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18071. EMSY.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi100 – 102VPL → APA: Abolishes interaction with CBX1. 1 Publication3
Mutagenesisi106L → A: Abolishes interaction with ZMYND11. 1 Publication1

Organism-specific databases

DisGeNETi56946.
OpenTargetsiENSG00000158636.
PharmGKBiPA134904392.

Polymorphism and mutation databases

BioMutaiEMSY.
DMDMi47605660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869681 – 1322BRCA2-interacting transcriptional repressor EMSYAdd BLAST1322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207PhosphothreonineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei213PhosphoserineBy similarity1
Glycosylationi228O-linked (GlcNAc)1 Publication1
Glycosylationi236O-linked (GlcNAc)1 Publication1
Modified residuei238PhosphoserineCombined sources1
Glycosylationi271O-linked (GlcNAc)1 Publication1
Glycosylationi501O-linked (GlcNAc)1 Publication1
Glycosylationi506O-linked (GlcNAc)1 Publication1
Glycosylationi557O-linked (GlcNAc)1 Publication1
Modified residuei818PhosphoserineBy similarity1
Modified residuei821PhosphoserineBy similarity1
Glycosylationi1120O-linked (GlcNAc)1 Publication1
Modified residuei1136PhosphoserineCombined sources1

Post-translational modificationi

O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z589.
MaxQBiQ7Z589.
PaxDbiQ7Z589.
PeptideAtlasiQ7Z589.
PRIDEiQ7Z589.

PTM databases

iPTMnetiQ7Z589.
PhosphoSitePlusiQ7Z589.

Expressioni

Gene expression databases

BgeeiENSG00000158636.
CleanExiHS_C11orf30.
ExpressionAtlasiQ7Z589. baseline and differential.
GenevisibleiQ7Z589. HS.

Organism-specific databases

HPAiCAB012234.
HPA050777.

Interactioni

Subunit structurei

Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with ZMYND11.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DDIT3P35638-23EBI-6598631,EBI-10173632
ZNF646O150153EBI-6598631,EBI-745608

Protein-protein interaction databases

BioGridi121270. 32 interactors.
DIPiDIP-29099N.
IntActiQ7Z589. 19 interactors.
STRINGi9606.ENSP00000334130.

Structurei

Secondary structure

11322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Helixi13 – 38Combined sources26
Helixi43 – 55Combined sources13
Helixi60 – 71Combined sources12
Helixi74 – 84Combined sources11
Helixi90 – 97Combined sources8
Beta strandi98 – 103Combined sources6
Helixi108 – 110Combined sources3
Beta strandi112 – 116Combined sources5
Beta strandi122 – 124Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UTUX-ray2.00A/B1-108[»]
1UZ3X-ray1.10A/B1-100[»]
2FMMX-ray1.80E9-139[»]
ProteinModelPortaliQ7Z589.
SMRiQ7Z589.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z589.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 100ENTPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 478Interaction with BRCA21 PublicationAdd BLAST478
Regioni104 – 108Interaction with ZMYND115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi209 – 213Poly-Ser5
Compositional biasi326 – 391Ser-richAdd BLAST66
Compositional biasi395 – 464Gln-richAdd BLAST70
Compositional biasi496 – 636Thr-richAdd BLAST141
Compositional biasi719 – 723Poly-Ser5
Compositional biasi945 – 1099Gln-richAdd BLAST155

Sequence similaritiesi

Contains 1 ENT (EMSY N-terminal) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4675. Eukaryota.
ENOG410YF3T. LUCA.
GeneTreeiENSGT00390000009554.
HOGENOMiHOG000112366.
HOVERGENiHBG051476.
InParanoidiQ7Z589.
OMAiKISMMEA.
OrthoDBiEOG091G04O2.
PhylomeDBiQ7Z589.
TreeFamiTF332401.

Family and domain databases

InterProiIPR033482. EMSY.
IPR005491. ENT_dom.
[Graphical view]
PANTHERiPTHR16500. PTHR16500. 1 hit.
PfamiPF03735. ENT. 1 hit.
[Graphical view]
SMARTiSM01191. ENT. 1 hit.
[Graphical view]
SUPFAMiSSF158639. SSF158639. 1 hit.
PROSITEiPS51138. ENT. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z589-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVVWPTLLD LSRDECKRIL RKLELEAYAG VISALRAQGD LTKEKKDLLG
60 70 80 90 100
ELSKVLSIST ERHRAEVRRA VNDERLTTIA HNMSGPNSSS EWSIEGRRLV
110 120 130 140 150
PLMPRLVPQT AFTVTANAVA NAAIQHNASL PVPAETGSKE VVCYSYTSTT
160 170 180 190 200
STPTSTPVPS GSIATVKSPR PASPASNVVV LPSGSTVYVK SVSCSDEDEK
210 220 230 240 250
PRKRRRTNSS SSSPVVLKEV PKAVVPVSKT ITVPVSGSPK MSNIMQSIAN
260 270 280 290 300
SLPPHMSPVK ITFTKPSTQT TNTTTQKVII VTTSPSSTFV PNILSKSHNY
310 320 330 340 350
AAVTKLVPTS VIASTTQKPP VVITASQSSL VSNSSSGSSS STPSPIPNTV
360 370 380 390 400
AVTAVVSSTP SVVMSTVAQG VSTSAIKMAS TRLPSPKSLV SAPTQILAQF
410 420 430 440 450
PKQHQQSPKQ QLYQVQQQTQ QQVAQPSPVS HQQQPQQSPL PPGIKPTIQI
460 470 480 490 500
KQESGVKIIT QQVQPSKILP KPVTATLPTS SNSPIMVVSS NGAIMTTKLV
510 520 530 540 550
TTPTGTQATY TRPTVSPSIG RMAATPGAAT YVKTTSGSII TVVPKSLATL
560 570 580 590 600
GGKIISSNIV SGTTTKITTI PMTSKPNVIV VQKTTGKGTT IQGLPGKNVV
610 620 630 640 650
TTLLNAGGEK TIQTVPTGAK PAILTATRPI TKMIVTQPKG IGSTVQPAAK
660 670 680 690 700
IIPTKIVYGQ QGKTQVLIKP KPVTFQATVV SEQTRQLVTE TLQQASRVAE
710 720 730 740 750
AGNSSIQEGK EEPQNYTDSS SSSTESSQSS QDSQPVVHVI ASRRQDWSEH
760 770 780 790 800
EIAMETSPTI IYQDVSSESQ SATSTIKALL ELQQTTVKEK LESKPRQPTI
810 820 830 840 850
DLSQMAVPIQ MTQEKRHSPE SPSIAVVESE LVAEYITTER TDEGTEVAFP
860 870 880 890 900
LLVSHRSQPQ QPSQPQRTLL QHVAQSQTAT QTSVVVKSIP ASSPGAITHI
910 920 930 940 950
MQQALSSHTA FTKHSEELGT EEGEVEEMDT LDPQTGLFYR SALTQSQSAK
960 970 980 990 1000
QQKLSQPPLE QTQLQVKTLQ CFQTKQKQTI HLQADQLQHK LPQMPQLSIR
1010 1020 1030 1040 1050
HQKLTPLQQE QAQPKPDVQH TQHPMVAKDR QLPTLMAQPP QTVVQVLAVK
1060 1070 1080 1090 1100
TTQQLPKLQQ APNQPKIYVQ PQTPQSQMSL PASSEKQTAS QVEQPIITQG
1110 1120 1130 1140 1150
SSVTKITFEG RQPPTVTKIT GGSSVPKLTS PVTSISPIQA SEKTAVSDIL
1160 1170 1180 1190 1200
KMSLMEAQID TNVEHMIVDP PKKALATSML TGEAGSLPST HMVVAGMANS
1210 1220 1230 1240 1250
TPQQQKCRES CSSPSTVGSS LTTRKIDPPA VPATGQFMRI QNVGQKKAEE
1260 1270 1280 1290 1300
SPAEIIIQAI PQYAIPCHSS SNVVVEPSGL LELNNFTSQQ LDDEETAMEQ
1310 1320
DIDSSTEDGT EPSPSQSSAE RS
Length:1,322
Mass (Da):141,468
Last modified:May 24, 2004 - v2
Checksum:i7F8C95E8BA0FC9F0
GO
Isoform 2 (identifier: Q7Z589-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1091-1257: Missing.

Note: No experimental confirmation available.
Show »
Length:1,155
Mass (Da):123,915
Checksum:iBF3921D979C50121
GO
Isoform 3 (identifier: Q7Z589-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-82: N → K
     83-1322: Missing.

Note: No experimental confirmation available.
Show »
Length:82
Mass (Da):9,352
Checksum:i61ECFDD214DF46A5
GO
Isoform 4 (identifier: Q7Z589-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-82: N → KMNLSLYLGERPSYS
     140-140: E → EV
     839-852: Missing.

Note: No experimental confirmation available.
Show »
Length:1,323
Mass (Da):141,634
Checksum:i48D4A27E0E96ABFF
GO
Isoform 5 (identifier: Q7Z589-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: E → EV

Note: No experimental confirmation available.
Show »
Length:1,323
Mass (Da):141,567
Checksum:i68F64DB83D342A02
GO
Isoform 6 (identifier: Q7Z589-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-82: N → KMNLSLYLGERPSYS
     733-747: SQPVVHVIASRRQDW → AVVISGEISSPPLFS
     748-852: Missing.

Note: No experimental confirmation available.
Show »
Length:1,231
Mass (Da):131,176
Checksum:i0BB9BB8A96B5F706
GO
Isoform 7 (identifier: Q7Z589-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-82: N → KMNLSLYLGERPSYS
     140-140: E → EV

Note: No experimental confirmation available.
Show »
Length:1,337
Mass (Da):143,193
Checksum:i9AD9C19FDB972AE6
GO

Sequence cautioni

The sequence AAF86947 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH29375 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL65260 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14627 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02077482N → K in isoform 3. 1 Publication1
Alternative sequenceiVSP_05413982N → KMNLSLYLGERPSYS in isoform 4, isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_02077583 – 1322Missing in isoform 3. 1 PublicationAdd BLAST1240
Alternative sequenceiVSP_054140140E → EV in isoform 4, isoform 5 and isoform 7. 1 Publication1
Alternative sequenceiVSP_054141733 – 747SQPVV…RRQDW → AVVISGEISSPPLFS in isoform 6. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_054142748 – 852Missing in isoform 6. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_054143839 – 852Missing in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0104311091 – 1257Missing in isoform 2. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430203 mRNA. Translation: CAD22881.1.
AP002360 Genomic DNA. No translation available.
AP003165 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74998.1.
BC029375 mRNA. Translation: AAH29375.1. Different initiation.
BC033404 mRNA. Translation: AAH33404.1.
BC117265 mRNA. Translation: AAI17266.1.
BC143370 mRNA. Translation: AAI43371.1.
BC143374 mRNA. Translation: AAI43375.1.
BC143376 mRNA. Translation: AAI43377.1.
AK023651 mRNA. Translation: BAB14627.1. Different initiation.
AY070433 mRNA. Translation: AAL65260.1. Different initiation.
AF226047 mRNA. Translation: AAF86947.1. Different initiation.
CCDSiCCDS73349.1. [Q7Z589-7]
CCDS73350.1. [Q7Z589-4]
CCDS73351.1. [Q7Z589-5]
CCDS8244.1. [Q7Z589-1]
RefSeqiNP_001287871.1. NM_001300942.1. [Q7Z589-7]
NP_001287872.1. NM_001300943.1. [Q7Z589-5]
NP_001287873.1. NM_001300944.1. [Q7Z589-4]
NP_064578.2. NM_020193.4. [Q7Z589-1]
UniGeneiHs.352588.

Genome annotation databases

EnsembliENST00000334736; ENSP00000334130; ENSG00000158636. [Q7Z589-1]
ENST00000524767; ENSP00000433205; ENSG00000158636. [Q7Z589-7]
ENST00000525038; ENSP00000436968; ENSG00000158636. [Q7Z589-4]
ENST00000525919; ENSP00000432010; ENSG00000158636. [Q7Z589-5]
ENST00000529032; ENSP00000432327; ENSG00000158636. [Q7Z589-1]
ENST00000533248; ENSP00000433634; ENSG00000158636. [Q7Z589-6]
ENST00000533988; ENSP00000434665; ENSG00000158636. [Q7Z589-3]
GeneIDi56946.
KEGGihsa:56946.
UCSCiuc001oxj.4. human. [Q7Z589-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430203 mRNA. Translation: CAD22881.1.
AP002360 Genomic DNA. No translation available.
AP003165 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74998.1.
BC029375 mRNA. Translation: AAH29375.1. Different initiation.
BC033404 mRNA. Translation: AAH33404.1.
BC117265 mRNA. Translation: AAI17266.1.
BC143370 mRNA. Translation: AAI43371.1.
BC143374 mRNA. Translation: AAI43375.1.
BC143376 mRNA. Translation: AAI43377.1.
AK023651 mRNA. Translation: BAB14627.1. Different initiation.
AY070433 mRNA. Translation: AAL65260.1. Different initiation.
AF226047 mRNA. Translation: AAF86947.1. Different initiation.
CCDSiCCDS73349.1. [Q7Z589-7]
CCDS73350.1. [Q7Z589-4]
CCDS73351.1. [Q7Z589-5]
CCDS8244.1. [Q7Z589-1]
RefSeqiNP_001287871.1. NM_001300942.1. [Q7Z589-7]
NP_001287872.1. NM_001300943.1. [Q7Z589-5]
NP_001287873.1. NM_001300944.1. [Q7Z589-4]
NP_064578.2. NM_020193.4. [Q7Z589-1]
UniGeneiHs.352588.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UTUX-ray2.00A/B1-108[»]
1UZ3X-ray1.10A/B1-100[»]
2FMMX-ray1.80E9-139[»]
ProteinModelPortaliQ7Z589.
SMRiQ7Z589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121270. 32 interactors.
DIPiDIP-29099N.
IntActiQ7Z589. 19 interactors.
STRINGi9606.ENSP00000334130.

PTM databases

iPTMnetiQ7Z589.
PhosphoSitePlusiQ7Z589.

Polymorphism and mutation databases

BioMutaiEMSY.
DMDMi47605660.

Proteomic databases

EPDiQ7Z589.
MaxQBiQ7Z589.
PaxDbiQ7Z589.
PeptideAtlasiQ7Z589.
PRIDEiQ7Z589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334736; ENSP00000334130; ENSG00000158636. [Q7Z589-1]
ENST00000524767; ENSP00000433205; ENSG00000158636. [Q7Z589-7]
ENST00000525038; ENSP00000436968; ENSG00000158636. [Q7Z589-4]
ENST00000525919; ENSP00000432010; ENSG00000158636. [Q7Z589-5]
ENST00000529032; ENSP00000432327; ENSG00000158636. [Q7Z589-1]
ENST00000533248; ENSP00000433634; ENSG00000158636. [Q7Z589-6]
ENST00000533988; ENSP00000434665; ENSG00000158636. [Q7Z589-3]
GeneIDi56946.
KEGGihsa:56946.
UCSCiuc001oxj.4. human. [Q7Z589-1]

Organism-specific databases

CTDi56946.
DisGeNETi56946.
GeneCardsiC11orf30.
HGNCiHGNC:18071. EMSY.
HPAiCAB012234.
HPA050777.
MIMi608574. gene.
neXtProtiNX_Q7Z589.
OpenTargetsiENSG00000158636.
PharmGKBiPA134904392.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4675. Eukaryota.
ENOG410YF3T. LUCA.
GeneTreeiENSGT00390000009554.
HOGENOMiHOG000112366.
HOVERGENiHBG051476.
InParanoidiQ7Z589.
OMAiKISMMEA.
OrthoDBiEOG091G04O2.
PhylomeDBiQ7Z589.
TreeFamiTF332401.

Miscellaneous databases

EvolutionaryTraceiQ7Z589.
GeneWikiiC11orf30.
GenomeRNAii56946.
PROiQ7Z589.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158636.
CleanExiHS_C11orf30.
ExpressionAtlasiQ7Z589. baseline and differential.
GenevisibleiQ7Z589. HS.

Family and domain databases

InterProiIPR033482. EMSY.
IPR005491. ENT_dom.
[Graphical view]
PANTHERiPTHR16500. PTHR16500. 1 hit.
PfamiPF03735. ENT. 1 hit.
[Graphical view]
SMARTiSM01191. ENT. 1 hit.
[Graphical view]
SUPFAMiSSF158639. SSF158639. 1 hit.
PROSITEiPS51138. ENT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMSY_HUMAN
AccessioniPrimary (citable) accession number: Q7Z589
Secondary accession number(s): B7ZKT8
, B7ZKU0, B7ZKU2, Q17RM7, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Defects in EMSY may be a cause of sporadic breast cancer and higher-grade ovarian cancers. Overexpressed through amplification almost exclusively in sporadic breast cancer (13%) and higher-grade ovarian cancer (17%). Amplification is associated with worse survival, particularly in node-negative breast cancer, suggesting that it may be of prognostic value.
Was named EMSY by PubMed:14651845 because the protein sequence contains the word 'SISTER', after the first author's sister, who is a breast cancer nurse.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.