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Protein

Spermatogenesis-associated protein 21

Gene

SPATA21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the differentiation of haploid spermatids.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi268 – 279PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 21
Gene namesi
Name:SPATA21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187144.11.
HGNCiHGNC:28026. SPATA21.

Pathology & Biotechi

Organism-specific databases

DisGeNETi374955.
OpenTargetsiENSG00000187144.
PharmGKBiPA142670886.

Polymorphism and mutation databases

BioMutaiSPATA21.
DMDMi215274212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003306861 – 469Spermatogenesis-associated protein 21Add BLAST469

Proteomic databases

EPDiQ7Z572.
PaxDbiQ7Z572.
PeptideAtlasiQ7Z572.
PRIDEiQ7Z572.

PTM databases

iPTMnetiQ7Z572.
PhosphoSitePlusiQ7Z572.

Expressioni

Gene expression databases

BgeeiENSG00000187144.
CleanExiHS_SPATA21.
ExpressionAtlasiQ7Z572. baseline and differential.
GenevisibleiQ7Z572. HS.

Organism-specific databases

HPAiHPA032080.

Interactioni

Protein-protein interaction databases

BioGridi131941. 1 interactor.
STRINGi9606.ENSP00000335612.

Structurei

3D structure databases

ProteinModelPortaliQ7Z572.
SMRiQ7Z572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 290EF-handPROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili198 – 225Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi114 – 170Pro-richAdd BLAST57

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00530000063748.
HOGENOMiHOG000154401.
HOVERGENiHBG107135.
InParanoidiQ7Z572.
OMAiTCKAQEM.
OrthoDBiEOG091G08U6.
PhylomeDBiQ7Z572.
TreeFamiTF328393.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z572-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNRNTQMYT EEEKTVNPFL PSTPGPKKAK GGGEAVETHP APGPLPPPEV
60 70 80 90 100
RDIGERREPD RAQQQPQKPA VAAGTQSLGN FRQGFMKCLL EVEKMEASHR
110 120 130 140 150
RASKARSQTA QKSPRTLTPV PTSAPSLPQT PASVPASGPS WARLPAPGPE
160 170 180 190 200
PAPMGAPVPT SMPCPVLLGP ALDLGWRRME LLHQSSERTL SYAKARQEPE
210 220 230 240 250
EQSLQKLYQN REKSEEQLTL KQEEAFRSYF EIFNGPGEVD AQSLKNILLL
260 270 280 290 300
MGFSVTLAQV EDALMSADVN GDGRVDFKDF LAVMTDTRRF FCSVEQNALS
310 320 330 340 350
DMAPHNPHTL LFEILSLLVE MLALPEAVLE EITNYYQKKL KEGTCKAQEM
360 370 380 390 400
EAAVGRLRLQ KLPYNPQQEE SSEVPERKVL SILSRLKQQN YAPNLQSPYA
410 420 430 440 450
QVPCILLCPQ LDKKMVRRQP SNHYALDQCT PPGLDPDIRS PFFQSGSQGN
460
REHNSDSRKW LSSVPARTH
Length:469
Mass (Da):52,207
Last modified:November 25, 2008 - v3
Checksum:i9F34A50331774C5D
GO
Isoform 2 (identifier: Q7Z572-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MDNRNTQMYTEEEKTVNPFLPSTPGPKKAKGGGEAVETHPAPGPLPPP → MAQPGAVEHACHPSTLGGQGGGSLE

Note: No experimental confirmation available.
Show »
Length:446
Mass (Da):49,484
Checksum:i583162496EB1BC90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti417R → C in AAI50599 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04271124P → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_04271253I → L. Corresponds to variant dbSNP:rs12087671Ensembl.1
Natural variantiVAR_042713184Q → R. Corresponds to variant dbSNP:rs4661746Ensembl.1
Natural variantiVAR_042714255V → L1 PublicationCorresponds to variant dbSNP:rs525409Ensembl.1
Natural variantiVAR_042715390N → K. Corresponds to variant dbSNP:rs12133574Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0538651 – 48MDNRN…PLPPP → MAQPGAVEHACHPSTLGGQG GGSLE in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327405 mRNA. Translation: AAP92797.1.
AL358794 Genomic DNA. No translation available.
CH471167 Genomic DNA. Translation: EAW51779.1.
BC150598 mRNA. Translation: AAI50599.1.
CCDSiCCDS172.1. [Q7Z572-1]
RefSeqiNP_940948.1. NM_198546.1. [Q7Z572-1]
XP_016856713.1. XM_017001224.1. [Q7Z572-2]
UniGeneiHs.705501.

Genome annotation databases

EnsembliENST00000335496; ENSP00000335612; ENSG00000187144. [Q7Z572-1]
ENST00000540400; ENSP00000440046; ENSG00000187144. [Q7Z572-2]
GeneIDi374955.
KEGGihsa:374955.
UCSCiuc001ayn.3. human. [Q7Z572-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPT21_HUMAN
AccessioniPrimary (citable) accession number: Q7Z572
Secondary accession number(s): B9EK40, F5GXP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 25, 2008
Last modified: September 27, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations