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Protein

Zinc finger protein 804A

Gene

ZNF804A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 81C2H2-typeAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 804A
Gene namesi
Name:ZNF804A
Synonyms:C2orf10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:21711. ZNF804A.

Pathology & Biotechi

Organism-specific databases

DisGeNETi91752.
OpenTargetsiENSG00000170396.
Orphaneti3140. Schizophrenia.
PharmGKBiPA162410599.

Polymorphism and mutation databases

BioMutaiZNF804A.
DMDMi224471869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325181 – 1209Zinc finger protein 804AAdd BLAST1209

Proteomic databases

EPDiQ7Z570.
PaxDbiQ7Z570.
PeptideAtlasiQ7Z570.
PRIDEiQ7Z570.

PTM databases

iPTMnetiQ7Z570.
PhosphoSitePlusiQ7Z570.

Expressioni

Gene expression databases

BgeeiENSG00000170396.
CleanExiHS_ZNF804A.
ExpressionAtlasiQ7Z570. baseline and differential.
GenevisibleiQ7Z570. HS.

Organism-specific databases

HPAiHPA029195.

Interactioni

Subunit structurei

Interacts with ATXN1.1 Publication

Protein-protein interaction databases

BioGridi124875. 2 interactors.
IntActiQ7Z570. 2 interactors.
MINTiMINT-2877891.
STRINGi9606.ENSP00000303252.

Structurei

3D structure databases

ProteinModelPortaliQ7Z570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 81C2H2-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGVP. Eukaryota.
ENOG410ZHVS. LUCA.
GeneTreeiENSGT00530000063305.
HOVERGENiHBG107108.
InParanoidiQ7Z570.
OMAiPCEVYQH.
OrthoDBiEOG091G01DY.
PhylomeDBiQ7Z570.
TreeFamiTF332138.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECYYIVISS THLSNGHFRN IKGVFRGPLS KNGNKTLDYA EKENTIAKAL
60 70 80 90 100
EDLKANFYCE LCDKQYYKHQ EFDNHINSYD HAHKQRLKEL KQREFARNVA
110 120 130 140 150
SKSRKDERKQ EKALQRLHKL AELRKETVCA PGSGPMFKST TVTVRENCNE
160 170 180 190 200
ISQRVVVDSV NNQQDFKYTL IHSEENTKDA TTVAEDPESA NNYTAKNNQV
210 220 230 240 250
GDQAQGIHRH KIGFSFAFPK KASVKLESSA AAFSEYSDDA SVGKGFSRKS
260 270 280 290 300
RFVPSACHLQ QSSPTDVLLS SEEKTNSFHP PEAMCRDKET VQTQEIKEVS
310 320 330 340 350
SEKDALLLPS FCKFQLQLSS DADNCQNSVP LADQIPLESV VINEDIPVSG
360 370 380 390 400
NSFELLGNKS TVLDMSNDCI SVQATTEENV KHNEASTTEV ENKNGPETLA
410 420 430 440 450
PSNTEEVNIT IHKKTNFCKR QCEPFVPVLN KHRSTVLQWP SEMLVYTTTK
460 470 480 490 500
PSISYSCNPL CFDFKSTKVN NNLDKNKPDL KDLCSQQKQE DICMGPLSDY
510 520 530 540 550
KDVSTEGLTD YEIGSSKNKC SQVTPLLADD ILSSSCDSGK NENTGQRYKN
560 570 580 590 600
ISCKIRETEK YNFTKSQIKQ DTLDEKYNKI RLKETHEYWF HKSRRKKKRK
610 620 630 640 650
KLCQHHHMEK TKESETRCKM EAENSYTENA GKYLLEPISE KQYLAAEQLL
660 670 680 690 700
DSHQLLDKRP KSESISLSDN EEMCKTWNTE YNTYDTISSK NHCKKNTILL
710 720 730 740 750
NGQSNATMIH SGKHNLTYSR TYCCWKTKMS SCSQDHRSLV LQNDMKHMSQ
760 770 780 790 800
NQAVKRGYNS VMNESERFYR KRRQHSHSYS SDESLNRQNH LPEEFLRPPS
810 820 830 840 850
TSVAPCKPKK KRRRKRGRFH PGFETLELKE NTDYPVKDNS SLNPLDRLIS
860 870 880 890 900
EDKKEKMKPQ EVAKIERNSE QTNQLRNKLS FHPNNLLPSE TNGETEHLEM
910 920 930 940 950
ETTSGELSDV SNDPTTSVCV ASAPTKEAID NTLLEHKERS ENINLNEKQI
960 970 980 990 1000
PFQVPNIERN FRQSQPKSYL CHYELAEALP QGKMNETPTE WLRYNSGILN
1010 1020 1030 1040 1050
TQPPLPFKEA HVSGHTFVTA EQILAPLALP EQALLIPLEN HDKFKNVPCE
1060 1070 1080 1090 1100
VYQHILQPNM LANKVKFTFP PAALPPPSTP LQPLPLQQSL CSTSVTTIHH
1110 1120 1130 1140 1150
TVLQQHAAAA AAAAAAAAAG TFKVLQPHQQ FLSQIPALTR TSLPQLSVGP
1160 1170 1180 1190 1200
VGPRLCPGNQ PTFVAPPQMP IIPASVLHPS HLAFPSLPHA LFPSLLSPHP

TVIPLQPLF
Length:1,209
Mass (Da):136,888
Last modified:March 3, 2009 - v3
Checksum:i467982636EF1DFC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti492I → V in AAI50199 (PubMed:15489334).Curated1
Sequence conflicti545G → S in AAI50199 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025943261Q → L.1 PublicationCorresponds to variant rs12476147dbSNPEnsembl.1
Natural variantiVAR_035599324N → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_054133479D → G.1 PublicationCorresponds to variant rs35676856dbSNPEnsembl.1
Natural variantiVAR_025944542E → K.1 PublicationCorresponds to variant rs4667001dbSNPEnsembl.1
Natural variantiVAR_054134600K → R.Corresponds to variant rs35925696dbSNPEnsembl.1
Natural variantiVAR_025945707T → K.Corresponds to variant rs1366842dbSNPEnsembl.1
Natural variantiVAR_025946747H → R.1 PublicationCorresponds to variant rs12477430dbSNPEnsembl.1
Natural variantiVAR_0259471081L → V.Corresponds to variant rs3731834dbSNPEnsembl.1
Natural variantiVAR_0541351152G → R.Corresponds to variant rs12105159dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327407 mRNA. Translation: AAP92799.1.
AC010747 Genomic DNA. No translation available.
AC112720 Genomic DNA. No translation available.
AC096667 Genomic DNA. No translation available.
BC150198 mRNA. Translation: AAI50199.1.
AK131402 mRNA. Translation: BAD18549.1.
CCDSiCCDS2291.1.
RefSeqiNP_919226.1. NM_194250.1.
UniGeneiHs.159528.

Genome annotation databases

EnsembliENST00000302277; ENSP00000303252; ENSG00000170396.
GeneIDi91752.
KEGGihsa:91752.
UCSCiuc002uph.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327407 mRNA. Translation: AAP92799.1.
AC010747 Genomic DNA. No translation available.
AC112720 Genomic DNA. No translation available.
AC096667 Genomic DNA. No translation available.
BC150198 mRNA. Translation: AAI50199.1.
AK131402 mRNA. Translation: BAD18549.1.
CCDSiCCDS2291.1.
RefSeqiNP_919226.1. NM_194250.1.
UniGeneiHs.159528.

3D structure databases

ProteinModelPortaliQ7Z570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124875. 2 interactors.
IntActiQ7Z570. 2 interactors.
MINTiMINT-2877891.
STRINGi9606.ENSP00000303252.

PTM databases

iPTMnetiQ7Z570.
PhosphoSitePlusiQ7Z570.

Polymorphism and mutation databases

BioMutaiZNF804A.
DMDMi224471869.

Proteomic databases

EPDiQ7Z570.
PaxDbiQ7Z570.
PeptideAtlasiQ7Z570.
PRIDEiQ7Z570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302277; ENSP00000303252; ENSG00000170396.
GeneIDi91752.
KEGGihsa:91752.
UCSCiuc002uph.4. human.

Organism-specific databases

CTDi91752.
DisGeNETi91752.
GeneCardsiZNF804A.
HGNCiHGNC:21711. ZNF804A.
HPAiHPA029195.
MIMi612282. gene.
neXtProtiNX_Q7Z570.
OpenTargetsiENSG00000170396.
Orphaneti3140. Schizophrenia.
PharmGKBiPA162410599.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVP. Eukaryota.
ENOG410ZHVS. LUCA.
GeneTreeiENSGT00530000063305.
HOVERGENiHBG107108.
InParanoidiQ7Z570.
OMAiPCEVYQH.
OrthoDBiEOG091G01DY.
PhylomeDBiQ7Z570.
TreeFamiTF332138.

Miscellaneous databases

ChiTaRSiZNF804A. human.
GeneWikiiZinc_finger_protein_804A.
GenomeRNAii91752.
PROiQ7Z570.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170396.
CleanExiHS_ZNF804A.
ExpressionAtlasiQ7Z570. baseline and differential.
GenevisibleiQ7Z570. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ804A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z570
Secondary accession number(s): A7E253, Q6ZN26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.