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Q7Z4Y8

- AT5L2_HUMAN

UniProt

Q7Z4Y8 - AT5L2_HUMAN

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Protein

ATP synthase subunit g 2, mitochondrial

Gene

ATP5L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).By similarity

GO - Molecular functioni

  1. hydrogen ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. ATP synthesis coupled proton transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit g 2, mitochondrial
Short name:
ATPase subunit g 2
Gene namesi
Name:ATP5L2
Synonyms:ATP5K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:13213. ATP5L2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100ATP synthase subunit g 2, mitochondrialPRO_0000225013Add
BLAST

Proteomic databases

PRIDEiQ7Z4Y8.

Expressioni

Gene expression databases

GenevestigatoriQ7Z4Y8.

Organism-specific databases

HPAiHPA044629.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase g subunit family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000009724.
HOGENOMiHOG000007506.
HOVERGENiHBG050614.
InParanoidiQ7Z4Y8.
OMAiATEVSTW.
OrthoDBiEOG7Z69FQ.
PhylomeDBiQ7Z4Y8.
TreeFamiTF313978.

Family and domain databases

InterProiIPR016702. ATP-Synthase_su_G_mt_met.
IPR006808. ATPase_F0-cplx_gsu_mt.
[Graphical view]
PfamiPF04718. ATP-synt_G. 1 hit.
[Graphical view]
PIRSFiPIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z4Y8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPFVRNLVE KTPALVNAAV TYLKPRLAAF WYYTTVELVP PTPAEIPRAI
60 70 80 90 100
QSLKKIVSSA QTGSFKQLTV KEALLNGLVA TEVSTWFYVR EITGKRGIIG
Length:100
Mass (Da):11,037
Last modified:October 1, 2003 - v1
Checksum:i660C6E40987172D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092923 mRNA. Translation: AAP97217.1.
BC093719 mRNA. No translation available.
BC093721 mRNA. No translation available.
CCDSiCCDS54534.1.
RefSeqiNP_001159349.1. NM_001165877.1.
UniGeneiHs.664737.

Genome annotation databases

EnsembliENST00000505920; ENSP00000421076; ENSG00000249222.
GeneIDi267020.
KEGGihsa:267020.
UCSCiuc003bda.1. human.

Polymorphism databases

DMDMi74762435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092923 mRNA. Translation: AAP97217.1 .
BC093719 mRNA. No translation available.
BC093721 mRNA. No translation available.
CCDSi CCDS54534.1.
RefSeqi NP_001159349.1. NM_001165877.1.
UniGenei Hs.664737.

3D structure databases

ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74762435.

Proteomic databases

PRIDEi Q7Z4Y8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000505920 ; ENSP00000421076 ; ENSG00000249222 .
GeneIDi 267020.
KEGGi hsa:267020.
UCSCi uc003bda.1. human.

Organism-specific databases

CTDi 267020.
GeneCardsi GC22M043036.
HGNCi HGNC:13213. ATP5L2.
HPAi HPA044629.
neXtProti NX_Q7Z4Y8.
PharmGKBi PA134948694.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000009724.
HOGENOMi HOG000007506.
HOVERGENi HBG050614.
InParanoidi Q7Z4Y8.
OMAi ATEVSTW.
OrthoDBi EOG7Z69FQ.
PhylomeDBi Q7Z4Y8.
TreeFami TF313978.

Miscellaneous databases

GenomeRNAii 267020.
NextBioi 93412.
PROi Q7Z4Y8.

Gene expression databases

Genevestigatori Q7Z4Y8.

Family and domain databases

InterProi IPR016702. ATP-Synthase_su_G_mt_met.
IPR006808. ATPase_F0-cplx_gsu_mt.
[Graphical view ]
Pfami PF04718. ATP-synt_G. 1 hit.
[Graphical view ]
PIRSFi PIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel human cDNA homology to cattle heart F1Fo-ATP synthase complex Fo membrane domain g subunit mRNA."
    Lin W., Yu L., Zhou Y., Zhang M., Wang X.K., Zhao S.Y.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiAT5L2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3