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Q7Z4Y8 (AT5L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit g 2, mitochondrial

Short name=ATPase subunit g 2
Gene names
Name:ATP5L2
Synonyms:ATP5K2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane By similarity.

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).

Subcellular location

Mitochondrion membrane By similarity.

Sequence similarities

Belongs to the ATPase g subunit family.

Caution

Could be the product of a pseudogene.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 100100ATP synthase subunit g 2, mitochondrial
PRO_0000225013

Sequences

Sequence LengthMass (Da)Tools
Q7Z4Y8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 660C6E40987172D6

FASTA10011,037
        10         20         30         40         50         60 
MAPFVRNLVE KTPALVNAAV TYLKPRLAAF WYYTTVELVP PTPAEIPRAI QSLKKIVSSA 

        70         80         90        100 
QTGSFKQLTV KEALLNGLVA TEVSTWFYVR EITGKRGIIG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel human cDNA homology to cattle heart F1Fo-ATP synthase complex Fo membrane domain g subunit mRNA."
Lin W., Yu L., Zhou Y., Zhang M., Wang X.K., Zhao S.Y.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF092923 mRNA. Translation: AAP97217.1.
BC093719 mRNA. No translation available.
BC093721 mRNA. No translation available.
RefSeqNP_001159349.1. NM_001165877.1.
UniGeneHs.664737.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74762435.

Proteomic databases

PRIDEQ7Z4Y8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000505920; ENSP00000421076; ENSG00000249222.
GeneID267020.
KEGGhsa:267020.
UCSCuc003bda.1. human.

Organism-specific databases

CTD267020.
GeneCardsGC22M043036.
HGNCHGNC:13213. ATP5L2.
HPAHPA044629.
neXtProtNX_Q7Z4Y8.
PharmGKBPA134948694.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000007506.
HOVERGENHBG050614.
OMAATEVSTW.
OrthoDBEOG7Z69FQ.
PhylomeDBQ7Z4Y8.
TreeFamTF313978.

Gene expression databases

GenevestigatorQ7Z4Y8.

Family and domain databases

InterProIPR016702. ATP-Synthase_su_G_mt_met.
IPR006808. ATPase_F0-cplx_gsu_mt.
[Graphical view]
PfamPF04718. ATP-synt_G. 1 hit.
[Graphical view]
PIRSFPIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi267020.
NextBio93412.
PROQ7Z4Y8.

Entry information

Entry nameAT5L2_HUMAN
AccessionPrimary (citable) accession number: Q7Z4Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM