Q7Z4Y8 (AT5L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit g 2, mitochondrial
Short name=ATPase subunit g 2

Gene names

Name:	ATP5L2
Synonyms:	ATP5K2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).
Subcellular location	Mitochondrion membrane By similarity.
Sequence similarities	Belongs to the ATPase g subunit family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Membrane Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: InterPro
Molecular_function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 100	100	ATP synthase subunit g 2, mitochondrial		PRO_0000225013

Sequences

	Sequence		Length	Mass (Da)
	Q7Z4Y8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 660C6E40987172D6	FASTA	100	11,037
	10 20 30 40 50 60 MAPFVRNLVE KTPALVNAAV TYLKPRLAAF WYYTTVELVP PTPAEIPRAI QSLKKIVSSA 70 80 90 100 QTGSFKQLTV KEALLNGLVA TEVSTWFYVR EITGKRGIIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel human cDNA homology to cattle heart F1Fo-ATP synthase complex Fo membrane domain g subunit mRNA." Lin W., Yu L., Zhou Y., Zhang M., Wang X.K., Zhao S.Y. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF092923 mRNA. Translation: AAP97217.1. BC093719 mRNA. No translation available. BC093721 mRNA. No translation available.
IPI	IPI00385203.
RefSeq	NP_001159349.1. NM_001165877.1.
UniGene	Hs.664737.
3D structure databases
ModBase	Search...
Polymorphism databases
DMDM	74762435.
Proteomic databases
PRIDE	Q7Z4Y8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000505920; ENSP00000421076; ENSG00000249222.
GeneID	267020.
KEGG	hsa:267020.
UCSC	uc003bda.1. human.
Organism-specific databases
CTD	267020.
GeneCards	GC22M043036.
HGNC	HGNC:13213. ATP5L2.
HPA	HPA044629.
neXtProt	NX_Q7Z4Y8.
PharmGKB	PA134948694.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000007506.
HOVERGEN	HBG050614.
OMA	ATEVSTW.
OrthoDB	EOG4C2HC2.
Gene expression databases
Genevestigator	Q7Z4Y8.
Family and domain databases
InterPro	IPR016702. ATP-Synthase_su_G_mt_met. IPR006808. ATPase_F0-cplx_gsu_mt. [Graphical view]
Pfam	PF04718. ATP-synt_G. 1 hit. [Graphical view]
PIRSF	PIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	267020.
NextBio	93412.

Entry information

Entry name

AT5L2_HUMAN

Accession

Primary (citable) accession number: Q7Z4Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	October 1, 2003
Last modified:	October 31, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.