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Q7Z4Y8

- AT5L2_HUMAN

UniProt

Q7Z4Y8 - AT5L2_HUMAN

Protein

ATP synthase subunit g 2, mitochondrial

Gene

ATP5L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Functioni

    Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane By similarity.By similarity

    GO - Molecular functioni

    1. hydrogen ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. ATP synthesis coupled proton transport Source: InterPro

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit g 2, mitochondrial
    Short name:
    ATPase subunit g 2
    Gene namesi
    Name:ATP5L2
    Synonyms:ATP5K2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:13213. ATP5L2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: InterPro

    Keywords - Cellular componenti

    CF(0), Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134948694.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 100100ATP synthase subunit g 2, mitochondrialPRO_0000225013Add
    BLAST

    Proteomic databases

    PRIDEiQ7Z4Y8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ7Z4Y8.

    Organism-specific databases

    HPAiHPA044629.

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase g subunit family.Curated

    Phylogenomic databases

    HOGENOMiHOG000007506.
    HOVERGENiHBG050614.
    OMAiATEVSTW.
    OrthoDBiEOG7Z69FQ.
    PhylomeDBiQ7Z4Y8.
    TreeFamiTF313978.

    Family and domain databases

    InterProiIPR016702. ATP-Synthase_su_G_mt_met.
    IPR006808. ATPase_F0-cplx_gsu_mt.
    [Graphical view]
    PfamiPF04718. ATP-synt_G. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7Z4Y8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPFVRNLVE KTPALVNAAV TYLKPRLAAF WYYTTVELVP PTPAEIPRAI    50
    QSLKKIVSSA QTGSFKQLTV KEALLNGLVA TEVSTWFYVR EITGKRGIIG 100
    Length:100
    Mass (Da):11,037
    Last modified:October 1, 2003 - v1
    Checksum:i660C6E40987172D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092923 mRNA. Translation: AAP97217.1.
    BC093719 mRNA. No translation available.
    BC093721 mRNA. No translation available.
    CCDSiCCDS54534.1.
    RefSeqiNP_001159349.1. NM_001165877.1.
    UniGeneiHs.664737.

    Genome annotation databases

    EnsembliENST00000505920; ENSP00000421076; ENSG00000249222.
    GeneIDi267020.
    KEGGihsa:267020.
    UCSCiuc003bda.1. human.

    Polymorphism databases

    DMDMi74762435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092923 mRNA. Translation: AAP97217.1 .
    BC093719 mRNA. No translation available.
    BC093721 mRNA. No translation available.
    CCDSi CCDS54534.1.
    RefSeqi NP_001159349.1. NM_001165877.1.
    UniGenei Hs.664737.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74762435.

    Proteomic databases

    PRIDEi Q7Z4Y8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000505920 ; ENSP00000421076 ; ENSG00000249222 .
    GeneIDi 267020.
    KEGGi hsa:267020.
    UCSCi uc003bda.1. human.

    Organism-specific databases

    CTDi 267020.
    GeneCardsi GC22M043036.
    HGNCi HGNC:13213. ATP5L2.
    HPAi HPA044629.
    neXtProti NX_Q7Z4Y8.
    PharmGKBi PA134948694.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000007506.
    HOVERGENi HBG050614.
    OMAi ATEVSTW.
    OrthoDBi EOG7Z69FQ.
    PhylomeDBi Q7Z4Y8.
    TreeFami TF313978.

    Miscellaneous databases

    GenomeRNAii 267020.
    NextBioi 93412.
    PROi Q7Z4Y8.

    Gene expression databases

    Genevestigatori Q7Z4Y8.

    Family and domain databases

    InterProi IPR016702. ATP-Synthase_su_G_mt_met.
    IPR006808. ATPase_F0-cplx_gsu_mt.
    [Graphical view ]
    Pfami PF04718. ATP-synt_G. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017835. ATP-synth_g_mitoch_animal. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel human cDNA homology to cattle heart F1Fo-ATP synthase complex Fo membrane domain g subunit mRNA."
      Lin W., Yu L., Zhou Y., Zhang M., Wang X.K., Zhao S.Y.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiAT5L2_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z4Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3