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Q7Z4W2

- LYZL2_HUMAN

UniProt

Q7Z4W2 - LYZL2_HUMAN

Protein

Lysozyme-like protein 2

Gene

LYZL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541PROSITE-ProRule annotation
    Active sitei71 – 711PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme-like protein 2 (EC:3.2.1.17)
    Short name:
    Lysozyme-2
    Gene namesi
    Name:LYZL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:29613. LYZL2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134920379.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 148129Lysozyme-like protein 2PRO_0000240637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 145PROSITE-ProRule annotation
    Disulfide bondi49 ↔ 133PROSITE-ProRule annotation
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi94 ↔ 112PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ7Z4W2.
    PRIDEiQ7Z4W2.

    Expressioni

    Tissue specificityi

    Expressed in testis, epididymis and placenta.1 Publication

    Gene expression databases

    BgeeiQ7Z4W2.
    CleanExiHS_LYZL2.
    GenevestigatoriQ7Z4W2.

    Organism-specific databases

    HPAiHPA052332.

    Interactioni

    Subunit structurei

    Monomer.Curated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000364467.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z4W2.
    SMRiQ7Z4W2. Positions 20-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG329028.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiQ7Z4W2.
    KOiK01185.
    OMAiXQGWKKH.
    OrthoDBiEOG7BW0M5.
    PhylomeDBiQ7Z4W2.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z4W2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKAAGILTLI GCLVTGAESK IYTRCKLAKI FSRAGLDNYW GFSLGNWICM    50
    AYYESGYNTT AQTVLDDGSI DYGIFQINSF AWCRRGKLKE NNHCHVACSA 100
    LVTDDLTDAI ICAKKIVKET QGMNYWQGWK KHCEGRDLSD WKKDCEVS 148
    Length:148
    Mass (Da):16,656
    Last modified:June 27, 2006 - v2
    Checksum:i4674158A2A5912F2
    GO
    Isoform 2 (identifier: Q7Z4W2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MQDAPLSCLSPTKWSSVSSADSTEKSASAAGTRNLPFQFCLRQALRM

    Show »
    Length:194
    Mass (Da):21,584
    Checksum:i81A2CCB4C2DD597E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441D → G.1 Publication
    Corresponds to variant rs1054570 [ dbSNP | Ensembl ].
    VAR_026818

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MQDAPLSCLSPTKWSSVSSA DSTEKSASAAGTRNLPFQFC LRQALRM in isoform 2. 1 PublicationVSP_019717

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139543 mRNA. Translation: AAP97272.1.
    AL451107 Genomic DNA. Translation: CAH70607.1.
    BC066294 mRNA. Translation: AAH66294.1.
    CCDSiCCDS7167.2. [Q7Z4W2-2]
    RefSeqiNP_898881.2. NM_183058.2.
    UniGeneiHs.522610.

    Genome annotation databases

    EnsembliENST00000375318; ENSP00000364467; ENSG00000151033. [Q7Z4W2-2]
    GeneIDi119180.
    KEGGihsa:119180.
    UCSCiuc001ivk.3. human. [Q7Z4W2-2]

    Polymorphism databases

    DMDMi109892575.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139543 mRNA. Translation: AAP97272.1 .
    AL451107 Genomic DNA. Translation: CAH70607.1 .
    BC066294 mRNA. Translation: AAH66294.1 .
    CCDSi CCDS7167.2. [Q7Z4W2-2 ]
    RefSeqi NP_898881.2. NM_183058.2.
    UniGenei Hs.522610.

    3D structure databases

    ProteinModelPortali Q7Z4W2.
    SMRi Q7Z4W2. Positions 20-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000364467.

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Polymorphism databases

    DMDMi 109892575.

    Proteomic databases

    PaxDbi Q7Z4W2.
    PRIDEi Q7Z4W2.

    Protocols and materials databases

    DNASUi 119180.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375318 ; ENSP00000364467 ; ENSG00000151033 . [Q7Z4W2-2 ]
    GeneIDi 119180.
    KEGGi hsa:119180.
    UCSCi uc001ivk.3. human. [Q7Z4W2-2 ]

    Organism-specific databases

    CTDi 119180.
    GeneCardsi GC10M030940.
    HGNCi HGNC:29613. LYZL2.
    HPAi HPA052332.
    MIMi 612748. gene.
    neXtProti NX_Q7Z4W2.
    PharmGKBi PA134920379.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329028.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi Q7Z4W2.
    KOi K01185.
    OMAi XQGWKKH.
    OrthoDBi EOG7BW0M5.
    PhylomeDBi Q7Z4W2.
    TreeFami TF324882.

    Miscellaneous databases

    GenomeRNAii 119180.
    NextBioi 80392.
    PROi Q7Z4W2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7Z4W2.
    CleanExi HS_LYZL2.
    Genevestigatori Q7Z4W2.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family."
      Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L.
      Biol. Reprod. 73:1064-1071(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLY-144, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.

    Entry informationi

    Entry nameiLYZL2_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z4W2
    Secondary accession number(s): Q6NZ69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3