Q7Z4W2 (LYZL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme-like protein 2
Short name=Lysozyme-2
EC=3.2.1.17

Gene names

Name:

LYZL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer Probable.
Subcellular location	Secreted Probable.
Tissue specificity	Expressed in testis, epididymis and placenta. Ref.1
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4W2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z4W2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQDAPLSCLSPTKWSSVSSADSTEKSASAAGTRNLPFQFCLRQALRM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 148	129	Lysozyme-like protein 2		PRO_0000240637
Sites
	Active site	54	1	By similarity
	Active site	71	1	By similarity
Amino acid modifications
	Glycosylation	58	1	N-linked (GlcNAc...) Potential
	Disulfide bond	25 ↔ 145		By similarity
	Disulfide bond	49 ↔ 133		By similarity
	Disulfide bond	83 ↔ 98		By similarity
	Disulfide bond	94 ↔ 112		By similarity
Natural variations
	Alternative sequence	1	1	M → MQDAPLSCLSPTKWSSVSSA DSTEKSASAAGTRNLPFQFC LRQALRM in isoform 2.		VSP_019717
	Natural variant	144	1	D → G. Ref.1 Corresponds to variant rs1054570 [ dbSNP | Ensembl ].		VAR_026818

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 4674158A2A5912F2	FASTA	148	16,656
	10 20 30 40 50 60 MKAAGILTLI GCLVTGAESK IYTRCKLAKI FSRAGLDNYW GFSLGNWICM AYYESGYNTT 70 80 90 100 110 120 AQTVLDDGSI DYGIFQINSF AWCRRGKLKE NNHCHVACSA LVTDDLTDAI ICAKKIVKET 130 140 QGMNYWQGWK KHCEGRDLSD WKKDCEVS
	Isoform 2 [UniParc]. Checksum: 81A2CCB4C2DD597E	FASTA	194	21,584
	10 20 30 40 50 60 MQDAPLSCLS PTKWSSVSSA DSTEKSASAA GTRNLPFQFC LRQALRMKAA GILTLIGCLV 70 80 90 100 110 120 TGAESKIYTR CKLAKIFSRA GLDNYWGFSL GNWICMAYYE SGYNTTAQTV LDDGSIDYGI 130 140 150 160 170 180 FQINSFAWCR RGKLKENNHC HVACSALVTD DLTDAIICAK KIVKETQGMN YWQGWKKHCE 190 GRDLSDWKKD CEVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family." Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L. Biol. Reprod. 73:1064-1071(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLY-144, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF139543 mRNA. Translation: AAP97272.1. AL451107 Genomic DNA. Translation: CAH70607.1. BC066294 mRNA. Translation: AAH66294.1.
IPI	IPI00054693. IPI00742810.
RefSeq	NP_898881.2. NM_183058.2.
UniGene	Hs.522610.
3D structure databases
ProteinModelPortal	Q7Z4W2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000364467.
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Polymorphism databases
DMDM	109892575.
Proteomic databases
PaxDb	Q7Z4W2.
PRIDE	Q7Z4W2.
Protocols and materials databases
DNASU	119180.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375318; ENSP00000364467; ENSG00000151033.
GeneID	119180.
KEGG	hsa:119180.
UCSC	uc001ivk.3. human.
Organism-specific databases
CTD	119180.
GeneCards	GC10M030940.
HGNC	HGNC:29613. LYZL2.
HPA	HPA052332.
MIM	612748. gene.
neXtProt	NX_Q7Z4W2.
PharmGKB	PA134920379.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329028.
HOGENOM	HOG000037357.
HOVERGEN	HBG052297.
InParanoid	Q7Z4W2.
KO	K01185.
OMA	XQGWKKH.
OrthoDB	EOG46WZ9C.
PhylomeDB	Q7Z4W2.
Gene expression databases
Bgee	Q7Z4W2.
CleanEx	HS_LYZL2.
Genevestigator	Q7Z4W2.
GermOnline	ENSG00000151033. Homo sapiens.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	119180.
NextBio	80392.
SOURCE	Search...

Entry information

Entry name

LYZL2_HUMAN

Accession

Primary (citable) accession number: Q7Z4W2
Secondary accession number(s): Q6NZ69

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.