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Q7Z4V5

- HDGR2_HUMAN

UniProt

Q7Z4V5 - HDGR2_HUMAN

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Protein

Hepatoma-derived growth factor-related protein 2

Gene

HDGFRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HRP-2
Alternative name(s):
Hepatoma-derived growth factor 2
Short name:
HDGF-2
Gene namesi
Name:HDGFRP2
Synonyms:HDGF2
ORF Names:UNQ785/PRO1604
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671Hepatoma-derived growth factor-related protein 2PRO_0000317643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei369 – 3691PhosphoserineBy similarity
Modified residuei370 – 3701PhosphoserineBy similarity
Modified residuei454 – 4541PhosphoserineBy similarity
Modified residuei640 – 6401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z4V5.
PaxDbiQ7Z4V5.
PeptideAtlasiQ7Z4V5.
PRIDEiQ7Z4V5.

PTM databases

PhosphoSiteiQ7Z4V5.

Miscellaneous databases

PMAP-CutDBQ7Z4V5.

Expressioni

Gene expression databases

BgeeiQ7Z4V5.
ExpressionAtlasiQ7Z4V5. baseline and differential.
GenevestigatoriQ7Z4V5.

Organism-specific databases

HPAiHPA042559.
HPA044208.

Interactioni

Subunit structurei

Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3.1 Publication

Protein-protein interaction databases

BioGridi124221. 22 interactions.
IntActiQ7Z4V5. 4 interactions.
MINTiMINT-5005346.
STRINGi9606.ENSP00000301284.

Structurei

Secondary structure

1
671
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 134
Beta strandi21 – 255
Turni28 – 303
Beta strandi40 – 445
Turni45 – 473
Beta strandi50 – 534
Helixi55 – 573
Beta strandi58 – 603
Helixi61 – 688
Helixi77 – 8610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAEX-ray2.24A/B1-93[»]
3QBYX-ray1.95A/B/C1-93[»]
3QJ6X-ray2.30A1-93[»]
ProteinModelPortaliQ7Z4V5.
SMRiQ7Z4V5. Positions 1-93, 470-539.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z4V5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6458PWWPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili521 – 58161Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 269128Ser-richAdd
BLAST
Compositional biasi299 – 3079Poly-Ser
Compositional biasi318 – 39174Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80217.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000230488.
HOVERGENiHBG099722.
InParanoidiQ7Z4V5.
OMAiANDKIFE.
OrthoDBiEOG7NKKMQ.
PhylomeDBiQ7Z4V5.
TreeFamiTF105385.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z4V5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET
60 70 80 90 100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS
110 120 130 140 150
SDSEAPEANP ADGSDADEDD EDRGVMAVTA VTATAASDRM ESDSDSDKSS
160 170 180 190 200
DNSGLKRKTP ALKMSVSKRA RKASSDLDQA SVSPSEEENS ESSSESEKTS
210 220 230 240 250
DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS DGAKPEPVAM
260 270 280 290 300
ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS
310 320 330 340 350
SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK
360 370 380 390 400
ERRRERADRG EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE
410 420 430 440 450
PEAELEREAK KSAKKPQSSS TEPARKPGQK EKRVRPEEKQ QAKPVKVERT
460 470 480 490 500
RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS EIKFALKVDS PDVKRCLNAL
510 520 530 540 550
EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA EVYTRLKSRV
560 570 580 590 600
LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA
610 620 630 640 650
PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP
660 670
GSDRQERERA RGDSEALDEE S
Length:671
Mass (Da):74,317
Last modified:October 1, 2003 - v1
Checksum:i66CA046E0E802741
GO
Isoform 2 (identifier: Q7Z4V5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-640: Missing.

Note: No experimental confirmation available.

Show »
Length:670
Mass (Da):74,230
Checksum:iBAA24291446BDBAD
GO
Isoform 3 (identifier: Q7Z4V5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE

Note: No experimental confirmation available.

Show »
Length:676
Mass (Da):74,816
Checksum:i78095562E5A10EAC
GO
Isoform 4 (identifier: Q7Z4V5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE
     640-640: Missing.

Show »
Length:675
Mass (Da):74,729
Checksum:iD9F34E7A654236BB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei574 – 5741K → KLAGEE in isoform 3 and isoform 4. CuratedVSP_047329
Alternative sequencei640 – 6401Missing in isoform 2 and isoform 4. 1 PublicationVSP_031116

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF294267 mRNA. Translation: AAP97281.1.
AY358600 mRNA. Translation: AAQ88963.1.
AC011498 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69215.1.
CH471139 Genomic DNA. Translation: EAW69216.1.
BC000755 mRNA. Translation: AAH00755.1.
BC009449 mRNA. Translation: AAH09449.1.
CCDSiCCDS42472.1. [Q7Z4V5-1]
CCDS59336.1. [Q7Z4V5-2]
RefSeqiNP_001001520.1. NM_001001520.2. [Q7Z4V5-1]
NP_116020.1. NM_032631.3. [Q7Z4V5-2]
UniGeneiHs.43071.

Genome annotation databases

GeneIDi84717.
KEGGihsa:84717.
UCSCiuc002mao.3. human. [Q7Z4V5-1]
uc002map.3. human. [Q7Z4V5-2]

Polymorphism databases

DMDMi74738715.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF294267 mRNA. Translation: AAP97281.1 .
AY358600 mRNA. Translation: AAQ88963.1 .
AC011498 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69215.1 .
CH471139 Genomic DNA. Translation: EAW69216.1 .
BC000755 mRNA. Translation: AAH00755.1 .
BC009449 mRNA. Translation: AAH09449.1 .
CCDSi CCDS42472.1. [Q7Z4V5-1 ]
CCDS59336.1. [Q7Z4V5-2 ]
RefSeqi NP_001001520.1. NM_001001520.2. [Q7Z4V5-1 ]
NP_116020.1. NM_032631.3. [Q7Z4V5-2 ]
UniGenei Hs.43071.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EAE X-ray 2.24 A/B 1-93 [» ]
3QBY X-ray 1.95 A/B/C 1-93 [» ]
3QJ6 X-ray 2.30 A 1-93 [» ]
ProteinModelPortali Q7Z4V5.
SMRi Q7Z4V5. Positions 1-93, 470-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124221. 22 interactions.
IntActi Q7Z4V5. 4 interactions.
MINTi MINT-5005346.
STRINGi 9606.ENSP00000301284.

PTM databases

PhosphoSitei Q7Z4V5.

Polymorphism databases

DMDMi 74738715.

Proteomic databases

MaxQBi Q7Z4V5.
PaxDbi Q7Z4V5.
PeptideAtlasi Q7Z4V5.
PRIDEi Q7Z4V5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 84717.
KEGGi hsa:84717.
UCSCi uc002mao.3. human. [Q7Z4V5-1 ]
uc002map.3. human. [Q7Z4V5-2 ]

Organism-specific databases

CTDi 84717.
GeneCardsi GC19P004472.
HPAi HPA042559.
HPA044208.
neXtProti NX_Q7Z4V5.

Phylogenomic databases

eggNOGi NOG80217.
GeneTreei ENSGT00530000063013.
HOGENOMi HOG000230488.
HOVERGENi HBG099722.
InParanoidi Q7Z4V5.
OMAi ANDKIFE.
OrthoDBi EOG7NKKMQ.
PhylomeDBi Q7Z4V5.
TreeFami TF105385.

Miscellaneous databases

ChiTaRSi HDGFRP2. human.
EvolutionaryTracei Q7Z4V5.
GenomeRNAii 84717.
NextBioi 35532148.
PMAP-CutDB Q7Z4V5.
PROi Q7Z4V5.

Gene expression databases

Bgeei Q7Z4V5.
ExpressionAtlasi Q7Z4V5. baseline and differential.
Genevestigatori Q7Z4V5.

Family and domain databases

Gene3Di 1.20.930.10. 1 hit.
InterProi IPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view ]
Pfami PF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view ]
SMARTi SM00293. PWWP. 1 hit.
[Graphical view ]
PROSITEi PS50812. PWWP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Yu L.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-671 (ISOFORM 1).
    Tissue: Kidney and Muscle.
  6. "Structural and histone binding ability characterizations of human PWWP domains."
    Wu H., Zeng H., Lam R., Tempel W., Amaya M.F., Xu C., Dombrovski L., Qiu W., Wang Y., Min J.
    PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-93 IN COMPLEX WITH HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.

Entry informationi

Entry nameiHDGR2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4V5
Secondary accession number(s): I3L080
, K7EQZ6, Q96GI5, Q9BW08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3