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Q7Z4V5

- HDGR2_HUMAN

UniProt

Q7Z4V5 - HDGR2_HUMAN

Protein

Hepatoma-derived growth factor-related protein 2

Gene

HDGFRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatoma-derived growth factor-related protein 2
    Short name:
    HRP-2
    Alternative name(s):
    Hepatoma-derived growth factor 2
    Short name:
    HDGF-2
    Gene namesi
    Name:HDGFRP2
    Synonyms:HDGF2
    ORF Names:UNQ785/PRO1604
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 671671Hepatoma-derived growth factor-related protein 2PRO_0000317643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei369 – 3691PhosphoserineBy similarity
    Modified residuei370 – 3701PhosphoserineBy similarity
    Modified residuei454 – 4541PhosphoserineBy similarity
    Modified residuei640 – 6401PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z4V5.
    PaxDbiQ7Z4V5.
    PeptideAtlasiQ7Z4V5.
    PRIDEiQ7Z4V5.

    PTM databases

    PhosphoSiteiQ7Z4V5.

    Miscellaneous databases

    PMAP-CutDBQ7Z4V5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z4V5.
    BgeeiQ7Z4V5.
    GenevestigatoriQ7Z4V5.

    Organism-specific databases

    HPAiHPA042559.
    HPA044208.

    Interactioni

    Subunit structurei

    Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3.1 Publication

    Protein-protein interaction databases

    BioGridi124221. 9 interactions.
    IntActiQ7Z4V5. 4 interactions.
    MINTiMINT-5005346.
    STRINGi9606.ENSP00000301284.

    Structurei

    Secondary structure

    1
    671
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 134
    Beta strandi21 – 255
    Turni28 – 303
    Beta strandi40 – 445
    Turni45 – 473
    Beta strandi50 – 534
    Helixi55 – 573
    Beta strandi58 – 603
    Helixi61 – 688
    Helixi77 – 8610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EAEX-ray2.24A/B1-93[»]
    3QBYX-ray1.95A/B/C1-93[»]
    3QJ6X-ray2.30A1-93[»]
    ProteinModelPortaliQ7Z4V5.
    SMRiQ7Z4V5. Positions 1-93, 470-539.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7Z4V5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 6458PWWPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili521 – 58161Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi142 – 269128Ser-richAdd
    BLAST
    Compositional biasi299 – 3079Poly-Ser
    Compositional biasi318 – 39174Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HDGF family.Curated
    Contains 1 PWWP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG80217.
    HOGENOMiHOG000230488.
    HOVERGENiHBG099722.
    InParanoidiQ7Z4V5.
    OMAiANDKIFE.
    OrthoDBiEOG7NKKMQ.
    PhylomeDBiQ7Z4V5.
    TreeFamiTF105385.

    Family and domain databases

    Gene3Di1.20.930.10. 1 hit.
    InterProiIPR021567. LEDGF.
    IPR000313. PWWP_dom.
    IPR017923. TFIIS_N.
    [Graphical view]
    PfamiPF11467. LEDGF. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view]
    SMARTiSM00293. PWWP. 1 hit.
    [Graphical view]
    PROSITEiPS50812. PWWP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z4V5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET    50
    AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS 100
    SDSEAPEANP ADGSDADEDD EDRGVMAVTA VTATAASDRM ESDSDSDKSS 150
    DNSGLKRKTP ALKMSVSKRA RKASSDLDQA SVSPSEEENS ESSSESEKTS 200
    DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS DGAKPEPVAM 250
    ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS 300
    SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK 350
    ERRRERADRG EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE 400
    PEAELEREAK KSAKKPQSSS TEPARKPGQK EKRVRPEEKQ QAKPVKVERT 450
    RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS EIKFALKVDS PDVKRCLNAL 500
    EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA EVYTRLKSRV 550
    LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA 600
    PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP 650
    GSDRQERERA RGDSEALDEE S 671
    Length:671
    Mass (Da):74,317
    Last modified:October 1, 2003 - v1
    Checksum:i66CA046E0E802741
    GO
    Isoform 2 (identifier: Q7Z4V5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         640-640: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:670
    Mass (Da):74,230
    Checksum:iBAA24291446BDBAD
    GO
    Isoform 3 (identifier: Q7Z4V5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         574-574: K → KLAGEE

    Note: No experimental confirmation available.

    Show »
    Length:676
    Mass (Da):74,816
    Checksum:i78095562E5A10EAC
    GO
    Isoform 4 (identifier: Q7Z4V5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         574-574: K → KLAGEE
         640-640: Missing.

    Show »
    Length:675
    Mass (Da):74,729
    Checksum:iD9F34E7A654236BB
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei574 – 5741K → KLAGEE in isoform 3 and isoform 4. CuratedVSP_047329
    Alternative sequencei640 – 6401Missing in isoform 2 and isoform 4. 1 PublicationVSP_031116

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294267 mRNA. Translation: AAP97281.1.
    AY358600 mRNA. Translation: AAQ88963.1.
    AC011498 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69215.1.
    CH471139 Genomic DNA. Translation: EAW69216.1.
    BC000755 mRNA. Translation: AAH00755.1.
    BC009449 mRNA. Translation: AAH09449.1.
    CCDSiCCDS42472.1. [Q7Z4V5-1]
    CCDS59336.1. [Q7Z4V5-2]
    RefSeqiNP_001001520.1. NM_001001520.2. [Q7Z4V5-1]
    NP_116020.1. NM_032631.3. [Q7Z4V5-2]
    UniGeneiHs.43071.

    Genome annotation databases

    EnsembliENST00000586684; ENSP00000468044; ENSG00000167674.
    GeneIDi84717.
    KEGGihsa:84717.
    UCSCiuc002mao.3. human. [Q7Z4V5-1]
    uc002map.3. human. [Q7Z4V5-2]

    Polymorphism databases

    DMDMi74738715.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294267 mRNA. Translation: AAP97281.1 .
    AY358600 mRNA. Translation: AAQ88963.1 .
    AC011498 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69215.1 .
    CH471139 Genomic DNA. Translation: EAW69216.1 .
    BC000755 mRNA. Translation: AAH00755.1 .
    BC009449 mRNA. Translation: AAH09449.1 .
    CCDSi CCDS42472.1. [Q7Z4V5-1 ]
    CCDS59336.1. [Q7Z4V5-2 ]
    RefSeqi NP_001001520.1. NM_001001520.2. [Q7Z4V5-1 ]
    NP_116020.1. NM_032631.3. [Q7Z4V5-2 ]
    UniGenei Hs.43071.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EAE X-ray 2.24 A/B 1-93 [» ]
    3QBY X-ray 1.95 A/B/C 1-93 [» ]
    3QJ6 X-ray 2.30 A 1-93 [» ]
    ProteinModelPortali Q7Z4V5.
    SMRi Q7Z4V5. Positions 1-93, 470-539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124221. 9 interactions.
    IntActi Q7Z4V5. 4 interactions.
    MINTi MINT-5005346.
    STRINGi 9606.ENSP00000301284.

    PTM databases

    PhosphoSitei Q7Z4V5.

    Polymorphism databases

    DMDMi 74738715.

    Proteomic databases

    MaxQBi Q7Z4V5.
    PaxDbi Q7Z4V5.
    PeptideAtlasi Q7Z4V5.
    PRIDEi Q7Z4V5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000586684 ; ENSP00000468044 ; ENSG00000167674 .
    GeneIDi 84717.
    KEGGi hsa:84717.
    UCSCi uc002mao.3. human. [Q7Z4V5-1 ]
    uc002map.3. human. [Q7Z4V5-2 ]

    Organism-specific databases

    CTDi 84717.
    GeneCardsi GC19P004472.
    HPAi HPA042559.
    HPA044208.
    neXtProti NX_Q7Z4V5.

    Phylogenomic databases

    eggNOGi NOG80217.
    HOGENOMi HOG000230488.
    HOVERGENi HBG099722.
    InParanoidi Q7Z4V5.
    OMAi ANDKIFE.
    OrthoDBi EOG7NKKMQ.
    PhylomeDBi Q7Z4V5.
    TreeFami TF105385.

    Miscellaneous databases

    ChiTaRSi HDGFRP2. human.
    EvolutionaryTracei Q7Z4V5.
    GenomeRNAii 84717.
    NextBioi 35532148.
    PMAP-CutDB Q7Z4V5.
    PROi Q7Z4V5.

    Gene expression databases

    ArrayExpressi Q7Z4V5.
    Bgeei Q7Z4V5.
    Genevestigatori Q7Z4V5.

    Family and domain databases

    Gene3Di 1.20.930.10. 1 hit.
    InterProi IPR021567. LEDGF.
    IPR000313. PWWP_dom.
    IPR017923. TFIIS_N.
    [Graphical view ]
    Pfami PF11467. LEDGF. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view ]
    SMARTi SM00293. PWWP. 1 hit.
    [Graphical view ]
    PROSITEi PS50812. PWWP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yu L.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-671 (ISOFORM 1).
      Tissue: Kidney and Muscle.
    6. "Structural and histone binding ability characterizations of human PWWP domains."
      Wu H., Zeng H., Lam R., Tempel W., Amaya M.F., Xu C., Dombrovski L., Qiu W., Wang Y., Min J.
      PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-93 IN COMPLEX WITH HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.

    Entry informationi

    Entry nameiHDGR2_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z4V5
    Secondary accession number(s): I3L080
    , K7EQZ6, Q96GI5, Q9BW08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3