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Q7Z4V5 (HDGR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatoma-derived growth factor-related protein 2

Short name=HRP-2
Alternative name(s):
Hepatoma-derived growth factor 2
Short name=HDGF-2
Gene names
Name:HDGFRP2
Synonyms:HDGF2
ORF Names:UNQ785/PRO1604
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Ref.6

Sequence similarities

Belongs to the HDGF family.

Contains 1 PWWP domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

chromatin binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z4V5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z4V5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     640-640: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q7Z4V5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE
Note: No experimental confirmation available.
Isoform 4 (identifier: Q7Z4V5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE
     640-640: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 671671Hepatoma-derived growth factor-related protein 2
PRO_0000317643

Regions

Domain7 – 6458PWWP
Coiled coil521 – 58161 Potential
Compositional bias142 – 269128Ser-rich
Compositional bias299 – 3079Poly-Ser
Compositional bias318 – 39174Arg-rich

Amino acid modifications

Modified residue3691Phosphoserine By similarity
Modified residue3701Phosphoserine By similarity
Modified residue4541Phosphoserine By similarity
Modified residue6401Phosphoserine By similarity

Natural variations

Alternative sequence5741K → KLAGEE in isoform 3 and isoform 4.
VSP_047329
Alternative sequence6401Missing in isoform 2 and isoform 4.
VSP_031116

Secondary structure

.................. 671
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 66CA046E0E802741

FASTA67174,317
        10         20         30         40         50         60 
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET AFLGPKDLFP 

        70         80         90        100        110        120 
YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS SDSEAPEANP ADGSDADEDD 

       130        140        150        160        170        180 
EDRGVMAVTA VTATAASDRM ESDSDSDKSS DNSGLKRKTP ALKMSVSKRA RKASSDLDQA 

       190        200        210        220        230        240 
SVSPSEEENS ESSSESEKTS DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS 

       250        260        270        280        290        300 
DGAKPEPVAM ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS 

       310        320        330        340        350        360 
SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK ERRRERADRG 

       370        380        390        400        410        420 
EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE PEAELEREAK KSAKKPQSSS 

       430        440        450        460        470        480 
TEPARKPGQK EKRVRPEEKQ QAKPVKVERT RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS 

       490        500        510        520        530        540 
EIKFALKVDS PDVKRCLNAL EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA 

       550        560        570        580        590        600 
EVYTRLKSRV LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA 

       610        620        630        640        650        660 
PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP GSDRQERERA 

       670 
RGDSEALDEE S 

« Hide

Isoform 2 [UniParc].

Checksum: BAA24291446BDBAD
Show »

FASTA67074,230
Isoform 3 [UniParc].

Checksum: 78095562E5A10EAC
Show »

FASTA67674,816
Isoform 4 [UniParc].

Checksum: D9F34E7A654236BB
Show »

FASTA67574,729

References

« Hide 'large scale' references
[1]Yu L.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-671 (ISOFORM 1).
Tissue: Kidney and Muscle.
[6]"Structural and histone binding ability characterizations of human PWWP domains."
Wu H., Zeng H., Lam R., Tempel W., Amaya M.F., Xu C., Dombrovski L., Qiu W., Wang Y., Min J.
PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-93 IN COMPLEX WITH HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF294267 mRNA. Translation: AAP97281.1.
AY358600 mRNA. Translation: AAQ88963.1.
AC011498 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69215.1.
CH471139 Genomic DNA. Translation: EAW69216.1.
BC000755 mRNA. Translation: AAH00755.1.
BC009449 mRNA. Translation: AAH09449.1.
CCDSCCDS42472.1. [Q7Z4V5-1]
CCDS59336.1. [Q7Z4V5-2]
RefSeqNP_001001520.1. NM_001001520.2. [Q7Z4V5-1]
NP_116020.1. NM_032631.3. [Q7Z4V5-2]
UniGeneHs.43071.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAEX-ray2.24A/B1-93[»]
3QBYX-ray1.95A/B/C1-93[»]
3QJ6X-ray2.30A1-93[»]
ProteinModelPortalQ7Z4V5.
SMRQ7Z4V5. Positions 1-93, 470-539.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124221. 9 interactions.
IntActQ7Z4V5. 4 interactions.
MINTMINT-5005346.
STRING9606.ENSP00000301284.

PTM databases

PhosphoSiteQ7Z4V5.

Polymorphism databases

DMDM74738715.

Proteomic databases

MaxQBQ7Z4V5.
PaxDbQ7Z4V5.
PeptideAtlasQ7Z4V5.
PRIDEQ7Z4V5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000586684; ENSP00000468044; ENSG00000167674.
GeneID84717.
KEGGhsa:84717.
UCSCuc002mao.3. human. [Q7Z4V5-1]
uc002map.3. human. [Q7Z4V5-2]

Organism-specific databases

CTD84717.
GeneCardsGC19P004472.
HPAHPA042559.
HPA044208.
neXtProtNX_Q7Z4V5.

Phylogenomic databases

eggNOGNOG80217.
HOGENOMHOG000230488.
HOVERGENHBG099722.
InParanoidQ7Z4V5.
OMAANDKIFE.
OrthoDBEOG7NKKMQ.
PhylomeDBQ7Z4V5.
TreeFamTF105385.

Gene expression databases

ArrayExpressQ7Z4V5.
BgeeQ7Z4V5.
GenevestigatorQ7Z4V5.

Family and domain databases

Gene3D1.20.930.10. 1 hit.
InterProIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHDGFRP2. human.
EvolutionaryTraceQ7Z4V5.
GenomeRNAi84717.
NextBio35532148.
PMAP-CutDBQ7Z4V5.
PROQ7Z4V5.

Entry information

Entry nameHDGR2_HUMAN
AccessionPrimary (citable) accession number: Q7Z4V5
Secondary accession number(s): I3L080 expand/collapse secondary AC list , K7EQZ6, Q96GI5, Q9BW08
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM