Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatoma-derived growth factor-related protein 2

Gene

HDGFRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cellular growth control, through the regulation of cyclin D1 expression.1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell growth Source: UniProtKB
  • transcription, DNA-templated Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HRP-2
Alternative name(s):
Hepatoma-derived growth factor 2
Short name:
HDGF-2
Gene namesi
Name:HDGFRP2
Synonyms:HDGF2
ORF Names:UNQ785/PRO1604
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiHDGFRP2.
DMDMi74738715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671Hepatoma-derived growth factor-related protein 2PRO_0000317643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei369 – 3691PhosphoserineBy similarity
Modified residuei370 – 3701PhosphoserineBy similarity
Modified residuei454 – 4541PhosphoserineBy similarity
Modified residuei633 – 6331Phosphoserine2 Publications
Modified residuei634 – 6341Phosphoserine1 Publication
Modified residuei640 – 6401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z4V5.
PaxDbiQ7Z4V5.
PeptideAtlasiQ7Z4V5.
PRIDEiQ7Z4V5.

PTM databases

PhosphoSiteiQ7Z4V5.

Miscellaneous databases

PMAP-CutDBQ7Z4V5.

Expressioni

Tissue specificityi

Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.1 Publication

Gene expression databases

BgeeiQ7Z4V5.
ExpressionAtlasiQ7Z4V5. baseline and differential.
GenevisibleiQ7Z4V5. HS.

Organism-specific databases

HPAiHPA042559.
HPA044208.

Interactioni

Subunit structurei

Interacts with HDGF (By similarity). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1 (PubMed:25689719).By similarity2 Publications

Protein-protein interaction databases

BioGridi124221. 27 interactions.
IntActiQ7Z4V5. 4 interactions.
MINTiMINT-5005346.
STRINGi9606.ENSP00000301284.

Structurei

Secondary structure

1
671
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 134Combined sources
Beta strandi21 – 255Combined sources
Turni28 – 303Combined sources
Beta strandi40 – 445Combined sources
Turni45 – 473Combined sources
Beta strandi50 – 534Combined sources
Helixi55 – 573Combined sources
Beta strandi58 – 603Combined sources
Helixi61 – 688Combined sources
Helixi77 – 8610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAEX-ray2.24A/B1-93[»]
3QBYX-ray1.95A/B/C1-93[»]
3QJ6X-ray2.30A1-93[»]
ProteinModelPortaliQ7Z4V5.
SMRiQ7Z4V5. Positions 1-93, 470-539.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z4V5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6458PWWPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili521 – 58161Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 269128Ser-richAdd
BLAST
Compositional biasi299 – 3079Poly-Ser
Compositional biasi318 – 39174Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80217.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000230488.
HOVERGENiHBG099722.
InParanoidiQ7Z4V5.
OMAiSDHSGLK.
OrthoDBiEOG7NKKMQ.
PhylomeDBiQ7Z4V5.
TreeFamiTF105385.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4V5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET
60 70 80 90 100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS
110 120 130 140 150
SDSEAPEANP ADGSDADEDD EDRGVMAVTA VTATAASDRM ESDSDSDKSS
160 170 180 190 200
DNSGLKRKTP ALKMSVSKRA RKASSDLDQA SVSPSEEENS ESSSESEKTS
210 220 230 240 250
DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS DGAKPEPVAM
260 270 280 290 300
ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS
310 320 330 340 350
SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK
360 370 380 390 400
ERRRERADRG EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE
410 420 430 440 450
PEAELEREAK KSAKKPQSSS TEPARKPGQK EKRVRPEEKQ QAKPVKVERT
460 470 480 490 500
RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS EIKFALKVDS PDVKRCLNAL
510 520 530 540 550
EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA EVYTRLKSRV
560 570 580 590 600
LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA
610 620 630 640 650
PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP
660 670
GSDRQERERA RGDSEALDEE S
Length:671
Mass (Da):74,317
Last modified:October 1, 2003 - v1
Checksum:i66CA046E0E802741
GO
Isoform 2 (identifier: Q7Z4V5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-640: Missing.

Note: No experimental confirmation available.
Show »
Length:670
Mass (Da):74,230
Checksum:iBAA24291446BDBAD
GO
Isoform 3 (identifier: Q7Z4V5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):74,816
Checksum:i78095562E5A10EAC
GO
Isoform 4 (identifier: Q7Z4V5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE
     640-640: Missing.

Show »
Length:675
Mass (Da):74,729
Checksum:iD9F34E7A654236BB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei574 – 5741K → KLAGEE in isoform 3 and isoform 4. CuratedVSP_047329
Alternative sequencei640 – 6401Missing in isoform 2 and isoform 4. 1 PublicationVSP_031116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294267 mRNA. Translation: AAP97281.1.
AY358600 mRNA. Translation: AAQ88963.1.
AC011498 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69215.1.
CH471139 Genomic DNA. Translation: EAW69216.1.
BC000755 mRNA. Translation: AAH00755.1.
BC009449 mRNA. Translation: AAH09449.1.
CCDSiCCDS42472.1. [Q7Z4V5-1]
CCDS59336.1. [Q7Z4V5-2]
RefSeqiNP_001001520.1. NM_001001520.2. [Q7Z4V5-1]
NP_116020.1. NM_032631.3. [Q7Z4V5-2]
UniGeneiHs.43071.

Genome annotation databases

GeneIDi84717.
KEGGihsa:84717.
UCSCiuc002mao.3. human. [Q7Z4V5-1]
uc002map.3. human. [Q7Z4V5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294267 mRNA. Translation: AAP97281.1.
AY358600 mRNA. Translation: AAQ88963.1.
AC011498 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69215.1.
CH471139 Genomic DNA. Translation: EAW69216.1.
BC000755 mRNA. Translation: AAH00755.1.
BC009449 mRNA. Translation: AAH09449.1.
CCDSiCCDS42472.1. [Q7Z4V5-1]
CCDS59336.1. [Q7Z4V5-2]
RefSeqiNP_001001520.1. NM_001001520.2. [Q7Z4V5-1]
NP_116020.1. NM_032631.3. [Q7Z4V5-2]
UniGeneiHs.43071.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAEX-ray2.24A/B1-93[»]
3QBYX-ray1.95A/B/C1-93[»]
3QJ6X-ray2.30A1-93[»]
ProteinModelPortaliQ7Z4V5.
SMRiQ7Z4V5. Positions 1-93, 470-539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124221. 27 interactions.
IntActiQ7Z4V5. 4 interactions.
MINTiMINT-5005346.
STRINGi9606.ENSP00000301284.

PTM databases

PhosphoSiteiQ7Z4V5.

Polymorphism and mutation databases

BioMutaiHDGFRP2.
DMDMi74738715.

Proteomic databases

MaxQBiQ7Z4V5.
PaxDbiQ7Z4V5.
PeptideAtlasiQ7Z4V5.
PRIDEiQ7Z4V5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84717.
KEGGihsa:84717.
UCSCiuc002mao.3. human. [Q7Z4V5-1]
uc002map.3. human. [Q7Z4V5-2]

Organism-specific databases

CTDi84717.
GeneCardsiGC19P004472.
HPAiHPA042559.
HPA044208.
neXtProtiNX_Q7Z4V5.

Phylogenomic databases

eggNOGiNOG80217.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000230488.
HOVERGENiHBG099722.
InParanoidiQ7Z4V5.
OMAiSDHSGLK.
OrthoDBiEOG7NKKMQ.
PhylomeDBiQ7Z4V5.
TreeFamiTF105385.

Miscellaneous databases

ChiTaRSiHDGFRP2. human.
EvolutionaryTraceiQ7Z4V5.
GenomeRNAii84717.
NextBioi35532148.
PMAP-CutDBQ7Z4V5.
PROiQ7Z4V5.

Gene expression databases

BgeeiQ7Z4V5.
ExpressionAtlasiQ7Z4V5. baseline and differential.
GenevisibleiQ7Z4V5. HS.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Yu L.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-671 (ISOFORM 1).
    Tissue: Kidney and Muscle.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633 AND SER-634, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma."
    Gao K., Xu C., Jin X., Wumaier R., Ma J., Peng J., Wang Y., Tang Y., Yu L., Zhang P.
    Biochem. Biophys. Res. Commun. 458:849-855(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH IWS1.
  10. "Structural and histone binding ability characterizations of human PWWP domains."
    Wu H., Zeng H., Lam R., Tempel W., Amaya M.F., Xu C., Dombrovski L., Qiu W., Wang Y., Min J.
    PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-93 IN COMPLEX WITH HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.

Entry informationi

Entry nameiHDGR2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4V5
Secondary accession number(s): I3L080
, K7EQZ6, Q96GI5, Q9BW08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.