Q7Z4V5 (HDGR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name=HRP-2

Alternative name(s):
Hepatoma-derived growth factor 2
Short name=HDGF-2

Gene names

Name:	HDGFRP2
Synonyms:	HDGF2
ORF Names:	UNQ785/PRO1604

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	May interact with trimethylated histone H3 (H3K79me3).
Sequence similarities	Belongs to the HDGF family. Contains 1 PWWP domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ARRB1	P49407	3	EBI-1049136,EBI-743313

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4V5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z4V5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     640-640: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 671

671

Hepatoma-derived growth factor-related protein 2

PRO_0000317643

Regions

Domain

7 – 64

58

PWWP

Coiled coil

521 – 581

61

Potential

Compositional bias

142 – 269

128

Ser-rich

Compositional bias

299 – 307

9

Poly-Ser

Compositional bias

318 – 391

74

Arg-rich

Amino acid modifications

Modified residue

232

1

Phosphoserine By similarity

Modified residue

234

1

Phosphoserine By similarity

Modified residue

236

1

Phosphoserine By similarity

Modified residue

369

1

Phosphoserine By similarity

Modified residue

370

1

Phosphoserine By similarity

Modified residue

395

1

Phosphoserine By similarity

Modified residue

396

1

Phosphoserine By similarity

Modified residue

397

1

Phosphoserine By similarity

Modified residue

399

1

Phosphoserine By similarity

Modified residue

454

1

Phosphoserine By similarity

Modified residue

625

1

Phosphoserine By similarity

Modified residue

633

1

Phosphoserine By similarity

Modified residue

640

1

Phosphoserine By similarity

Modified residue

664

1

Phosphoserine By similarity

Natural variations

Alternative sequence

640

1

Missing in isoform 2.

VSP_031116

Secondary structure

1

.

.

.

.

.

.

.

.

.

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.

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671

Helix Strand Turn

Details...

Beta strand

10 – 13

4

Beta strand

21 – 25

5

Turn

28 – 30

3

Beta strand

40 – 44

5

Turn

45 – 47

3

Beta strand

50 – 53

4

Helix

55 – 57

3

Beta strand

58 – 60

3

Helix

61 – 68

8

Helix

77 – 86

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 66CA046E0E802741	FASTA	671	74,317
	10 20 30 40 50 60 MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET AFLGPKDLFP 70 80 90 100 110 120 YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS SDSEAPEANP ADGSDADEDD 130 140 150 160 170 180 EDRGVMAVTA VTATAASDRM ESDSDSDKSS DNSGLKRKTP ALKMSVSKRA RKASSDLDQA 190 200 210 220 230 240 SVSPSEEENS ESSSESEKTS DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS 250 260 270 280 290 300 DGAKPEPVAM ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS 310 320 330 340 350 360 SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK ERRRERADRG 370 380 390 400 410 420 EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE PEAELEREAK KSAKKPQSSS 430 440 450 460 470 480 TEPARKPGQK EKRVRPEEKQ QAKPVKVERT RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS 490 500 510 520 530 540 EIKFALKVDS PDVKRCLNAL EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA 550 560 570 580 590 600 EVYTRLKSRV LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA 610 620 630 640 650 660 PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP GSDRQERERA 670 RGDSEALDEE S
	Isoform 2 [UniParc]. Checksum: BAA24291446BDBAD	FASTA	670	74,230
	10 20 30 40 50 60 MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET AFLGPKDLFP 70 80 90 100 110 120 YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS SDSEAPEANP ADGSDADEDD 130 140 150 160 170 180 EDRGVMAVTA VTATAASDRM ESDSDSDKSS DNSGLKRKTP ALKMSVSKRA RKASSDLDQA 190 200 210 220 230 240 SVSPSEEENS ESSSESEKTS DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS 250 260 270 280 290 300 DGAKPEPVAM ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS 310 320 330 340 350 360 SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK ERRRERADRG 370 380 390 400 410 420 EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE PEAELEREAK KSAKKPQSSS 430 440 450 460 470 480 TEPARKPGQK EKRVRPEEKQ QAKPVKVERT RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS 490 500 510 520 530 540 EIKFALKVDS PDVKRCLNAL EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA 550 560 570 580 590 600 EVYTRLKSRV LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA 610 620 630 640 650 660 PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDV REGPDLDRPG SDRQERERAR 670 GDSEALDEES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Yu L. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-671 (ISOFORM 1). Tissue: Kidney and Muscle.
[5]	"The crystal structure of pWWp domain of human hepatoma-derived growth factor 2 in complex with H3K79me3 peptide." Structural genomics consortium (SGC) Submitted (FEB-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-93 IN COMPLEX WITH METHYLATED HISTONE H3.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF294267 mRNA. Translation: AAP97281.1.
AY358600 mRNA. Translation: AAQ88963.1.
CH471139 Genomic DNA. Translation: EAW69215.1.
CH471139 Genomic DNA. Translation: EAW69216.1.
BC000755 mRNA. Translation: AAH00755.1.
BC009449 mRNA. Translation: AAH09449.1.

IPI

IPI00013290.
IPI01018333.

RefSeq

NP_001001520.1. NM_001001520.1.
NP_116020.1. NM_032631.2.

UniGene

Hs.43071.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EAE	X-ray	2.24	A/B	1-93	[»]
3QBY	X-ray	1.95	A/B/C	1-93	[»]
3QJ6	X-ray	2.30	A	1-93	[»]

ProteinModelPortal

Q7Z4V5.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q7Z4V5. 4 interactions.

STRING

9606.ENSP00000301284.

PTM databases

PhosphoSite

Q7Z4V5.

Polymorphism databases

DMDM

74738715.

Proteomic databases

PaxDb

Q7Z4V5.

PeptideAtlas

Q7Z4V5.

PRIDE

Q7Z4V5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

84717.

KEGG

hsa:84717.

UCSC

uc002mao.3. human.
uc002map.3. human.

Organism-specific databases

CTD

84717.

GeneCards

GC19P004472.

HPA

HPA042559.
HPA044208.

neXtProt

NX_Q7Z4V5.

Phylogenomic databases

eggNOG

NOG80217.

HOGENOM

HOG000230488.

HOVERGEN

HBG099722.

InParanoid

Q7Z4V5.

Gene expression databases

ArrayExpress

Q7Z4V5.

Bgee

Q7Z4V5.

Genevestigator

Q7Z4V5.

Family and domain databases

Gene3D

1.20.930.10. 1 hit.

InterPro

IPR021567. LEDGF.
IPR000313. PWWP.
IPR017923. TFIIS_N.
[Graphical view]

Pfam

PF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]

SMART

SM00293. PWWP. 1 hit.
[Graphical view]

PROSITE

PS50812. PWWP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HDGFRP2. human.

EvolutionaryTrace

Q7Z4V5.

GenomeRNAi

84717.

NextBio

74813.

PMAP-CutDB

Q7Z4V5.

Entry information

Entry name

HDGR2_HUMAN

Accession

Primary (citable) accession number: Q7Z4V5
Secondary accession number(s): Q96GI5, Q9BW08

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.