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Q7Z4V0 (ZN438_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 438
Gene names
Name:ZNF438
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length828 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Isoform 1 acts as a transcriptional repressor. Ref.8

Subcellular location

Nucleus Ref.8.

Tissue specificity

Ubiquitous. Ref.8

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 4 C2H2-type zinc fingers.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z4V0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z4V0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MQNSVSVPPKDEG → MDS
Isoform 3 (identifier: Q7Z4V0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 828828Zinc finger protein 438
PRO_0000245847

Regions

Zinc finger507 – 52923C2H2-type 1
Zinc finger535 – 55723C2H2-type 2
Zinc finger567 – 59024C2H2-type 3
Zinc finger776 – 79924C2H2-type 4

Natural variations

Alternative sequence1 – 4949Missing in isoform 3.
VSP_019799
Alternative sequence1 – 1313MQNSV…PKDEG → MDS in isoform 2.
VSP_019800
Natural variant1731P → S. Ref.3 Ref.4
Corresponds to variant rs10160116 [ dbSNP | Ensembl ].
VAR_027013
Natural variant3811K → N in a breast cancer sample; somatic mutation. Ref.7
VAR_035580
Natural variant6931L → V.
Corresponds to variant rs35346752 [ dbSNP | Ensembl ].
VAR_061946

Experimental info

Sequence conflict6681D → G in BAD18510. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5C2F2253D932F578

FASTA82891,836
        10         20         30         40         50         60 
MQNSVSVPPK DEGESNIPSG TIQSRKGLQN KSQFRTIAPK IVPKVLTSRM LPCHSPSRSD 

        70         80         90        100        110        120 
QVNLGPSINS KLLGMSTQNY ALMQVAGQEG TFSLVALPHV ASAQPIQKPR MSLPENLKLP 

       130        140        150        160        170        180 
IPRYQPPRNS KASRKKPILI FPKSGCSKAP AQTQMCPQMS PSPPHHPELL YKPSPFEEVP 

       190        200        210        220        230        240 
SLEQAPASIS TAALTNGSDH GDLRPPVTNT HGSLNPPATP ASSTPEEPAK QDLTALSGKA 

       250        260        270        280        290        300 
HFVSKITSSK PSAVASEKFK EQVDLAKTMT NLSPTILGNA VQLISSVPKG KLPIPPYSRM 

       310        320        330        340        350        360 
KTMEVYKIKS DANIAGFSLP GPKADCDKIP STTEGFNAAT KVASRLPVPQ VSQQSACESA 

       370        380        390        400        410        420 
FCPPTKLDLN HKTKLNSGAA KRKGRKRKVP DEILAFQGKR RKYIINKCRD GKERVKNDPQ 

       430        440        450        460        470        480 
EFRDQKLGTL KKYRSIMPKP IMVIPTLASL ASPTTLQSQM LGGLGQDVLL NNSLTPKYLG 

       490        500        510        520        530        540 
CKQDNSSSPK PSSVFRNGFS GIKKPWHRCH VCNHHFQFKQ HLRDHMNTHT NRRPYSCRIC 

       550        560        570        580        590        600 
RKSYVRPGSL STHMKLHHGE NRLKKLMCCE FCAKVFGHIR VYFGHLKEVH RVVISTEPAP 

       610        620        630        640        650        660 
SELQPGDIPK NRDMSVRGME GSLERENKSN LEEDFLLNQA DEVKLQIKCG RCQITAQSFA 

       670        680        690        700        710        720 
EIKFHLLDVH GEEIEGRLQE GTFPGSKGTQ EELVQHASPD WKRHPERGKP EKVHSSSEES 

       730        740        750        760        770        780 
HACPRLKRQL HLHQNGVEML MENEGPQSGT NKPRETCQGP ECPGLHTFLL WSHSGFNCLL 

       790        800        810        820 
CAEMLGRKED LLHHWKHQHN CEDPSKLWAI LNTVSNQGVI ELSSEAEK 

« Hide

Isoform 2 [UniParc].

Checksum: 6D0B236C816EBE67
Show »

FASTA81890,800
Isoform 3 [UniParc].

Checksum: 9869C0DC0FE34783
Show »

FASTA77986,504

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel human C2H2 zinc finger gene, ZNF438."
Zhong C.M., Wan B., Yu L.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]Guo J.H., She X.Y., Yu L.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-173.
Tissue: Kidney and Trachea.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-173.
Tissue: Stomach.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Heart and Lung.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-381.
[8]"Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity."
Zhong Z., Wan B., Qiu Y., Ni J., Tang W., Chen X., Yang Y., Shen S., Wang Y., Bai M., Lang Q., Yu L.
J. Biochem. Mol. Biol. 40:517-524(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ356012 mRNA. Translation: ABC86955.1.
DQ356011 mRNA. Translation: ABC86954.1.
AF428258 mRNA. Translation: AAP97298.1.
AK131357 mRNA. Translation: BAD18510.1.
AK292730 mRNA. Translation: BAF85419.1.
AL833056 mRNA. Translation: CAH56317.1.
AL359532 Genomic DNA. Translation: CAM17193.1.
AL359532 Genomic DNA. Translation: CAI13438.1.
BC104757 mRNA. Translation: AAI04758.1.
BC101622 mRNA. Translation: AAI01623.1.
CCDSCCDS44369.1. [Q7Z4V0-2]
CCDS53504.1. [Q7Z4V0-3]
CCDS7168.1. [Q7Z4V0-1]
RefSeqNP_001137238.1. NM_001143766.1. [Q7Z4V0-1]
NP_001137239.1. NM_001143767.1. [Q7Z4V0-1]
NP_001137240.1. NM_001143768.1. [Q7Z4V0-1]
NP_001137241.1. NM_001143769.1. [Q7Z4V0-3]
NP_001137242.1. NM_001143770.1. [Q7Z4V0-2]
NP_001137243.1. NM_001143771.1. [Q7Z4V0-2]
NP_877432.1. NM_182755.2. [Q7Z4V0-1]
XP_006717456.1. XM_006717393.1. [Q7Z4V0-1]
XP_006717457.1. XM_006717394.1. [Q7Z4V0-1]
XP_006717458.1. XM_006717395.1. [Q7Z4V0-1]
XP_006717459.1. XM_006717396.1. [Q7Z4V0-1]
XP_006717460.1. XM_006717397.1. [Q7Z4V0-1]
XP_006717461.1. XM_006717398.1. [Q7Z4V0-2]
XP_006717462.1. XM_006717399.1. [Q7Z4V0-2]
UniGeneHs.660642.

3D structure databases

ProteinModelPortalQ7Z4V0.
SMRQ7Z4V0. Positions 480-591, 642-679, 769-809.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128661. 1 interaction.
STRING9606.ENSP00000354663.

PTM databases

PhosphoSiteQ7Z4V0.

Polymorphism databases

DMDM74759173.

Proteomic databases

MaxQBQ7Z4V0.
PaxDbQ7Z4V0.
PRIDEQ7Z4V0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331737; ENSP00000333571; ENSG00000183621. [Q7Z4V0-2]
ENST00000361310; ENSP00000354663; ENSG00000183621. [Q7Z4V0-1]
ENST00000413025; ENSP00000387546; ENSG00000183621. [Q7Z4V0-1]
ENST00000436087; ENSP00000406934; ENSG00000183621. [Q7Z4V0-1]
ENST00000442986; ENSP00000412363; ENSG00000183621. [Q7Z4V0-1]
ENST00000444692; ENSP00000410898; ENSG00000183621. [Q7Z4V0-2]
ENST00000452305; ENSP00000413060; ENSG00000183621. [Q7Z4V0-2]
ENST00000538351; ENSP00000445461; ENSG00000183621. [Q7Z4V0-3]
GeneID220929.
KEGGhsa:220929.
UCSCuc001ivn.3. human. [Q7Z4V0-1]
uc001ivp.4. human. [Q7Z4V0-2]

Organism-specific databases

CTD220929.
GeneCardsGC10M031133.
HGNCHGNC:21029. ZNF438.
HPAHPA039843.
neXtProtNX_Q7Z4V0.
PharmGKBPA143485677.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000139653.
HOVERGENHBG057441.
InParanoidQ7Z4V0.
OMAYALMQVA.
OrthoDBEOG7XPZ51.
PhylomeDBQ7Z4V0.
TreeFamTF332657.

Gene expression databases

ArrayExpressQ7Z4V0.
BgeeQ7Z4V0.
CleanExHS_ZNF438.
GenevestigatorQ7Z4V0.

Family and domain databases

Gene3D3.30.160.60. 1 hit.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi220929.
NextBio91099.
PROQ7Z4V0.

Entry information

Entry nameZN438_HUMAN
AccessionPrimary (citable) accession number: Q7Z4V0
Secondary accession number(s): A2A3J4 expand/collapse secondary AC list , A8K9L5, Q5T426, Q658Q4, Q6ZN65
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM