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Protein

SH2 domain-containing protein 6

Gene

SH2D6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ7Z4S9.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 6
Gene namesi
Name:SH2D6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30439. SH2D6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152292.
PharmGKBiPA162403243.

Polymorphism and mutation databases

BioMutaiSH2D6.
DMDMi74723338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003086031 – 175SH2 domain-containing protein 6Add BLAST175

Proteomic databases

PaxDbiQ7Z4S9.
PRIDEiQ7Z4S9.

Expressioni

Gene expression databases

BgeeiENSG00000152292.
CleanExiHS_SH2D6.
GenevisibleiQ7Z4S9. HS.

Organism-specific databases

HPAiHPA053873.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341867.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4S9.
SMRiQ7Z4S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 173SH2PROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 28Pro-richAdd BLAST22

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IZDG. Eukaryota.
ENOG41124U2. LUCA.
GeneTreeiENSGT00530000063094.
HOGENOMiHOG000154312.
HOVERGENiHBG097730.
InParanoidiQ7Z4S9.
OMAiCDRYAVE.
OrthoDBiEOG091G053I.
PhylomeDBiQ7Z4S9.
TreeFamiTF343096.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYASSYPPPP QLSPRSHLCP PPPHPTPPQL NNLLLLEGRK SSLPSVAPTG
60 70 80 90 100
SASAAEDSDL LTQPWYSGNC DRYAVESALL HLQKDGAYTV RPSSGPHGSQ
110 120 130 140 150
PFTLAVLLRG RVFNIPIRRL DGGRHYALGR EGRNREELFS SVAAMVQHFM
160 170
WHPLPLVDRH SGSRELTCLL FPTKP
Length:175
Mass (Da):19,279
Last modified:October 1, 2003 - v1
Checksum:i4978232EE5C87FCD
GO
Isoform 2 (identifier: Q7Z4S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MYASSYPPPPQLSPRSHLCPPPPHPTPPQLNNLLLL → MPSGPLPRTSVVPRPTTAPQETRNGTADAASK
     57-84: Missing.

Note: No experimental confirmation available.
Show »
Length:143
Mass (Da):15,393
Checksum:i23C189EF52A7F044
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115I → T in AAR98781 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0290141 – 36MYASS…NLLLL → MPSGPLPRTSVVPRPTTAPQ ETRNGTADAASK in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_02901557 – 84Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450483 mRNA. Translation: AAP97677.1.
AY517502 mRNA. Translation: AAR98781.1.
AC062037 Genomic DNA. No translation available.
RefSeqiXP_016859347.1. XM_017003858.1. [Q7Z4S9-2]
UniGeneiHs.209542.

Genome annotation databases

EnsembliENST00000340326; ENSP00000341867; ENSG00000152292. [Q7Z4S9-1]
ENST00000389938; ENSP00000374588; ENSG00000152292. [Q7Z4S9-2]
GeneIDi284948.
UCSCiuc002spq.3. human. [Q7Z4S9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450483 mRNA. Translation: AAP97677.1.
AY517502 mRNA. Translation: AAR98781.1.
AC062037 Genomic DNA. No translation available.
RefSeqiXP_016859347.1. XM_017003858.1. [Q7Z4S9-2]
UniGeneiHs.209542.

3D structure databases

ProteinModelPortaliQ7Z4S9.
SMRiQ7Z4S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341867.

Polymorphism and mutation databases

BioMutaiSH2D6.
DMDMi74723338.

Proteomic databases

PaxDbiQ7Z4S9.
PRIDEiQ7Z4S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340326; ENSP00000341867; ENSG00000152292. [Q7Z4S9-1]
ENST00000389938; ENSP00000374588; ENSG00000152292. [Q7Z4S9-2]
GeneIDi284948.
UCSCiuc002spq.3. human. [Q7Z4S9-1]

Organism-specific databases

GeneCardsiSH2D6.
HGNCiHGNC:30439. SH2D6.
HPAiHPA053873.
neXtProtiNX_Q7Z4S9.
OpenTargetsiENSG00000152292.
PharmGKBiPA162403243.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZDG. Eukaryota.
ENOG41124U2. LUCA.
GeneTreeiENSGT00530000063094.
HOGENOMiHOG000154312.
HOVERGENiHBG097730.
InParanoidiQ7Z4S9.
OMAiCDRYAVE.
OrthoDBiEOG091G053I.
PhylomeDBiQ7Z4S9.
TreeFamiTF343096.

Enzyme and pathway databases

SignaLinkiQ7Z4S9.

Miscellaneous databases

GenomeRNAii284948.
PROiQ7Z4S9.

Gene expression databases

BgeeiENSG00000152292.
CleanExiHS_SH2D6.
GenevisibleiQ7Z4S9. HS.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSH2D6_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4S9
Secondary accession number(s): A6ND14, Q6R306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.