Q7Z4S9 (SH2D6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH2 domain-containing protein 6

Gene names

Name:

SH2D6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH2 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	SH2 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4S9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z4S9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MYASSYPPPPQLSPRSHLCPPPPHPTPPQLNNLLLL → MPSGPLPRTSVVPRPTTAPQETRNGTADAASK
     57-84: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	SH2 domain-containing protein 6		PRO_0000308603
Regions
	Domain	65 – 173	109	SH2
	Compositional bias	7 – 28	22	Pro-rich
Natural variations
	Alternative sequence	1 – 36	36	MYASS…NLLLL → MPSGPLPRTSVVPRPTTAPQ ETRNGTADAASK in isoform 2.		VSP_029014
	Alternative sequence	57 – 84	28	Missing in isoform 2.		VSP_029015
Experimental info
	Sequence conflict	115	1	I → T in AAR98781. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 4978232EE5C87FCD	FASTA	175	19,279
	10 20 30 40 50 60 MYASSYPPPP QLSPRSHLCP PPPHPTPPQL NNLLLLEGRK SSLPSVAPTG SASAAEDSDL 70 80 90 100 110 120 LTQPWYSGNC DRYAVESALL HLQKDGAYTV RPSSGPHGSQ PFTLAVLLRG RVFNIPIRRL 130 140 150 160 170 DGGRHYALGR EGRNREELFS SVAAMVQHFM WHPLPLVDRH SGSRELTCLL FPTKP
	Isoform 2 [UniParc]. Checksum: 23C189EF52A7F044	FASTA	143	15,393
	10 20 30 40 50 60 MPSGPLPRTS VVPRPTTAPQ ETRNGTADAA SKEGRKSSLP SVAPTGSASA AEDGAYTVRP 70 80 90 100 110 120 SSGPHGSQPF TLAVLLRGRV FNIPIRRLDG GRHYALGREG RNREELFSSV AAMVQHFMWH 130 140 PLPLVDRHSG SRELTCLLFP TKP

References

[1]	Zan Q., Guo J.H., Yu L. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF450483 mRNA. Translation: AAP97677.1. AY517502 mRNA. Translation: AAR98781.1. AC062037 Genomic DNA. No translation available.
IPI	IPI00394759. IPI00401786.
RefSeq	NP_940884.1. NM_198482.1.
UniGene	Hs.209542.
3D structure databases
HSSP	HSSP built from PDB template 1AYA based on UniProtKB P35235.
ProteinModelPortal	Q7Z4S9.
ModBase	Search...
Polymorphism databases
DMDM	74723338.
Proteomic databases
PaxDb	Q7Z4S9.
PRIDE	Q7Z4S9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340326; ENSP00000341867; ENSG00000152292. ENST00000389938; ENSP00000374588; ENSG00000152292.
GeneID	284948.
KEGG	hsa:284948.
UCSC	uc002spq.3. human.
Organism-specific databases
CTD	284948.
GeneCards	GC02P085645.
HGNC	HGNC:30439. SH2D6.
HPA	HPA053873.
neXtProt	NX_Q7Z4S9.
PharmGKB	PA162403243.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45165.
HOGENOM	HOG000154312.
HOVERGEN	HBG097730.
InParanoid	Q7Z4S9.
OMA	CDRYAVE.
PhylomeDB	Q7Z4S9.
Gene expression databases
Bgee	Q7Z4S9.
CleanEx	HS_SH2D6.
Genevestigator	Q7Z4S9.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. [Graphical view]
Pfam	PF00017. SH2. 1 hit. [Graphical view]
SMART	SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284948.
NextBio	95184.

Entry information

Entry name

SH2D6_HUMAN

Accession

Primary (citable) accession number: Q7Z4S9
Secondary accession number(s): A6ND14, Q6R306

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.