Q7Z4S6 (KI21A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF21A

Alternative name(s):
Kinesin-like protein KIF2
Renal carcinoma antigen NY-REN-62

Gene names

Name:	KIF21A
Synonyms:	KIAA1708, KIF2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1674 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity By similarity.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Involvement in disease	Congenital fibrosis of extraocular muscles 1 (CFEOM1) [MIM:135700]: A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Patients affected by congenital fibrosis of extraocular muscles type 1 show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.17
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Contains 7 WD repeats.
Sequence caution	The sequence AAD42883.1 differs from that shown. Reason: Frameshift at positions 185, 191, 380 and 405. The sequence AAH41430.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAP97680.1 differs from that shown. Reason: Frameshift at positions 185 and 191. The sequence BAA90916.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Coiled coil Repeat WD repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ARFGEF1	Q9Y6D6	4	EBI-6251716,EBI-1044254
KANK1	Q14678	2	EBI-2691397,EBI-2556221
KANK1	Q14678-2	3	EBI-2691397,EBI-6173812

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4S6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z4S6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     558-570: Missing.

Isoform 3 (identifier: Q7Z4S6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1260-1319: HSDSGTSEASLSPPSSPPSRPRNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHRSSR → QSDESDSSLSEVH

Note: No experimental confirmation available.

Isoform 4 (identifier: Q7Z4S6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1315-1315: H → HS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1674	1674	Kinesin-like protein KIF21A		PRO_0000125462
Regions
	Domain	1 – 299	299	Kinesin-motor
	Repeat	1345 – 1382	38	WD 1
	Repeat	1385 – 1423	39	WD 2
	Repeat	1449 – 1487	39	WD 3
	Repeat	1490 – 1532	43	WD 4
	Repeat	1541 – 1578	38	WD 5
	Repeat	1582 – 1621	40	WD 6
	Repeat	1624 – 1661	38	WD 7
	Nucleotide binding	88 – 95	8	ATP By similarity
	Coiled coil	365 – 575	211	Potential
	Coiled coil	931 – 1019	89	Potential
	Coiled coil	1053 – 1083	31	Potential
Amino acid modifications
	Modified residue	80	1	Phosphotyrosine By similarity
	Modified residue	87	1	Phosphotyrosine By similarity
	Modified residue	524	1	Phosphoserine Ref.14
	Modified residue	1212	1	Phosphoserine Ref.12 Ref.14 Ref.16
	Modified residue	1239	1	Phosphoserine Ref.12 Ref.14 Ref.16
	Modified residue	1662	1	Phosphoserine Ref.14
	Modified residue	1664	1	Phosphothreonine Ref.14
	Modified residue	1673	1	Phosphoserine Ref.12 Ref.14
Natural variations
	Alternative sequence	558 – 570	13	Missing in isoform 2.		VSP_010870
	Alternative sequence	1260 – 1319	60	HSDSG…HRSSR → QSDESDSSLSEVH in isoform 3.		VSP_010871
	Alternative sequence	1315	1	H → HS in isoform 4.		VSP_010872
	Natural variant	356	1	M → T in CFEOM1. Ref.1		VAR_019399
	Natural variant	947	1	M → R in CFEOM1. Ref.1		VAR_019400
	Natural variant	947	1	M → T in CFEOM1. Ref.17		VAR_027021
	Natural variant	947	1	M → V in CFEOM1. Ref.1		VAR_019401
	Natural variant	954	1	R → Q in CFEOM1. Ref.1		VAR_019402
	Natural variant	954	1	R → W in CFEOM1. Ref.1		VAR_019403
	Natural variant	1010	1	I → T in CFEOM1. Ref.1		VAR_019404
Experimental info
	Sequence conflict	596 – 597	2	NN → TQ in AAP97680. Ref.2
	Sequence conflict	596 – 597	2	NN → TQ in AAD42883. Ref.6
	Sequence conflict	653	1	E → D in AAP97680. Ref.2
	Sequence conflict	801 – 802	2	DQ → AP in AAP97680. Ref.2
	Sequence conflict	813	1	E → G in AAP97680. Ref.2
	Sequence conflict	826	1	K → Q in AAP97680. Ref.2
	Sequence conflict	1503	1	I → T in CAD97863. Ref.10
	Sequence conflict	1511	1	I → T in CAD97863. Ref.10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 292AFA5F2C0C6F9A	FASTA	1,674	187,179
	10 20 30 40 50 60 MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH 130 140 150 160 170 180 LFKSIEEKKH IAIKNGLPAP DFKVNAQFLE LYNEEVLDLF DTTRDIDAKS KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTESE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQIDADNATD NKIISESAQM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR SRITQLVSDQ ANHVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARAPYFSGS STFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKRKKKRLQ KLEESNREER SVAGKEDNTD TDQEKKEEKG VSERENNELE 610 620 630 640 650 660 VEESQEVSDH EDEEEEEEEE EDDIDGGESS DESDSESDEK ANYQADLANI TCEIAIKQKL 670 680 690 700 710 720 IDELENSQKR LQTLKKQYEE KLMMLQHKIR DTQLERDQVL QNLGSVESYS EEKAKKVRSE 730 740 750 760 770 780 YEKKLQAMNK ELQRLQAAQK EHARLLKNQS QYEKQLKKLQ QDVMEMKKTK VRLMKQMKEE 790 800 810 820 830 840 QEKARLTESR RNREIAQLKK DQRKRDHQLR LLEAQKRNQE VVLRRKTEEV TALRRQVRPM 850 860 870 880 890 900 SDKVAGKVTR KLSSSDAPAQ DTGSSAAAVE TDASRTGAQQ KMRIPVARVQ ALPTPATNGN 910 920 930 940 950 960 RKKYQRKGLT GRVFISKTAR MKWQLLERRV TDIIMQKMTI SNMEADMNRL LKQREELTKR 970 980 990 1000 1010 1020 REKLSKRREK IVKENGEGDK NVANINEEME SLTANIDYIN DSISDCQANI MQMEEAKEEG 1030 1040 1050 1060 1070 1080 ETLDVTAVIN ACTLTEARYL LDHFLSMGIN KGLQAAQKEA QIKVLEGRLK QTEITSATQN 1090 1100 1110 1120 1130 1140 QLLFHMLKEK AELNPELDAL LGHALQDLDS VPLENVEDST DEDAPLNSPG SEGSTLSSDL 1150 1160 1170 1180 1190 1200 MKLCGEVKPK NKARRRTTTQ MELLYADSSE LASDTSTGDA SLPGPLTPVA EGQEIGMNTE 1210 1220 1230 1240 1250 1260 TSGTSAREKE LSPPPGLPSK IGSISRQSSL SEKKIPEPSP VTRRKAYEKA EKSKAKEQKH 1270 1280 1290 1300 1310 1320 SDSGTSEASL SPPSSPPSRP RNELNVFNRL TVSQGNTSVQ QDKSDESDSS LSEVHRSSRR 1330 1340 1350 1360 1370 1380 GIINPFPASK GIRAFPLQCI HIAEGHTKAV LCVDSTDDLL FTGSKDRTCK VWNLVTGQEI 1390 1400 1410 1420 1430 1440 MSLGGHPNNV VSVKYCNYTS LVFTVSTSYI KVWDIRDSAK CIRTLTSSGQ VTLGDACSAS 1450 1460 1470 1480 1490 1500 TSRTVAIPSG ENQINQIALN PTGTFLYAAS GNAVRMWDLK RFQSTGKLTG HLGPVMCLTV 1510 1520 1530 1540 1550 1560 DQISSGQDLI ITGSKDHYIK MFDVTEGALG TVSPTHNFEP PHYDGIEALT IQGDNLFSGS 1570 1580 1590 1600 1610 1620 RDNGIKKWDL TQKDLLQQVP NAHKDWVCAL GVVPDHPVLL SGCRGGILKV WNMDTFMPVG 1630 1640 1650 1660 1670 EMKGHDSPIN AICVNSTHIF TAADDRTVRI WKARNLQDGQ ISDTGDLGED IASN
	Isoform 2 [UniParc]. Checksum: 62AAF4804167A918	FASTA	1,661	185,510
	10 20 30 40 50 60 MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH 130 140 150 160 170 180 LFKSIEEKKH IAIKNGLPAP DFKVNAQFLE LYNEEVLDLF DTTRDIDAKS KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTESE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQIDADNATD NKIISESAQM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR SRITQLVSDQ ANHVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARAPYFSGS STFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKRKKKSVA GKEDNTDTDQ EKKEEKGVSE RENNELEVEE SQEVSDHEDE 610 620 630 640 650 660 EEEEEEEEDD IDGGESSDES DSESDEKANY QADLANITCE IAIKQKLIDE LENSQKRLQT 670 680 690 700 710 720 LKKQYEEKLM MLQHKIRDTQ LERDQVLQNL GSVESYSEEK AKKVRSEYEK KLQAMNKELQ 730 740 750 760 770 780 RLQAAQKEHA RLLKNQSQYE KQLKKLQQDV MEMKKTKVRL MKQMKEEQEK ARLTESRRNR 790 800 810 820 830 840 EIAQLKKDQR KRDHQLRLLE AQKRNQEVVL RRKTEEVTAL RRQVRPMSDK VAGKVTRKLS 850 860 870 880 890 900 SSDAPAQDTG SSAAAVETDA SRTGAQQKMR IPVARVQALP TPATNGNRKK YQRKGLTGRV 910 920 930 940 950 960 FISKTARMKW QLLERRVTDI IMQKMTISNM EADMNRLLKQ REELTKRREK LSKRREKIVK 970 980 990 1000 1010 1020 ENGEGDKNVA NINEEMESLT ANIDYINDSI SDCQANIMQM EEAKEEGETL DVTAVINACT 1030 1040 1050 1060 1070 1080 LTEARYLLDH FLSMGINKGL QAAQKEAQIK VLEGRLKQTE ITSATQNQLL FHMLKEKAEL 1090 1100 1110 1120 1130 1140 NPELDALLGH ALQDLDSVPL ENVEDSTDED APLNSPGSEG STLSSDLMKL CGEVKPKNKA 1150 1160 1170 1180 1190 1200 RRRTTTQMEL LYADSSELAS DTSTGDASLP GPLTPVAEGQ EIGMNTETSG TSAREKELSP 1210 1220 1230 1240 1250 1260 PPGLPSKIGS ISRQSSLSEK KIPEPSPVTR RKAYEKAEKS KAKEQKHSDS GTSEASLSPP 1270 1280 1290 1300 1310 1320 SSPPSRPRNE LNVFNRLTVS QGNTSVQQDK SDESDSSLSE VHRSSRRGII NPFPASKGIR 1330 1340 1350 1360 1370 1380 AFPLQCIHIA EGHTKAVLCV DSTDDLLFTG SKDRTCKVWN LVTGQEIMSL GGHPNNVVSV 1390 1400 1410 1420 1430 1440 KYCNYTSLVF TVSTSYIKVW DIRDSAKCIR TLTSSGQVTL GDACSASTSR TVAIPSGENQ 1450 1460 1470 1480 1490 1500 INQIALNPTG TFLYAASGNA VRMWDLKRFQ STGKLTGHLG PVMCLTVDQI SSGQDLIITG 1510 1520 1530 1540 1550 1560 SKDHYIKMFD VTEGALGTVS PTHNFEPPHY DGIEALTIQG DNLFSGSRDN GIKKWDLTQK 1570 1580 1590 1600 1610 1620 DLLQQVPNAH KDWVCALGVV PDHPVLLSGC RGGILKVWNM DTFMPVGEMK GHDSPINAIC 1630 1640 1650 1660 VNSTHIFTAA DDRTVRIWKA RNLQDGQISD TGDLGEDIAS N
	Isoform 3 [UniParc]. Checksum: B4B2415E2E95010F	FASTA	1,627	182,129
	10 20 30 40 50 60 MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH 130 140 150 160 170 180 LFKSIEEKKH IAIKNGLPAP DFKVNAQFLE LYNEEVLDLF DTTRDIDAKS KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTESE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQIDADNATD NKIISESAQM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR SRITQLVSDQ ANHVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARAPYFSGS STFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKRKKKRLQ KLEESNREER SVAGKEDNTD TDQEKKEEKG VSERENNELE 610 620 630 640 650 660 VEESQEVSDH EDEEEEEEEE EDDIDGGESS DESDSESDEK ANYQADLANI TCEIAIKQKL 670 680 690 700 710 720 IDELENSQKR LQTLKKQYEE KLMMLQHKIR DTQLERDQVL QNLGSVESYS EEKAKKVRSE 730 740 750 760 770 780 YEKKLQAMNK ELQRLQAAQK EHARLLKNQS QYEKQLKKLQ QDVMEMKKTK VRLMKQMKEE 790 800 810 820 830 840 QEKARLTESR RNREIAQLKK DQRKRDHQLR LLEAQKRNQE VVLRRKTEEV TALRRQVRPM 850 860 870 880 890 900 SDKVAGKVTR KLSSSDAPAQ DTGSSAAAVE TDASRTGAQQ KMRIPVARVQ ALPTPATNGN 910 920 930 940 950 960 RKKYQRKGLT GRVFISKTAR MKWQLLERRV TDIIMQKMTI SNMEADMNRL LKQREELTKR 970 980 990 1000 1010 1020 REKLSKRREK IVKENGEGDK NVANINEEME SLTANIDYIN DSISDCQANI MQMEEAKEEG 1030 1040 1050 1060 1070 1080 ETLDVTAVIN ACTLTEARYL LDHFLSMGIN KGLQAAQKEA QIKVLEGRLK QTEITSATQN 1090 1100 1110 1120 1130 1140 QLLFHMLKEK AELNPELDAL LGHALQDLDS VPLENVEDST DEDAPLNSPG SEGSTLSSDL 1150 1160 1170 1180 1190 1200 MKLCGEVKPK NKARRRTTTQ MELLYADSSE LASDTSTGDA SLPGPLTPVA EGQEIGMNTE 1210 1220 1230 1240 1250 1260 TSGTSAREKE LSPPPGLPSK IGSISRQSSL SEKKIPEPSP VTRRKAYEKA EKSKAKEQKQ 1270 1280 1290 1300 1310 1320 SDESDSSLSE VHRGIINPFP ASKGIRAFPL QCIHIAEGHT KAVLCVDSTD DLLFTGSKDR 1330 1340 1350 1360 1370 1380 TCKVWNLVTG QEIMSLGGHP NNVVSVKYCN YTSLVFTVST SYIKVWDIRD SAKCIRTLTS 1390 1400 1410 1420 1430 1440 SGQVTLGDAC SASTSRTVAI PSGENQINQI ALNPTGTFLY AASGNAVRMW DLKRFQSTGK 1450 1460 1470 1480 1490 1500 LTGHLGPVMC LTVDQISSGQ DLIITGSKDH YIKMFDVTEG ALGTVSPTHN FEPPHYDGIE 1510 1520 1530 1540 1550 1560 ALTIQGDNLF SGSRDNGIKK WDLTQKDLLQ QVPNAHKDWV CALGVVPDHP VLLSGCRGGI 1570 1580 1590 1600 1610 1620 LKVWNMDTFM PVGEMKGHDS PINAICVNST HIFTAADDRT VRIWKARNLQ DGQISDTGDL GEDIASN
	Isoform 4 [UniParc]. Checksum: DA1BD09FE7D3C1AF	FASTA	1,675	187,266
	10 20 30 40 50 60 MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH 130 140 150 160 170 180 LFKSIEEKKH IAIKNGLPAP DFKVNAQFLE LYNEEVLDLF DTTRDIDAKS KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTESE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQIDADNATD NKIISESAQM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR SRITQLVSDQ ANHVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARAPYFSGS STFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKRKKKRLQ KLEESNREER SVAGKEDNTD TDQEKKEEKG VSERENNELE 610 620 630 640 650 660 VEESQEVSDH EDEEEEEEEE EDDIDGGESS DESDSESDEK ANYQADLANI TCEIAIKQKL 670 680 690 700 710 720 IDELENSQKR LQTLKKQYEE KLMMLQHKIR DTQLERDQVL QNLGSVESYS EEKAKKVRSE 730 740 750 760 770 780 YEKKLQAMNK ELQRLQAAQK EHARLLKNQS QYEKQLKKLQ QDVMEMKKTK VRLMKQMKEE 790 800 810 820 830 840 QEKARLTESR RNREIAQLKK DQRKRDHQLR LLEAQKRNQE VVLRRKTEEV TALRRQVRPM 850 860 870 880 890 900 SDKVAGKVTR KLSSSDAPAQ DTGSSAAAVE TDASRTGAQQ KMRIPVARVQ ALPTPATNGN 910 920 930 940 950 960 RKKYQRKGLT GRVFISKTAR MKWQLLERRV TDIIMQKMTI SNMEADMNRL LKQREELTKR 970 980 990 1000 1010 1020 REKLSKRREK IVKENGEGDK NVANINEEME SLTANIDYIN DSISDCQANI MQMEEAKEEG 1030 1040 1050 1060 1070 1080 ETLDVTAVIN ACTLTEARYL LDHFLSMGIN KGLQAAQKEA QIKVLEGRLK QTEITSATQN 1090 1100 1110 1120 1130 1140 QLLFHMLKEK AELNPELDAL LGHALQDLDS VPLENVEDST DEDAPLNSPG SEGSTLSSDL 1150 1160 1170 1180 1190 1200 MKLCGEVKPK NKARRRTTTQ MELLYADSSE LASDTSTGDA SLPGPLTPVA EGQEIGMNTE 1210 1220 1230 1240 1250 1260 TSGTSAREKE LSPPPGLPSK IGSISRQSSL SEKKIPEPSP VTRRKAYEKA EKSKAKEQKH 1270 1280 1290 1300 1310 1320 SDSGTSEASL SPPSSPPSRP RNELNVFNRL TVSQGNTSVQ QDKSDESDSS LSEVHSRSSR 1330 1340 1350 1360 1370 1380 RGIINPFPAS KGIRAFPLQC IHIAEGHTKA VLCVDSTDDL LFTGSKDRTC KVWNLVTGQE 1390 1400 1410 1420 1430 1440 IMSLGGHPNN VVSVKYCNYT SLVFTVSTSY IKVWDIRDSA KCIRTLTSSG QVTLGDACSA 1450 1460 1470 1480 1490 1500 STSRTVAIPS GENQINQIAL NPTGTFLYAA SGNAVRMWDL KRFQSTGKLT GHLGPVMCLT 1510 1520 1530 1540 1550 1560 VDQISSGQDL IITGSKDHYI KMFDVTEGAL GTVSPTHNFE PPHYDGIEAL TIQGDNLFSG 1570 1580 1590 1600 1610 1620 SRDNGIKKWD LTQKDLLQQV PNAHKDWVCA LGVVPDHPVL LSGCRGGILK VWNMDTFMPV 1630 1640 1650 1660 1670 GEMKGHDSPI NAICVNSTHI FTAADDRTVR IWKARNLQDG QISDTGDLGE DIASN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1)." Yamada K., Andrews C., Chan W.M., McKeown C.A., Magli A., De Berardinis T., Loewenstein A., Lazar M., O'Keefe M., Letson R., London A., Ruttum M., Matsumoto N., Saito N., Morris L., Monte M.D., Johnson R.H., Uyama E. , Houtman W.A., De Vries B., Carlow T.J., Hart B.L., Krawiecki N., Shoffner J., Vogel M.C., Katowitz J., Goldstein S.M., Levin A.V., Sener E.C., Ozturk B.T., Akarsu A.N., Brodsky M.C., Hanisch F., Cruse R.P., Zubcov A.A., Robb R.M., Roggenkaemper P., Gottlob I., Kowal L., Battu R., Traboulsi E.I., Franceschini P., Newlin A., Demer J.L., Engle E.C. Nat. Genet. 35:318-321(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS CFEOM1 THR-356; ARG-947; VAL-947; GLN-954; TRP-954 AND THR-1010.
[2]	Zan Q., Guo J.H., Yu L. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free recombination: preparation of full-length cDNA clones encoding motor proteins." Yamakawa H., Kikuno R.F., Nagase T., Ohara O. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-597 (ISOFORM 2), IDENTIFICATION AS A RENAL CANCER ANTIGEN.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-586 (ISOFORM 2). Tissue: Colon.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-543 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1243-1674 (ISOFORM 4). Tissue: Adrenal cortex and Brain.
[9]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-1674 (ISOFORM 2). Tissue: Brain.
[10]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 654-1674 (ISOFORM 3). Tissue: Liver.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1212; SER-1239 AND SER-1673, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524; SER-1212; SER-1239; SER-1662; THR-1664 AND SER-1673, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1212 AND SER-1239, MASS SPECTROMETRY.
[17]	"A novel KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Marcus Gunn jaw-winking phenomenon." Yamada K., Hunter D.G., Andrews C., Engle E.C. Arch. Ophthalmol. 123:1254-1259(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CFEOM1 THR-947.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY368076 mRNA. Translation: AAR04774.1. AF450487 mRNA. Translation: AAP97680.1. Frameshift. AB290166 mRNA. Translation: BAG06720.1. AC084373 Genomic DNA. No translation available. AC090668 Genomic DNA. No translation available. AC121334 Genomic DNA. No translation available. AF155117 mRNA. Translation: AAD42883.1. Sequence problems. AK000059 mRNA. Translation: BAA90916.1. Sequence problems. CH471111 Genomic DNA. Translation: EAW57803.1. BC041430 mRNA. Translation: AAH41430.1. Sequence problems. BC047572 mRNA. Translation: AAH47572.1. AB051495 mRNA. Translation: BAB21799.2. BX537855 mRNA. Translation: CAD97863.1.
IPI	IPI00425404. IPI00425405. IPI00425407. IPI00425409.
RefSeq	NP_001166934.1. NM_001173463.1. NP_001166935.1. NM_001173464.1. NP_001166936.1. NM_001173465.1. NP_060111.2. NM_017641.3.
UniGene	Hs.374201.
3D structure databases
ProteinModelPortal	Q7Z4S6.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-56253N.
IntAct	Q7Z4S6. 3 interactions.
PTM databases
PhosphoSite	Q7Z4S6.
Polymorphism databases
DMDM	50400977.
Proteomic databases
PaxDb	Q7Z4S6.
PeptideAtlas	Q7Z4S6.
PRIDE	Q7Z4S6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361418; ENSP00000354878; ENSG00000139116. ENST00000361961; ENSP00000354851; ENSG00000139116.
GeneID	55605.
KEGG	hsa:55605.
UCSC	uc001rlw.3. human. uc001rlx.3. human. uc001rly.3. human.
Organism-specific databases
CTD	55605.
GeneCards	GC12M039687.
HGNC	HGNC:19349. KIF21A.
HPA	CAB022079.
MIM	135700. phenotype. 608283. gene.
neXtProt	NX_Q7Z4S6.
Orphanet	45358. Congenital fibrosis of extraocular muscles.
PharmGKB	PA134882934.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOVERGEN	HBG052247.
KO	K10395.
Gene expression databases
ArrayExpress	Q7Z4S6.
Bgee	Q7Z4S6.
CleanEx	HS_KIF21A.
Genevestigator	Q7Z4S6.
GermOnline	ENSG00000139116. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 3.40.850.10. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR009053. Prefoldin. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. PF00400. WD40. 4 hits. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF46579. Prefoldin. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KIF21A. human.
GenomeRNAi	55605.
NextBio	60157.
SOURCE	Search...

Entry information

Entry name

KI21A_HUMAN

Accession

Primary (citable) accession number: Q7Z4S6
Secondary accession number(s): A8MX28 , B0I1R9, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.