ID   Q7Z4R6_HUMAN            Unreviewed;       136 AA.
AC   Q7Z4R6;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Prothymosin alpha {ECO:0000256|ARBA:ARBA00040447};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAP97694.1};
RN   [1] {ECO:0000313|EMBL:AAP97694.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:AAP97694.1};
RA   Zan Q., Guo J.H., Yu L.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prothymosin alpha may mediate immune function by conferring
CC       resistance to certain opportunistic infections.
CC       {ECO:0000256|ARBA:ARBA00037621}.
CC   -!- SUBUNIT: Interacts with NUPR1; regulates apoptotic process.
CC       {ECO:0000256|ARBA:ARBA00038744}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the pro/parathymosin family.
CC       {ECO:0000256|ARBA:ARBA00008032}.
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DR   EMBL; AF452640; AAP97694.1; -; mRNA.
DR   AlphaFoldDB; Q7Z4R6; -.
DR   MaxQB; Q7Z4R6; -.
DR   PeptideAtlas; Q7Z4R6; -.
DR   InterPro; IPR004931; Pro/parathymosin.
DR   PANTHER; PTHR22745; PROTHYMOSIN ALPHA; 1.
DR   PANTHER; PTHR22745:SF0; PROTHYMOSIN ALPHA; 1.
DR   Pfam; PF03247; Prothymosin; 1.
PE   2: Evidence at transcript level;
FT   REGION          1..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..107
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   136 AA;  14577 MW;  287460E61D83C820 CRC64;
     MQTFGPAGVA AVGRRVESPA DRRATRARAT CKLCLPAGSL QGLKGEEGSV EEAENGRDAP
     ANGNANEENG EQEADNEVDE EEEEGGEEEE EEEEGDGEEE DGDEDEEAES ATGKRAAEDD
     EDDDVDTKKQ KTDEDD
//