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Protein

HEAT repeat-containing protein 3

Gene

HEATR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 3
Gene namesi
Name:HEATR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26087. HEATR3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596426.

Polymorphism and mutation databases

BioMutaiHEATR3.
DMDMi45477280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680HEAT repeat-containing protein 3PRO_0000050821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei340 – 3401PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z4Q2.
MaxQBiQ7Z4Q2.
PaxDbiQ7Z4Q2.
PeptideAtlasiQ7Z4Q2.
PRIDEiQ7Z4Q2.

PTM databases

iPTMnetiQ7Z4Q2.
PhosphoSiteiQ7Z4Q2.

Expressioni

Gene expression databases

BgeeiQ7Z4Q2.
CleanExiHS_HEATR3.
GenevisibleiQ7Z4Q2. HS.

Organism-specific databases

HPAiHPA041990.

Interactioni

Protein-protein interaction databases

BioGridi120357. 44 interactions.
IntActiQ7Z4Q2. 16 interactions.
STRINGi9606.ENSP00000299192.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 6932HEAT 1Add
BLAST
Repeati74 – 11037HEAT 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 287Poly-Ala

Sequence similaritiesi

Contains 2 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGCR. Eukaryota.
ENOG410Y5P1. LUCA.
GeneTreeiENSGT00390000012529.
HOGENOMiHOG000008167.
HOVERGENiHBG047958.
InParanoidiQ7Z4Q2.
OMAiQTMASKN.
OrthoDBiEOG7S7SD8.
PhylomeDBiQ7Z4Q2.
TreeFamiTF324159.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKSRTKRFK RPQFSPTGDC QAEAAAAANG TGGEEDDGPA AELLEKLQHP
60 70 80 90 100
SAEVRECACA GLARLVQQRP ALPGLARRDA VRRLGPLLLD PSLAVRETAA
110 120 130 140 150
GALRNLSACG GFEVCDDMVT KDIMTPLVAL LKECSAGLDS NEMSLQEKKD
160 170 180 190 200
QNRNSIENIA NETVNVLWNI CECSSRAVSI FNKEGCLEIV LKYLSRFPTN
210 220 230 240 250
VDLAISVAYC LQTVTEDNPE LLKSFSATAL NMLESALLSP VSSMESLLLK
260 270 280 290 300
TLVAGTIWNL KDIIPCKSQA EIINALLKIL SEVLGMDAGE MVIQMKEAET
310 320 330 340 350
QRLKTAAEAE EILENTNGDD LIEDDEMEGI SHKRRVRRKT FVSDLLPPTD
360 370 380 390 400
KELRETIALL TAQQTALEII VNMCCNEDPS DDEWEELSSS DESDAFMENS
410 420 430 440 450
FSECGGQLFS PLCLSHEVHT ALTNYLIPKK IFEKTAFPNS IAVDLCSRNP
460 470 480 490 500
TWKPLIRKMN TIQCRALFCL QSLVSLLDVE HLGGAAALQT LAQHLSQLLF
510 520 530 540 550
SQPDFAKHVD FLEAISSALR ALLQTMASKN ISQCMTPDQL MTLCKAGIHS
560 570 580 590 600
SNVGVRVNVV SILGITGSVL AKEDGTLETL KNIGCFLLEV TTKDPSLVVA
610 620 630 640 650
GEALDALFDV FADGKEAERA SIQIKLLSAL KEFQPVFKMK IRKEGRGNYS
660 670 680
TDQLCVLDNV KMNLRRFIAY QETVEKRLTS
Length:680
Mass (Da):74,583
Last modified:March 15, 2004 - v2
Checksum:iF7892F94AC5103B5
GO
Isoform 2 (identifier: Q7Z4Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGKSRTKRFK...ETAAGALRNL → MGPEARRTTGRRRSCWKRNP

Show »
Length:594
Mass (Da):65,813
Checksum:i4B68D5E367072F4D
GO
Isoform 3 (identifier: Q7Z4Q2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGKSRTKRFK...ETAAGALRNL → MGPEARRTTGRRRSCWKRNP
     378-400: DPSDDEWEELSSSDESDAFMENS → GLLTFTFRHFPPEPRGKLPWRFS
     401-680: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:314
Mass (Da):35,134
Checksum:iF762BC9F4F7B61A4
GO

Sequence cautioni

The sequence AAH14415.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971F → L in AAP97710 (Ref. 1) Curated
Isoform 3 (identifier: Q7Z4Q2-3)
Sequence conflicti20 – 201P → L in AAP97710 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti302 – 3021R → S.
Corresponds to variant rs34703459 [ dbSNP | Ensembl ].
VAR_033989

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106MGKSR…ALRNL → MGPEARRTTGRRRSCWKRNP in isoform 2 and isoform 3. 2 PublicationsVSP_009640Add
BLAST
Alternative sequencei378 – 40023DPSDD…FMENS → GLLTFTFRHFPPEPRGKLPW RFS in isoform 3. 1 PublicationVSP_009641Add
BLAST
Alternative sequencei401 – 680280Missing in isoform 3. 1 PublicationVSP_009642Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462442 mRNA. Translation: AAP97710.1.
AK000725 mRNA. Translation: BAA91342.1.
AK289949 mRNA. Translation: BAF82638.1.
CH471092 Genomic DNA. Translation: EAW82743.1.
BC014415 mRNA. Translation: AAH14415.1. Different initiation.
BC018730 mRNA. Translation: AAH18730.2.
BC033077 mRNA. Translation: AAH33077.1.
CCDSiCCDS10739.1. [Q7Z4Q2-1]
RefSeqiNP_891552.1. NM_182922.2. [Q7Z4Q2-1]
UniGeneiHs.733027.

Genome annotation databases

EnsembliENST00000299192; ENSP00000299192; ENSG00000155393. [Q7Z4Q2-1]
GeneIDi55027.
KEGGihsa:55027.
UCSCiuc002efw.4. human. [Q7Z4Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462442 mRNA. Translation: AAP97710.1.
AK000725 mRNA. Translation: BAA91342.1.
AK289949 mRNA. Translation: BAF82638.1.
CH471092 Genomic DNA. Translation: EAW82743.1.
BC014415 mRNA. Translation: AAH14415.1. Different initiation.
BC018730 mRNA. Translation: AAH18730.2.
BC033077 mRNA. Translation: AAH33077.1.
CCDSiCCDS10739.1. [Q7Z4Q2-1]
RefSeqiNP_891552.1. NM_182922.2. [Q7Z4Q2-1]
UniGeneiHs.733027.

3D structure databases

ProteinModelPortaliQ7Z4Q2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120357. 44 interactions.
IntActiQ7Z4Q2. 16 interactions.
STRINGi9606.ENSP00000299192.

PTM databases

iPTMnetiQ7Z4Q2.
PhosphoSiteiQ7Z4Q2.

Polymorphism and mutation databases

BioMutaiHEATR3.
DMDMi45477280.

Proteomic databases

EPDiQ7Z4Q2.
MaxQBiQ7Z4Q2.
PaxDbiQ7Z4Q2.
PeptideAtlasiQ7Z4Q2.
PRIDEiQ7Z4Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299192; ENSP00000299192; ENSG00000155393. [Q7Z4Q2-1]
GeneIDi55027.
KEGGihsa:55027.
UCSCiuc002efw.4. human. [Q7Z4Q2-1]

Organism-specific databases

CTDi55027.
GeneCardsiHEATR3.
H-InvDBHIX0013021.
HGNCiHGNC:26087. HEATR3.
HPAiHPA041990.
MIMi614951. gene.
neXtProtiNX_Q7Z4Q2.
PharmGKBiPA144596426.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGCR. Eukaryota.
ENOG410Y5P1. LUCA.
GeneTreeiENSGT00390000012529.
HOGENOMiHOG000008167.
HOVERGENiHBG047958.
InParanoidiQ7Z4Q2.
OMAiQTMASKN.
OrthoDBiEOG7S7SD8.
PhylomeDBiQ7Z4Q2.
TreeFamiTF324159.

Miscellaneous databases

ChiTaRSiHEATR3. human.
GenomeRNAii55027.
PROiQ7Z4Q2.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z4Q2.
CleanExiHS_HEATR3.
GenevisibleiQ7Z4Q2. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Wu Q., Guo J.H., Yu L.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Hepatoma and Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas, Skin and Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-340, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHEAT3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4Q2
Secondary accession number(s): A8K1N4
, Q8N525, Q8WV56, Q96CC9, Q9NWN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.