ID   GDF7_HUMAN              Reviewed;         450 AA.
AC   Q7Z4P5;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   27-MAR-2024, entry version 135.
DE   RecName: Full=Growth/differentiation factor 7;
DE            Short=GDF-7;
DE   Flags: Precursor;
GN   Name=GDF7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RA   Guo J.H., Yu L.;
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- FUNCTION: May play an active role in the motor area of the primate
CC       neocortex. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR   EMBL; AF522369; AAP97720.1; -; mRNA.
DR   EMBL; AC012065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS1701.1; -.
DR   RefSeq; NP_878248.2; NM_182828.3.
DR   AlphaFoldDB; Q7Z4P5; -.
DR   SMR; Q7Z4P5; -.
DR   STRING; 9606.ENSP00000272224; -.
DR   GlyCosmos; Q7Z4P5; 1 site, No reported glycans.
DR   GlyGen; Q7Z4P5; 1 site.
DR   iPTMnet; Q7Z4P5; -.
DR   PhosphoSitePlus; Q7Z4P5; -.
DR   BioMuta; GDF7; -.
DR   DMDM; 296434517; -.
DR   jPOST; Q7Z4P5; -.
DR   MassIVE; Q7Z4P5; -.
DR   PaxDb; 9606-ENSP00000272224; -.
DR   PeptideAtlas; Q7Z4P5; -.
DR   ProteomicsDB; 69219; -.
DR   Antibodypedia; 27314; 281 antibodies from 28 providers.
DR   DNASU; 151449; -.
DR   Ensembl; ENST00000272224.5; ENSP00000272224.3; ENSG00000143869.7.
DR   GeneID; 151449; -.
DR   KEGG; hsa:151449; -.
DR   MANE-Select; ENST00000272224.5; ENSP00000272224.3; NM_182828.4; NP_878248.2.
DR   UCSC; uc002rdz.2; human.
DR   AGR; HGNC:4222; -.
DR   CTD; 151449; -.
DR   DisGeNET; 151449; -.
DR   GeneCards; GDF7; -.
DR   HGNC; HGNC:4222; GDF7.
DR   HPA; ENSG00000143869; Tissue enhanced (cervix, seminal vesicle).
DR   MIM; 604651; gene.
DR   neXtProt; NX_Q7Z4P5; -.
DR   OpenTargets; ENSG00000143869; -.
DR   PharmGKB; PA28637; -.
DR   VEuPathDB; HostDB:ENSG00000143869; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   GeneTree; ENSGT00940000160140; -.
DR   HOGENOM; CLU_020515_0_1_1; -.
DR   InParanoid; Q7Z4P5; -.
DR   OMA; RAPRAFC; -.
DR   OrthoDB; 2912454at2759; -.
DR   PhylomeDB; Q7Z4P5; -.
DR   TreeFam; TF316134; -.
DR   PathwayCommons; Q7Z4P5; -.
DR   SignaLink; Q7Z4P5; -.
DR   BioGRID-ORCS; 151449; 15 hits in 1144 CRISPR screens.
DR   GeneWiki; GDF7; -.
DR   GenomeRNAi; 151449; -.
DR   Pharos; Q7Z4P5; Tbio.
DR   PRO; PR:Q7Z4P5; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q7Z4P5; Protein.
DR   Bgee; ENSG00000143869; Expressed in seminal vesicle and 129 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0032924; P:activin receptor signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR   GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0048853; P:forebrain morphogenesis; IEA:Ensembl.
DR   GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
DR   GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR   GO; GO:0060571; P:morphogenesis of an epithelial fold; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:BHF-UCL.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IDA:BHF-UCL.
DR   GO; GO:2001051; P:positive regulation of tendon cell differentiation; IEA:Ensembl.
DR   GO; GO:0048608; P:reproductive structure development; IEA:Ensembl.
DR   GO; GO:0021509; P:roof plate formation; IEA:Ensembl.
DR   GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
DR   CDD; cd13766; TGF_beta_GDF5_6_7; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF160; GROWTH_DIFFERENTIATION FACTOR 7; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
DR   Genevisible; Q7Z4P5; HS.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..321
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033922"
FT   CHAIN           322..450
FT                   /note="Growth/differentiation factor 7"
FT                   /id="PRO_0000033923"
FT   REGION          296..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        349..415
FT                   /evidence="ECO:0000250"
FT   DISULFID        378..447
FT                   /evidence="ECO:0000250"
FT   DISULFID        382..449
FT                   /evidence="ECO:0000250"
FT   DISULFID        414
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        330
FT                   /note="A -> S (in Ref. 1; AAP97720)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   450 AA;  46950 MW;  C7D4D417685D25BD CRC64;
     MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG RTLAQAAGAA
     AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA GRAPAGAAAV SASGHGRADT
     ITGFTDQATQ DESAAETGQS FLFDVSSLND ADEVVGAELR VLRRGSPESG PGSWTSPPLL
     LLSTCPGAAR APRLLYSRAA EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP
     VPSPLALRRL GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL
     PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS RKPLHVDFKE
     LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT LLNSMAPDAA PASCCVPARL
     SPISILYIDA ANNVVYKQYE DMVVEACGCR
//