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Protein

Growth/differentiation factor 7

Gene

GDF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play an active role in the motor area of the primate neocortex.By similarity

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  1. activin receptor signaling pathway Source: BHF-UCL
  2. axon guidance Source: Ensembl
  3. BMP signaling pathway Source: BHF-UCL
  4. branching morphogenesis of an epithelial tube Source: Ensembl
  5. cell development Source: GO_Central
  6. cell fate commitment Source: Ensembl
  7. epithelial cell differentiation Source: Ensembl
  8. forebrain morphogenesis Source: Ensembl
  9. gland morphogenesis Source: Ensembl
  10. growth Source: InterPro
  11. midbrain development Source: Ensembl
  12. morphogenesis of an epithelial fold Source: Ensembl
  13. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  14. positive regulation of neuron differentiation Source: Ensembl
  15. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  16. positive regulation of tendon cell differentiation Source: Ensembl
  17. positive regulation of transcription, DNA-templated Source: BHF-UCL
  18. regulation of apoptotic process Source: GO_Central
  19. regulation of MAPK cascade Source: GO_Central
  20. reproductive structure development Source: Ensembl
  21. roof plate formation Source: Ensembl
  22. SMAD protein signal transduction Source: GO_Central
  23. spinal cord association neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 7
Short name:
GDF-7
Gene namesi
Name:GDF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4222. GDF7.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 321302Sequence AnalysisPRO_0000033922Add
BLAST
Chaini322 – 450129Growth/differentiation factor 7PRO_0000033923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi349 ↔ 415By similarity
Disulfide bondi378 ↔ 447By similarity
Disulfide bondi382 ↔ 449By similarity
Disulfide bondi414 – 414InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z4P5.
PRIDEiQ7Z4P5.

Expressioni

Gene expression databases

BgeeiQ7Z4P5.
CleanExiHS_GDF7.
ExpressionAtlasiQ7Z4P5. baseline.
GenevestigatoriQ7Z4P5.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000272224.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4P5.
SMRiQ7Z4P5. Positions 347-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOVERGENiHBG107938.
InParanoidiQ7Z4P5.
KOiK04664.
OMAiITGFTDQ.
OrthoDBiEOG7WMCK0.
PhylomeDBiQ7Z4P5.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG
60 70 80 90 100
RTLAQAAGAA AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA
110 120 130 140 150
GRAPAGAAAV SASGHGRADT ITGFTDQATQ DESAAETGQS FLFDVSSLND
160 170 180 190 200
ADEVVGAELR VLRRGSPESG PGSWTSPPLL LLSTCPGAAR APRLLYSRAA
210 220 230 240 250
EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP VPSPLALRRL
260 270 280 290 300
GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL
310 320 330 340 350
PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS
360 370 380 390 400
RKPLHVDFKE LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT
410 420 430 440 450
LLNSMAPDAA PASCCVPARL SPISILYIDA ANNVVYKQYE DMVVEACGCR
Length:450
Mass (Da):46,950
Last modified:May 18, 2010 - v2
Checksum:iC7D4D417685D25BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301A → S in AAP97720 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522369 mRNA. Translation: AAP97720.1.
AC012065 Genomic DNA. No translation available.
CCDSiCCDS1701.1.
RefSeqiNP_878248.2. NM_182828.2.
UniGeneiHs.447688.

Genome annotation databases

EnsembliENST00000272224; ENSP00000272224; ENSG00000143869.
GeneIDi151449.
KEGGihsa:151449.
UCSCiuc002rdz.1. human.

Polymorphism databases

DMDMi296434517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522369 mRNA. Translation: AAP97720.1.
AC012065 Genomic DNA. No translation available.
CCDSiCCDS1701.1.
RefSeqiNP_878248.2. NM_182828.2.
UniGeneiHs.447688.

3D structure databases

ProteinModelPortaliQ7Z4P5.
SMRiQ7Z4P5. Positions 347-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000272224.

Polymorphism databases

DMDMi296434517.

Proteomic databases

PaxDbiQ7Z4P5.
PRIDEiQ7Z4P5.

Protocols and materials databases

DNASUi151449.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272224; ENSP00000272224; ENSG00000143869.
GeneIDi151449.
KEGGihsa:151449.
UCSCiuc002rdz.1. human.

Organism-specific databases

CTDi151449.
GeneCardsiGC02P020788.
HGNCiHGNC:4222. GDF7.
MIMi604651. gene.
neXtProtiNX_Q7Z4P5.
PharmGKBiPA28637.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOVERGENiHBG107938.
InParanoidiQ7Z4P5.
KOiK04664.
OMAiITGFTDQ.
OrthoDBiEOG7WMCK0.
PhylomeDBiQ7Z4P5.
TreeFamiTF316134.

Miscellaneous databases

GeneWikiiGDF7.
GenomeRNAii151449.
NextBioi86692.
PROiQ7Z4P5.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z4P5.
CleanExiHS_GDF7.
ExpressionAtlasiQ7Z4P5. baseline.
GenevestigatoriQ7Z4P5.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Guo J.H., Yu L.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGDF7_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.