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Q7Z4P5

- GDF7_HUMAN

UniProt

Q7Z4P5 - GDF7_HUMAN

Protein

Growth/differentiation factor 7

Gene

GDF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May play an active role in the motor area of the primate neocortex.By similarity

    GO - Molecular functioni

    1. protein binding Source: BHF-UCL

    GO - Biological processi

    1. activin receptor signaling pathway Source: BHF-UCL
    2. axon guidance Source: Ensembl
    3. BMP signaling pathway Source: BHF-UCL
    4. branching morphogenesis of an epithelial tube Source: Ensembl
    5. cell fate commitment Source: Ensembl
    6. epithelial cell differentiation Source: Ensembl
    7. forebrain morphogenesis Source: Ensembl
    8. gland morphogenesis Source: Ensembl
    9. growth Source: InterPro
    10. midbrain development Source: Ensembl
    11. morphogenesis of an epithelial fold Source: Ensembl
    12. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    13. positive regulation of neuron differentiation Source: Ensembl
    14. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    15. positive regulation of tendon cell differentiation Source: Ensembl
    16. positive regulation of transcription, DNA-templated Source: BHF-UCL
    17. reproductive structure development Source: Ensembl
    18. roof plate formation Source: Ensembl
    19. spinal cord association neuron differentiation Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 7
    Short name:
    GDF-7
    Gene namesi
    Name:GDF7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4222. GDF7.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28637.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 321302Sequence AnalysisPRO_0000033922Add
    BLAST
    Chaini322 – 450129Growth/differentiation factor 7PRO_0000033923Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi349 ↔ 415By similarity
    Disulfide bondi378 ↔ 447By similarity
    Disulfide bondi382 ↔ 449By similarity
    Disulfide bondi414 – 414InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ7Z4P5.
    PRIDEiQ7Z4P5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z4P5.
    BgeeiQ7Z4P5.
    CleanExiHS_GDF7.
    GenevestigatoriQ7Z4P5.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000272224.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z4P5.
    SMRiQ7Z4P5. Positions 347-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG317866.
    HOVERGENiHBG107938.
    InParanoidiQ7Z4P5.
    KOiK04664.
    OMAiITGFTDQ.
    OrthoDBiEOG7WMCK0.
    PhylomeDBiQ7Z4P5.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z4P5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG    50
    RTLAQAAGAA AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA 100
    GRAPAGAAAV SASGHGRADT ITGFTDQATQ DESAAETGQS FLFDVSSLND 150
    ADEVVGAELR VLRRGSPESG PGSWTSPPLL LLSTCPGAAR APRLLYSRAA 200
    EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP VPSPLALRRL 250
    GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL 300
    PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS 350
    RKPLHVDFKE LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT 400
    LLNSMAPDAA PASCCVPARL SPISILYIDA ANNVVYKQYE DMVVEACGCR 450
    Length:450
    Mass (Da):46,950
    Last modified:May 18, 2010 - v2
    Checksum:iC7D4D417685D25BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti330 – 3301A → S in AAP97720. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF522369 mRNA. Translation: AAP97720.1.
    AC012065 Genomic DNA. No translation available.
    CCDSiCCDS1701.1.
    RefSeqiNP_878248.2. NM_182828.2.
    UniGeneiHs.447688.

    Genome annotation databases

    EnsembliENST00000272224; ENSP00000272224; ENSG00000143869.
    GeneIDi151449.
    KEGGihsa:151449.
    UCSCiuc002rdz.1. human.

    Polymorphism databases

    DMDMi296434517.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF522369 mRNA. Translation: AAP97720.1 .
    AC012065 Genomic DNA. No translation available.
    CCDSi CCDS1701.1.
    RefSeqi NP_878248.2. NM_182828.2.
    UniGenei Hs.447688.

    3D structure databases

    ProteinModelPortali Q7Z4P5.
    SMRi Q7Z4P5. Positions 347-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000272224.

    Polymorphism databases

    DMDMi 296434517.

    Proteomic databases

    PaxDbi Q7Z4P5.
    PRIDEi Q7Z4P5.

    Protocols and materials databases

    DNASUi 151449.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272224 ; ENSP00000272224 ; ENSG00000143869 .
    GeneIDi 151449.
    KEGGi hsa:151449.
    UCSCi uc002rdz.1. human.

    Organism-specific databases

    CTDi 151449.
    GeneCardsi GC02P020788.
    HGNCi HGNC:4222. GDF7.
    MIMi 604651. gene.
    neXtProti NX_Q7Z4P5.
    PharmGKBi PA28637.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317866.
    HOVERGENi HBG107938.
    InParanoidi Q7Z4P5.
    KOi K04664.
    OMAi ITGFTDQ.
    OrthoDBi EOG7WMCK0.
    PhylomeDBi Q7Z4P5.
    TreeFami TF316134.

    Miscellaneous databases

    GeneWikii GDF7.
    GenomeRNAii 151449.
    NextBioi 86692.
    PROi Q7Z4P5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z4P5.
    Bgeei Q7Z4P5.
    CleanExi HS_GDF7.
    Genevestigatori Q7Z4P5.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Guo J.H., Yu L.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGDF7_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z4P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3