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Q7Z4P5

- GDF7_HUMAN

UniProt

Q7Z4P5 - GDF7_HUMAN

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Protein

Growth/differentiation factor 7

Gene

GDF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play an active role in the motor area of the primate neocortex.By similarity

GO - Biological processi

  1. activin receptor signaling pathway Source: BHF-UCL
  2. axon guidance Source: Ensembl
  3. BMP signaling pathway Source: BHF-UCL
  4. branching morphogenesis of an epithelial tube Source: Ensembl
  5. cell fate commitment Source: Ensembl
  6. epithelial cell differentiation Source: Ensembl
  7. forebrain morphogenesis Source: Ensembl
  8. gland morphogenesis Source: Ensembl
  9. growth Source: InterPro
  10. midbrain development Source: Ensembl
  11. morphogenesis of an epithelial fold Source: Ensembl
  12. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  13. positive regulation of neuron differentiation Source: Ensembl
  14. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  15. positive regulation of tendon cell differentiation Source: Ensembl
  16. positive regulation of transcription, DNA-templated Source: BHF-UCL
  17. reproductive structure development Source: Ensembl
  18. roof plate formation Source: Ensembl
  19. spinal cord association neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 7
Short name:
GDF-7
Gene namesi
Name:GDF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4222. GDF7.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 321302Sequence AnalysisPRO_0000033922Add
BLAST
Chaini322 – 450129Growth/differentiation factor 7PRO_0000033923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi349 ↔ 415By similarity
Disulfide bondi378 ↔ 447By similarity
Disulfide bondi382 ↔ 449By similarity
Disulfide bondi414 – 414InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z4P5.
PRIDEiQ7Z4P5.

Expressioni

Gene expression databases

BgeeiQ7Z4P5.
CleanExiHS_GDF7.
ExpressionAtlasiQ7Z4P5. baseline.
GenevestigatoriQ7Z4P5.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000272224.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4P5.
SMRiQ7Z4P5. Positions 347-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOVERGENiHBG107938.
InParanoidiQ7Z4P5.
KOiK04664.
OMAiITGFTDQ.
OrthoDBiEOG7WMCK0.
PhylomeDBiQ7Z4P5.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4P5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG
60 70 80 90 100
RTLAQAAGAA AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA
110 120 130 140 150
GRAPAGAAAV SASGHGRADT ITGFTDQATQ DESAAETGQS FLFDVSSLND
160 170 180 190 200
ADEVVGAELR VLRRGSPESG PGSWTSPPLL LLSTCPGAAR APRLLYSRAA
210 220 230 240 250
EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP VPSPLALRRL
260 270 280 290 300
GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL
310 320 330 340 350
PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS
360 370 380 390 400
RKPLHVDFKE LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT
410 420 430 440 450
LLNSMAPDAA PASCCVPARL SPISILYIDA ANNVVYKQYE DMVVEACGCR
Length:450
Mass (Da):46,950
Last modified:May 18, 2010 - v2
Checksum:iC7D4D417685D25BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301A → S in AAP97720. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF522369 mRNA. Translation: AAP97720.1.
AC012065 Genomic DNA. No translation available.
CCDSiCCDS1701.1.
RefSeqiNP_878248.2. NM_182828.2.
UniGeneiHs.447688.

Genome annotation databases

EnsembliENST00000272224; ENSP00000272224; ENSG00000143869.
GeneIDi151449.
KEGGihsa:151449.
UCSCiuc002rdz.1. human.

Polymorphism databases

DMDMi296434517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF522369 mRNA. Translation: AAP97720.1 .
AC012065 Genomic DNA. No translation available.
CCDSi CCDS1701.1.
RefSeqi NP_878248.2. NM_182828.2.
UniGenei Hs.447688.

3D structure databases

ProteinModelPortali Q7Z4P5.
SMRi Q7Z4P5. Positions 347-450.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000272224.

Polymorphism databases

DMDMi 296434517.

Proteomic databases

PaxDbi Q7Z4P5.
PRIDEi Q7Z4P5.

Protocols and materials databases

DNASUi 151449.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272224 ; ENSP00000272224 ; ENSG00000143869 .
GeneIDi 151449.
KEGGi hsa:151449.
UCSCi uc002rdz.1. human.

Organism-specific databases

CTDi 151449.
GeneCardsi GC02P020788.
HGNCi HGNC:4222. GDF7.
MIMi 604651. gene.
neXtProti NX_Q7Z4P5.
PharmGKBi PA28637.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317866.
GeneTreei ENSGT00760000118883.
HOVERGENi HBG107938.
InParanoidi Q7Z4P5.
KOi K04664.
OMAi ITGFTDQ.
OrthoDBi EOG7WMCK0.
PhylomeDBi Q7Z4P5.
TreeFami TF316134.

Miscellaneous databases

GeneWikii GDF7.
GenomeRNAii 151449.
NextBioi 86692.
PROi Q7Z4P5.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z4P5.
CleanExi HS_GDF7.
ExpressionAtlasi Q7Z4P5. baseline.
Genevestigatori Q7Z4P5.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Guo J.H., Yu L.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGDF7_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3