Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth/differentiation factor 7

Gene

GDF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play an active role in the motor area of the primate neocortex.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 7
Short name:
GDF-7
Gene namesi
Name:GDF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4222. GDF7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi151449.
OpenTargetsiENSG00000143869.
PharmGKBiPA28637.

Polymorphism and mutation databases

BioMutaiGDF7.
DMDMi296434517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003392220 – 321Sequence analysisAdd BLAST302
ChainiPRO_0000033923322 – 450Growth/differentiation factor 7Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi349 ↔ 415By similarity
Disulfide bondi378 ↔ 447By similarity
Disulfide bondi382 ↔ 449By similarity
Disulfide bondi414InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z4P5.
PeptideAtlasiQ7Z4P5.
PRIDEiQ7Z4P5.

PTM databases

iPTMnetiQ7Z4P5.
PhosphoSitePlusiQ7Z4P5.

Expressioni

Gene expression databases

BgeeiENSG00000143869.
CleanExiHS_GDF7.
GenevisibleiQ7Z4P5. HS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000272224.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOVERGENiHBG107938.
InParanoidiQ7Z4P5.
KOiK20013.
OMAiHFMMSLY.
OrthoDBiEOG091G09KP.
PhylomeDBiQ7Z4P5.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG
60 70 80 90 100
RTLAQAAGAA AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA
110 120 130 140 150
GRAPAGAAAV SASGHGRADT ITGFTDQATQ DESAAETGQS FLFDVSSLND
160 170 180 190 200
ADEVVGAELR VLRRGSPESG PGSWTSPPLL LLSTCPGAAR APRLLYSRAA
210 220 230 240 250
EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP VPSPLALRRL
260 270 280 290 300
GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL
310 320 330 340 350
PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS
360 370 380 390 400
RKPLHVDFKE LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT
410 420 430 440 450
LLNSMAPDAA PASCCVPARL SPISILYIDA ANNVVYKQYE DMVVEACGCR
Length:450
Mass (Da):46,950
Last modified:May 18, 2010 - v2
Checksum:iC7D4D417685D25BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330A → S in AAP97720 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522369 mRNA. Translation: AAP97720.1.
AC012065 Genomic DNA. No translation available.
CCDSiCCDS1701.1.
RefSeqiNP_878248.2. NM_182828.3.
UniGeneiHs.447688.
Hs.596282.

Genome annotation databases

EnsembliENST00000272224; ENSP00000272224; ENSG00000143869.
GeneIDi151449.
KEGGihsa:151449.
UCSCiuc002rdz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522369 mRNA. Translation: AAP97720.1.
AC012065 Genomic DNA. No translation available.
CCDSiCCDS1701.1.
RefSeqiNP_878248.2. NM_182828.3.
UniGeneiHs.447688.
Hs.596282.

3D structure databases

ProteinModelPortaliQ7Z4P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000272224.

PTM databases

iPTMnetiQ7Z4P5.
PhosphoSitePlusiQ7Z4P5.

Polymorphism and mutation databases

BioMutaiGDF7.
DMDMi296434517.

Proteomic databases

PaxDbiQ7Z4P5.
PeptideAtlasiQ7Z4P5.
PRIDEiQ7Z4P5.

Protocols and materials databases

DNASUi151449.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272224; ENSP00000272224; ENSG00000143869.
GeneIDi151449.
KEGGihsa:151449.
UCSCiuc002rdz.2. human.

Organism-specific databases

CTDi151449.
DisGeNETi151449.
GeneCardsiGDF7.
HGNCiHGNC:4222. GDF7.
MIMi604651. gene.
neXtProtiNX_Q7Z4P5.
OpenTargetsiENSG00000143869.
PharmGKBiPA28637.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOVERGENiHBG107938.
InParanoidiQ7Z4P5.
KOiK20013.
OMAiHFMMSLY.
OrthoDBiEOG091G09KP.
PhylomeDBiQ7Z4P5.
TreeFamiTF316134.

Miscellaneous databases

GeneWikiiGDF7.
GenomeRNAii151449.
PROiQ7Z4P5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143869.
CleanExiHS_GDF7.
GenevisibleiQ7Z4P5. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDF7_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.