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Q7Z4P5 (GDF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth/differentiation factor 7

Short name=GDF-7
Gene names
Name:GDF7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an active role in the motor area of the primate neocortex By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 16049014. Source: BHF-UCL

activin receptor signaling pathway

Inferred from direct assay PubMed 16049014. Source: BHF-UCL

axon guidance

Inferred from electronic annotation. Source: Ensembl

branching morphogenesis of an epithelial tube

Inferred from electronic annotation. Source: Ensembl

cell fate commitment

Inferred from electronic annotation. Source: Ensembl

epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

forebrain morphogenesis

Inferred from electronic annotation. Source: Ensembl

gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

growth

Inferred from electronic annotation. Source: InterPro

midbrain development

Inferred from electronic annotation. Source: Ensembl

morphogenesis of an epithelial fold

Inferred from electronic annotation. Source: Ensembl

pathway-restricted SMAD protein phosphorylation

Inferred from direct assay PubMed 16049014. Source: BHF-UCL

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from direct assay PubMed 16049014. Source: BHF-UCL

positive regulation of tendon cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 16049014. Source: BHF-UCL

reproductive structure development

Inferred from electronic annotation. Source: Ensembl

roof plate formation

Inferred from electronic annotation. Source: Ensembl

spinal cord association neuron differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 321302 Potential
PRO_0000033922
Chain322 – 450129Growth/differentiation factor 7
PRO_0000033923

Amino acid modifications

Glycosylation831N-linked (GlcNAc...) Potential
Disulfide bond349 ↔ 415 By similarity
Disulfide bond378 ↔ 447 By similarity
Disulfide bond382 ↔ 449 By similarity
Disulfide bond414Interchain By similarity

Experimental info

Sequence conflict3301A → S in AAP97720. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z4P5 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: C7D4D417685D25BD

FASTA45046,950
        10         20         30         40         50         60 
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG RTLAQAAGAA 

        70         80         90        100        110        120 
AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA GRAPAGAAAV SASGHGRADT 

       130        140        150        160        170        180 
ITGFTDQATQ DESAAETGQS FLFDVSSLND ADEVVGAELR VLRRGSPESG PGSWTSPPLL 

       190        200        210        220        230        240 
LLSTCPGAAR APRLLYSRAA EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP 

       250        260        270        280        290        300 
VPSPLALRRL GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL 

       310        320        330        340        350        360 
PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS RKPLHVDFKE 

       370        380        390        400        410        420 
LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT LLNSMAPDAA PASCCVPARL 

       430        440        450 
SPISILYIDA ANNVVYKQYE DMVVEACGCR 

« Hide

References

[1]Guo J.H., Yu L.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF522369 mRNA. Translation: AAP97720.1.
AC012065 Genomic DNA. No translation available.
RefSeqNP_878248.2. NM_182828.2.
UniGeneHs.447688.

3D structure databases

ProteinModelPortalQ7Z4P5.
SMRQ7Z4P5. Positions 347-450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000272224.

Polymorphism databases

DMDM296434517.

Proteomic databases

PaxDbQ7Z4P5.
PRIDEQ7Z4P5.

Protocols and materials databases

DNASU151449.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272224; ENSP00000272224; ENSG00000143869.
GeneID151449.
KEGGhsa:151449.
UCSCuc002rdz.1. human.

Organism-specific databases

CTD151449.
GeneCardsGC02P020788.
HGNCHGNC:4222. GDF7.
MIM604651. gene.
neXtProtNX_Q7Z4P5.
PharmGKBPA28637.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317866.
HOVERGENHBG107938.
InParanoidQ7Z4P5.
KOK04664.
OMAITGFTDQ.
OrthoDBEOG7WMCK0.
PhylomeDBQ7Z4P5.
TreeFamTF316134.

Gene expression databases

ArrayExpressQ7Z4P5.
BgeeQ7Z4P5.
CleanExHS_GDF7.
GenevestigatorQ7Z4P5.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGDF7.
GenomeRNAi151449.
NextBio86692.
PROQ7Z4P5.
SOURCESearch...

Entry information

Entry nameGDF7_HUMAN
AccessionPrimary (citable) accession number: Q7Z4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM