Q7Z4P5 (GDF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Growth/differentiation factor 7
Short name=GDF-7

Gene names

Name:

GDF7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play an active role in the motor area of the primate neocortex By similarity.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay PubMed 16049014. Source: BHF-UCL activin receptor signaling pathway Inferred from direct assay PubMed 16049014. Source: BHF-UCL axon guidance Inferred from electronic annotation. Source: Compara branching morphogenesis of an epithelial tube Inferred from electronic annotation. Source: Compara cell fate commitment Inferred from electronic annotation. Source: Compara epithelial cell differentiation Inferred from electronic annotation. Source: Compara forebrain morphogenesis Inferred from electronic annotation. Source: Compara gland morphogenesis Inferred from electronic annotation. Source: Compara growth Inferred from electronic annotation. Source: InterPro midbrain development Inferred from electronic annotation. Source: Compara morphogenesis of an epithelial fold Inferred from electronic annotation. Source: Compara pathway-restricted SMAD protein phosphorylation Inferred from direct assay PubMed 16049014. Source: BHF-UCL positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from direct assay PubMed 16049014. Source: BHF-UCL positive regulation of tendon cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 16049014. Source: BHF-UCL reproductive structure development Inferred from electronic annotation. Source: Compara roof plate formation Inferred from electronic annotation. Source: Compara spinal cord association neuron differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 321	302	Potential		PRO_0000033922
	Chain	322 – 450	129	Growth/differentiation factor 7		PRO_0000033923
Amino acid modifications
	Glycosylation	83	1	N-linked (GlcNAc...) Potential
	Disulfide bond	349 ↔ 415		By similarity
	Disulfide bond	378 ↔ 447		By similarity
	Disulfide bond	382 ↔ 449		By similarity
	Disulfide bond	414		Interchain By similarity
Experimental info
	Sequence conflict	330	1	A → S in AAP97720. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z4P5 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: C7D4D417685D25BD	FASTA	450	46,950
	10 20 30 40 50 60 MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG RTLAQAAGAA 70 80 90 100 110 120 AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA GRAPAGAAAV SASGHGRADT 130 140 150 160 170 180 ITGFTDQATQ DESAAETGQS FLFDVSSLND ADEVVGAELR VLRRGSPESG PGSWTSPPLL 190 200 210 220 230 240 LLSTCPGAAR APRLLYSRAA EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP 250 260 270 280 290 300 VPSPLALRRL GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL 310 320 330 340 350 360 PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS RKPLHVDFKE 370 380 390 400 410 420 LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT LLNSMAPDAA PASCCVPARL 430 440 450 SPISILYIDA ANNVVYKQYE DMVVEACGCR

References

[1]	Guo J.H., Yu L. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF522369 mRNA. Translation: AAP97720.1. AC012065 Genomic DNA. No translation available.
IPI	IPI00337348.
RefSeq	NP_878248.2. NM_182828.2.
UniGene	Hs.447688.
3D structure databases
ProteinModelPortal	Q7Z4P5.
SMR	Q7Z4P5. Positions 347-450.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000272224.
Polymorphism databases
DMDM	296434517.
Proteomic databases
PaxDb	Q7Z4P5.
PRIDE	Q7Z4P5.
Protocols and materials databases
DNASU	151449.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272224; ENSP00000272224; ENSG00000143869.
GeneID	151449.
KEGG	hsa:151449.
UCSC	uc002rdz.1. human.
Organism-specific databases
CTD	151449.
GeneCards	GC02P020788.
HGNC	HGNC:4222. GDF7.
MIM	604651. gene.
neXtProt	NX_Q7Z4P5.
PharmGKB	PA28637.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317866.
HOVERGEN	HBG107938.
InParanoid	Q7Z4P5.
KO	K04664.
OMA	DTITGFT.
OrthoDB	EOG4QJRPP.
PhylomeDB	Q7Z4P5.
Gene expression databases
ArrayExpress	Q7Z4P5.
Bgee	Q7Z4P5.
CleanEx	HS_GDF7.
Genevestigator	Q7Z4P5.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	151449.
NextBio	86692.
SOURCE	Search...

Entry information

Entry name

GDF7_HUMAN

Accession

Primary (citable) accession number: Q7Z4P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.