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Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

COX8C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31869-MONOMER.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Short name:
COX8-3
Cytochrome c oxidase subunit VIIIC
Gene namesi
Name:COX8C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:24382. COX8C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 40Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei41 – 64HelicalBy similarityAdd BLAST24
Topological domaini65 – 72Mitochondrial intermembraneBy similarity8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187581.
ENSG00000277018.
PharmGKBiPA134909890.

Polymorphism and mutation databases

BioMutaiCOX8C.
DMDMi41017026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000000620130 – 72Cytochrome c oxidase subunit 8C, mitochondrialAdd BLAST43

Proteomic databases

PaxDbiQ7Z4L0.
PRIDEiQ7Z4L0.

Expressioni

Tissue specificityi

It is not yet known where COX8C is expressed.

Gene expression databases

BgeeiENSG00000187581.
CleanExiHS_COX8C.
GenevisibleiQ7Z4L0. HS.

Organism-specific databases

HPAiHPA003127.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340568.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4L0.
SMRiQ7Z4L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JK2D. Eukaryota.
ENOG41114SW. LUCA.
GeneTreeiENSGT00390000012036.
HOGENOMiHOG000111895.
InParanoidiQ7Z4L0.
KOiK02273.
OMAiCPARRHY.
OrthoDBiEOG091G1A16.
PhylomeDBiQ7Z4L0.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV
60 70
FFTTFLTPAA YVLGNLKQFR RN
Length:72
Mass (Da):8,129
Last modified:October 1, 2003 - v1
Checksum:i53C47863EC761638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161004 mRNA. Translation: AAO26193.1.
BC101125 mRNA. Translation: AAI01126.1.
BC101126 mRNA. Translation: AAI01127.1.
CCDSiCCDS9910.1.
RefSeqiNP_892016.1. NM_182971.2.
UniGeneiHs.666459.

Genome annotation databases

EnsembliENST00000342144; ENSP00000340568; ENSG00000187581.
ENST00000620478; ENSP00000480706; ENSG00000277018.
GeneIDi341947.
KEGGihsa:341947.
UCSCiuc001ybt.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161004 mRNA. Translation: AAO26193.1.
BC101125 mRNA. Translation: AAI01126.1.
BC101126 mRNA. Translation: AAI01127.1.
CCDSiCCDS9910.1.
RefSeqiNP_892016.1. NM_182971.2.
UniGeneiHs.666459.

3D structure databases

ProteinModelPortaliQ7Z4L0.
SMRiQ7Z4L0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340568.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Polymorphism and mutation databases

BioMutaiCOX8C.
DMDMi41017026.

Proteomic databases

PaxDbiQ7Z4L0.
PRIDEiQ7Z4L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342144; ENSP00000340568; ENSG00000187581.
ENST00000620478; ENSP00000480706; ENSG00000277018.
GeneIDi341947.
KEGGihsa:341947.
UCSCiuc001ybt.2. human.

Organism-specific databases

CTDi341947.
GeneCardsiCOX8C.
HGNCiHGNC:24382. COX8C.
HPAiHPA003127.
MIMi616855. gene.
neXtProtiNX_Q7Z4L0.
OpenTargetsiENSG00000187581.
ENSG00000277018.
PharmGKBiPA134909890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JK2D. Eukaryota.
ENOG41114SW. LUCA.
GeneTreeiENSGT00390000012036.
HOGENOMiHOG000111895.
InParanoidiQ7Z4L0.
KOiK02273.
OMAiCPARRHY.
OrthoDBiEOG091G1A16.
PhylomeDBiQ7Z4L0.

Enzyme and pathway databases

BioCyciZFISH:G66-31869-MONOMER.

Miscellaneous databases

GenomeRNAii341947.
PROiQ7Z4L0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187581.
CleanExiHS_COX8C.
GenevisibleiQ7Z4L0. HS.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX8C_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4L0
Secondary accession number(s): Q495K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.