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Q7Z4L0

- COX8C_HUMAN

UniProt

Q7Z4L0 - COX8C_HUMAN

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Protein
Cytochrome c oxidase subunit 8C, mitochondrial
Gene
COX8C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Gene namesi
Name:COX8C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:24382. COX8C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 4011Mitochondrial matrix By similarity
Add
BLAST
Transmembranei41 – 6424Helical; By similarity
Add
BLAST
Topological domaini65 – 728Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion By similarity
Add
BLAST
Chaini30 – 7243Cytochrome c oxidase subunit 8C, mitochondrial
PRO_0000006201Add
BLAST

Proteomic databases

PaxDbiQ7Z4L0.
PRIDEiQ7Z4L0.

Expressioni

Tissue specificityi

It is not yet known where COX8C is expressed.

Gene expression databases

BgeeiQ7Z4L0.
CleanExiHS_COX8C.
GenevestigatoriQ7Z4L0.

Organism-specific databases

HPAiHPA003127.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340568.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4L0.
SMRiQ7Z4L0. Positions 29-71.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG120170.
HOGENOMiHOG000111895.
InParanoidiQ7Z4L0.
KOiK02273.
OMAiCPARRHY.
OrthoDBiEOG72ZCJ7.
PhylomeDBiQ7Z4L0.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4L0-1 [UniParc]FASTAAdd to Basket

« Hide

MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV   50
FFTTFLTPAA YVLGNLKQFR RN 72
Length:72
Mass (Da):8,129
Last modified:October 1, 2003 - v1
Checksum:i53C47863EC761638
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY161004 mRNA. Translation: AAO26193.1.
BC101125 mRNA. Translation: AAI01126.1.
BC101126 mRNA. Translation: AAI01127.1.
CCDSiCCDS9910.1.
RefSeqiNP_892016.1. NM_182971.2.
UniGeneiHs.666459.

Genome annotation databases

EnsembliENST00000342144; ENSP00000340568; ENSG00000187581.
GeneIDi341947.
KEGGihsa:341947.
UCSCiuc001ybt.1. human.

Polymorphism databases

DMDMi41017026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY161004 mRNA. Translation: AAO26193.1 .
BC101125 mRNA. Translation: AAI01126.1 .
BC101126 mRNA. Translation: AAI01127.1 .
CCDSi CCDS9910.1.
RefSeqi NP_892016.1. NM_182971.2.
UniGenei Hs.666459.

3D structure databases

ProteinModelPortali Q7Z4L0.
SMRi Q7Z4L0. Positions 29-71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000340568.

Protein family/group databases

TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Polymorphism databases

DMDMi 41017026.

Proteomic databases

PaxDbi Q7Z4L0.
PRIDEi Q7Z4L0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342144 ; ENSP00000340568 ; ENSG00000187581 .
GeneIDi 341947.
KEGGi hsa:341947.
UCSCi uc001ybt.1. human.

Organism-specific databases

CTDi 341947.
GeneCardsi GC14P093813.
HGNCi HGNC:24382. COX8C.
HPAi HPA003127.
neXtProti NX_Q7Z4L0.
PharmGKBi PA134909890.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG120170.
HOGENOMi HOG000111895.
InParanoidi Q7Z4L0.
KOi K02273.
OMAi CPARRHY.
OrthoDBi EOG72ZCJ7.
PhylomeDBi Q7Z4L0.

Miscellaneous databases

GenomeRNAii 341947.
NextBioi 98216.
PROi Q7Z4L0.

Gene expression databases

Bgeei Q7Z4L0.
CleanExi HS_COX8C.
Genevestigatori Q7Z4L0.

Family and domain databases

Gene3Di 4.10.81.10. 1 hit.
InterProi IPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view ]
PANTHERi PTHR16717. PTHR16717. 1 hit.
Pfami PF02285. COX8. 1 hit.
[Graphical view ]
SUPFAMi SSF81431. SSF81431. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A third isoform of cytochrome c oxidase subunit VIII is present in mammals."
    Huettemann M., Schmidt T.R., Grossman L.I.
    Gene 312:95-102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCOX8C_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4L0
Secondary accession number(s): Q495K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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