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Q7Z4L0

- COX8C_HUMAN

UniProt

Q7Z4L0 - COX8C_HUMAN

Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

COX8C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Protein family/group databases

    TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 8C, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide 8 isoform 3
    Cytochrome c oxidase polypeptide VIII isoform 3
    Short name:
    COX VIII-3
    Cytochrome c oxidase subunit 8-3
    Gene namesi
    Name:COX8C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:24382. COX8C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909890.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionBy similarityAdd
    BLAST
    Chaini30 – 7243Cytochrome c oxidase subunit 8C, mitochondrialPRO_0000006201Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z4L0.
    PRIDEiQ7Z4L0.

    Expressioni

    Tissue specificityi

    It is not yet known where COX8C is expressed.

    Gene expression databases

    BgeeiQ7Z4L0.
    CleanExiHS_COX8C.
    GenevestigatoriQ7Z4L0.

    Organism-specific databases

    HPAiHPA003127.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000340568.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z4L0.
    SMRiQ7Z4L0. Positions 29-71.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 4011Mitochondrial matrixBy similarityAdd
    BLAST
    Topological domaini65 – 728Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6424HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIII family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG120170.
    HOGENOMiHOG000111895.
    InParanoidiQ7Z4L0.
    KOiK02273.
    OMAiCPARRHY.
    OrthoDBiEOG72ZCJ7.
    PhylomeDBiQ7Z4L0.

    Family and domain databases

    Gene3Di4.10.81.10. 1 hit.
    InterProiIPR003205. Cyt_c_oxidase_su8.
    IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
    [Graphical view]
    PANTHERiPTHR16717. PTHR16717. 1 hit.
    PfamiPF02285. COX8. 1 hit.
    [Graphical view]
    SUPFAMiSSF81431. SSF81431. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z4L0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV   50
    FFTTFLTPAA YVLGNLKQFR RN 72
    Length:72
    Mass (Da):8,129
    Last modified:October 1, 2003 - v1
    Checksum:i53C47863EC761638
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY161004 mRNA. Translation: AAO26193.1.
    BC101125 mRNA. Translation: AAI01126.1.
    BC101126 mRNA. Translation: AAI01127.1.
    CCDSiCCDS9910.1.
    RefSeqiNP_892016.1. NM_182971.2.
    UniGeneiHs.666459.

    Genome annotation databases

    EnsembliENST00000342144; ENSP00000340568; ENSG00000187581.
    GeneIDi341947.
    KEGGihsa:341947.
    UCSCiuc001ybt.1. human.

    Polymorphism databases

    DMDMi41017026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY161004 mRNA. Translation: AAO26193.1 .
    BC101125 mRNA. Translation: AAI01126.1 .
    BC101126 mRNA. Translation: AAI01127.1 .
    CCDSi CCDS9910.1.
    RefSeqi NP_892016.1. NM_182971.2.
    UniGenei Hs.666459.

    3D structure databases

    ProteinModelPortali Q7Z4L0.
    SMRi Q7Z4L0. Positions 29-71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000340568.

    Protein family/group databases

    TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Polymorphism databases

    DMDMi 41017026.

    Proteomic databases

    PaxDbi Q7Z4L0.
    PRIDEi Q7Z4L0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342144 ; ENSP00000340568 ; ENSG00000187581 .
    GeneIDi 341947.
    KEGGi hsa:341947.
    UCSCi uc001ybt.1. human.

    Organism-specific databases

    CTDi 341947.
    GeneCardsi GC14P093813.
    HGNCi HGNC:24382. COX8C.
    HPAi HPA003127.
    neXtProti NX_Q7Z4L0.
    PharmGKBi PA134909890.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG120170.
    HOGENOMi HOG000111895.
    InParanoidi Q7Z4L0.
    KOi K02273.
    OMAi CPARRHY.
    OrthoDBi EOG72ZCJ7.
    PhylomeDBi Q7Z4L0.

    Miscellaneous databases

    GenomeRNAii 341947.
    NextBioi 98216.
    PROi Q7Z4L0.

    Gene expression databases

    Bgeei Q7Z4L0.
    CleanExi HS_COX8C.
    Genevestigatori Q7Z4L0.

    Family and domain databases

    Gene3Di 4.10.81.10. 1 hit.
    InterProi IPR003205. Cyt_c_oxidase_su8.
    IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
    [Graphical view ]
    PANTHERi PTHR16717. PTHR16717. 1 hit.
    Pfami PF02285. COX8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81431. SSF81431. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A third isoform of cytochrome c oxidase subunit VIII is present in mammals."
      Huettemann M., Schmidt T.R., Grossman L.I.
      Gene 312:95-102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCOX8C_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z4L0
    Secondary accession number(s): Q495K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3