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Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

COX8C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Short name:
COX8-3
Cytochrome c oxidase subunit VIIIC
Gene namesi
Name:COX8C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000187581.2
HGNCiHGNC:24382 COX8C
MIMi616855 gene
neXtProtiNX_Q7Z4L0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 40Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei41 – 64HelicalBy similarityAdd BLAST24
Topological domaini65 – 72Mitochondrial intermembraneBy similarity8

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187581
PharmGKBiPA134909890

Polymorphism and mutation databases

BioMutaiCOX8C
DMDMi41017026

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000000620130 – 72Cytochrome c oxidase subunit 8C, mitochondrialAdd BLAST43

Proteomic databases

PaxDbiQ7Z4L0
PeptideAtlasiQ7Z4L0
PRIDEiQ7Z4L0

Expressioni

Tissue specificityi

It is not yet known where COX8C is expressed.

Gene expression databases

BgeeiENSG00000187581
CleanExiHS_COX8C
GenevisibleiQ7Z4L0 HS

Organism-specific databases

HPAiHPA003127

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340568

Structurei

3D structure databases

ProteinModelPortaliQ7Z4L0
SMRiQ7Z4L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JK2D Eukaryota
ENOG41114SW LUCA
GeneTreeiENSGT00390000012036
HOGENOMiHOG000111895
InParanoidiQ7Z4L0
KOiK02273
OMAiCPARRHY
OrthoDBiEOG091G1A16
PhylomeDBiQ7Z4L0

Family and domain databases

Gene3Di4.10.81.10, 1 hit
InterProiView protein in InterPro
IPR003205 Cyt_c_oxidase_su8
IPR036548 Cyt_c_oxidase_su8_sf
PANTHERiPTHR16717 PTHR16717, 1 hit
PfamiView protein in Pfam
PF02285 COX8, 1 hit
SUPFAMiSSF81431 SSF81431, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV
60 70
FFTTFLTPAA YVLGNLKQFR RN
Length:72
Mass (Da):8,129
Last modified:October 1, 2003 - v1
Checksum:i53C47863EC761638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161004 mRNA Translation: AAO26193.1
BC101125 mRNA Translation: AAI01126.1
BC101126 mRNA Translation: AAI01127.1
CCDSiCCDS9910.1
RefSeqiNP_892016.1, NM_182971.2
UniGeneiHs.666459

Genome annotation databases

EnsembliENST00000342144; ENSP00000340568; ENSG00000187581
ENST00000620478; ENSP00000480706; ENSG00000277018
GeneIDi341947
KEGGihsa:341947
UCSCiuc001ybt.2 human

Similar proteinsi

Entry informationi

Entry nameiCOX8C_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4L0
Secondary accession number(s): Q495K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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