Q7Z4L0 (COX8C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name=COX VIII-3
Cytochrome c oxidase subunit 8-3

Gene names

Name:

COX8C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Tissue specificity	It is not yet known where COX8C is expressed.
Sequence similarities	Belongs to the cytochrome c oxidase VIII family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 12762575. Source: MGI
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 29	29	Mitochondrion By similarity
	Chain	30 – 72	43	Cytochrome c oxidase subunit 8C, mitochondrial		PRO_0000006201
Regions
	Topological domain	30 – 40	11	Mitochondrial matrix By similarity
	Transmembrane	41 – 64	24	Helical; By similarity
	Topological domain	65 – 72	8	Mitochondrial intermembrane By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7Z4L0 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 53C47863EC761638	FASTA	72	8,129
	10 20 30 40 50 60 MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV FFTTFLTPAA 70 YVLGNLKQFR RN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A third isoform of cytochrome c oxidase subunit VIII is present in mammals." Huettemann M., Schmidt T.R., Grossman L.I. Gene 312:95-102(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY161004 mRNA. Translation: AAO26193.1. BC101125 mRNA. Translation: AAI01126.1. BC101126 mRNA. Translation: AAI01127.1.
IPI	IPI00376004.
RefSeq	NP_892016.1. NM_182971.2.
UniGene	Hs.666459.
3D structure databases
ProteinModelPortal	Q7Z4L0.
SMR	Q7Z4L0. Positions 30-71.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000340568.
Protein family/group databases
TCDB	3.D.4.11.1. proton-translocating cytochrome oxidase (COX) superfamily.
Polymorphism databases
DMDM	41017026.
Proteomic databases
PaxDb	Q7Z4L0.
PRIDE	Q7Z4L0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342144; ENSP00000340568; ENSG00000187581.
GeneID	341947.
KEGG	hsa:341947.
UCSC	uc001ybt.1. human.
Organism-specific databases
CTD	341947.
GeneCards	GC14P093813.
HGNC	HGNC:24382. COX8C.
HPA	HPA003127.
neXtProt	NX_Q7Z4L0.
PharmGKB	PA134909890.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG120170.
HOGENOM	HOG000111895.
InParanoid	Q7Z4L0.
KO	K02273.
OMA	AHSEPPR.
OrthoDB	EOG4VX271.
Gene expression databases
Bgee	Q7Z4L0.
CleanEx	HS_COX8C.
Genevestigator	Q7Z4L0.
GermOnline	ENSG00000187581. Homo sapiens.
Family and domain databases
Gene3D	4.10.81.10. 1 hit.
InterPro	IPR003205. Cyt_c_oxidase_su8. IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9. [Graphical view]
PANTHER	PTHR16717. PTHR16717. 1 hit.
Pfam	PF02285. COX8. 1 hit. [Graphical view]
SUPFAM	SSF81431. Cyt_c_oxidase_8. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	341947.
NextBio	98216.

Entry information

Entry name

COX8C_HUMAN

Accession

Primary (citable) accession number: Q7Z4L0
Secondary accession number(s): Q495K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.