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Q7Z4L0 (COX8C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name=COX VIII-3
Cytochrome c oxidase subunit 8-3
Gene names
Name:COX8C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Tissue specificity

It is not yet known where COX8C is expressed.

Sequence similarities

Belongs to the cytochrome c oxidase VIII family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion By similarity
Chain30 – 7243Cytochrome c oxidase subunit 8C, mitochondrial
PRO_0000006201

Regions

Topological domain30 – 4011Mitochondrial matrix By similarity
Transmembrane41 – 6424Helical; By similarity
Topological domain65 – 728Mitochondrial intermembrane By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7Z4L0 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 53C47863EC761638

FASTA728,129
        10         20         30         40         50         60 
MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV FFTTFLTPAA 

        70 
YVLGNLKQFR RN 

« Hide

References

« Hide 'large scale' references
[1]"A third isoform of cytochrome c oxidase subunit VIII is present in mammals."
Huettemann M., Schmidt T.R., Grossman L.I.
Gene 312:95-102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY161004 mRNA. Translation: AAO26193.1.
BC101125 mRNA. Translation: AAI01126.1.
BC101126 mRNA. Translation: AAI01127.1.
CCDSCCDS9910.1.
RefSeqNP_892016.1. NM_182971.2.
UniGeneHs.666459.

3D structure databases

ProteinModelPortalQ7Z4L0.
SMRQ7Z4L0. Positions 29-71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000340568.

Protein family/group databases

TCDB3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Polymorphism databases

DMDM41017026.

Proteomic databases

PaxDbQ7Z4L0.
PRIDEQ7Z4L0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342144; ENSP00000340568; ENSG00000187581.
GeneID341947.
KEGGhsa:341947.
UCSCuc001ybt.1. human.

Organism-specific databases

CTD341947.
GeneCardsGC14P093813.
HGNCHGNC:24382. COX8C.
HPAHPA003127.
neXtProtNX_Q7Z4L0.
PharmGKBPA134909890.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG120170.
HOGENOMHOG000111895.
InParanoidQ7Z4L0.
KOK02273.
OMACPARRHY.
OrthoDBEOG72ZCJ7.
PhylomeDBQ7Z4L0.

Gene expression databases

BgeeQ7Z4L0.
CleanExHS_COX8C.
GenevestigatorQ7Z4L0.

Family and domain databases

Gene3D4.10.81.10. 1 hit.
InterProIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERPTHR16717. PTHR16717. 1 hit.
PfamPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMSSF81431. SSF81431. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi341947.
NextBio98216.
PROQ7Z4L0.

Entry information

Entry nameCOX8C_HUMAN
AccessionPrimary (citable) accession number: Q7Z4L0
Secondary accession number(s): Q495K7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM