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Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

COX8C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Gene namesi
Name:COX8C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 14, Unplaced

Organism-specific databases

HGNCiHGNC:24382. COX8C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 4011Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei41 – 6424HelicalBy similarityAdd
BLAST
Topological domaini65 – 728Mitochondrial intermembraneBy similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionBy similarityAdd
BLAST
Chaini30 – 7243Cytochrome c oxidase subunit 8C, mitochondrialPRO_0000006201Add
BLAST

Proteomic databases

PaxDbiQ7Z4L0.
PRIDEiQ7Z4L0.

Expressioni

Tissue specificityi

It is not yet known where COX8C is expressed.

Gene expression databases

BgeeiQ7Z4L0.
CleanExiHS_COX8C.
GenevestigatoriQ7Z4L0.

Organism-specific databases

HPAiHPA003127.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340568.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4L0.
SMRiQ7Z4L0. Positions 29-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG120170.
GeneTreeiENSGT00390000012036.
HOGENOMiHOG000111895.
InParanoidiQ7Z4L0.
KOiK02273.
OMAiCPARRHY.
OrthoDBiEOG72ZCJ7.
PhylomeDBiQ7Z4L0.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV
60 70
FFTTFLTPAA YVLGNLKQFR RN
Length:72
Mass (Da):8,129
Last modified:September 30, 2003 - v1
Checksum:i53C47863EC761638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161004 mRNA. Translation: AAO26193.1.
BC101125 mRNA. Translation: AAI01126.1.
BC101126 mRNA. Translation: AAI01127.1.
CCDSiCCDS9910.1.
RefSeqiNP_892016.1. NM_182971.2.
UniGeneiHs.666459.

Genome annotation databases

EnsembliENST00000342144; ENSP00000340568; ENSG00000187581.
ENST00000620478; ENSP00000480706; ENSG00000277018.
GeneIDi341947.
KEGGihsa:341947.
UCSCiuc001ybt.1. human.

Polymorphism databases

DMDMi41017026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161004 mRNA. Translation: AAO26193.1.
BC101125 mRNA. Translation: AAI01126.1.
BC101126 mRNA. Translation: AAI01127.1.
CCDSiCCDS9910.1.
RefSeqiNP_892016.1. NM_182971.2.
UniGeneiHs.666459.

3D structure databases

ProteinModelPortaliQ7Z4L0.
SMRiQ7Z4L0. Positions 29-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340568.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Polymorphism databases

DMDMi41017026.

Proteomic databases

PaxDbiQ7Z4L0.
PRIDEiQ7Z4L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342144; ENSP00000340568; ENSG00000187581.
ENST00000620478; ENSP00000480706; ENSG00000277018.
GeneIDi341947.
KEGGihsa:341947.
UCSCiuc001ybt.1. human.

Organism-specific databases

CTDi341947.
GeneCardsiGC14P093813.
HGNCiHGNC:24382. COX8C.
HPAiHPA003127.
neXtProtiNX_Q7Z4L0.
PharmGKBiPA134909890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG120170.
GeneTreeiENSGT00390000012036.
HOGENOMiHOG000111895.
InParanoidiQ7Z4L0.
KOiK02273.
OMAiCPARRHY.
OrthoDBiEOG72ZCJ7.
PhylomeDBiQ7Z4L0.

Miscellaneous databases

GenomeRNAii341947.
NextBioi98216.
PROiQ7Z4L0.

Gene expression databases

BgeeiQ7Z4L0.
CleanExiHS_COX8C.
GenevestigatoriQ7Z4L0.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A third isoform of cytochrome c oxidase subunit VIII is present in mammals."
    Huettemann M., Schmidt T.R., Grossman L.I.
    Gene 312:95-102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCOX8C_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4L0
Secondary accession number(s): Q495K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2004
Last sequence update: September 30, 2003
Last modified: January 6, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.