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Protein

Tripartite motif-containing protein 46

Gene

TRIM46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 73RING-type 1; degenerateAdd BLAST41
Zinc fingeri172 – 231RING-type 2; degenerateAdd BLAST60
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 46
Alternative name(s):
Gene Y protein
Short name:
GeneY
Tripartite, fibronectin type-III and C-terminal SPRY motif protein
Gene namesi
Name:TRIM46
Synonyms:TRIFIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19019. TRIM46.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163462.
PharmGKBiPA134914315.

Polymorphism and mutation databases

BioMutaiTRIM46.
DMDMi55976496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562681 – 759Tripartite motif-containing protein 46Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330PhosphoserineBy similarity1
Modified residuei627PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7Z4K8.
PeptideAtlasiQ7Z4K8.
PRIDEiQ7Z4K8.

PTM databases

iPTMnetiQ7Z4K8.
PhosphoSitePlusiQ7Z4K8.

Expressioni

Gene expression databases

BgeeiENSG00000163462.
CleanExiHS_TRIM46.
ExpressionAtlasiQ7Z4K8. baseline and differential.
GenevisibleiQ7Z4K8. HS.

Organism-specific databases

HPAiHPA030389.

Interactioni

Protein-protein interaction databases

BioGridi123129. 20 interactors.
IntActiQ7Z4K8. 13 interactors.
MINTiMINT-7009485.
STRINGi9606.ENSP00000334657.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4K8.
SMRiQ7Z4K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini370 – 427COSPROSITE-ProRule annotationAdd BLAST58
Domaini429 – 528Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini526 – 747B30.2/SPRYPROSITE-ProRule annotationAdd BLAST222

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili322 – 400Sequence analysisAdd BLAST79

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 2 RING-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 73RING-type 1; degenerateAdd BLAST41
Zinc fingeri172 – 231RING-type 2; degenerateAdd BLAST60
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF7. Eukaryota.
ENOG411139C. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000049213.
HOVERGENiHBG059072.
InParanoidiQ7Z4K8.
KOiK12022.
OMAiSVAVMCQ.
OrthoDBiEOG091G020H.
PhylomeDBiQ7Z4K8.
TreeFamiTF315216.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH
60 70 80 90 100
NVCQACAREV LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD
110 120 130 140 150
RLDRLLKSGF GTYPGRKRGA LHPQVIMFPC PACQGDVELG ERGLAGLFRN
160 170 180 190 200
LTLERVVERY RQSVSVGGAI LCQLCKPPPL EATKGCTECR ATFCNECFKL
210 220 230 240 250
FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT CQRLVCQLCR
260 270 280 290 300
VRRTHSGHKI TPVLSAYQAL KDKLTKSLTY ILGNQDTVQT QICELEEAVR
310 320 330 340 350
HTEVSGQQAK EEVSQLVRGL GAVLEEKRAS LLQAIEECQQ ERLARLSAQI
360 370 380 390 400
QEHRSLLDGS GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR
410 420 430 440 450
PAASSSFRHC QLDVGREMKL LTELNFLRVP EAPVIDTQRT FAYDQIFLCW
460 470 480 490 500
RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW QRREEVRGTS ALLENPDTGS
510 520 530 540 550
VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDSRWG ASRERLAISK
560 570 580 590 600
DQRAVRSVPG LPLLLAADRL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP
610 620 630 640 650
ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDATVEASPP
660 670 680 690 700
FAFLTIGMGK ILLGSGASSN AGLTGRDGPT AGCTVPLPPR LGICLDYERG
710 720 730 740 750
RVSFLDAVSF RGLLECPLDC SGPVCPAFCF IGGGAVQLQE PVGTKPERKV

TIGGFAKLD
Length:759
Mass (Da):83,424
Last modified:November 23, 2004 - v2
Checksum:iFEA9DDE1434EB7AA
GO
Isoform 2 (identifier: Q7Z4K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-551: VLHFFLDSRWGASRERLAISKD → GIQNLARRGGACLQFQLLGRLR
     552-759: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):61,777
Checksum:i798F2654D3251055
GO
Isoform 3 (identifier: Q7Z4K8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MAEGEDMQTFTSIMDALVRIS → MERAGWSANLAWLSGGITLCSGEREARDRGLGRSVNQPKAGALEKLQ
     429-498: VPEAPVIDTQ...TSALLENPDT → GCGHRGLCSG...APPAGSGGRR
     499-759: Missing.

Note: No experimental confirmation available.
Show »
Length:524
Mass (Da):57,448
Checksum:iCE999C807B0DA817
GO
Isoform 4 (identifier: Q7Z4K8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-498: VPEAPVIDTQ...TSALLENPDT → GCGHRGLCSG...APPAGSGGRR
     499-759: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):54,752
Checksum:i95C02CA96EC0B539
GO
Isoform 5 (identifier: Q7Z4K8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:736
Mass (Da):80,908
Checksum:iB1EC233420ED4E50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18V → A in AAH69568 (PubMed:15489334).Curated1
Sequence conflicti161R → H in AAP51206 (PubMed:16434393).Curated1
Sequence conflicti161R → H in BAB15580 (PubMed:14702039).Curated1
Sequence conflicti254T → A in AAP51206 (PubMed:16434393).Curated1
Sequence conflicti254T → A in BAB15580 (PubMed:14702039).Curated1
Sequence conflicti401P → R in AAH69568 (PubMed:15489334).Curated1
Sequence conflicti406S → P in AK096158 (PubMed:14702039).Curated1
Sequence conflicti414V → A in AK096158 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459761 – 23Missing in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0119801 – 21MAEGE…LVRIS → MERAGWSANLAWLSGGITLC SGEREARDRGLGRSVNQPKA GALEKLQ in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011981429 – 498VPEAP…ENPDT → GCGHRGLCSGAPQCLRPPSL TPSAPLPMIRSSCAGGCPPI HHLPGTIPLSSGARMCLLSQ APPAGSGGRR in isoform 3 and isoform 4. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_011982499 – 759Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST261
Alternative sequenceiVSP_011983530 – 551VLHFF…AISKD → GIQNLARRGGACLQFQLLGR LR in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_011984552 – 759Missing in isoform 2. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251386 mRNA. Translation: AAP51206.1.
AK026882 mRNA. Translation: BAB15580.1.
AK096158 mRNA. No translation available.
AK128139 mRNA. Translation: BAC87293.1.
AL607067, AL713999 Genomic DNA. Translation: CAH71197.1.
AL607067, AL713999 Genomic DNA. Translation: CAH71199.1.
AL713999, AL607067 Genomic DNA. Translation: CAI95081.1.
AL713999, AL607067 Genomic DNA. Translation: CAI95083.1.
CH471121 Genomic DNA. Translation: EAW53120.1.
CH471121 Genomic DNA. Translation: EAW53123.1.
BC069416 mRNA. Translation: AAH69416.1.
BC069568 mRNA. Translation: AAH69568.1.
BC126372 mRNA. Translation: AAI26373.1.
CCDSiCCDS1097.1. [Q7Z4K8-1]
CCDS58033.1. [Q7Z4K8-5]
CCDS60285.1. [Q7Z4K8-2]
RefSeqiNP_001243528.1. NM_001256599.1. [Q7Z4K8-5]
NP_001243529.1. NM_001256600.1.
NP_001243530.1. NM_001256601.1.
NP_001269307.1. NM_001282378.1.
NP_001269308.1. NM_001282379.1. [Q7Z4K8-2]
NP_079334.3. NM_025058.4. [Q7Z4K8-1]
UniGeneiHs.287735.

Genome annotation databases

EnsembliENST00000334634; ENSP00000334657; ENSG00000163462. [Q7Z4K8-1]
ENST00000368382; ENSP00000357366; ENSG00000163462. [Q7Z4K8-5]
ENST00000368385; ENSP00000357369; ENSG00000163462. [Q7Z4K8-2]
ENST00000543729; ENSP00000442719; ENSG00000163462. [Q7Z4K8-4]
GeneIDi80128.
KEGGihsa:80128.
UCSCiuc001fhr.6. human. [Q7Z4K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251386 mRNA. Translation: AAP51206.1.
AK026882 mRNA. Translation: BAB15580.1.
AK096158 mRNA. No translation available.
AK128139 mRNA. Translation: BAC87293.1.
AL607067, AL713999 Genomic DNA. Translation: CAH71197.1.
AL607067, AL713999 Genomic DNA. Translation: CAH71199.1.
AL713999, AL607067 Genomic DNA. Translation: CAI95081.1.
AL713999, AL607067 Genomic DNA. Translation: CAI95083.1.
CH471121 Genomic DNA. Translation: EAW53120.1.
CH471121 Genomic DNA. Translation: EAW53123.1.
BC069416 mRNA. Translation: AAH69416.1.
BC069568 mRNA. Translation: AAH69568.1.
BC126372 mRNA. Translation: AAI26373.1.
CCDSiCCDS1097.1. [Q7Z4K8-1]
CCDS58033.1. [Q7Z4K8-5]
CCDS60285.1. [Q7Z4K8-2]
RefSeqiNP_001243528.1. NM_001256599.1. [Q7Z4K8-5]
NP_001243529.1. NM_001256600.1.
NP_001243530.1. NM_001256601.1.
NP_001269307.1. NM_001282378.1.
NP_001269308.1. NM_001282379.1. [Q7Z4K8-2]
NP_079334.3. NM_025058.4. [Q7Z4K8-1]
UniGeneiHs.287735.

3D structure databases

ProteinModelPortaliQ7Z4K8.
SMRiQ7Z4K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123129. 20 interactors.
IntActiQ7Z4K8. 13 interactors.
MINTiMINT-7009485.
STRINGi9606.ENSP00000334657.

PTM databases

iPTMnetiQ7Z4K8.
PhosphoSitePlusiQ7Z4K8.

Polymorphism and mutation databases

BioMutaiTRIM46.
DMDMi55976496.

Proteomic databases

PaxDbiQ7Z4K8.
PeptideAtlasiQ7Z4K8.
PRIDEiQ7Z4K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334634; ENSP00000334657; ENSG00000163462. [Q7Z4K8-1]
ENST00000368382; ENSP00000357366; ENSG00000163462. [Q7Z4K8-5]
ENST00000368385; ENSP00000357369; ENSG00000163462. [Q7Z4K8-2]
ENST00000543729; ENSP00000442719; ENSG00000163462. [Q7Z4K8-4]
GeneIDi80128.
KEGGihsa:80128.
UCSCiuc001fhr.6. human. [Q7Z4K8-1]

Organism-specific databases

CTDi80128.
GeneCardsiTRIM46.
H-InvDBHIX0001120.
HGNCiHGNC:19019. TRIM46.
HPAiHPA030389.
MIMi600986. gene.
neXtProtiNX_Q7Z4K8.
OpenTargetsiENSG00000163462.
PharmGKBiPA134914315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITF7. Eukaryota.
ENOG411139C. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000049213.
HOVERGENiHBG059072.
InParanoidiQ7Z4K8.
KOiK12022.
OMAiSVAVMCQ.
OrthoDBiEOG091G020H.
PhylomeDBiQ7Z4K8.
TreeFamiTF315216.

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiTRIM46. human.
GenomeRNAii80128.
PROiQ7Z4K8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163462.
CleanExiHS_TRIM46.
ExpressionAtlasiQ7Z4K8. baseline and differential.
GenevisibleiQ7Z4K8. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI46_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4K8
Secondary accession number(s): A0AVI6
, B1AVQ4, Q5VT60, Q5VT62, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.