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Protein

Tripartite motif-containing protein 46

Gene

TRIM46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 59RING-type 1; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri172 – 231RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST60
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 46
Alternative name(s):
Gene Y protein
Short name:
GeneY
Tripartite, fibronectin type-III and C-terminal SPRY motif protein
Gene namesi
Name:TRIM46
Synonyms:TRIFIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163462.17
HGNCiHGNC:19019 TRIM46
MIMi600986 gene
neXtProtiNX_Q7Z4K8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi80128
OpenTargetsiENSG00000163462
PharmGKBiPA134914315

Polymorphism and mutation databases

BioMutaiTRIM46
DMDMi55976496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562681 – 759Tripartite motif-containing protein 46Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330PhosphoserineBy similarity1
Modified residuei627PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7Z4K8
PeptideAtlasiQ7Z4K8
PRIDEiQ7Z4K8

PTM databases

iPTMnetiQ7Z4K8
PhosphoSitePlusiQ7Z4K8

Expressioni

Gene expression databases

BgeeiENSG00000163462
CleanExiHS_TRIM46
ExpressionAtlasiQ7Z4K8 baseline and differential
GenevisibleiQ7Z4K8 HS

Organism-specific databases

HPAiHPA030389

Interactioni

Subunit structurei

Interacts with TUBB3 and TUBA4A.By similarity

Protein-protein interaction databases

BioGridi123129, 20 interactors
IntActiQ7Z4K8, 13 interactors
MINTiQ7Z4K8
STRINGi9606.ENSP00000334657

Structurei

3D structure databases

ProteinModelPortaliQ7Z4K8
SMRiQ7Z4K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini370 – 427COSPROSITE-ProRule annotationAdd BLAST58
Domaini429 – 528Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini526 – 747B30.2/SPRYPROSITE-ProRule annotationAdd BLAST222

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 166Required for proximal axon localization, axon formation and migrationBy similarityAdd BLAST166
Regioni411 – 429Required for microtubule association, proximal axon localization and axon formationBy similarityAdd BLAST19

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili322 – 400Sequence analysisAdd BLAST79

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 59RING-type 1; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri172 – 231RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST60
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF7 Eukaryota
ENOG411139C LUCA
GeneTreeiENSGT00760000118878
HOGENOMiHOG000049213
HOVERGENiHBG059072
InParanoidiQ7Z4K8
KOiK12022
OMAiNRNADQT
OrthoDBiEOG091G020H
PhylomeDBiQ7Z4K8
TreeFamiTF315216

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
cd12895 SPRY_PRY_TRIM46, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035731 SPRY/PRY_TRIM46
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH
60 70 80 90 100
NVCQACAREV LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD
110 120 130 140 150
RLDRLLKSGF GTYPGRKRGA LHPQVIMFPC PACQGDVELG ERGLAGLFRN
160 170 180 190 200
LTLERVVERY RQSVSVGGAI LCQLCKPPPL EATKGCTECR ATFCNECFKL
210 220 230 240 250
FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT CQRLVCQLCR
260 270 280 290 300
VRRTHSGHKI TPVLSAYQAL KDKLTKSLTY ILGNQDTVQT QICELEEAVR
310 320 330 340 350
HTEVSGQQAK EEVSQLVRGL GAVLEEKRAS LLQAIEECQQ ERLARLSAQI
360 370 380 390 400
QEHRSLLDGS GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR
410 420 430 440 450
PAASSSFRHC QLDVGREMKL LTELNFLRVP EAPVIDTQRT FAYDQIFLCW
460 470 480 490 500
RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW QRREEVRGTS ALLENPDTGS
510 520 530 540 550
VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDSRWG ASRERLAISK
560 570 580 590 600
DQRAVRSVPG LPLLLAADRL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP
610 620 630 640 650
ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDATVEASPP
660 670 680 690 700
FAFLTIGMGK ILLGSGASSN AGLTGRDGPT AGCTVPLPPR LGICLDYERG
710 720 730 740 750
RVSFLDAVSF RGLLECPLDC SGPVCPAFCF IGGGAVQLQE PVGTKPERKV

TIGGFAKLD
Length:759
Mass (Da):83,424
Last modified:November 23, 2004 - v2
Checksum:iFEA9DDE1434EB7AA
GO
Isoform 2 (identifier: Q7Z4K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-551: VLHFFLDSRWGASRERLAISKD → GIQNLARRGGACLQFQLLGRLR
     552-759: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):61,777
Checksum:i798F2654D3251055
GO
Isoform 3 (identifier: Q7Z4K8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MAEGEDMQTFTSIMDALVRIS → MERAGWSANLAWLSGGITLCSGEREARDRGLGRSVNQPKAGALEKLQ
     429-498: VPEAPVIDTQ...TSALLENPDT → GCGHRGLCSG...APPAGSGGRR
     499-759: Missing.

Note: No experimental confirmation available.
Show »
Length:524
Mass (Da):57,448
Checksum:iCE999C807B0DA817
GO
Isoform 4 (identifier: Q7Z4K8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-498: VPEAPVIDTQ...TSALLENPDT → GCGHRGLCSG...APPAGSGGRR
     499-759: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):54,752
Checksum:i95C02CA96EC0B539
GO
Isoform 5 (identifier: Q7Z4K8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:736
Mass (Da):80,908
Checksum:iB1EC233420ED4E50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18V → A in AAH69568 (PubMed:15489334).Curated1
Sequence conflicti161R → H in AAP51206 (PubMed:16434393).Curated1
Sequence conflicti161R → H in BAB15580 (PubMed:14702039).Curated1
Sequence conflicti254T → A in AAP51206 (PubMed:16434393).Curated1
Sequence conflicti254T → A in BAB15580 (PubMed:14702039).Curated1
Sequence conflicti401P → R in AAH69568 (PubMed:15489334).Curated1
Sequence conflicti406S → P in AK096158 (PubMed:14702039).Curated1
Sequence conflicti414V → A in AK096158 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459761 – 23Missing in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0119801 – 21MAEGE…LVRIS → MERAGWSANLAWLSGGITLC SGEREARDRGLGRSVNQPKA GALEKLQ in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011981429 – 498VPEAP…ENPDT → GCGHRGLCSGAPQCLRPPSL TPSAPLPMIRSSCAGGCPPI HHLPGTIPLSSGARMCLLSQ APPAGSGGRR in isoform 3 and isoform 4. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_011982499 – 759Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST261
Alternative sequenceiVSP_011983530 – 551VLHFF…AISKD → GIQNLARRGGACLQFQLLGR LR in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_011984552 – 759Missing in isoform 2. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251386 mRNA Translation: AAP51206.1
AK026882 mRNA Translation: BAB15580.1
AK096158 mRNA No translation available.
AK128139 mRNA Translation: BAC87293.1
AL607067, AL713999 Genomic DNA Translation: CAH71197.1
AL607067, AL713999 Genomic DNA Translation: CAH71199.1
AL713999, AL607067 Genomic DNA Translation: CAI95081.1
AL713999, AL607067 Genomic DNA Translation: CAI95083.1
CH471121 Genomic DNA Translation: EAW53120.1
CH471121 Genomic DNA Translation: EAW53123.1
BC069416 mRNA Translation: AAH69416.1
BC069568 mRNA Translation: AAH69568.1
BC126372 mRNA Translation: AAI26373.1
CCDSiCCDS1097.1 [Q7Z4K8-1]
CCDS58033.1 [Q7Z4K8-5]
CCDS60285.1 [Q7Z4K8-2]
RefSeqiNP_001243528.1, NM_001256599.1 [Q7Z4K8-5]
NP_001243529.1, NM_001256600.1
NP_001243530.1, NM_001256601.1
NP_001269307.1, NM_001282378.1
NP_001269308.1, NM_001282379.1 [Q7Z4K8-2]
NP_079334.3, NM_025058.4 [Q7Z4K8-1]
UniGeneiHs.287735

Genome annotation databases

EnsembliENST00000334634; ENSP00000334657; ENSG00000163462 [Q7Z4K8-1]
ENST00000368382; ENSP00000357366; ENSG00000163462 [Q7Z4K8-5]
ENST00000368385; ENSP00000357369; ENSG00000163462 [Q7Z4K8-2]
ENST00000543729; ENSP00000442719; ENSG00000163462 [Q7Z4K8-4]
GeneIDi80128
KEGGihsa:80128
UCSCiuc001fhr.6 human [Q7Z4K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRI46_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4K8
Secondary accession number(s): A0AVI6
, B1AVQ4, Q5VT60, Q5VT62, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health