Reviewed, UniProtKB/Swiss-Prot Q7Z4J2 (GL6D1_HUMAN)

Names and origin

Protein names

Recommended name:
    Glycosyltransferase 6 domain-containing protein 1
    EC=2.4.1.-
Alternative name(s):
    Galactosyltransferase family 6 domain-containing 1

Gene names

Name:	GLT6D1
Synonyms:	GLTDC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the glycosyltransferase 6 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring hexosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Glycosyltransferase 6 domain-containing protein 1		PRO_0000311971
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 23	17	Signal-anchor for type II membrane protein Potential
	Topological domain	24 – 308	285	Lumenal Potential
Amino acid modifications
	Glycosylation	74	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	195	1	H → R: dbSNP rs35762223.		VAR_037382
	Natural variant	219	1	P → S: dbSNP rs17040344.		VAR_037383
	Natural variant	282	1	A → E: dbSNP rs12336965.		VAR_037384

Sequences

	Sequence		Length	Mass (Da)
	Q7Z4J2-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: DB3D7E444D12988C	FASTA	308	36,274
	10 20 30 40 50 60 MNSKRMLLLV LFAFSLMLVE RYFRNHQVEE LRLSDWFHPR KRPDVITKTD WLAPVLWEGT 70 80 90 100 110 120 FDRRVLEKHY RRRNITVGLA VFATGRFAEE YLRPFLHSAN KHFMTGYRVI FYIMVDAFFK 130 140 150 160 170 180 LPDIEPSPLR TFKAFKVGTE RWWLDGPLVH VKSLGEHIAS HIQDEVDFLF SMAANQVFQN 190 200 210 220 230 240 EFGVETLGPL VAQLHAWWYF RNTKNFPYER RPTSAACIPF GQGDFYYGNL MVGGTPHNIL 250 260 270 280 290 300 DFIKEYLNGV IHDIKNGLNS TYEKHLNKYF YLNKPTKLLS PAYSWDLAFS PPPQIQYVKV AHDSQRKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Shan Y.X., Yu L. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY336054 mRNA. Translation: AAQ01588.1. AL354761 Genomic DNA. No translation available.
IPI	IPI00375986.
RefSeq	NP_892019.2.
UniGene	Hs.522491
3D structure databases
HSSP	HSSP built from PDB template 1G93 based on UniProtKB P14769.
ModBase	Search...
Protein family/group databases
CAZy	GT6. Glycosyltransferase Family 6.
Proteomic databases
PRIDE	Q7Z4J2.
Genome annotation databases
Ensembl	ENSG00000204007. Homo sapiens. [Contig view]
GeneID	360203.
KEGG	hsa:360203.
Organism-specific databases
GeneCards	GC09M137655.
HGNC	HGNC:23671. GLT6D1.
PharmGKB	PA134906610.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q7Z4J2.
HOVERGEN	Q7Z4J2.
Gene expression databases
CleanEx	HS_GLT6D1.
Family and domain databases
InterPro	IPR005076. Glyco_trans_6. [Graphical view]
PANTHER	PTHR10462. Glyco_trans_6. 1 hit.
Pfam	PF03414. Glyco_transf_6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	100088.

Entry information

Entry name

GL6D1_HUMAN

Accession

Primary (citable) accession number: Q7Z4J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	October 1, 2003
Last modified:	April 14, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)