Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycosyltransferase 6 domain-containing protein 1

Gene

GLT6D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei263NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyltransferase 6 domain-containing protein 1 (EC:2.4.1.-)
Alternative name(s):
Galactosyltransferase family 6 domain-containing 1
Gene namesi
Name:GLT6D1
Synonyms:GLTDC1, GT6M7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23671. GLT6D1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 23Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini24 – 308LumenalSequence analysisAdd BLAST285

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi360203.
PharmGKBiPA134906610.

Chemistry databases

DrugBankiDB04465. Lactose.

Polymorphism and mutation databases

BioMutaiGLT6D1.
DMDMi74713517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119711 – 308Glycosyltransferase 6 domain-containing protein 1Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z4J2.
PRIDEiQ7Z4J2.

PTM databases

iPTMnetiQ7Z4J2.
PhosphoSitePlusiQ7Z4J2.

Expressioni

Tissue specificityi

Expressed in both healthy and inflamed gingival tissue samples at similar levels, with higher expression in the gingival connective tissue compared to gingival epithelium. Strongest expression in testis, followed by leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000204007.
CleanExiHS_GLT6D1.
ExpressionAtlasiQ7Z4J2. baseline and differential.

Organism-specific databases

HPAiHPA023424.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360829.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4J2.
SMRiQ7Z4J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 87Substrate bindingBy similarity6
Regioni173 – 175Substrate bindingBy similarity3
Regioni195 – 198Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the glycosyltransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE7. Eukaryota.
ENOG4111IPQ. LUCA.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiQ7Z4J2.
PhylomeDBiQ7Z4J2.
TreeFamiTF330991.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z4J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKRMLLLV LFAFSLMLVE RYFRNHQVEE LRLSDWFHPR KRPDVITKTD
60 70 80 90 100
WLAPVLWEGT FDRRVLEKHY RRRNITVGLA VFATGRFAEE YLRPFLHSAN
110 120 130 140 150
KHFMTGYRVI FYIMVDAFFK LPDIEPSPLR TFKAFKVGTE RWWLDGPLVH
160 170 180 190 200
VKSLGEHIAS HIQDEVDFLF SMAANQVFQN EFGVETLGPL VAQLHAWWYF
210 220 230 240 250
RNTKNFPYER RPTSAACIPF GQGDFYYGNL MVGGTPHNIL DFIKEYLNGV
260 270 280 290 300
IHDIKNGLNS TYEKHLNKYF YLNKPTKLLS PAYSWDLAFS PPPQIQYVKV

AHDSQRKL
Length:308
Mass (Da):36,274
Last modified:October 1, 2003 - v1
Checksum:iDB3D7E444D12988C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037382195H → R.1 PublicationCorresponds to variant rs35762223dbSNPEnsembl.1
Natural variantiVAR_037383219P → S.1 PublicationCorresponds to variant rs17040344dbSNPEnsembl.1
Natural variantiVAR_037384282A → E.Corresponds to variant rs12336965dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336054 mRNA. Translation: AAQ01588.1.
AL354761 Genomic DNA. No translation available.
RefSeqiNP_892019.2. NM_182974.2.
UniGeneiHs.522491.

Genome annotation databases

EnsembliENST00000371763; ENSP00000360829; ENSG00000204007.
GeneIDi360203.
KEGGihsa:360203.
UCSCiuc010nbd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336054 mRNA. Translation: AAQ01588.1.
AL354761 Genomic DNA. No translation available.
RefSeqiNP_892019.2. NM_182974.2.
UniGeneiHs.522491.

3D structure databases

ProteinModelPortaliQ7Z4J2.
SMRiQ7Z4J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360829.

Chemistry databases

DrugBankiDB04465. Lactose.

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

PTM databases

iPTMnetiQ7Z4J2.
PhosphoSitePlusiQ7Z4J2.

Polymorphism and mutation databases

BioMutaiGLT6D1.
DMDMi74713517.

Proteomic databases

PaxDbiQ7Z4J2.
PRIDEiQ7Z4J2.

Protocols and materials databases

DNASUi360203.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371763; ENSP00000360829; ENSG00000204007.
GeneIDi360203.
KEGGihsa:360203.
UCSCiuc010nbd.1. human.

Organism-specific databases

CTDi360203.
DisGeNETi360203.
GeneCardsiGLT6D1.
H-InvDBHIX0034812.
HGNCiHGNC:23671. GLT6D1.
HPAiHPA023424.
MIMi613699. gene.
neXtProtiNX_Q7Z4J2.
PharmGKBiPA134906610.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHE7. Eukaryota.
ENOG4111IPQ. LUCA.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiQ7Z4J2.
PhylomeDBiQ7Z4J2.
TreeFamiTF330991.

Miscellaneous databases

GenomeRNAii360203.
PROiQ7Z4J2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204007.
CleanExiHS_GLT6D1.
ExpressionAtlasiQ7Z4J2. baseline and differential.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGL6D1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

An alternative sequence, characterized by a stop codon in position 277, has been described and proposed to be the product of a pseudogene. This shorter sequence does not fulfill all criteria expected for a pseudogene and could be functional (PubMed:19218399). This short form is not supported by the available cDNA sequence, nor by orthologous sequences in other mammalian species.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.